KEGG T01001: 54464

Homo sapiens (human): 54464

Entry

54464 CDS T01001

Gene name

XRN1, SEP1

Definition

5'-3' exoribonuclease 1

Orthology

K12618

5'-3' exoribonuclease 1 [EC:3.1.13.-]

Organism

hsa Homo sapiens (human)

Pathway

hsa03008	Ribosome biogenesis in eukaryotes
hsa03018	RNA degradation

Class

Genetic Information Processing; Translation; Ribosome biogenesis in eukaryotes [PATH:hsa03008]
Genetic Information Processing; Folding, sorting and degradation; RNA degradation [PATH:hsa03018]

SSDB

Motif

Pfam:

XRN_N

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

3q23

AA seq 1693 aa
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKI
FTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGE
TLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHK
IMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHL
HINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKW
FESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDET
EDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSP
IIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLM
CWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFP
TLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWP
HLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEH
YLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFD
SRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDAL
IQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFN
KKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGEN
ENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTV
KPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLF
EVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSS
SSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVL
PQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIEN
FLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQI
ANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVS
TPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALF
ALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTANIMPSSSHLFGSMPWGPSVP
VPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQT
SQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSR
KLAVNFGVSKPSE

NT seq 5082 nt +upstreamnt +downstreamnt
atgggagtccccaagttttacagatggatctcagagcggtatccctgtctcagcgaagtg
gtgaaagagcatcagattcctgaatttgacaacttgtacctggatatgaatggaattata
catcagtgctcccatcctaatgatgatgatgttcactttagaatttcagatgataaaatc
tttactgatatttttcactacctggaggtgttgtttcgcattattaaacccaggaaagtg
ttctttatggctgtagatggtgtggctcctcgagcaaaaatgaaccagcagcgtgggagg
cgttttaggtcagcaaaggaggcagaagacaaaattaaaaaggcaatagagaagggagaa
actcttcctacagaggccagatttgattccaactgtatcacaccaggaactgaatttatg
gccaggttacatgaacatctgaagtattttgtaaatatgaaaatttccacagacaagtca
tggcaaggagttaccatctacttctcaggccatgagactcctggagaaggagagcataaa
atcatggaatttatcagatccgagaaagcaaagccagatcatgatccaaacaccagacac
tgtctttatggtttagatgctgacttgattatgcttggattaacaagtcatgaggcacat
ttttctctcttaagagaagaagttcgatttggtggcaaaaaaacacaacgggtatgtgct
ccagaagaaactacatttcaccttctacacttgtctttaatgagagagtatattgactat
gagttttcagtattaaaagaaaagatcacatttaaatatgatattgaaaggataatagat
gattggattttgatggggtttcttgttggtaatgattttatccctcatctacctcattta
catattaatcatgatgcactgcctcttctttatggaacatatgttaccatcctgccagaa
cttgggggttatattaatgaaagtgggcacctcaacttacctcgatttgagaaatacctt
gtgaaactatcagattttgatcgggagcacttcagtgaagtttttgtggacctaaaatgg
tttgaaagcaaagttggtaacaagtacctcaatgaagcagcaggtgtcgcagcagaagaa
gccaggaactacaaggaaaagaaaaagttaaagggccaggaaaattctctgtgttggact
gctttagacaaaaatgaaggcgaaatgataacttctaaggataatttagaagatgagact
gaagatgatgacctatttgaaactgagtttagacaatataaaagaacatattacatgacg
aagatgggggttgacgtagtatctgatgactttctggctgatcaagctgcatgttatgtt
caggcaatacagtggattttgcactattactatcatggagttcagtcctggagctggtat
tatccttatcattatgcacctttcctgtctgatatacacaacatcagtacactcaaaatc
cattttgaactaggaaaaccttttaagccatttgaacagcttcttgctgtacttccagca
gccagcaaaaatttacttcctgcatgctaccagcatttgatgaccaatgaagactcacca
attatagaatattacccacctgattttaaaactgacctaaatgggaaacaacaggaatgg
gaagctgtggtgttaatcccttttattgatgagaagcgattattggaagccatggagaca
tgtaaccactccctcaaaaaggaagagaggaaaagaaaccaacatagtgagtgcctaatg
tgctggtatgatagagacacagagtttatctatccttctccatggccagaaaagttccct
gccatagaacgatgttgtacaaggtataaaataatatccttagatgcttggcgtgtagac
ataaacaaaaacaaaataaccagaattgaccagaaagcattatatttctgtggatttcct
actctgaaacacatcagacacaaattttttttgaagaaaagtggtgttcaagtattccag
caaagcagtcgtggagaaaacatgatgttggaaatcttagtggatgcagaatcagatgaa
cttaccgtagaaaatgtagcttcatcagtgcttggaaaatctgtctttgttaattggcct
caccttgaggaagctagagtcgtggctgtatcagatggagaaactaagttttacttggaa
gaacctccaggaacacagaagctttattcaggaagaactgccccaccatctaaagtggtt
catcttggagataaagaacaatctaactgggcaaaagaagtacaaggaatttcagaacac
tacctgagaagaaaaggaataataataaatgaaacatctgcagttgtgtatgctcagtta
ctcacaggtcgtaaatatcaaataaatcaaaatggtgaagttcgtctagagaaacagtgg
tcaaaacaagttgttccttttgtttatcaaactattgtcaaggacatccgagctttcgac
tcccgtttctccaatatcaaaacattggatgatttgtttcctctgagaagtatggtcttt
atgctgggaactccctattatggctgcactggagaagttcaggattcaggtgatgtgatt
acagaaggtaggattcgtgtgattttcagcattccatgtgaacccaatcttgatgcttta
atacagaaccagcataaatattctataaagtacaacccaggatatgtgttggccagtcgc
cttggagtgagtggataccttgtttcaaggtttacaggaagtatttttattggaagagga
tctaggagaaaccctcatggagaccataaagcaaatgtgggtttaaatctcaaattcaac
aagaaaaatgaggaggtacctggatatactaagaaagttggaagtgaatggatgtattca
tctgcagcagaacaacttctggcagagtacttagagagagctccagaactatttagttat
atagccaaaaatagccaagaggatgtgttctatgaagatgacatttggcctggagaaaat
gagaatggtgctgaaaaagttcaagaaattattacttggctaaaaggacatcctgtcagt
actttatctcgttcttcttgtgatttacaaattctggatgcagctattgttgagaaaatt
gaggaagaagtcgaaaagtgcaagcaaagaaagaataataagaaggtgcgagtaacagtg
aaaccccatttgctatacagacctttagaacagcaacatggagtcattcctgatcgggat
gcagaattttgtctttttgaccgtgttgtaaatgtgagagaaaacttctcagttccagtt
ggccttcgaggcaccatcataggaataaaaggagctaatagagaagccgatgtactattt
gaagtattatttgatgaagaatttcctggagggttaacaataagatgctcacctggtaga
ggttatcgactgccaacaagtgccttggtgaacctttctcatgggagtcgctctgaaact
ggaaatcagaagttgacagccatcgtaaaaccacaaccagctgtacatcaacatagctca
agttcatcagtttcctctgggcatttgggagccctcaaccattcccctcaatcacttttt
gttcctactcaagtacctactaaagatgatgatgaattctgcaacatttggcagtcctta
cagggatctggaaagatgcaatactttcagccaactatacaagagaagggtgcagttcta
cctcaagaaataagccaagtaaatcaacatcataaatctggctttaatgacaacagtgtt
aaatatcagcaaagaaaacatgaccctcacagaaaatttaaagaagagtgtaagagtcct
aaagctgagtgttggtcccaaaaaatgtccaataagcagcctaactctggaattgagaac
tttttagcatctttgaatatctccaaagaaaatgaagtacagtcatctcatcatggggag
cctccaagtgaagagcatttgtcaccacagtcatttgccatgggaacacggatgcttaaa
gaaattctaaaaattgatggctctaacactgtggaccataagaatgaaatcaaacagatt
gctaatgaaatccctgtttcctctaacagaagagatgaatatggattaccctctcagcct
aaacaaaataagaaattagcatcttatatgaacaagcctcacagtgctaatgagtaccat
aatgttcagtctatggacaatatgtgttggcctgcccccagccagatccctcctgtatcc
acaccagtaactgaactttctcgaatttgttcccttgttggaatgccacaacctgatttc
tcctttcttaggatgccacagacaatgaccgtttgccaagtaaaattatctaatggctta
ctggtacatgggccacagtgccactctgaaaatgaagccaaagagaaagctgcacttttt
gctttacaacagttgggctccttaggcatgaatttccctttgccttcacaagtatttgca
aattatccttcagctgtaccacctggaaccattcctccagcctttcccccacctactgct
aatataatgccttcgtcgtctcatctctttggctcaatgccatggggaccatcggtgcca
gttcctgggaagcccttccatcatactttatattctgggaccatgcccatggctggggga
ataccagggggtgtgcacaatcagtttatacctctgcaggttactaaaaaaagggttgca
aacaaaaagaactttgagaataaggaagcccagagttctcaagccactccagttcagact
agccagccagattcttccaacattgtcaaagtaagtccacgggagagctcatcagcttct
ttgaagtcctctccgattgctcaacctgcatcttcttttcaagttgaaactgcctctcaa
ggccatagtatatctcaccataagtcaacaccaatctcttcttcaagaagaaaatcaaga
aaactggctgttaattttggtgtttctaaaccttctgagtaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (12)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
Protein domain (1)   
   Pfam (1)   
All databases (60)   

Download RDF

DBGET integrated database retrieval system