KEGG   Homo sapiens (human): 54576Help
Entry
54576             CDS       T01001                                 

Gene name
UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H
Definition
(RefSeq) UDP glucuronosyltransferase family 1 member A8
  KO
K00699  glucuronosyltransferase [EC:2.4.1.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00040  Pentose and glucuronate interconversions
hsa00053  Ascorbate and aldarate metabolism
hsa00140  Steroid hormone biosynthesis
hsa00830  Retinol metabolism
hsa00860  Porphyrin and chlorophyll metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis
Module
hsa_M00014  Glucuronate pathway (uronate pathway)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    54576 (UGT1A8)
   00053 Ascorbate and aldarate metabolism
    54576 (UGT1A8)
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    54576 (UGT1A8)
  Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    54576 (UGT1A8)
   00860 Porphyrin and chlorophyll metabolism
    54576 (UGT1A8)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    54576 (UGT1A8)
   00982 Drug metabolism - cytochrome P450
    54576 (UGT1A8)
   00983 Drug metabolism - other enzymes
    54576 (UGT1A8)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    54576 (UGT1A8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.17  glucuronosyltransferase
     54576 (UGT1A8)
Glycosyltransferases [BR:hsa01003]
 Others
  Hydrophobic molecule
   54576 (UGT1A8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: UDPGT Glyco_tran_28_C
Motif
Other DBs
NCBI-GeneID: 54576
NCBI-ProteinID: NP_061949
OMIM: 606433
HGNC: 12540
Ensembl: ENSG00000242366
Vega: OTTHUMG00000059123
Pharos: Q9HAW9(Tbio)
UniProt: Q9HAW9 Q5DSZ6
Position
2q37.1
AA seq 530 aa AA seqDB search
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
NT seq 1593 nt NT seq  +upstreamnt  +downstreamnt
atggctcgcacagggtggaccagccccattcccctatgtgtttctctgctgctgacctgt
ggctttgctgaggcagggaagctgctggtagtgcccatggatgggagtcactggttcacc
atgcagtcggtggtggagaaacttatcctcagggggcatgaggtggttgtagtcatgcca
gaggtgagttggcaactgggaaaatcactgaattgcacagtgaagacttactcaacctca
tacactctggaggatctggaccgggaattcatggatttcgccgatgctcaatggaaagca
caagtacgaagtttgttttctctatttctgagttcatccaatggtttttttaacttattt
ttttcgcattgcaggagtttgtttaatgaccgaaaattagtagaatacttaaaggagagt
tcttttgatgcggtgtttcttgatccttttgatgcctgtggcttaattgttgccaaatat
ttctccctcccctctgtggtcttcgccaggggaatagcttgccactatcttgaagaaggt
gcacagtgccctgctcctctttcctatgtccccagaattctcttagggttctcagatgcc
atgactttcaaggagagagtacggaaccacatcatgcacttggaggaacatttattttgc
cagtatttttccaaaaatgccctagaaatagcctctgaaattctccaaacacctgtcaca
gcatatgatctctacagccacacatcaatttggttgttgcgaacagactttgttttggac
tatcccaaacccgtgatgcccaatatgatcttcattggtggtatcaactgccatcaggga
aagccattgcctatggaatttgaagcctacattaatgcttctggagaacatggaattgtg
gttttctctttgggatcaatggtctcagaaattccagagaagaaagctatggcaattgct
gatgctttgggcaaaatccctcagacagtcctgtggcggtacactggaacccgaccatcg
aatcttgcgaacaacacgatacttgttaagtggctaccccaaaacgatctgcttggtcac
ccgatgacccgtgcctttatcacccatgctggttcccatggtgtttatgaaagcatatgc
aatggcgttcccatggtgatgatgcccttgtttggtgatcagatggacaatgcaaagcgc
atggagactaagggagctggagtgaccctgaatgttctggaaatgacttctgaagattta
gaaaatgctctaaaagcagtcatcaatgacaaaagttacaaggagaacatcatgcgcctc
tccagccttcacaaggaccgcccggtggagccgctggacctggccgtgttctgggtggag
tttgtgatgaggcacaagggcgcgccacacctgcgccccgcagcccacgacctcacctgg
taccagtaccattccttggacgtgattggtttcctcttggccgtcgtgctgacagtggcc
ttcatcacctttaaatgttgtgcttatggctaccggaaatgcttggggaaaaaagggcga
gttaagaaagcccacaaatccaagacccattga

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