KEGG   Homo sapiens (human): 5499Help
Entry
5499              CDS       T01001                                 

Gene name
PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A
Definition
(RefSeq) protein phosphatase 1 catalytic subunit alpha
  KO
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
mRNA surveillance pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Hippo signaling pathway
Focal adhesion
Platelet activation
Long-term potentiation
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Oxytocin signaling pathway
Insulin resistance
Amphetamine addiction
Alcoholism
Herpes simplex infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    5499 (PPP1CA)
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    5499 (PPP1CA)
   04024 cAMP signaling pathway
    5499 (PPP1CA)
   04022 cGMP - PKG signaling pathway
    5499 (PPP1CA)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    5499 (PPP1CA)
   04218 Cellular senescence
    5499 (PPP1CA)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5499 (PPP1CA)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5499 (PPP1CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5499 (PPP1CA)
  Endocrine system
   04910 Insulin signaling pathway
    5499 (PPP1CA)
   04921 Oxytocin signaling pathway
    5499 (PPP1CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5499 (PPP1CA)
   04270 Vascular smooth muscle contraction
    5499 (PPP1CA)
  Nervous system
   04728 Dopaminergic synapse
    5499 (PPP1CA)
   04720 Long-term potentiation
    5499 (PPP1CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5499 (PPP1CA)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    5499 (PPP1CA)
  Substance dependence
   05031 Amphetamine addiction
    5499 (PPP1CA)
   05034 Alcoholism
    5499 (PPP1CA)
  Endocrine and metabolic diseases
   04931 Insulin resistance
    5499 (PPP1CA)
  Infectious diseases
   05168 Herpes simplex infection
    5499 (PPP1CA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5499 (PPP1CA)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5499 (PPP1CA)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5499 (PPP1CA)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic Type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5499 (PPP1CA)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5499 (PPP1CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P62136(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
11q13.2
AA seq 330 aa AA seqDB search
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
NT seq 993 nt NT seq  +upstreamnt  +downstreamnt
atgtccgacagcgagaagctcaacctggactcgatcatcgggcgcctgctggaagtgcag
ggctcgcggcctggcaagaatgtacagctgacagagaacgagatccgcggtctgtgcctg
aaatcccgggagatttttctgagccagcccattcttctggagctggaggcacccctcaag
atctgcggtgacatacacggccagtactacgaccttctgcgactatttgagtatggcggt
ttccctcccgagagcaactacctctttctgggggactatgtggacaggggcaagcagtcc
ttggagaccatctgcctgctgctggcctataagatcaagtaccccgagaacttcttcctg
ctccgtgggaaccacgagtgtgccagcatcaaccgcatctatggtttctacgatgagtgc
aagagacgctacaacatcaaactgtggaaaaccttcactgactgcttcaactgcctgccc
atcgcggccatagtggacgaaaagatcttctgctgccacggaggcctgtccccggacctg
cagtctatggagcagattcggcggatcatgcggcccacagatgtgcctgaccagggcctg
ctgtgtgacctgctgtggtctgaccctgacaaggacgtgcagggctggggcgagaacgac
cgtggcgtctcttttacctttggagccgaggtggtggccaagttcctccacaagcacgac
ttggacctcatctgccgagcacaccaggtggtagaagacggctacgagttctttgccaag
cggcagctggtgacacttttctcagctcccaactactgtggcgagtttgacaatgctggc
gccatgatgagtgtggacgagaccctcatgtgctctttccagatcctcaagcccgccgac
aagaacaaggggaagtacgggcagttcagtggcctgaaccctggaggccgacccatcacc
ccaccccgcaattccgccaaagccaagaaatag

KEGG   Homo sapiens (human): 5500Help
Entry
5500              CDS       T01001                                 

Gene name
PPP1CB, HEL-S-80p, NSLH2, PP-1B, PP1B, PP1beta, PPP1CD
Definition
(RefSeq) protein phosphatase 1 catalytic subunit beta
  KO
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
mRNA surveillance pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Hippo signaling pathway
Focal adhesion
Platelet activation
Long-term potentiation
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Oxytocin signaling pathway
Insulin resistance
Amphetamine addiction
Alcoholism
Herpes simplex infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    5500 (PPP1CB)
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    5500 (PPP1CB)
   04024 cAMP signaling pathway
    5500 (PPP1CB)
   04022 cGMP - PKG signaling pathway
    5500 (PPP1CB)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    5500 (PPP1CB)
   04218 Cellular senescence
    5500 (PPP1CB)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5500 (PPP1CB)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5500 (PPP1CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5500 (PPP1CB)
  Endocrine system
   04910 Insulin signaling pathway
    5500 (PPP1CB)
   04921 Oxytocin signaling pathway
    5500 (PPP1CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5500 (PPP1CB)
   04270 Vascular smooth muscle contraction
    5500 (PPP1CB)
  Nervous system
   04728 Dopaminergic synapse
    5500 (PPP1CB)
   04720 Long-term potentiation
    5500 (PPP1CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5500 (PPP1CB)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    5500 (PPP1CB)
  Substance dependence
   05031 Amphetamine addiction
    5500 (PPP1CB)
   05034 Alcoholism
    5500 (PPP1CB)
  Endocrine and metabolic diseases
   04931 Insulin resistance
    5500 (PPP1CB)
  Infectious diseases
   05168 Herpes simplex infection
    5500 (PPP1CB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5500 (PPP1CB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5500 (PPP1CB)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5500 (PPP1CB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic Type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5500 (PPP1CB)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5500 (PPP1CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P62140(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
2p23.2
AA seq 327 aa AA seqDB search
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKI
CGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ
SMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
KAKYQYGGLNSGRPVTPPRTANPPKKR
NT seq 984 nt NT seq  +upstreamnt  +downstreamnt
atggcggacggggagctgaacgtggacagcctcatcacccggctgctggaggtacgagga
tgtcgtccaggaaagattgtgcagatgactgaagcagaagttcgaggcttatgtatcaag
tctcgggagatctttctcagccagcctattcttttggaattggaagcaccgctgaaaatt
tgtggagatattcatggacaatatacagatttactgagattatttgaatatggaggtttc
ccaccagaagccaactatcttttcttaggagattatgtggacagaggaaagcagtctttg
gaaaccatttgtttgctattggcttataaaatcaaatatccagagaacttctttctctta
agaggaaaccatgagtgtgctagcatcaatcgcatttatggattctatgatgaatgcaaa
cgaagatttaatattaaattgtggaagaccttcactgattgttttaactgtctgcctata
gcagccattgtggatgagaagatcttctgttgtcatggaggattgtcaccagacctgcaa
tctatggagcagattcggagaattatgagacctactgatgtccctgatacaggtttgctc
tgtgatttgctatggtctgatccagataaggatgtgcaaggctggggagaaaatgatcgt
ggtgtttcctttacttttggagctgatgtagtcagtaaatttctgaatcgtcatgattta
gatttgatttgtcgagctcatcaggtggtggaagatggatatgaattttttgctaaacga
cagttggtaaccttattttcagccccaaattactgtggcgagtttgataatgctggtgga
atgatgagtgtggatgaaactttgatgtgttcatttcagatattgaaaccatctgaaaag
aaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaaca
gctaatccgccgaagaaaaggtga

KEGG   Homo sapiens (human): 5501Help
Entry
5501              CDS       T01001                                 

Gene name
PPP1CC, PP-1G, PP1C, PPP1G
Definition
(RefSeq) protein phosphatase 1 catalytic subunit gamma
  KO
K06269  
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
mRNA surveillance pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Oocyte meiosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Hippo signaling pathway
Focal adhesion
Platelet activation
Long-term potentiation
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Oxytocin signaling pathway
Insulin resistance
Amphetamine addiction
Alcoholism
Herpes simplex infection
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Translation
   03015 mRNA surveillance pathway
    5501 (PPP1CC)
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    5501 (PPP1CC)
   04024 cAMP signaling pathway
    5501 (PPP1CC)
   04022 cGMP - PKG signaling pathway
    5501 (PPP1CC)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    5501 (PPP1CC)
   04218 Cellular senescence
    5501 (PPP1CC)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5501 (PPP1CC)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5501 (PPP1CC)
 Organismal Systems
  Immune system
   04611 Platelet activation
    5501 (PPP1CC)
  Endocrine system
   04910 Insulin signaling pathway
    5501 (PPP1CC)
   04921 Oxytocin signaling pathway
    5501 (PPP1CC)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5501 (PPP1CC)
   04270 Vascular smooth muscle contraction
    5501 (PPP1CC)
  Nervous system
   04728 Dopaminergic synapse
    5501 (PPP1CC)
   04720 Long-term potentiation
    5501 (PPP1CC)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5501 (PPP1CC)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    5501 (PPP1CC)
  Substance dependence
   05031 Amphetamine addiction
    5501 (PPP1CC)
   05034 Alcoholism
    5501 (PPP1CC)
  Endocrine and metabolic diseases
   04931 Insulin resistance
    5501 (PPP1CC)
  Infectious diseases
   05168 Herpes simplex infection
    5501 (PPP1CC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5501 (PPP1CC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5501 (PPP1CC)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5501 (PPP1CC)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic Type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5501 (PPP1CC)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5501 (PPP1CC)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P36873(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
12q24.11
AA seq 323 aa AA seqDB search
MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE
KKKPNATRPVTPPRGMITKQAKK
NT seq 972 nt NT seq  +upstreamnt  +downstreamnt
atggcggatttagataaactcaacatcgacagcattatccaacggctgctggaagtgaga
gggtccaagcctggtaagaatgtccagcttcaggagaatgaaatcagaggactgtgctta
aagtctcgtgaaatctttctcagtcagcctatcctactagaacttgaagcaccactcaaa
atatgtggtgacatccatggacaatactatgatttgctgcgactttttgagtacggtggt
ttcccaccagaaagcaactacctgtttcttggggactatgtggacaggggaaagcagtca
ttggagacgatctgcctcttactggcctacaaaataaaatatcctgagaatttttttctt
ctcagagggaaccatgaatgtgccagcatcaacagaatttatggattttatgatgaatgt
aaaagaagatacaacattaaactatggaaaactttcacagactgttttaactgtttaccg
atagcagccatcgtggatgagaagatattctgctgtcatggaggtttatcaccagatctt
caatctatggagcagattcggcgaattatgcgaccaactgatgtaccagatcaaggtctt
ctttgtgatcttttgtggtctgaccccgataaagatgtcttaggctggggtgaaaatgac
agaggagtgtccttcacatttggtgcagaagtggttgcaaaatttctccataagcatgat
ttggatcttatatgtagagcccatcaggtggttgaagatggatatgaattttttgcaaag
aggcagttggtcactctgttttctgcgcccaattattgcggagagtttgacaatgcaggt
gccatgatgagtgtggatgaaacactaatgtgttcttttcagattttaaagcctgcagag
aaaaagaagccaaatgccacgagacctgtaacgcctccaaggggtatgatcacaaagcaa
gcaaagaaatag

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