KEGG   Homo sapiens (human): 55656
Entry
55656             CDS       T01001                                 
Symbol
INTS8, C8orf52, INT8, NEDCHS
Name
(RefSeq) integrator complex subunit 8
  KO
K13145  integrator complex subunit 8
Organism
hsa  Homo sapiens (human)
Disease
H02470  Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    55656 (INTS8)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Proteins involved in snRNP biogenesis
   Integrator complex
    55656 (INTS8)
SSDB
Motif
Pfam: TPR_2 TPR_11
Other DBs
NCBI-GeneID: 55656
NCBI-ProteinID: NP_060334
OMIM: 611351
HGNC: 26048
Ensembl: ENSG00000164941
UniProt: Q75QN2
Structure
Position
8:94823287..94881746
AA seq 995 aa
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
NT seq 2988 nt   +upstreamnt  +downstreamnt
atgagcgcggaggcggcggaccgggaggcggccacctccagccggccctgcaccccgccg
cagacctgctggtttgagtttctgctggaggagtcactgttggagaaacatctgcgcaag
ccctgcccggatcctgcaccagttcaacttatagttcagtttttggaacaggcttccaaa
ccttcagttaatgaacaaaaccaagttcaacctccgcctgataacaagagaaatcgtatt
ttaaaactacttgctcttaaagttgctgcacatttgaagtgggacttagacatattagag
aaaagtttgtctgttccagtattgaatatgctactaaatgaactactctgcatcagtaaa
gttcctcctgggacaaagcatgtagacatggatctggccactttacctccgaccactgcc
atggctgtacttctctataatagatgggcaattaggacaattgttcaaagtagttttcca
gtcaaacaggcaaaacccggaccccctcagttaagtgttatgaatcaaatgcaacaggaa
aaagagctaacagaaaacattttgaaagtgctcaaagaacaagctgctgattctattttg
gtactagaagcagccctaaaattaaacaaggatctttatgtccatacgatgagaactcta
gatttattggccatggaaccaggcatggtaaatggagaaactgagagttctactgctgga
ttgaaagtcaaaaccgaagaaatgcagtgccaggtgtgctatgatttgggcgcagcatac
ttccagcaaggctccacaaattcagctgtctatgaaaatgccagggaaaaattttttaga
accaaagaactaattgcagagataggttcattatctcttcattgtaccatagatgagaag
cggttagctggctattgtcaagcatgtgatgttcttgtaccttcttctgatagtacatct
caacagttgactccatatagtcaagtccatatttgtttgagatctggcaactatcaggag
gtaatacagattttcattgaagacaacttaaccttgagtttacctgtccagttccgacag
tcagtcctaagagaactctttaagaaagctcaacagggaaatgaagctctagatgaaatc
tgttttaaagtttgtgcctgtaatacagtccgtgatatactggaaggcagaacaattagt
gttcaatttaaccagctatttcttagaccaaataaagagaaaatagactttcttcttgag
gtatgttcaagatcagtaaatttagaaaaagcttcagagtctttgaaaggaaacatggct
gcttttctaaagaatgtgtgtctggggttggaagatctgcagtatgttttcatgatttct
tcacatgagcttttcattacattgttgaaagatgaagaacgaaagctacttgttgatcag
atgaggaagagatcccctagagtaaatctgtgcattaaacctgtaacttcattttatgat
atcccagcttcagcaagtgtcaacattggtcagttagagcatcaacttatattgtcagtg
gatccttggaggattagacaaattttaattgaattacatggtatgacttcagagcgccag
ttctggacagtgtctaataagtgggaagtaccttctgtctatagtggtgttatcctggga
attaaagacaatttaacaagagatttggtttatattcttatggccaaaggtttgcactgc
agtactgttaaggacttttcccatgctaaacagctctttgctgcttgtttggagttggta
acagagttctcaccgaagcttcgtcaggtcatgctgaatgagatgttgcttttggatatt
catacacacgaagctgggacagggcaggcaggagagagaccgccatccgaccttataagt
agagtacgaggctatctggaaatgaggcttcctgatattcctcttcgtcaagttatagct
gaggaatgtgttgcctttatgttaaactggagagaaaatgaataccttacactccaagtt
cctgcatttttgcttcagagtaatccatatgtaaagcttggacagcttttagcagctaca
tgcaaagaacttccaggccctaaagaaagtagacggactgccaaagacctttgggaagtt
gttgttcaaatctgtagtgtgtccagtcagcacaaacgaggaaatgatggcagagttagt
ttaataaaacagagggaatctacgttaggtatcatgtatcggagtgaactgctttctttt
atcaaaaaattacgagaaccactcgttttgactattattttatcactctttgtgaaactt
cacaatgttcgggaggacattgtgaatgatattacagctgaacacatttctatttggcca
tcttccattcccaacctccagtctgtggactttgaagctgtggcaatcacagtgaaagag
ctagttcgatatacactcagtataaatccaaataaccattcttggttaattatccaggca
gatatttactttgcaacgaatcagtattcagcagctcttcactattacctccaggcagga
gctgtgtgttctgacttctttaacaaggctgtgccccctgatgtttatacagaccaggta
ataaaacgaatgataaaatgttgttctttgctgaattgccacacacaggtggccatttta
tgtcagttcctcagagaaattgactacaaaacagcgtttaaatctctgcaagaacaaaac
agtcatgatgctatggactcctactacgactacatatgggatgttaccattttggaatac
ttgacttatcttcatcataaaagaggagaaacagataaaagacaaattgcaatcaaagcc
atcggccagacagagttgaatgcaagcaatccagaagaagtgttacagctggcagcgcag
agaaggaaaaaaaagtttctccaagcaatggcaaaactttacttttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (40)   
   RefSeq(nuc) (6)   
   GenBank (17)   
   EMBL (17)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (72)   

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