KEGG T01001: 56848

Homo sapiens (human): 56848

Entry

56848 CDS T01001

Gene name

SPHK2, SK_2, SK-2, SPK_2, SPK-2

Definition

sphingosine kinase 2 (EC:2.7.1.91)

Orthology

K04718

sphingosine kinase [EC:2.7.1.91]

Organism

hsa Homo sapiens (human)

Pathway

hsa00600	Sphingolipid metabolism
hsa01100	Metabolic pathways
hsa04020	Calcium signaling pathway
hsa04370	VEGF signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa05152	Tuberculosis

Module

hsa_M00100

Sphingosine degradation

Class

Metabolism; Lipid metabolism; Sphingolipid metabolism [PATH:hsa00600]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:hsa04370]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:hsa04020]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:hsa04666]
Human Diseases; Infectious diseases; Tuberculosis [PATH:hsa05152]

SSDB

Motif

Pfam:

DAGK_cat

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

19q13.2

AA seq 595 aa
MNGHLEAEEQQDQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYT
YPRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPR
PPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWD
GIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLD
LLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFT
LGTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRS
VSDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPK
AALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFV
LMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQ
LGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP

NT seq 1788 nt +upstreamnt +downstreamnt
atgaatggacaccttgaagcagaggagcagcaggaccaggccctgcacatacagcggctg
cgccccaaacctgaagccaggccccggggtggcctggtcccgttggccgaggtctcaggc
tgctgcaccctgcgaagccgcagcccctcagactcagcggcctacttctgcatctacacc
taccctcggggccggcgcggggcccggcgcagagccactcgcaccttccgggcagatggg
gccgccacctacgaagagaaccgtgccgaggcccagcgctgggccactgccctcacctgt
ctgctccgaggactgccactgcccggggatggggagatcacccctgacctgctacctcgg
ccgccccggttgcttctattggtcaatccctttgggggtcggggcctggcctggcagtgg
tgtaagaaccacgtgcttcccatgatctctgaagctgggctgtccttcaacctcatccag
acagaacgacagaaccacgcccgggagctggtccaggggctgagcctgagtgagtgggat
ggcatcgtcacggtctcgggagacgggctgctccatgaggtgctgaacgggctcctagat
cgccctgactgggaggaagctgtgaagatgcctgtgggcatcctcccctgcggctcgggc
aacgcgctggccggagcagtgaaccagcacgggggatttgagccagccctgggcctcgac
ctgttgctcaactgctcactgttgctgtgccggggtggtggccacccactggacctgctc
tccgtgacgctggcctcgggctcccgctgtttctccttcctgtctgtggcctggggcttc
gtgtcagatgtggatatccagagcgagcgcttcagggccttgggcagtgcccgcttcaca
ctgggcacggtgctgggcctcgccacactgcacacctaccgcggacgcctctcctacctc
cccgccactgtggaacctgcctcgcccacccctgcccatagcctgcctcgtgccaagtcg
gagctgaccctaaccccagacccagccccgcccatggcccactcacccctgcatcgttct
gtgtctgacctgcctcttcccctgccccagcctgccctggcctctcctggctcgccagaa
cccctgcccatcctgtccctcaacggtgggggcccagagctggctggggactggggtggg
gctggggatgctccgctgtccccggacccactgctgtcttcacctcctggctctcccaag
gcagctctacactcacccgtctccgaaggggcccccgtaattcccccatcctctgggctc
ccacttcccacccctgatgcccgggtaggggcctccacctgcggcccgcccgaccacctg
ctgcctccgctgggcaccccgctgcccccagactgggtgacgctggagggggactttgtg
ctcatgttggccatctcgcccagccacctaggcgctgacctggtggcagctccgcatgcg
cgcttcgacgacggcctggtgcacctgtgctgggtgcgtagcggcatctcgcgggctgcg
ctgctgcgccttttcttggccatggagcgtggtagccacttcagcctgggctgtccgcag
ctgggctacgccgcggcccgtgccttccgcctagagccgctcacaccacgcggcgtgctc
acagtggacggggagcaggtggagtatgggccgctacaggcacagatgcaccctggcatc
ggtacactgctcactgggcctcctggctgcccggggcgggagccctga

All links

Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (14)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (3)   
   RefSeq(pep) (5)   
DNA sequence (41)   
   RefSeq(nuc) (5)   
   GenBank (18)   
   EMBL (18)   
Protein domain (1)   
   Pfam (1)   
All databases (90)   

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