KEGG T01001: 57154

Homo sapiens (human): 57154

Entry

57154 CDS T01001

Gene name

SMURF1

Definition

SMAD specific E3 ubiquitin protein ligase 1

Orthology

K04678

E3 ubiquitin ligase SMURF1/2 [EC:6.3.2.19]

Organism

hsa Homo sapiens (human)

Pathway

hsa04120	Ubiquitin mediated proteolysis
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway

Class

Genetic Information Processing; Folding, sorting and degradation; Ubiquitin mediated proteolysis [PATH:hsa04120]
Environmental Information Processing; Signal transduction; TGF-beta signaling pathway [PATH:hsa04350]
Cellular Processes; Transport and catabolism; Endocytosis [PATH:hsa04144]

SSDB

Motif

Pfam:

HECT WW C2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3PYC 2LTX 2LAZ 2LB0 2LB1

Position

7q22.1

AA seq 728 aa
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD
HNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLR
HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVARE
WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYI
NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL
QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK
ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR
VPLQGFKALQGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE
ETCGFAVE

NT seq 2187 nt +upstreamnt +downstreamnt
atgtcgaaccccgggacacgcaggaacggctccagcatcaagatccgtctgacagtgtta
tgtgccaagaaccttgcaaagaaagacttcttcaggctccctgacccttttgcaaagatt
gtcgtggatgggtctgggcagtgccactcaaccgacactgtgaaaaacacattggaccca
aagtggaaccagcactatgatctatatgttgggaaaacggattcgataaccattagcgtg
tggaaccataagaaaattcacaagaaacagggagctggcttcctgggctgtgtgcggctg
ctctccaatgccatcagcagattaaaagataccggataccagcgtttggatctatgcaaa
ctaaacccctcagatactgatgcagttcgtggccagatagtggtcagtttacagacacga
gacagaataggaaccggcggctcggtggtggactgcagaggactgttagaaaatgaagga
acggtgtatgaagactccgggcctgggaggccgctcagctgcttcatggaggaaccagcc
ccttacacagatagcaccggtgctgctgctggaggagggaattgcaggttcgtggagtcc
ccaagtcaagatcaaagacttcaggcacagcggcttcgaaaccctgatgtgcgaggttca
ctacagacgccccagaaccgaccacacggccaccagtccccggaactgcccgaaggctac
gaacaaagaacaacagtccagggccaagtttactttttgcatacacagactggagttagc
acgtggcacgaccccaggataccaagagaccttaacagtgtgaactgtgatgaacttgga
ccactgccgccaggctgggaagtcagaagtacagtttctgggaggatatattttgtagat
cataataaccgaacaacccagtttacagacccaaggttacaccacatcatgaatcaccag
tgccaactcaaggagcccagccagccgctgccactgcccagtgagggctctctggaggac
gaggagcttcctgcccagagatacgaaagagatctagtccagaagctgaaagtcctcaga
cacgaactgtcgcttcagcagccccaagctggtcattgccgcatcgaagtgtccagagaa
gaaatctttgaggagtcttaccgccagataatgaagatgcgaccgaaagacttgaaaaaa
cggctgatggtgaaattccgtggggaagaaggtttggattacggtggtgtggccagggag
tggctttacttgctgtgccatgaaatgctgaatccttattacgggctcttccagtattct
acggacaatatttacatgttgcaaataaatccggattcttcaatcaaccccgaccacttg
tcttatttccactttgtggggcggatcatggggctggctgtgttccatggacactacatc
aacgggggcttcacagtgcccttctacaagcagctgctggggaagcccatccagctctca
gatctggaatctgtggacccagagctgcataagagcttggtgtggatcctagagaacgac
atcacgcctgtactggaccacaccttctgcgtggaacacaacgccttcgggcggatcctg
cagcatgaactgaaacccaatggcagaaatgtgccagtcacagaggagaataagaaagaa
tacgtccggttgtatgtaaactggaggtttatgagaggaatcgaagcccagttcttagct
ctgcagaaggggttcaatgagctcatccctcaacatctgctgaagccttttgaccagaag
gaactggagctgatcataggcggcctggataaaatagacttgaacgactggaagtcgaac
acgcggctgaagcactgtgtggccgacagcaacatcgtgcggtggttctggcaagcggtg
gagacgttcgatgaagaaaggagggccaggctcctgcagtttgtgactgggtccacgcga
gtcccgctccaaggcttcaaggctttgcaaggcgcggcagggccccggctgttcaccatc
cacctgatagacgcgaacacagacaaccttccgaaggcccatacctgctttaaccggatc
gacattccaccatatgagtcctatgagaagctctacgagaagctgctgacagccgtggag
gagacctgcgggtttgctgtggagtga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
3D Structure (5)   
   PDB (5)   
Protein domain (3)   
   Pfam (3)   
All databases (65)   

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