KEGG   Homo sapiens (human): 57154Help
Entry
57154             CDS       T01001                                 

Gene name
SMURF1
Definition
(RefSeq) SMAD specific E3 ubiquitin protein ligase 1
  KO
K04678  
E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
Ubiquitin mediated proteolysis
Endocytosis
Hedgehog signaling pathway
TGF-beta signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    57154 (SMURF1)
 Environmental Information Processing
  Signal transduction
   04340 Hedgehog signaling pathway
    57154 (SMURF1)
   04350 TGF-beta signaling pathway
    57154 (SMURF1)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    57154 (SMURF1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     57154 (SMURF1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    57154 (SMURF1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   57154 (SMURF1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    57154 (SMURF1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
7q22.1
AA seq 757 aa AA seqDB search
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
NT seq 2274 nt NT seq  +upstreamnt  +downstreamnt
atgtcgaaccccgggacacgcaggaacggctccagcatcaagatccgtctgacagtgtta
tgtgccaagaaccttgcaaagaaagacttcttcaggctccctgacccttttgcaaagatt
gtcgtggatgggtctgggcagtgccactcaaccgacactgtgaaaaacacattggaccca
aagtggaaccagcactatgatctatatgttgggaaaacggattcgataaccattagcgtg
tggaaccataagaaaattcacaagaaacagggagctggcttcctgggctgtgtgcggctg
ctctccaatgccatcagcagattaaaagataccggataccagcgtttggatctatgcaaa
ctaaacccctcagatactgatgcagttcgtggccagatagtggtcagtttacagacacga
gacagaataggaaccggcggctcggtggtggactgcagaggactgttagaaaatgaagga
acggtgtatgaagactccgggcctgggaggccgctcagctgcttcatggaggaaccagcc
ccttacacagatagcaccggtgctgctgctggaggagggaattgcaggttcgtggagtcc
ccaagtcaagatcaaagacttcaggcacagcggcttcgaaaccctgatgtgcgaggttca
ctacagacgccccagaaccgaccacacggccaccagtccccggaactgcccgaaggctac
gaacaaagaacaacagtccagggccaagtttactttttgcatacacagactggagttagc
acgtggcacgaccccaggataccaagtccctcggggaccattcctgggggagatgcagct
tttctatacgaattccttctacaaggccatacatctgagcccagagaccttaacagtgtg
aactgtgatgaacttggaccactgccgccaggctgggaagtcagaagtacagtttctggg
aggatatattttgtagatcataataaccgaacaacccagtttacagacccaaggttacac
cacatcatgaatcaccagtgccaactcaaggagcccagccagccgctgccactgcccagt
gagggctctctggaggacgaggagcttcctgcccagagatacgaaagagatctagtccag
aagctgaaagtcctcagacacgaactgtcgcttcagcagccccaagctggtcattgccgc
atcgaagtgtccagagaagaaatctttgaggagtcttaccgccagataatgaagatgcga
ccgaaagacttgaaaaaacggctgatggtgaaattccgtggggaagaaggtttggattac
ggtggtgtggccagggagtggctttacttgctgtgccatgaaatgctgaatccttattac
gggctcttccagtattctacggacaatatttacatgttgcaaataaatccggattcttca
atcaaccccgaccacttgtcttatttccactttgtggggcggatcatggggctggctgtg
ttccatggacactacatcaacgggggcttcacagtgcccttctacaagcagctgctgggg
aagcccatccagctctcagatctggaatctgtggacccagagctgcataagagcttggtg
tggatcctagagaacgacatcacgcctgtactggaccacaccttctgcgtggaacacaac
gccttcgggcggatcctgcagcatgaactgaaacccaatggcagaaatgtgccagtcaca
gaggagaataagaaagaatacgtccggttgtatgtaaactggaggtttatgagaggaatc
gaagcccagttcttagctctgcagaaggggttcaatgagctcatccctcaacatctgctg
aagccttttgaccagaaggaactggagctgatcataggcggcctggataaaatagacttg
aacgactggaagtcgaacacgcggctgaagcactgtgtggccgacagcaacatcgtgcgg
tggttctggcaagcggtggagacgttcgatgaagaaaggagggccaggctcctgcagttt
gtgactgggtccacgcgagtcccgctccaaggcttcaaggctttgcaaggttctacaggc
gcggcagggccccggctgttcaccatccacctgatagacgcgaacacagacaaccttccg
aaggcccatacctgctttaaccggatcgacattccaccatatgagtcctatgagaagctc
tacgagaagctgctgacagccgtggaggagacctgcgggtttgctgtggagtga

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