KEGG T01001: 5770

Homo sapiens (human): 5770

Entry

5770 CDS T01001

Gene name

PTPN1, PTP1B

Definition

protein tyrosine phosphatase, non-receptor type 1 (EC:3.1.3.48)

Orthology

K05696

tyrosine-protein phosphatase non-receptor type 1 [EC:3.1.3.48]

Organism

hsa Homo sapiens (human)

Pathway

hsa04520	Adherens junction
hsa04910	Insulin signaling pathway

Drug target

Other:

D04050

Class

Cellular Processes; Cell communication; Adherens junction [PATH:hsa04520]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]

SSDB

Motif

Pfam:

Y_phosphatase DSPc PTPlike_phytase Y_phosphatase3

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2F71 3CWE 1PA1 3SME 3A5J 2F6T 2F6V 2F6Z 2VEV 1G7F 1C88 1C83 1EEO 3A5K 1PTY 3EAX 1T49 1EEN 1AAX 1SUG 1ECV 2HB1 2F6F 2AZR 1G1F 3QKP 2ZN7 2ZMM 2QBQ 2QBS 2NT7 2NTA 2FJM 2B07 1Q6N 1I57 1C87 1BZH 2F70 1GFY 2F6Y 1PXH 1OEO 1ONY 3QKQ 2VEX 2VEY 2FJN 2F6W 1T48 1Q6J 1Q6M 1Q6S 1PYN 1PH0 1JF7 1G7G 1G1G 3I80 1BZJ 3I7Z 3D9C 2QBR 2H4K 2B4S 1QXK 1Q6P 1Q6T 1OET 1C86 1PTV 1KAV 1C84 1BZC 3EB1 2VEU 1ONZ 1NZ7 1NWL 1NO6 1NNY 1NL9 1G1H 4I8N 2QBP 2H4G 1XBO 1LQF 1L8G 1KAK 1A5Y 1Q1M 1PTU 3EU0 1T4J 1C85 3ZV2 2HNQ 2HNP 1PTT 1NWE 2VEW 2CNE 2CNF 2CNG 2CNH 2CNI 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2BGD 2BGE 1WAX 1OES 1OEU 1OEV 1OEM

Position

20q13.1-q13.2

AA seq 435 aa
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT

NT seq 1308 nt +upstreamnt +downstreamnt
atggagatggaaaaggagttcgagcagatcgacaagtccgggagctgggcggccatttac
caggatatccgacatgaagccagtgacttcccatgtagagtggccaagcttcctaagaac
aaaaaccgaaataggtacagagacgtcagtccctttgaccatagtcggattaaactacat
caagaagataatgactatatcaacgctagtttgataaaaatggaagaagcccaaaggagt
tacattcttacccagggccctttgcctaacacatgcggtcacttttgggagatggtgtgg
gagcagaaaagcaggggtgtcgtcatgctcaacagagtgatggagaaaggttcgttaaaa
tgcgcacaatactggccacaaaaagaagaaaaagagatgatctttgaagacacaaatttg
aaattaacattgatctctgaagatatcaagtcatattatacagtgcgacagctagaattg
gaaaaccttacaacccaagaaactcgagagatcttacatttccactataccacatggcct
gactttggagtccctgaatcaccagcctcattcttgaactttcttttcaaagtccgagag
tcagggtcactcagcccggagcacgggcccgttgtggtgcactgcagtgcaggcatcggc
aggtctggaaccttctgtctggctgatacctgcctcttgctgatggacaagaggaaagac
ccttcttccgttgatatcaagaaagtgctgttagaaatgaggaagtttcggatggggctg
atccagacagccgaccagctgcgcttctcctacctggctgtgatcgaaggtgccaaattc
atcatgggggactcttccgtgcaggatcagtggaaggagctttcccacgaggacctggag
cccccacccgagcatatccccccacctccccggccacccaaacgaatcctggagccacac
aatgggaaatgcagggagttcttcccaaatcaccagtgggtgaaggaagagacccaggag
gataaagactgccccatcaaggaagaaaaaggaagccccttaaatgccgcaccctacggc
atcgaaagcatgagtcaagacactgaagttagaagtcgggtcgtggggggaagtcttcga
ggtgcccaggctgcctccccagccaaaggggagccgtcactgcccgagaaggacgaggac
catgcactgagttactggaagcccttcctggtcaacatgtgcgtggctacggtcctcacg
gccggcgcttacctctgctacaggttcctgttcaacagcaacacatag

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (9)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
3D Structure (121)   
   PDB (121)   
Protein domain (4)   
   Pfam (4)   
All databases (171)   

Download RDF

DBGET integrated database retrieval system