KEGG T01001: 5980

Homo sapiens (human): 5980

Entry

5980 CDS T01001

Gene name

REV3L, POLZ, REV3

Definition

REV3-like, polymerase (DNA directed), zeta, catalytic subunit (EC:2.7.7.7)

Orthology

K02350

DNA polymerase zeta [EC:2.7.7.7]

Organism

hsa Homo sapiens (human)

Pathway

hsa01100	Metabolic pathways
hsa03460	Fanconi anemia pathway

Module

hsa_M00293

DNA polymerase zeta complex

Class

Genetic Information Processing; Replication and repair; Fanconi anemia pathway [PATH:hsa03460]

SSDB

Motif

Pfam:

DNA_pol_B DNA_pol_B_exo1 zf-C4pol

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

4EXT 3ABD 3ABE 4GK0 3VU7 4GK5

Position

6q21

AA seq 3130 aa
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPY
LYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKER
HFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDA
VAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKK
FQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD
KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAG
LESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH
CAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN
SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLS
QTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIF
DYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS
SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQ
EHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGH
QETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG
DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLK
SRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPL
KDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR
SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIM
AAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKL
VDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL
LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSS
KIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE
TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAI
SQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKN
ISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS
PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSD
AVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRR
HNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ
GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTS
SPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPR
EIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS
SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSS
VNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASA
SDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF
LKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLS
PLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKV
SIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTEKT
ELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDI
LLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVG
RITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHY
VSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVT
PSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENL
GKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMV
KQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETL
ERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF
EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFET
RDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRR
SEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSL
IGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKA
PYLRQLLDQF

NT seq 9393 nt +upstreamnt +downstreamnt
atgttttcagtaaggatagtgactgcagactactacatggccagcccgctgcaggggctg
gatacctgccaatcccccctcacccaggcccctgtcaagaaggtgccggtggtgcgagtc
ttcggagcgaccccggcaggtcagaagacatgtcttcatctacatggcatctttccttac
ctctatgtgccatacgatggttatggacagcagccagaaagctatctttctcagatggca
ttcagtatcgacagagcacttaatgtggctttaggcaatccatcttccactgctcagcat
gtgttcaaagtgtcattagtatcaggaatgcctttttatggttatcatgagaaggaaaga
cactttatgaagatctatctttacaatcctacaatggtgaaaaggatatgtgaacttttg
caaagcggagccataatgaataaattttaccagcctcatgaagcgcatattccctacctc
ctacagctcttcattgactacaatctttatggcatgaatttaataaatctggctgctgtc
aagttccgaaaagcaagaaggaaaagtaatacattgcatgcaactggatcctgcaagaat
catttatcaggaaattctcttgctgatactttatttcggtgggaacaagatgaaatacca
agctctttaatattggaaggtgttgaaccacagagtacatgtgaattagaagtggatgct
gtagctgctgatatcttaaatcgtctggacattgaagctcaaattggtggaaaccctggt
ctacaggccatatgggaagatgaaaagcaacggcgaagaaacagaaatgaaacttctcaa
atgagccaacctgagtcacaagatcacaggtttgtgccagcaacagaaagtgaaaaaaaa
tttcagaagagacttcaggaaattctcaaacagaatgatttctctgtaacattatcagga
tctgtggactacagcgatggatcccaggagttctctgctgagttaacattgcactctgag
gttctgtctcctgaaatgcttcagtgtacaccagccaatatggtagaagttcacaaagac
aaagagtcaagcaaaggtcacactagacacaaagtggaagaagctcttattaatgaagaa
gcaattttgaaccttatggaaaatagtcagacttttcagcctttgacccaaagactgagt
gagtcacctgttttcatggacagtagtcctgatgaggctctggtacatcttcttgctggt
ttggaaagtgatggatatcggggggaaagaaataggatgccatcaccatgtcgctccttt
ggaaataataaatatccacaaaatagtgatgatgaagaaaatgaaccacagattgaaaaa
gaggaaatggagcttagtttggtgatgtcccagagatgggacagcaatattgaagaacat
tgtgccaaaaagagatcactgtgcagaaatacccacagaagttcaactgaagatgatgac
tcatcttcaggagaagaaatggaatggagtgataacagtttgcttctagccagtctttct
atacctcagttagatggaactgcagatgaaaatagtgacaatccattgaacaatgaaaat
tctagaacccactcttctgtaattgcaacaagcaagctttcagttaaaccctccatcttt
cacaaagatgctgctacattagaaccctcatcttctgctaagattacctttcagtgtaaa
cacacaagtgccctttcttcccatgttttgaacaaggaagatttaattgaagacctttca
cagacaaacaaaaatacagaaaaaggtctagataactcagtcacttcttttacaaacgaa
agcacttattctatgaaataccctggatctttaagcagtactgttcattcagaaaattct
cataaagagaatagtaagaaagagatcctcccagtatcttcctgtgaaagtagtattttt
gattatgaagaagatattccatctgttacaagacaagtaccaagtagaaaatatacaaac
attagaaaaatcgaaaaggattccccttttatacatatgcaccgtcaccctaacgagaat
acattgggcaaaaattctttcaacttttctgacttaaatcattcaaaaaataaagtatcc
tctgaaggaaatgaaaaaggaaacagcacagctctgagtagtttattcccttcatcattt
actgaaaattgtgaattactgtcatgctcaggggagaatagaactatggtgcattctctt
aatagcactgctgatgaaagtggactaaataaacttaaaattaggtatgaagaatttcaa
gaacataaaacagaaaagccaagcctcagccagcaagcagcacactatatgttttttccc
agtgttgttctttctaactgtcttactagaccacagaaactatctcctgtcacatataaa
ttacaacctggcaataaaccatcccggttaaaattgaataaaaggaaacttgcaggtcat
caggagacttctaccaaaagtagtgagactggatccacaaaagataattttatacaaaat
aatccttgtaatagtaatcctgagaaggataatgcattggctagtgatttaactaaaacc
actcgtggagcttttgaaaataaaacacccacagatggttttatagactgtcactttgga
gatggaacgttagaaactgagcagtcctttggactatatggaaataaatacacacttaga
gccaaacgcaaggtaaattatgagactgaagacagtgagtcaagttttgtaactcacaac
tcaaaaattagtctacctcatcccatggaaattggtgaaagtttagatggaactctcaaa
tcccgaaaacgaagaaaaatgtctaaaaagctgccccctgtcatcataaagtatattatt
attaatagatttagagggagaaaaaatatgcttgtgaagctaggaaaaatagactctaaa
gaaaaacaagtaatattaacagaagaaaaaatggaactatataaaaagcttgcacctttg
aaggacttttggccaaaagttcccgactcccctgcaaccaaatatcccatttatccacta
acaccaaagaaaagtcacagaagaaagtcaaaacataaatctgctaagaaaaaaactggt
aaacaacaaaggacaaataatgaaaatattaaaagaactttgtctttcaggaaaaaacgg
tcacatgctattctttctcctccctcaccatcttacaatgctgaaaccgaagattgtgac
ctgaattatagtgatgttatgtctaaactaggttttctttctgagagaagcacaagtccc
ataaattcttctccacctcgctgctggtctcccacagatccaagagctgaagaaatcatg
gctgctgcagaaaaagaggcaatgctttttaagggtcctaatgtatataagaagactgtt
aattctcgtataggaaaaactagtcgcgcaagagcacagattaagaaatcaaaagcaaag
cttgctaatccctctatagttactaagaaaaggaacaaacgaaatcagacaaataaacta
gtagatgatggaaaaaagaaaccaagagcaaaacaaaaaacaaatgagaaaggtacatcg
agaaagcatacaacacttaaggatgaaaaaataaaatctcagtctggtgctgaggttaag
tttgtactgaaacaccagaatgtgtctgaatttgcaagtagttctggaggctctcaacta
ctttttaaacagaaagatatgccactaatgggctctgctgtagatcatcccctttctgct
tccctacccactggaattaatgcacaacagaagttatctggctgcttttcttctttctta
gaaagcaagaagtctgtagatttgcagacattccccagttcacgagatgatttgcatcca
tcagttgtttgtaattctataggacctggagtctcaaaaattaatgttcaaaggcctcat
aatcaaagtgctatgtttactctaaaggaatcaacgttaattcaaaaaaatatatttgac
ctttccaatcatttatctcaggtagcacagaatacacagatatcttctggtatgtcctca
aagatagaagataatgcaaataatatacaaagaaactatttgtcatcaatcggaaagtta
agtgaatatcgcaattccctagaatcaaagctggaccaagcatatacccctaattttttg
cattgcaaagacagtcagcagcagattgtgtgcatagcggaacagtcaaagcacagtgaa
acttgttctccgggaaatacagcttcagaggaaagccaaatgcctaataattgctttgta
acttccttgagaagtccaatcaaacaaatagcatgggagcaaaagcaaaggggctttatt
ttagatatgtcaaattttaaacctgaaagagtaaaaccgaggtcgttatcagaagcaatt
tcacaaaccaaagcactttctcagtgtaaaaatcgaaatgtgtcaacaccttcagcattt
ggtgaaggacagtctggactggcagttctaaaagaattgttacaaaaaagacagcagaaa
gcacaaaatgcaaatactacacaagacccattatccaataaacatcaaccaaataaaaat
atttctggttcccttgagcataacaaagcaaataaacggacacgatcggtaacgtcccca
agaaaacctcgaactcccagaagtacaaaacaaaaagaaaaaatccccaaacttctcaaa
gtagactctttaaatttacaaaactctagccagttggataactctgtatcagatgatagt
cccatctttttttcagatccaggctttgaaagttgttactcacttgaagatagtttatct
cctgaacataattataattttgatattaacacaataggtcagactggattttgtagcttt
tattctggaagtcagtttgtcccagctgatcagaatttgcctcagaagttcctaagtgat
gctgttcaggatctttttccaggacaagctatagaaaaaaatgagtttttaagtcatgac
aaccagaaatgtgatgaagacaagcatcataccacagactcagcctcatggattagatct
ggtactttaagtcctgaaatttttgagaagtcaaccatagatagcaatgagaatcgtcgc
cacaaccagtggaaaaatagctttcatcctctaacaactcggtctaactcaataatggat
tctttctgtgttcagcaggcagaagactgtctaagtgaaaaatctagattgaataggagt
tcagtaagcaaagaagtgtttcttagcctcccacagccaaacaattcagactggattcaa
ggtcacaccagaaaagaaatgggacagtctcttgactcagccaatacctcttttactgca
atactctcctcccctgatggtgaacttgtagacgtggcctgtgaagatttagaactgtat
gtttcaagaaacaatgatatgttgacaccaactcctgatagttcaccaagatctactagc
tctccttcacaatctaaaaatggcagcttcacccctcgaactgctaacattctgaaacca
cttatgtcccccccaagtagggaagaaattatggcaactttgttggatcatgacctgtct
gagactatttaccaggaaccattttgcagtaatccttctgatgtaccagaaaagcccagg
gagattggtggacggctcctcatggtagaaactcgacttgcaaatgatctggctgagttt
gagggagacttttccttggaaggacttcgtctttggaaaacagcattctcagcaatgact
cagaatccaaggccagggtcaccccttcgcagtggccaaggagttgtcaataaagggtca
agtaatagccctaagatggttgaagataaaaaaattgtgattatgccttgcaaatgtgcc
ccaagtcgacaactggttcaagtgtggcttcaagccaaagaagaatacgaacgttccaag
aaactgcctaaaaccaagccaactggagttgtaaaatctgctgagaactttagctcttca
gttaacccagatgacaaacctgtagtgcctccaaaaatggatgtaagtccatgtatactc
cccactacagcacataccaaggaggatgttgataattctcagattgctttacaagcacca
accacgggatgtagtcaaactgcaagtgaaagtcagatgctgccaccagttgcctctgca
agtgatcccgaaaaagatgaagatgatgatgataactattacattagttatagctcccct
gattctccagtaattcccccttggcaacaaccaatatccccagattccaaagcattaaat
ggagatgatagaccctcatcaccagtagaggagctgccttcattggcttttgagaacttc
ttaaagccaataaaagatggtatacaaaaaagcccctgcagtgagcctcaagagcctcta
gtgatatctccaattaatactagggcaagaactgggaaatgtgaatcactttgctttcat
agtacaccaatcatacagagaaaacttctggaaaggcttcctgaagcacctggccttagc
ccattatcaacagaaccaaaaacacagaagttgagtaataagaaaggaagtaatactgac
actcttagaagagtactgttaacacaagcaaagaatcaatttgcagcagtaaatacccca
cagaaagaaacttctcagattgatggaccatctttaaacaatacttacggtttcaaagtc
agcatacaaaacttacaggaggcaaaagctttacatgagatacaaaatcttaccctaatc
agtgtggagttgcatgctcgaactagacgagacttagaaccggatcctgaatttgaccca
atctgtgctctgttctactgcatctcatctgacactccactgccagatacagaaaaaaca
gaactcacaggtgtaatagtgattgataaagacaagacagttttcagtcaagatatcaga
tatcagactccattacttattagatctggaattacaggactcgaagtcacctatgctgct
gatgagaaggcactttttcatgaaattgcaaatataataaagaggtatgatcctgatatt
ctgctaggatatgagattcagatgcattcctggggttacctcttacaaagggctgccgct
ttaagtattgacttatgtcggatgatctctcgggtgccagatgacaaaattgagaacaga
tttgcagctgaaagagatgagtatggatcatatacaatgagtgagataaatattgttggc
cgaattacactaaatctttggagaatcatgagaaatgaggtggctctaactaactacacc
tttgaaaatgtgagctttcatgttcttcatcagcgttttcccctctttacctttcgagtc
ttgtcagactggtttgataacaagacagatctatacagatggaaaatggttgatcattat
gttagccgtgtccgtggaaatctccaaatgttagaacagctggacctgattgggaaaacc
agtgagatggctagactttttggcattcagtttttacatgtactgacaaggggttcacag
taccgtgtggaatcaatgatgttgcgtattgctaaaccaatgaactatattcctgtgaca
cctagtgttcagcaaagatcccagatgagagccccacagtgtgttcctctaattatggag
cctgaatcccgcttctatagcaactctgttctcgttttggatttccaatcactttatcct
tctattgtgattgcatataactactgcttttccacctgccttggccatgtggagaacttg
ggaaagtatgatgagttcaaatttggctgtacctctctgagagtacctccagatttactt
taccaagttaggcatgatatcacagtgtcccccaatggagtagcttttgtcaagccttca
gtaagaaaaggtgtactaccaagaatgcttgaagaaattttgaagactagatttatggtg
aagcagtcaatgaaggcttacaagcaagacagagccctgtcacgaatgcttgatgcgcgt
cagttgggacttaagctgatagcaaatgtcacatttggctatacatctgctaatttttct
gggagaatgccatgcattgaggttggcgatagtattgttcacaaagccagagagaccttg
gaacgagctattaaactggtgaatgataccaagaaatggggggctagggttgtatatggc
gatactgacagtatgtttgtgctactgaaaggagccactaaggagcagtcttttaagatt
ggtcaggaaattgccgaagctgtaactgctaccaatcctaaaccagtgaaattgaagttt
gaaaaggtatatttgccctgtgttttacaaacaaaaaagaggtatgtgggttacatgtat
gaaacactggatcagaaggacccagtatttgatgcaaaaggaatagaaacagtcagaaga
gattcctgccctgctgtttctaagatacttgagcgttctctaaagctgctatttgaaacg
agagatataagtctaattaaacagtatgttcagcgacaatgtatgaagcttctggaagga
aaggccagcatacaagactttatctttgccaaggaatacagaggaagtttttcttataaa
ccaggagcttgtgtgccagcccttgaacttacaaggaaaatgctgacttatgaccggcgc
tctgagcctcaggttggggagcgagtgccatacgtcatcatttatgggacccccggagta
ccacttatccagcttgtaaggcgcccagtggaagtcctgcaggacccaactctgagactg
aatgctacttactatattaccaagcaaatccttccacccttggcaagaatcttctcactt
attggtattgatgtcttcagctggtatcatgaattaccaaggatccataaagctaccagc
tcctcgcgaagtgaacctgaagggcggaaaggcactatttcacaatattttactacctta
cactgtcctgtgtgtgatgacctaactcagcatggcatctgtagtaaatgtcggagccaa
cctcagcatgttgcagtcatcctcaaccaagaaatccgggagttggaacgtcaacaggag
caacttgtaaagatatgcaagaactgtacaggttgctttgatcgacacatcccatgtgtt
tctctgaactgcccagtacttttcaaactctcccgagtaaatagagaattgtccaaggca
ccatatctccggcagttattagaccagttttaa

All links

Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (13)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (69)   

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