| Entry |
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| Gene name |
RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
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| Definition |
ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)
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| Orthology |
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| Organism |
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| Pathway |
| MAPK signaling pathway | | Oocyte meiosis | | mTOR signaling pathway | | Long-term potentiation | | Neurotrophin signaling pathway | | Progesterone-mediated oocyte maturation |
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| Disease |
| Non-syndromic X-linked mental retardation | | Coffin-Lowry syndrome (CLS) |
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| Class |
Environmental Information Processing; Signal transduction; MAPK signaling pathway [PATH: hsa04010]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH: hsa04150]
Cellular Processes; Cell growth and death; Oocyte meiosis [PATH: hsa04114]
Organismal Systems; Endocrine system; Progesterone-mediated oocyte maturation [PATH: hsa04914]
Organismal Systems; Nervous system; Long-term potentiation [PATH: hsa04720]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH: hsa04722]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
Xp22.2-p22.1
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| AA seq |
740 aa  
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
VGRSTLAQRRGIKKITSTAL |
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| NT seq |
2223 nt  +upstreamnt +downstreamnt
atgccgctggcgcagctggcggacccgtggcagaagatggctgtggagagcccgtccgac
agcgctgagaatggacagcaaattatggatgaacctatgggagaggaggagattaaccca
caaactgaagaagtcagtatcaaagaaattgcaatcacacatcatgtaaaggaaggacat
gaaaaggcagatccttcccagtttgaacttttaaaagtattagggcagggatcatttgga
aaggttttcttagttaaaaaaatctcaggctctgatgctaggcagctttatgccatgaag
gtattgaagaaggccacactgaaagttcgagaccgagttcggacaaaaatggaacgtgat
atcttggtagaggttaatcatccttttattgtcaagttgcattatgcttttcaaactgaa
gggaagttgtatcttattttggattttctcaggggaggagatttgtttacacgcttatcc
aaagaggtgatgttcacagaagaagatgtcaaattctacttggctgaacttgcacttgct
ttagaccatctacatagcctgggaataatttatagagacttaaaaccagaaaatatactt
cttgatgaagaaggtcacatcaagttaacagatttcggcctaagtaaagagtctattgac
catgaaaagaaggcatattctttttgtggaactgtggagtatatggctccagaagtagtt
aatcgtcgaggtcatactcagagtgctgactggtggtcttttggtgtgttaatgtttgaa
atgcttactggtacactccctttccaaggaaaagatcgaaaagaaacaatgactatgatt
cttaaagccaaacttggaatgccacagtttttgagtcctgaagcgcagagtcttttacga
atgcttttcaagcgaaatcctgcaaacagattaggtgcaggaccagatggagttgaagaa
attaaaagacattcatttttctcaacgatagactggaataaactgtatagaagagaaatt
catccgccatttaaacctgcaacgggcaggcctgaagatacattctattttgatcctgag
tttactgcaaaaactcccaaagattcacctggcattccacctagtgctaatgcacatcag
ctttttcgggggtttagttttgttgctattacctcagatgatgaaagccaagctatgcag
acagttggtgtacattcaattgttcagcagttacacaggaacagtattcagtttactgat
ggatatgaagtaaaagaagatattggagttggctcctactctgtttgcaagagatgtata
cataaagctacaaacatggagtttgcagtgaagattattgataaaagcaagagagaccca
acagaagaaattgaaattcttcttcgttatggacagcatccaaacattatcactctaaag
gatgtatatgatgatggaaagtatgtgtatgtagtaacagaacttatgaaaggaggtgaa
ttgctggataaaattcttagacaaaaatttttctctgaacgagaggccagtgctgtcctg
ttcactataactaaaaccgttgaatatcttcacgcacaaggggtggttcatagagacttg
aaacctagcaacattctttatgtggatgaatctggtaatccggaatctattcgaatttgt
gattttggctttgcaaaacagctgagagcggaaaatggtcttctcatgactccttgttac
actgcaaattttgttgcaccagaggttttaaaaagacaaggctatgatgctgcttgtgat
atatggagtcttggtgtcctactctatacaatgcttaccggttacactccatttgcaaat
ggtcctgatgatacaccagaggaaatattggcacgaataggtagcggaaaattctcactc
agtggtggttactggaattctgtttcagacacagcaaaggacctggtgtcaaagatgctt
catgtagaccctcatcagagactgactgctgctcttgtgctcagacatccttggatcgtc
cactgggaccaactgccacaataccaactaaacagacaggatgcaccacatctagtaaag
ggtgccatggcagctacatattctgctttgaaccgtaatcagtcaccagttttggaacca
gtaggccgctctactcttgctcagcggagaggtattaaaaaaatcacctcaacagccctg
tga |
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