KEGG   Homo sapiens (human): 6197Help
Entry
6197              CDS       T01001                                 

Gene name
RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2
Definition
ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)
Orthology
K04373  
p90 ribosomal S6 kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Oocyte meiosis
mTOR signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Progesterone-mediated oocyte maturation
Disease
H00480  
Non-syndromic X-linked mental retardation
H00574  
Coffin-Lowry syndrome (CLS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    6197 (RPS6KA3)
   04150 mTOR signaling pathway
    6197 (RPS6KA3)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    6197 (RPS6KA3)
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    6197 (RPS6KA3)
  Nervous system
   04720 Long-term potentiation
    6197 (RPS6KA3)
   04722 Neurotrophin signaling pathway
    6197 (RPS6KA3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6197 (RPS6KA3)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  RSK family [OT]
   6197 (RPS6KA3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
Xp22.2-p22.1
AA seq 740 aa AA seqDB search
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
VGRSTLAQRRGIKKITSTAL
NT seq 2223 nt NT seq  +upstreamnt  +downstreamnt
atgccgctggcgcagctggcggacccgtggcagaagatggctgtggagagcccgtccgac
agcgctgagaatggacagcaaattatggatgaacctatgggagaggaggagattaaccca
caaactgaagaagtcagtatcaaagaaattgcaatcacacatcatgtaaaggaaggacat
gaaaaggcagatccttcccagtttgaacttttaaaagtattagggcagggatcatttgga
aaggttttcttagttaaaaaaatctcaggctctgatgctaggcagctttatgccatgaag
gtattgaagaaggccacactgaaagttcgagaccgagttcggacaaaaatggaacgtgat
atcttggtagaggttaatcatccttttattgtcaagttgcattatgcttttcaaactgaa
gggaagttgtatcttattttggattttctcaggggaggagatttgtttacacgcttatcc
aaagaggtgatgttcacagaagaagatgtcaaattctacttggctgaacttgcacttgct
ttagaccatctacatagcctgggaataatttatagagacttaaaaccagaaaatatactt
cttgatgaagaaggtcacatcaagttaacagatttcggcctaagtaaagagtctattgac
catgaaaagaaggcatattctttttgtggaactgtggagtatatggctccagaagtagtt
aatcgtcgaggtcatactcagagtgctgactggtggtcttttggtgtgttaatgtttgaa
atgcttactggtacactccctttccaaggaaaagatcgaaaagaaacaatgactatgatt
cttaaagccaaacttggaatgccacagtttttgagtcctgaagcgcagagtcttttacga
atgcttttcaagcgaaatcctgcaaacagattaggtgcaggaccagatggagttgaagaa
attaaaagacattcatttttctcaacgatagactggaataaactgtatagaagagaaatt
catccgccatttaaacctgcaacgggcaggcctgaagatacattctattttgatcctgag
tttactgcaaaaactcccaaagattcacctggcattccacctagtgctaatgcacatcag
ctttttcgggggtttagttttgttgctattacctcagatgatgaaagccaagctatgcag
acagttggtgtacattcaattgttcagcagttacacaggaacagtattcagtttactgat
ggatatgaagtaaaagaagatattggagttggctcctactctgtttgcaagagatgtata
cataaagctacaaacatggagtttgcagtgaagattattgataaaagcaagagagaccca
acagaagaaattgaaattcttcttcgttatggacagcatccaaacattatcactctaaag
gatgtatatgatgatggaaagtatgtgtatgtagtaacagaacttatgaaaggaggtgaa
ttgctggataaaattcttagacaaaaatttttctctgaacgagaggccagtgctgtcctg
ttcactataactaaaaccgttgaatatcttcacgcacaaggggtggttcatagagacttg
aaacctagcaacattctttatgtggatgaatctggtaatccggaatctattcgaatttgt
gattttggctttgcaaaacagctgagagcggaaaatggtcttctcatgactccttgttac
actgcaaattttgttgcaccagaggttttaaaaagacaaggctatgatgctgcttgtgat
atatggagtcttggtgtcctactctatacaatgcttaccggttacactccatttgcaaat
ggtcctgatgatacaccagaggaaatattggcacgaataggtagcggaaaattctcactc
agtggtggttactggaattctgtttcagacacagcaaaggacctggtgtcaaagatgctt
catgtagaccctcatcagagactgactgctgctcttgtgctcagacatccttggatcgtc
cactgggaccaactgccacaataccaactaaacagacaggatgcaccacatctagtaaag
ggtgccatggcagctacatattctgctttgaaccgtaatcagtcaccagttttggaacca
gtaggccgctctactcttgctcagcggagaggtattaaaaaaatcacctcaacagccctg
tga

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