KEGG   Homo sapiens (human): 6199Help
Entry
6199              CDS       T01001                                 

Gene name
RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb
Definition
ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1)
Orthology
K04688  
p70 ribosomal S6 kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Proteoglycans in cancer
Acute myeloid leukemia
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    6199 (RPS6KB2)
   04350 TGF-beta signaling pathway
    6199 (RPS6KB2)
   04066 HIF-1 signaling pathway
    6199 (RPS6KB2)
   04151 PI3K-Akt signaling pathway
    6199 (RPS6KB2)
   04152 AMPK signaling pathway
    6199 (RPS6KB2)
   04150 mTOR signaling pathway
    6199 (RPS6KB2)
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    6199 (RPS6KB2)
  Endocrine system
   04910 Insulin signaling pathway
    6199 (RPS6KB2)
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    6199 (RPS6KB2)
   05205 Proteoglycans in cancer
    6199 (RPS6KB2)
   05221 Acute myeloid leukemia
    6199 (RPS6KB2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6199 (RPS6KB2)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  RSK family [OT]
   6199 (RPS6KB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
11q13.2
AA seq 482 aa AA seqDB search
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
NT seq 1449 nt NT seq  +upstreamnt  +downstreamnt
atggcggccgtgtttgatttggatttggagacggaggaaggcagcgagggcgagggcgag
ccagagctcagccccgcggacgcatgtccccttgccgagttgagggcagctggcctagag
cctgtgggacactatgaagaggtggagctgactgagaccagcgtgaacgttggcccagag
cgcatcgggccccactgctttgagctgctgcgtgtgctgggcaaggggggctatggcaag
gtgttccaggtgcgaaaggtgcaaggcaccaacttgggcaaaatatatgccatgaaagtc
ctaaggaaggccaaaattgtgcgcaatgccaaggacacagcacacacacgggctgagcgg
aacattctagagtcagtgaagcacccctttattgtggaactggcctatgccttccagact
ggtggcaaactctacctcatccttgagtgcctcagtggtggcgagctcttcacgcatctg
gagcgagagggcatcttcctggaagatacggcctgcttctacctggctgagatcacgctg
gccctgggccatctccactcccagggcatcatctaccgggacctcaagcccgagaacatc
atgctcagcagccagggccacatcaaactgaccgactttggactctgcaaggagtctatc
catgagggcgccgtcactcacaccttctgcggcaccattgagtacatggcccctgagatt
ctggtgcgcagtggccacaaccgggctgtggactggtggagcctgggggccctgatgtac
gacatgctcactggatcgccgcccttcaccgcagagaaccggaagaaaaccatggataag
atcatcaggggcaagctggcactgcccccctacctcaccccagatgcccgggaccttgtc
aaaaagtttctgaaacggaatcccagccagcggattgggggtggcccaggggatgctgct
gatgtgcagagacatccctttttccggcacatgaattgggacgaccttctggcctggcgt
gtggacccccctttcaggccctgtctgcagtcagaggaggacgtgagccagtttgatacc
cgcttcacacggcagacgccggtggacagtcctgatgacacagccctcagcgagagtgcc
aaccaggccttcctgggcttcacatacgtggcgccgtctgtcctggacagcatcaaggag
ggcttctccttccagcccaagctgcgctcacccaggcgcctcaacagtagcccccgggcc
cccgtcagccccctcaagttctccccttttgaggggtttcggcccagccccagcctgccg
gagcccacggagctacctctacctccactcctgccaccgccgccgccctcgaccaccgcc
cctctccccatccgtcccccctcagggaccaagaagtccaagaggggccgtgggcgtcca
gggcgctag

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