KEGG   Homo sapiens (human): 6199Help
Entry
6199              CDS       T01001                                 

Gene name
RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb
Definition
ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1)
Orthology
K04688  
p70 ribosomal S6 kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Insulin signaling pathway
Proteoglycans in cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    6199 (RPS6KB2)
   04350 TGF-beta signaling pathway
    6199 (RPS6KB2)
   04066 HIF-1 signaling pathway
    6199 (RPS6KB2)
   04151 PI3K-Akt signaling pathway
    6199 (RPS6KB2)
   04152 AMPK signaling pathway
    6199 (RPS6KB2)
   04150 mTOR signaling pathway
    6199 (RPS6KB2)
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    6199 (RPS6KB2)
  Endocrine system
   04910 Insulin signaling pathway
    6199 (RPS6KB2)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    6199 (RPS6KB2)
   05221 Acute myeloid leukemia
    6199 (RPS6KB2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6199 (RPS6KB2)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: AGC group
  RSK family [OT]
   6199 (RPS6KB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Position
11q13.2
AA seq 482 aa AA seqDB search
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
NT seq 1449 nt NT seq  +upstreamnt  +downstreamnt
atggcggccgtgtttgatttggatttggagacggaggaaggcagcgagggcgagggcgag
ccagagctcagccccgcggacgcatgtccccttgccgagttgagggcagctggcctagag
cctgtgggacactatgaagaggtggagctgactgagaccagcgtgaacgttggcccagag
cgcatcgggccccactgctttgagctgctgcgtgtgctgggcaaggggggctatggcaag
gtgttccaggtgcgaaaggtgcaaggcaccaacttgggcaaaatatatgccatgaaagtc
ctaaggaaggccaaaattgtgcgcaatgccaaggacacagcacacacacgggctgagcgg
aacattctagagtcagtgaagcacccctttattgtggaactggcctatgccttccagact
ggtggcaaactctacctcatccttgagtgcctcagtggtggcgagctcttcacgcatctg
gagcgagagggcatcttcctggaagatacggcctgcttctacctggctgagatcacgctg
gccctgggccatctccactcccagggcatcatctaccgggacctcaagcccgagaacatc
atgctcagcagccagggccacatcaaactgaccgactttggactctgcaaggagtctatc
catgagggcgccgtcactcacaccttctgcggcaccattgagtacatggcccctgagatt
ctggtgcgcagtggccacaaccgggctgtggactggtggagcctgggggccctgatgtac
gacatgctcactggatcgccgcccttcaccgcagagaaccggaagaaaaccatggataag
atcatcaggggcaagctggcactgcccccctacctcaccccagatgcccgggaccttgtc
aaaaagtttctgaaacggaatcccagccagcggattgggggtggcccaggggatgctgct
gatgtgcagagacatccctttttccggcacatgaattgggacgaccttctggcctggcgt
gtggacccccctttcaggccctgtctgcagtcagaggaggacgtgagccagtttgatacc
cgcttcacacggcagacgccggtggacagtcctgatgacacagccctcagcgagagtgcc
aaccaggccttcctgggcttcacatacgtggcgccgtctgtcctggacagcatcaaggag
ggcttctccttccagcccaagctgcgctcacccaggcgcctcaacagtagcccccgggcc
cccgtcagccccctcaagttctccccttttgaggggtttcggcccagccccagcctgccg
gagcccacggagctacctctacctccactcctgccaccgccgccgccctcgaccaccgcc
cctctccccatccgtcccccctcagggaccaagaagtccaagaggggccgtgggcgtcca
gggcgctag

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