KEGG T01001: 6332

Homo sapiens (human): 6332

Entry

6332 CDS T01001

Gene name

SCN7A, NaG, Nav2.1, Nav2.2, SCN6A

Definition

(RefSeq) sodium voltage-gated channel alpha subunit 7

K04839

voltage-gated sodium channel type VII alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

Drug target

Prilocaine (DG00803):

D00553 D01243

Brite

KEGG Orthology (KO) [BR:hsa00001]
Organismal Systems
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    6332 (SCN7A)
Ion channels [BR:hsa04040]
Voltage-gated cation channels
  Na+ channel, SCN alpha, NaV1.x
   6332 (SCN7A)

SSDB

Motif

Pfam:

Ion_trans Na_trans_assoc GPHH IQ

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q01118(Tclin)

UniProt:

Q01118

Position

2q24.3

AA seq 1682 aa
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG
MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF
QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW
NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV
IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG
ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH
QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK
ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK
TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG
NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM
LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI
DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV
LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH
VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS
GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG
CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ
RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR
EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF
AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT
FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK
IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL
ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL
LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML
DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN
IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI
ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL
KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS
QI

NT seq 5049 nt +upstreamnt +downstreamnt
atgttggcttcaccagaacctaagggccttgttcccttcactaaagagtcttttgaactt
ataaaacagcatattgctaaaacacataatgaagaccatgaagaagaagacttaaagcca
actcctgatttggaagttggcaaaaagcttccatttatttatggaaacctttctcaagga
atggtgtcagagcccttggaagatgtggacccatattactacaagaaaaaaaatactttc
atagtattaaataaaaatagaacaatcttcagattcaatgcggcttccatcttgtgtaca
ttgtctcctttcaattgtattagaagaacaactatcaaggttttggtacatccctttttc
caactgtttattctaattagtgtcctgattgattgcgtattcatgtccctgactaatttg
ccaaaatggagaccagtattagagaatactttgcttggaatttacacatttgaaatactt
gtaaaactctttgcaagaggtgtctgggcaggatcattttccttcctcggtgatccatgg
aactggctcgatttcagcgtaactgtgtttgaggttattataagatactcacctctggac
ttcattccaacgcttcaaactgcaagaactttgagaattttaaaaattattcctttaaat
caaggtctgaaatcccttgtaggggtcctgatccactgcttgaagcagcttattggtgtc
attatcctaactctgttttttctgagcatattttctctaattgggatggggctcttcatg
ggcaacttgaaacataaatgttttcgatggccccaagagaatgaaaatgaaaccctgcac
aacagaactggaaacccatattatattcgagaaacagaaaacttttattatttggaagga
gaaagatatgctctcctttgtggcaacaggacagatgctggtcagtgtcctgaaggatat
gtgtgtgtaaaagctggcataaatcctgatcaaggcttcacaaattttgacagttttggc
tgggccttatttgccctatttcggttaatggctcaggattaccctgaagtactttatcac
cagatactttatgcttctgggaaggtctacatgatattttttgtggtggtaagttttttg
ttttccttttatatggcaagtttgttcttaggcatacttgccatggcctatgaagaagaa
aagcagagagttggtgaaatatctaagaagattgaaccaaaatttcaacagactggaaaa
gaacttcaagaaggaaatgaaacagatgaggccaagaccatacaaatagaaatgaagaaa
aggtcaccaatttccacagacacatcattggatgtgttggaagatgctactctcagacat
aaggaagaacttgaaaaatccaagaagatatgcccattatactggtataagtttgctaaa
actttcttgatctggaattgttctccctgttggttaaaattgaaagagtttgtccatagg
attataatggcaccatttactgatcttttccttatcatatgcataattttaaacgtatgt
tttctgaccttggagcattatccaatgagtaaacaaactaacactcttctcaacattgga
aacctggttttcattggaattttcacagcagaaatgatttttaaaataattgcaatgcat
ccatatgggtatttccaagtaggttggaacatttttgatagcatgatagtgttccatggt
ttaatagaactttgtctagcaaatgttgcaggaatggctcttcttcgattattcaggatg
ttaagaattttcaagttgggaaagtattggccaacattccagattttgatgtggtctctt
agtaactcatgggtggccctgaaagacttggtcctgttgttgttcacattcatcttcttt
tctgctgcattcggcatgaagctgtttggtaagaattatgaagaatttgtctgccacata
gacaaagactgtcaactcccacgctggcacatgcatgactttttccactccttcctgaat
gtgttccgaattctctgtggagagtgggtagagaccttgtgggactgtatggaggttgca
ggccaatcctggtgtattcctttttacctgatggtcattttaattggaaatttactggta
ctttacctgtttctggcattggtgagctcatttagttcatgcaaggatgtaacagctgaa
gagaataatgaagcaaaaaatctccagcttgcagtggcaagaattaaaaaaggaataaac
tatgtgcttcttaaaatactatgcaaaacacaaaatgtcccaaaggacacaatggaccat
gtaaatgaggtatatgttaaagaagatatttctgaccataccctttctgaattgagcaac
acccaagattttctcaaagataaggaaaaaagcagtggcacagagaaaaacgctactgaa
aatgagagccaatcacttatccccagtcctagtgtctcagaaactgtaccaattgcttca
ggagaatctgatatagaaaatctggataataaggagattcagagtaagtctggtgatgga
ggcagcaaagagaaaataaagcaatctagctcatctgaatgcagtactgttgatattgct
atctctgaagaagaagaaatgttctatggaggtgaaagatcaaagcatctgaaaaatggt
tgcagacgcggatcttcacttggtcaaatcagtggagcatccaagaaaggaaaaatctgg
cagaacatcaggaaaacctgctgcaagattgtagagaacaattggtttaagtgttttatt
gggcttgttactctgctcagcactggcactctggcttttgaagatatatatatggatcag
agaaagacaattaaaattttattagaatatgctgacatgatctttacttatatcttcatt
ctggaaatgcttctaaaatggatggcatatggttttaaggcctatttctctaatggctgg
tacaggctggacttcgtggttgttattgtgttttgtcttagcttaataggcaaaactcgg
gaagaactaaaacctcttatttccatgaaattccttcggcccctcagagttctatctcaa
tttgaaagaatgaaggtggttgtgagagctttgatcaaaacaaccttacccactttgaat
gtgtttcttgtctgcctgatgatctggctgatttttagtatcatgggagtagacttattt
gctggcagattctatgaatgcattgacccaacaagtggagaaaggtttccttcatctgaa
gtcatgaataagagtcggtgtgaaagccttctgtttaacgaatccatgctatgggaaaat
gcaaaaatgaactttgataatgttggaaatggtttcctttctctgcttcaagtagcaaca
tttaatggatggatcactattatgaattcagcaattgattctgttgctgttaatatacag
cctcattttgaagtcaacatctacatgtattgttactttatcaactttattatatttgga
gtatttctccctctgagtatgctgattactgttattattgataatttcaacaagcataaa
ataaagctgggaggctcaaatatctttataacggttaaacagagaaaacagtaccgcagg
ctgaagaagctaatgtatgaggattctcaaagaccagtacctcgcccattaaacaagctc
caaggattcatctttgatgtggtaacaagccaagcttttaatgtcattgttatggttctt
atatgtttccaagcaatagccatgatgatagacactgatgttcagagtctacaaatgtcc
attgctctctactggattaactcaatttttgttatgctatatactatggaatgtatactg
aagctcatcgctttccgttgtttttatttcaccattgcgtggaacatttttgattttatg
gtggttattttctccatcacaggactatgtctgcctatgacagtaggatcctaccttgtg
cctccttcacttgtgcaactgatacttctctcacggatcattcacatgctgcgtcttgga
aaaggaccaaaggtgtttcataatctgatgcttcctttgatgctgtccctcccagcatta
ttgaacatcattcttctcatcttcctggtcatgttcatctatgccgtatttggaatgtat
aattttgcctatgttaaaaaagaagctggaattaatgatgtgtctaattttgaaaccttt
ggcaacagtatgctctgtctttttcaagttgcaatatttgctggttgggatgggatgctt
gatgcaattttcaacagtaaatggtctgactgtgatcctgataaaattaaccctgggact
caagttagaggagattgtgggaacccctctgttgggattttttattttgtcagttatatc
ctcatatcatggctgatcattgtaaatatgtacattgttgttgtcatggagtttttaaat
attgcttctaagaagaaaaacaagaccttgagtgaagatgattttaggaaattctttcag
gtatggaaaaggtttgatcctgataggacccagtacatagactctagcaagctttcagat
tttgcagctgctcttgatcctcctcttttcatggcaaaaccaaacaagggccagctcatt
gctttggacctccccatggctgttggggacagaattcattgcctcgatatcttacttgct
tttacaaagagagttatgggtcaagatgtgaggatggagaaagttgtttcagaaatagaa
tcagggtttttgttagccaacccttttaagatcacatgtgagccaattacgactactttg
aaacgaaaacaagaggcagtttcagcaaccatcattcaacgtgcttataaaaattaccgc
ttgaggcgaaatgacaaaaatacatcagatattcatatgatagatggtgacagagatgtt
catgctactaaagaaggtgcctattttgacaaagctaaggaaaagtcacctattcaaagc
cagatctaa

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (2)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (21)   
   RefSeq(nuc) (7)   
   GenBank (7)   
   EMBL (7)   
Protein domain (4)   
   Pfam (4)   
All databases (57)   

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