KEGG T01001: 64135

Homo sapiens (human): 64135

Entry

64135 CDS T01001

Gene name

IFIH1, Hlcd, IDDM19, MDA-5, MDA5, RLR-2

Definition

interferon induced with helicase C domain 1 (EC:3.6.4.13)

Orthology

K12647

interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]

Organism

hsa Homo sapiens (human)

Pathway

hsa04622	RIG-I-like receptor signaling pathway
hsa05161	Hepatitis B
hsa05162	Measles
hsa05164	Influenza A
hsa05168	Herpes simplex infection

Disease

H00408

Type I diabetes mellitus

Class

Organismal Systems; Immune system; RIG-I-like receptor signaling pathway [PATH:hsa04622]
Human Diseases; Infectious diseases; Measles [PATH:hsa05162]
Human Diseases; Infectious diseases; Influenza A [PATH:hsa05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:hsa05161]
Human Diseases; Infectious diseases; Herpes simplex infection [PATH:hsa05168]

SSDB

Motif

Pfam:

RIG-I_C-RD ResIII DEAD Helicase_C CARD AAA_22 AAA_19

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3GA3 3B6E 4GL2 2RQB

Position

2q24

AA seq 1025 aa
MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVE
LLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNL
LQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSA
FLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGM
ENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARA
SPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVI
VLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENS
LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP
LPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFA
IADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVC
AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDE
DDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESAR
GIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRT
GKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGV
IEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNP
SLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEI
ICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCL
FSDED

NT seq 3078 nt +upstreamnt +downstreamnt
atgtcgaatgggtattccacagacgagaatttccgctatctcatctcgtgcttcagggcc
agggtgaaaatgtacatccaggtggagcctgtgctggactacctgacctttctgcctgca
gaggtgaaggagcagattcagaggacagtcgccacctccgggaacatgcaggcagttgaa
ctgctgctgagcaccttggagaagggagtctggcaccttggttggactcgggaattcgtg
gaggccctccggagaaccggcagccctctggccgcccgctacatgaaccctgagctcacg
gacttgccctctccatcgtttgagaacgctcatgatgaatatctccaactgctgaacctc
cttcagcccactctggtggacaagcttctagttagagacgtcttggataagtgcatggag
gaggaactgttgacaattgaagacagaaaccggattgctgctgcagaaaacaatggaaat
gaatcaggtgtaagagagctactaaaaaggattgtgcagaaagaaaactggttctctgca
tttctgaatgttcttcgtcaaacaggaaacaatgaacttgtccaagagttaacaggctct
gattgctcagaaagcaatgcagagattgagaatttatcacaagttgatggtcctcaagtg
gaagagcaacttctttcaaccacagttcagccaaatctggagaaggaggtctggggcatg
gagaataactcatcagaatcatcttttgcagattcttctgtagtttcagaatcagacaca
agtttggcagaaggaagtgtcagctgcttagatgaaagtcttggacataacagcaacatg
ggcagtgattcaggcaccatgggaagtgattcagatgaagagaatgtggcagcaagagca
tccccggagccagaactccagctcaggccttaccaaatggaagttgcccagccagccttg
gaagggaagaatatcatcatctgcctccctacagggagtggaaaaaccagagtggctgtt
tacattgccaaggatcacttagacaagaagaaaaaagcatctgagcctggaaaagttata
gttcttgtcaataaggtactgctagttgaacagctcttccgcaaggagttccaaccattt
ttgaagaaatggtatcgtgttattggattaagtggtgatacccaactgaaaatatcattt
ccagaagttgtcaagtcctgtgatattattatcagtacagctcaaatccttgaaaactcc
ctcttaaacttggaaaatggagaagatgctggtgttcaattgtcagacttttccctcatt
atcattgatgaatgtcatcacaccaacaaagaagcagtgtataataacatcatgaggcat
tatttgatgcagaagttgaaaaacaatagactcaagaaagaaaacaaaccagtgattccc
cttcctcagatactgggactaacagcttcacctggtgttggaggggccacgaagcaagcc
aaagctgaagaacacattttaaaactatgtgccaatcttgatgcatttactattaaaact
gttaaagaaaaccttgatcaactgaaaaaccaaatacaggagccatgcaagaagtttgcc
attgcagatgcaaccagagaagatccatttaaagagaaacttctagaaataatgacaagg
attcaaacttattgtcaaatgagtccaatgtcagattttggaactcaaccctatgaacaa
tgggccattcaaatggaaaaaaaagctgcaaaagaaggaaatcgcaaagaacgtgtttgt
gcagaacatttgaggaagtacaatgaggccctacaaattaatgacacaattcgaatgata
gatgcgtatactcatcttgaaactttctataatgaagagaaagataagaagtttgcagtc
atagaagatgatagtgatgagggtggtgatgatgagtattgtgatggtgatgaagatgag
gatgatttaaagaaacctttgaaactggatgaaacagatagatttctcatgactttattt
tttgaaaacaataaaatgttgaaaaggctggctgaaaacccagaatatgaaaatgaaaag
ctgaccaaattaagaaataccataatggagcaatatactaggactgaggaatcagcacga
ggaataatctttacaaaaacacgacagagtgcatatgcgctttcccagtggattactgaa
aatgaaaaatttgctgaagtaggagtcaaagcccaccatctgattggagctggacacagc
agtgagttcaaacccatgacacagaatgaacaaaaagaagtcattagtaaatttcgcact
ggaaaaataaatctgcttatcgctaccacagtggcagaagaaggtctggatattaaagaa
tgtaacattgttatccgttatggtctcgtcaccaatgaaatagccatggtccaggcccgt
ggtcgagccagagctgatgagagcacctacgtcctggttgctcacagtggttcaggagtt
atcgaacatgagacagttaatgatttccgagagaagatgatgtataaagctatacattgt
gttcaaaatatgaaaccagaggagtatgctcataagattttggaattacagatgcaaagt
ataatggaaaagaaaatgaaaaccaagagaaatattgccaagcattacaagaataaccca
tcactaataactttcctttgcaaaaactgcagtgtgctagcctgttctggggaagatatc
catgtaattgagaaaatgcatcacgtcaatatgaccccagaattcaaggaactttacatt
gtaagagaaaacaaagcactgcaaaagaagtgtgccgactatcaaataaatggtgaaatc
atctgcaaatgtggccaggcttggggaacaatgatggtgcacaaaggcttagatttgcct
tgtctcaaaataaggaattttgtagtggttttcaaaaataattcaacaaagaaacaatac
aaaaagtgggtagaattacctatcacatttcccaatcttgactattcagaatgctgttta
tttagtgatgaggattag

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (8)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (7)   
   Pfam (7)   
All databases (64)   

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