KEGG T01001: 6476

Homo sapiens (human): 6476

Entry

6476 CDS T01001

Gene name

Definition

sucrase-isomaltase (alpha-glucosidase) (EC:3.2.1.10 3.2.1.48)

Orthology

K01203

sucrase-isomaltase / oligo-1,6-glucosidase [EC:3.2.1.48 3.2.1.10]

Organism

hsa Homo sapiens (human)

Pathway

hsa00052	Galactose metabolism
hsa00500	Starch and sucrose metabolism
hsa01100	Metabolic pathways
hsa04973	Carbohydrate digestion and absorption

Disease

H00115

Congenital sucrase-isomaltase deficiency

Class

Metabolism; Carbohydrate metabolism; Galactose metabolism [PATH:hsa00052]
Metabolism; Carbohydrate metabolism; Starch and sucrose metabolism [PATH:hsa00500]
Organismal Systems; Digestive system; Carbohydrate digestion and absorption [PATH:hsa04973]

SSDB

Motif

Pfam:

Glyco_hydro_31 Trefoil Gal_mutarotas_2

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3LPP 3LPO

Position

3q25.2-q26.2

AA seq 1827 aa
MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDS
GKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMT
TTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEF
TGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYG
IGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSN
AMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRW
NYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQ
KYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNP
NCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMY
SKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAH
WLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSR
NHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHE
FYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDM
YLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDT
IQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMN
AHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGC
VWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRV
EVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRS
SGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPP
GYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGP
TPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDI
DYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVF
VKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVD
FYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEA
EQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGD
NYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNI
ANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKP
TWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDT
INLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLY
LSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNE
DTTNMILRIDLTTHNVTLEEPIEINWS

NT seq 5484 nt +upstreamnt +downstreamnt
atggcaagaaagaaatttagtggattggaaatctctctgattgtcctttttgtcatagtt
actataatagctattgccttaattgttgttttagcaactaagacacctgctgttgatgaa
attagtgattctacttcaactccagctactactcgtgtgactacaaatccttctgattca
ggaaaatgtccaaatgtgttaaatgatcctgtcaatgtgagaataaactgcattccagaa
caattcccaacagagggaatttgtgcacagagaggctgctgctggaggccgtggaatgac
tctcttattccttggtgcttcttcgttgataatcatggttataacgttcaagacatgaca
acaacaagtattggagttgaagccaaattaaacaggataccttcacctacactatttgga
aatgacatcaacagtgttctcttcacaactcaaaatcagacacccaatcgtttccggttc
aagattactgatccaaataatagaagatatgaagttcctcatcagtatgtaaaagagttt
actggacccacagtttctgatacgttgtatgatgtgaaggttgcccaaaacccatttagc
atccaagttattaggaaaagcaacggtaaaactttgtttgacaccagcattggtccctta
gtgtactctgaccagtacttacagatctcaacccgtcttccaagtgattatatttatggt
attggagaacaagttcataagagatttcgtcatgatttatcctggaaaacatggccaatt
tttactcgagaccaacttcctggtgataataataataatttatacggccatcaaacattc
tttatgtgtattgaagatacatctggaaagtcattcggtgtttttttaatgaatagcaat
gcaatggagatttttatccagcctactccaatagtaacatatagagttaccggtggcatt
ctggatttttacatccttctaggagatacaccagaacaagtagttcaacagtatcaacag
cttgttggactaccagcaatgccagcatattggaatcttggattccaactaagtcgctgg
aattataagtcactagatgtagtgaaagaagtggtaaggagaaaccgggaagctggcata
ccatttgatacacaggtcactgatattgactacatggaagacaagaaagactttacttat
gatcaagttgcgtttaacggactccctcaatttgtgcaagatttgcatgaccatggacag
aaatatgtcatcatcttggaccctgcaatttccataggtcgacgtgccaatggaacaaca
tatgcaacctatgagaggggaaacacacaacatgtgtggataaatgagtcagatggaagt
acaccaattattggagaggtatggccaggattaacagtataccctgatttcactaaccca
aactgcattgattggtgggcaaatgaatgcagtattttccatcaagaagtgcaatatgat
ggactttggattgacatgaatgaagtttccagctttattcaaggttcaacaaaaggatgt
aatgtaaacaaattgaattatccaccgtttactcctgatattcttgacaaactcatgtat
tccaaaacaatttgcatggatgctgtgcagaactggggtaaacagtatgatgttcatagc
ctctatggatacagcatggctatagccacagagcaagctgtacaaaaagtttttcctaat
aagagaagcttcattcttacccgctcaacatttgctggatctggaagacatgctgcgcat
tggttaggagacaatactgcttcatgggaacaaatggaatggtctataactggaatgctg
gagttcagtttgtttggaatacctttggttggagcagacatctgtggatttgtggctgaa
accacagaagaactttgcagaagatggatgcaacttggggcattttatccattttccaga
aaccataattctgacggatatgaacatcaggatcctgcattttttgggcagaattcactt
ttggttaaatcatcaaggcagtatttaactattcgctacaccttattacccttcctctac
actctgttttataaagcccatgtgtttggagaaacagtagcaagaccagttcttcatgag
ttttatgaggatacgaacagctggattgaggacactgagtttttgtggggccctgcatta
cttattactcctgttctaaaacagggagcagatactgtgagtgcctacatccctgatgct
atttggtatgattatgaatctggtgcaaaaaggccatggaggaaacaacgggttgatatg
tatcttccagcagacaaaataggattacatcttagaggaggttatatcatccccattcaa
gaaccagatgtaacaacaacagcaagccgtaagaatcctctaggacttatagtcgcatta
ggtgaaaacaacacagccaaaggagactttttctgggatgatggagaaactaaagataca
atacaaaatggcaactacatattatatacattttcagtttctaataacacattagatatt
gtgtgcacacattcatcatatcaggaaggaactaccttagcatttcagactgtaaaaatc
cttgggttgacagacagtgttacagaagttagagtggcggaaaataatcaaccaatgaac
gctcattccaatttcacttatgatgcttctaaccaggttctcctaattgcagatctcaaa
cttaatcttggaagaaactttagtgttcaatggaatcaaattttctcagaaaatgaaaga
tttaattgttatccagatgcagatttggcaactgaacaaaagtgcacacaacgtggctgt
gtatggagaacgggttcttctctatccaaagcacctgagtgttactttcccagacaagat
aactcttattcagtcaactcagctcgctattcatccatgggtataacagctgacctccaa
ctaaatactgcaaatgccagaataaagttaccttctgaccccatctcaactcttcgtgtg
gaggtgaaatatcacaaaaatgatatgttgcagtttaagatttatgatccccaaaagaag
agatatgaagtaccagtaccgttaaacattccaaccaccccaataagtacttatgaagac
agactttatgatgtggaaatcaaggaaaatccttttggcatccagattcgacggagaagc
agtggaagagtcatttgggattcttggctgcctggatttgcttttaatgaccagttcatt
caaatatcgactcgcctgccatcagaatatatatatggttttggggaagtggaacataca
gcatttaagcgagatctgaactggaatacttggggaatgttcacaagagaccaaccccct
ggttacaaacttaattcctatggatttcatccctattacatggctctggaagaggagggc
aatgctcatggtgttttcttactcaacagcaatgcaatggatgttacattccagccaact
cctgctctaacttaccgtacagttggagggatcttggatttttatatgtttttgggccca
actccagaagttgcaacaaagcaataccatgaagtaattggccatccagtcatgccagct
tattgggctttgggattccaattatgtcgttatggatatgcaaatacttcagaggttcgg
gaattatatgacgctatggtggctgctaacatcccctatgatgttcagtacacagacatt
gactacatggaaaggcagctagactttacaattggtgaagcattccaggaccttcctcag
tttgttgacaaaataagaggagaaggaatgagatacattattatcctggatccagcaatt
tcaggaaatgaaacaaagacttaccctgcatttgaaagaggacagcagaatgatgtcttt
gtcaaatggccaaacaccaatgacatttgttgggcaaaggtttggccagatttgcccaac
ataacaatagataaaactctaacggaagatgaagctgttaatgcttccagagctcatgta
gctttcccagatttcttcaggacttccacagcagagtggtgggccagagaaattgtggac
ttttacaatgaaaagatgaagtttgatggtttgtggattgatatgaatgagccatcaagt
tttgtaaatggaacaactactaatcaatgcagaaatgacgaactaaattatccaccttat
ttcccagaactcacaaaaagaactgatggattacatttcagaacaatttgcatggaagct
gagcagattcttagtgatggaacatcagttttgcattacgatgttcacaatctctatgga
tggtcacagatgaaacctactcatgatgcattgcagaagacaactggaaaaagagggatt
gtaatttctcgttccacgtatcctactagtggacgatggggaggacactggcttggagac
aactatgcacgatgggacaacatggacaaatcaatcattggtatgatggaatttagtctg
tttggaatgtcatatactggagcagacatctgtggttttttcaacaactcagaatatcat
ctctgtacccgctggatgcaacttggagcattttatccatactcaaggaatcacaacatt
gcaaatactagaagacaagatcccgcttcctggaatgaaacttttgctgaaatgtcaagg
aatattctaaatattagatacaccttattgccctatttttacacacaaatgcatgaaatt
catgctaatggtggcactgttatccgaccccttttgcatgagttctttgatgaaaaacca
acctgggatatattcaagcagttcttatggggtccagcatttatggttaccccagtactg
gaaccttatgttcaaactgtaaatgcctacgtccccaatgctcggtggtttgactaccat
acaggcaaagatattggcgtcagaggacaatttcaaacatttaatgcttcttatgacaca
ataaacctacatgtccgtggtggtcacatcctaccatgtcaagagccagctcaaaacaca
ttttacagtcgacaaaaacacatgaagctcattgttgctgcagatgataatcagatggca
cagggttctctgttttgggatgatggagagagtatagacacctatgaaagagacctatat
ttatctgtacaatttaatttaaaccagaccaccttaacaagcactatattgaagagaggt
tacataaataaaagtgaaacgaggcttggatcccttcatgtatgggggaaaggaactact
cctgtcaatgcagttactctaacgtataacggaaataaaaattcgcttccttttaatgaa
gacactaccaacatgatattacgtattgatctgaccacacacaatgttactctagaagaa
ccaatagaaatcaactggtcatga

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (71)   

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