KEGG T01001: 6477

Homo sapiens (human): 6477

Entry

6477 CDS T01001

Gene name

SIAH1, SIAH1A

Definition

siah E3 ubiquitin protein ligase 1 (EC:6.3.2.-)

Orthology

K04506

E3 ubiquitin-protein ligase SIAH1 [EC:6.3.2.19]

Organism

hsa Homo sapiens (human)

Pathway

hsa04115	p53 signaling pathway
hsa04120	Ubiquitin mediated proteolysis
hsa04310	Wnt signaling pathway

Class

Genetic Information Processing; Folding, sorting and degradation; Ubiquitin mediated proteolysis [PATH:hsa04120]
Environmental Information Processing; Signal transduction; Wnt signaling pathway [PATH:hsa04310]
Cellular Processes; Cell growth and death; p53 signaling pathway [PATH:hsa04115]

SSDB

Motif

Pfam:

Sina

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

2A25

Position

16q12

AA seq 313 aa
MTGKATPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRVPALTGTT
ASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEK
VANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM
HQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIV
QLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAE
NGNLGINVTISMC

NT seq 942 nt +upstreamnt +downstreamnt
atgacgggaaaggctactccaccttctctgtactcctggaggggagtcttgttcacatgt
ttaccagcggccaggacaaggaagagaaaagaaatgagccgtcagactgctacagcatta
cctaccggtacctcgaagtgtccaccatcccagagggtgcctgccctgactggcacaact
gcatccaacaatgacttggcgagtctttttgagtgtccagtctgctttgactatgtgtta
ccgcccattcttcaatgtcagagtggccatcttgtttgtagcaactgtcgcccaaagctc
acatgttgtccaacttgccggggccctttgggatccattcgcaacttggctatggagaaa
gtggctaattcagtacttttcccctgtaaatatgcgtcttctggatgtgaaataactctg
ccacacacagaaaaagcagaccatgaagagctctgtgagtttaggccttattcctgtccg
tgccctggtgcttcctgtaaatggcaaggctctctggatgctgtaatgccccatctgatg
catcagcataagtccattacaaccctacagggagaggatatagtttttcttgctacagac
attaatcttcctggtgctgttgactgggtgatgatgcagtcctgttttggctttcacttc
atgttagtcttagagaaacaggaaaaatacgatggtcaccagcagttcttcgcaatcgta
cagctgataggaacacgcaagcaagctgaaaattttgcttaccgacttgagctaaatggt
cataggcgacgattgacttgggaagcgactcctcgatctattcatgaaggaattgcaaca
gccattatgaatagcgactgtctagtctttgacaccagcattgcacagctttttgcagaa
aatggcaatttaggcatcaatgtaactatttccatgtgttga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (14)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (71)   

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