KEGG   Homo sapiens (human): 6546Help
Entry
6546              CDS       T01001                                 

Gene name
SLC8A1, NCX1
Definition
solute carrier family 8 (sodium/calcium exchanger), member 1
Orthology
K05849  
solute carrier family 8 (sodium/calcium exchanger)
Organism
hsa  Homo sapiens (human)
Pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Endocrine and other factor-regulated calcium reabsorption
Protein digestion and absorption
Mineral absorption
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    6546 (SLC8A1)
   04022 cGMP - PKG signaling pathway
    6546 (SLC8A1)
 Organismal Systems
  Circulatory system
   04260 Cardiac muscle contraction
    6546 (SLC8A1)
   04261 Adrenergic signaling in cardiomyocytes
    6546 (SLC8A1)
  Digestive system
   04974 Protein digestion and absorption
    6546 (SLC8A1)
   04978 Mineral absorption
    6546 (SLC8A1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    6546 (SLC8A1)
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    6546 (SLC8A1)
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    6546 (SLC8A1)
   05414 Dilated cardiomyopathy (DCM)
    6546 (SLC8A1)
Heparan sulfate/heparin binding proteins [BR:hsa00536]
 Others
  6546 (SLC8A1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
Position
2p22.1
AA seq 968 aa AA seqDB search
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPVFRKVH
AREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKST
VDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFW
KVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGT
SVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG
TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLE
AYCHIKGF
NT seq 2907 nt NT seq  +upstreamnt  +downstreamnt
atgtacaacatgcggcgattaagtctttcacccaccttttcaatgggatttcatctgtta
gttactgtgagtctcttattttcccatgtggaccatgtaattgctgagacagaaatggaa
ggagaaggaaatgaaactggtgaatgtactggatcatattactgtaagaaaggggtgatt
ttgcccatttgggaaccccaagacccttcttttggggacaaaattgctagagctactgtg
tattttgtggccatggtctacatgtttcttggagtctctatcatagctgatcggttcatg
tcctctatagaagtcatcacatctcaagaaaaagaaataaccataaagaaacccaatgga
gagaccaccaagacaactgtgaggatctggaatgaaacagtttctaacctgaccttgatg
gccctgggatcttctgctcctgagattctcctttcagtaattgaagtgtgtggccataac
ttcactgcaggagacctcggtcctagcaccatcgtgggaagtgctgcattcaatatgttc
atcattattgcactctgtgtttatgtggtgcctgacggagagacaaggaagattaagcat
ttgcgtgtcttctttgtgacagcagcctggagcatctttgcctacacctggctttacatt
attttgtctgtcatatctcctggtgttgtggaggtctgggaaggtttgcttactttcttc
ttctttcccatctgtgttgtgttcgcttgggtagcggataggagacttctgttttacaag
tatgtctacaagaggtatcgagctggcaagcagagggggatgattattgaacatgaagga
gacaggccatcttctaagactgaaattgaaatggacgggaaagtggtcaattctcatgtt
gaaaatttcttagatggtgctctggttctggaggtggatgagagggaccaagatgatgaa
gaagctaggcgagaaatggctaggattctgaaggaacttaagcagaagcatccagataaa
gaaatagagcaattaatagaattagctaactaccaagtcctaagtcagcagcaaaaaagt
agagcattttatcgcattcaagctactcgcctcatgactggagctggcaacattttaaag
aggcatgcagctgaccaagcaaggaaggctgtcagcatgcacgaggtcaacactgaagtg
actgaaaatgaccctgttagtaagatcttctttgaacaagggacatatcagtgtctggag
aactgtggtactgtggcccttaccattatccgcagaggtggtgatttgactaacactgtg
tttgttgacttcagaacagaggatggcacagcaaatgctgggtctgattatgaatttact
gaaggaactgtggtgtttaagcctggtgatacccagaaggaaatcagagtgggtatcata
gatgatgatatctttgaggaggatgaaaatttccttgtgcatctcagcaatgtcaaagta
tcttctgaagcttcagaagatggcatactggaagccaatcatgtttctacacttgcttgc
ctcggatctccctccactgccactgtaactatttttgatgatgaccacgcaggcattttt
acttttgaggaacctgtgactcatgtgagtgagagcattggcatcatggaggtgaaagta
ttgagaacatctggagctcgaggaaatgttatcgttccatataaaaccatcgaagggact
gccagaggtggaggggaggattttgaggacacttgtggagagctcgaattccagaatgat
gaaattgtcaaaacaatatcagtcaaggtaattgatgatgaggagtatgagaaaaacaag
accttcttccttgagattggagagccccgcctggtggagatgagtgagaagaaagccctg
ttattgaatgagcttggtggcttcacaataacaggccaacctgtcttcaggaaggttcat
gctagagaacatccgattctctctactgtaatcaccattgcagacgaatatgatgacaag
cagccactgaccagcaaagaggaagaggagaggcgcattgcagaaatggggcgccccatc
ctgggagagcacaccaagttggaagtgatcattgaagaatcctatgaattcaagagtact
gtggacaaactcattaagaagacaaacctggcccttgtggttgggactaacagctggaga
gaacagttcattgaagctatcactgtcagtgctggggaagatgatgacgacgatgaatgt
ggggaagagaagctgccctcctgtttcgattacgtgatgcactttctgactgtgttctgg
aaggtcctgtttgccttcgtcccccctactgaatactggaatggctgggcgtgtttcatt
gtctccatcctcatgattggcctactgacagctttcattggagacctggcttcccacttt
ggctgcaccattggcctgaaagattctgtgactgcagtcgtgttcgtcgcacttggaaca
tcagtgccagacacatttgccagcaaagtggcagccacccaggaccagtatgcagacgcc
tccataggtaacgtcacgggcagcaacgcggtgaatgtcttcctgggaatcggtgtggcc
tggtccatcgctgccatctaccacgcagccaatggggaacagttcaaagtgtcccctggc
acactagctttctctgtcactctcttcaccatttttgctttcatcaatgtgggggtgctg
ctgtatcggcggaggccagaaatcggaggtgagctgggtgggccccggactgccaagctc
ctcacatcctgcctctttgtgctcctatggctcttgtacattttcttctcctccctggag
gcctactgccacataaaaggcttctaa

DBGET integrated database retrieval system