KEGG   Homo sapiens (human): 6654Help
Entry
6654              CDS       T01001                                 

Gene name
SOS1, GF1, GGF1, GINGF, HGF, NS4
Definition
(RefSeq) SOS Ras/Rac guanine nucleotide exchange factor 1
  KO
K03099  
son of sevenless
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Disease
H00523  
Noonan syndrome and related disorders
H01250  
Hereditary gingival fibromatosis (HGF)
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    6654 (SOS1)
   04010 MAPK signaling pathway
    6654 (SOS1)
   04012 ErbB signaling pathway
    6654 (SOS1)
   04630 Jak-STAT signaling pathway
    6654 (SOS1)
   04068 FoxO signaling pathway
    6654 (SOS1)
   04072 Phospholipase D signaling pathway
    6654 (SOS1)
   04151 PI3K-Akt signaling pathway
    6654 (SOS1)
   04150 mTOR signaling pathway
    6654 (SOS1)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    6654 (SOS1)
   04540 Gap junction
    6654 (SOS1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    6654 (SOS1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    6654 (SOS1)
   04660 T cell receptor signaling pathway
    6654 (SOS1)
   04662 B cell receptor signaling pathway
    6654 (SOS1)
   04664 Fc epsilon RI signaling pathway
    6654 (SOS1)
   04062 Chemokine signaling pathway
    6654 (SOS1)
  Endocrine system
   04910 Insulin signaling pathway
    6654 (SOS1)
   04912 GnRH signaling pathway
    6654 (SOS1)
   04915 Estrogen signaling pathway
    6654 (SOS1)
   04917 Prolactin signaling pathway
    6654 (SOS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    6654 (SOS1)
  Development
   04320 Dorso-ventral axis formation
    6654 (SOS1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    6654 (SOS1)
   05231 Choline metabolism in cancer
    6654 (SOS1)
   05206 MicroRNAs in cancer
    6654 (SOS1)
   05205 Proteoglycans in cancer
    6654 (SOS1)
   05214 Glioma
    6654 (SOS1)
   05221 Acute myeloid leukemia
    6654 (SOS1)
   05220 Chronic myeloid leukemia
    6654 (SOS1)
   05211 Renal cell carcinoma
    6654 (SOS1)
   05215 Prostate cancer
    6654 (SOS1)
   05213 Endometrial cancer
    6654 (SOS1)
   05224 Breast cancer
    6654 (SOS1)
   05223 Non-small cell lung cancer
    6654 (SOS1)
  Substance dependence
   05034 Alcoholism
    6654 (SOS1)
  Infectious diseases
   05160 Hepatitis C
    6654 (SOS1)
   05165 Human papillomavirus infection
    6654 (SOS1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    6654 (SOS1)
   01522 Endocrine resistance
    6654 (SOS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q07889(Tbio)
UniProt: 
Structure
PDB: 

Jmol
Position
2p22.1
AA seq 1333 aa AA seqDB search
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
NT seq 4002 nt NT seq  +upstreamnt  +downstreamnt
atgcaggcgcagcagctgccctacgagtttttcagcgaagagaacgcgcccaagtggcgg
ggactactggtgcctgcgctgaaaaaggtccaggggcaagttcatcctactctcgagtct
aatgatgatgctcttcagtatgttgaagaattaattttgcaattattaaatatgctatgc
caagctcagccccgaagtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcat
ccaattgataaatgggcaatagctgatgcccaatcagctattgaaaagaggaagcgaaga
aaccctttatctctcccagtagaaaaaattcatcctttattaaaggaggtcctaggttat
aaaattgaccaccaggtttctgtttacatagtagcagtcttagaatacatttctgcagac
attttaaagctggttgggaattatgtaagaaatatacggcattatgaaattacaaaacaa
gatattaaagtggcaatgtgtgctgacaaggtattgatggatatgtttcatcaagatgta
gaagatattaatatattatctttaactgacgaagagccttccacctcaggagaacaaact
tactatgatttggtaaaagcatttatggcagaaattcgacaatatataagggaactaaat
ctaattataaaagtttttagagagccctttgtctccaattcaaaattgttttcagctaat
gatgtagaaaatatatttagtcgcatagtagatatacatgaacttagtgtaaagttactg
ggccatatagaagatacagtagaaatgacagatgaaggcagtccccatccactagtagga
agctgctttgaagacttagcagaggaactggcatttgatccatatgaatcgtatgctcga
gatattttgcgacctggttttcatgatcgtttccttagtcagttatcaaagcctggggca
gcactttatttgcagtcaataggcgaaggtttcaaagaagctgttcaatatgttttaccc
aggctgcttctggcccctgtttaccactgtctccattactttgaacttttgaagcagtta
gaagaaaaaagtgaagatcaagaagacaaggaatgtttaaaacaagcaataacagctttg
cttaatgttcagagtggtatggaaaaaatatgttctaaaagtcttgcaaaacgaagactg
agtgaatctgcatgtcggttttatagtcagcaaatgaaggggaaacaactagcaatcaag
aagatgaacgagattcagaagaatattgatggttgggagggaaaagacattggacagtgt
tgtaatgaatttataatggaaggaactcttacacgtgtaggagccaaacatgagagacac
atatttctctttgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagaatatcgtcttaaagaaaagttttttatgcgaaaggtacaa
attaatgataaagatgacaccaatgaatacaagcatgcttttgaaataattttaaaagat
gaaaatagtgttatattttctgccaagtcagctgaagagaaaaacaattggatggcagca
ttgatatctttacagtaccggagtacactggaaaggatgcttgatgtaacaatgctacag
gaagagaaagaggagcagatgaggctgcctagtgctgatgtttatagatttgcagagcct
gactctgaagagaatattatatttgaagagaacatgcagcccaaggctggaattccaatt
atcaaagcaggaactgttattaaacttatagagaggcttacgtaccatatgtacgcagat
cccaattttgttcggacatttcttacaacatacagatccttttgcaaacctcaagaacta
ctgagtcttataatagaaaggtttgaaattccagagcctgagccaacagaagctgatcgc
atagctatagagaatggagatcaacccttgagtgcagaactgaaaagatttagaaaagaa
tatatacagcctgtgcaactgcgagtattaaatgtatgtcggcactgggtagagcaccac
ttctatgattttgaaagagatgcatatcttttgcaacgaatggaagaatttattggaaca
gtaagaggtaaagcaatgaaaaaatgggttgaatccatcactaaaataatccaaaggaaa
aaaattgcaagagacaatggaccaggtcataatattacatttcagagttcacctcccaca
gttgagtggcatataagcagacctgggcacatagagacttttgacctgctcaccttacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctataccgagctgtacag
ccatcagaattagttggaagtgtgtggacaaaagaagacaaagaaattaactctcctaat
cttctgaaaatgattcgacataccaccaacctcactctgtggtttgagaaatgtattgta
gaaactgaaaatttagaagaaagagtagctgtggtgagtcgaattattgagattctacaa
gtctttcaagagttgaacaactttaatggtgtccttgaggttgtcagtgctatgaattca
tcacctgtttacagactagaccacacatttgagcaaataccaagtcgccagaagaaaatt
ttagaagaagctcatgaattgagtgaagatcactataagaaatatttggcaaaactcagg
tctattaatccaccatgtgtgcctttctttggaatttatctcactaatatcttgaaaaca
gaagaaggcaaccctgaggtcctaaaaagacatggaaaagagcttataaactttagcaaa
aggaggaaagtagcagaaataacaggagagatccagcagtaccaaaatcagccttactgt
ttacgagtagaatcagatatcaaaaggttctttgaaaacttgaatccgatgggaaatagc
atggagaaggaatttacagattatcttttcaacaaatccctagaaatagaaccacgaaac
cctaagcctctcccaagatttccaaaaaaatatagctatcccctaaaatctcctggtgtt
cgtccatcaaacccaagaccaggtaccatgaggcatcccacacctctgcagcaggagcca
aggaaaattagttatagtaggatccctgaaagtgaaacagaaagtacagcatctgcacca
aattctccaagaacaccgttaacacctccgcctgcttctggtgcttccagtaccacagat
gtttgcagtgtatttgattccgatcattcgagcccttttcactcaagcaatgataccgtc
tttatccaagttactctgccccatggcccaagatctgcttctgtatcatctataagttta
accaaaggcactgatgaagtgcctgtccctcctcctgttcctccacgaagacgaccagaa
tctgccccagcagaatcttcaccatctaagattatgtctaagcatttggacagtccccca
gccattcctcctaggcaacccacatcaaaagcctattcaccacgatattcaatatcagac
cggacctctatctcagaccctcctgaaagccctcccttattaccaccacgagaacctgtg
aggacacctgatgttttctcaagctcaccactacatctccaacctccccctttgggcaaa
aaaagtgaccatggcaatgccttcttcccaaacagcccttccccctttacaccacctcct
cctcaaacaccttctcctcacggcacaagaaggcatctgccatcaccaccattgacacaa
gaagtggaccttcattccattgctgggccgcctgttcctccacgacaaagcacttctcaa
catatccctaaactccctccaaaaacttacaaaagggagcacacacacccatccatgcac
agagatggaccaccactgttggagaatgcccattcttcctga

KEGG   Homo sapiens (human): 6655Help
Entry
6655              CDS       T01001                                 

Gene name
SOS2, NS9, SOS-2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  
son of sevenless
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Disease
H01738  
Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    6655 (SOS2)
   04010 MAPK signaling pathway
    6655 (SOS2)
   04012 ErbB signaling pathway
    6655 (SOS2)
   04630 Jak-STAT signaling pathway
    6655 (SOS2)
   04068 FoxO signaling pathway
    6655 (SOS2)
   04072 Phospholipase D signaling pathway
    6655 (SOS2)
   04151 PI3K-Akt signaling pathway
    6655 (SOS2)
   04150 mTOR signaling pathway
    6655 (SOS2)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    6655 (SOS2)
   04540 Gap junction
    6655 (SOS2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    6655 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    6655 (SOS2)
   04660 T cell receptor signaling pathway
    6655 (SOS2)
   04662 B cell receptor signaling pathway
    6655 (SOS2)
   04664 Fc epsilon RI signaling pathway
    6655 (SOS2)
   04062 Chemokine signaling pathway
    6655 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    6655 (SOS2)
   04912 GnRH signaling pathway
    6655 (SOS2)
   04915 Estrogen signaling pathway
    6655 (SOS2)
   04917 Prolactin signaling pathway
    6655 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    6655 (SOS2)
  Development
   04320 Dorso-ventral axis formation
    6655 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    6655 (SOS2)
   05231 Choline metabolism in cancer
    6655 (SOS2)
   05206 MicroRNAs in cancer
    6655 (SOS2)
   05205 Proteoglycans in cancer
    6655 (SOS2)
   05214 Glioma
    6655 (SOS2)
   05221 Acute myeloid leukemia
    6655 (SOS2)
   05220 Chronic myeloid leukemia
    6655 (SOS2)
   05211 Renal cell carcinoma
    6655 (SOS2)
   05215 Prostate cancer
    6655 (SOS2)
   05213 Endometrial cancer
    6655 (SOS2)
   05224 Breast cancer
    6655 (SOS2)
   05223 Non-small cell lung cancer
    6655 (SOS2)
  Substance dependence
   05034 Alcoholism
    6655 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    6655 (SOS2)
   05165 Human papillomavirus infection
    6655 (SOS2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    6655 (SOS2)
   01522 Endocrine resistance
    6655 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q07890(Tbio)
UniProt: 
Position
14q21.3
AA seq 1332 aa AA seqDB search
MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLA
IEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLS
EEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPS
TPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
RLPLLENAETPQ
NT seq 3999 nt NT seq  +upstreamnt  +downstreamnt
atgcagcaggcgccgcagccttacgagttcttcagcgaggagaacagtccgaaatggcgg
ggactgttggtctcggccctgcggaaggttcaggaacaagtgcatcccactctctcagct
aatgaagagtctctctattatattgaagagctgatttttcagctgcttaataaattatgc
atggcccagccaaggactgttcaagatgtagaggagcgagttcagaagacctttcctcac
ccaattgataaatgggccattgctgatgcacaatctgctatagaaaaacgaaaacgaaga
aatcctcttttactgcctgtggacaaaatccatccttcgttgaaggaagtattagggtac
aaagtggactaccatgtatccctatatattgtggctgtactagagtatatctcagctgat
attttaaaattggctggtaattatgtttttaatatccggcattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcggataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttctctctgtgaagatgaacctagttcttctggtgaattaaactactat
gatcttgtcagaactgaaatcgcagaagaaagacagtatctacgggaattaaatatgatc
ataaaagtgtttcgagaagcctttctttctgatagaaagctgtttaaaccttctgatatc
gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggtttg
attgaagacacagttgaaatgactgatgaaagcagtcctcatcccttagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggacatt
ctttcaccagagtttcatgaacatttcaataaattgatggccagacctgcagttgctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgtctt
atgctggtgccagtgtatcactgttggcactactttgagttactaaagcaattgaaagca
tgtagtgaagaacaagaagacagagaatgtttgaaccaagctattactgctctcatgaat
ctccaaggtagcatggaccgaatttacaagcagtattcacctagacgtcgacctggagat
cctgtttgccctttttatagtcaccaattaagaagcaaacacctggctatcaaaaaaatg
aatgaaattcagaaaaatatcgatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggagggaccattgacaagaatcggtgccaaacatgaacggcatattttt
ctgtttgatggcttaatgatcagttgtaaacctaatcatggccagactcggcttccaggt
tacagtagtgcagaatacaggttaaaagaaaaatttgtcatgaggaaaatacaaatttgt
gataaagaagatacttgtgagcacaagcatgcatttgaattagtatccaaagatgagaac
agcataatatttgctgctaagtctgctgaagaaaaaaacaactggatggcagcccttatt
tctcttcattatcgtagtactctagatcgaatgttagattcagtattattgaaagaagaa
aatgagcaaccactgagattaccaagtcctgaagtatatcgttttgtagtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggcatccccattattaaa
ggaggaactgtagtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgttcgtacttttcttaccacatatcgttcattttgtaaaccacaggaattgctgagc
ttactgattgaacggtttgaaattccagagccagaacctactgacgcagacaaattggca
atagagaaaggcgagcagccaatcagtgcagaccttaaaagatttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtatttcggcattgggttgaacatcatttttat
gactttgaaagagacttggaattgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagctatgaaaaaatgggtagagtcaattgctaagatcatcaggaggaagaagcaa
gctcaggcaaacggagtaagccataatattacctttgaaagtccacctccaccaattgaa
tggcatatcagcaaaccaggacagtttgaaacatttgatctcatgacacttcatccaata
gaaattgcacgtcagctgacacttttggagtctgatctttacaggaaagttcaaccgtct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaaatgcattgtggaagca
gaaaattttgaagaacgggtggcagtactaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggcgtattggagatagtcagtgcagtaaattcagtgtca
gtatacagactagaccatacctttgaggcactgcaggaaaggaaaaggaaaattttggac
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagaccgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcagccttactgtttacgg
atagaaccagatatgaggagattctttgaaaaccttaaccccatgggaagtgcatctgaa
aaagagtttacagattatttgttcaacaagtcactagaaattgaacctcgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttttccttaaaatctcctggaataaggcct
aacacaggccgacatggctctacctcaggtactttacgaggtcacccaacaccattagaa
agagaaccatgtaaaataagctttagtcggattgctgaaactgagctggaatcaacagtg
tcagcaccaacctctccaaatacaccatctactccaccagtatctgcttcttcagacctt
agtgtatttttagatgtggatctcaacagctcctgtggcagcaatagcatctttgctcca
gtgcttttgccacattcaaagtctttctttagttcatgtggtagtttacataaactaagt
gaagagcccctgattcctcctcctcttcctcctcgaaaaaagtttgatcatgatgcttca
aattccaagggaaatatgaaatctgatgatgatcctcctgctattccaccgagacagcct
cctcctccaaaggtaaaacccagagttcctgttcctactggtgcatttgatgggcctctg
catagtccacctccgccaccaccaagagatcctcttcctgatacccctccaccagttccc
cttcggcctccagaacactttataaactgtccatttaatcttcagccacctccactgggg
catcttcacagagattcagactggctcagagacattagtacgtgtccaaattcgccaagc
actcctcctagcacaccctctccaagggtaccgcgtcgatgctatgtgctcagttctagt
cagaataatcttgctcatcctccagctccccctgttccaccaaggcagaattcaagccct
catctgccaaaactgccaccaaagacttacaaacgggagctttcgcaccccccattgtac
agactgcctttgctagaaaatgcagaaactccccaatga

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