| Entry |
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| Gene name |
AKR1D1, 3o5bred, CBAS2, SRD5B1
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| Definition |
aldo-keto reductase family 1, member D1 (EC:1.3.1.3)
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| Orthology |
| 3-oxo-5-beta-steroid 4-dehydrogenase [EC: 1.3.1.3] |
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| Organism |
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| Pathway |
| Primary bile acid biosynthesis | | Steroid hormone biosynthesis | | Metabolic pathways |
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| Module |
| Bile acid biosynthesis, cholesterol => cholate |
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| Disease |
| Congenital bile acid synthesis defect (CBAS) |
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| Class |
Metabolism; Lipid metabolism; Primary bile acid biosynthesis [PATH: hsa00120]
Metabolism; Lipid metabolism; Steroid hormone biosynthesis [PATH: hsa00140]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| Structure |
PDB: |
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| Position |
7q32-q33
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| AA seq |
285 aa  
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEVECHPYFTQPKLLKFCQQHDIVITAYSP
LGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIK
ENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY |
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| NT seq |
858 nt  +upstreamnt +downstreamnt
atggatctcagtgctgcaagtcaccgcatacctctaagtgatggaaacagcattcccatc
atcggacttggtacctactcagaacctaaatcgacccctaagggagcctgtgcaacatcg
gtgaaggttgctattgacacagggtaccgacatattgatggggcctacatctaccaaaat
gaacacgaagttggggaggccatcagggagaagatagcagaaggaaaggtgcggagggaa
gatatcttctactgtggaaagctatgggctacaaatcatgtcccagagatggtccgccca
accctggagaggacactcagggtcctccagctagattatgtggatctttacatcattgaa
gtacccatggcctttaagccaggagatgaaatataccctagagatgagaatggcaaatgg
ttatatcacaagtcaaatctgtgtgccacttgggaggttgagtgccatccgtatttcacc
cagccaaaactcttgaaattttgccaacaacatgacattgtcattactgcatatagccct
ttggggaccagtaggaatccaatctgggtgaatgtttcttctccacctttgttaaaggat
gcacttctaaactcattggggaaaaggtacaataagacagcagctcaaattgttttgcgt
ttcaacatccagcgaggggtggttgtcattcctaaaagctttaatcttgaaaggatcaaa
gaaaattttcagatctttgacttttctctcactgaagaagaaatgaaggacattgaagcc
ttgaataaaaatgtccgctttgtagaattgctcatgtggcgcgatcatcctgaataccca
tttcatgatgaatactga |
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