KEGG   Homo sapiens (human): 673Help
Entry
673               CDS       T01001                                 

Gene name
BRAF, B-RAF1, B-raf, BRAF1, NS7, RAFB1
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
  KO
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
mTOR signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Natural killer cell mediated cytotoxicity
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Parathyroid hormone synthesis, secretion and action
Cushing's syndrome
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Module
MAPK (ERK1/2) signaling
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  
Mutation-activated BRAF to ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00023  
EGF-EGFR-PLCG-ERK signaling pathway
N00024  
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
N00276  
EGF-overexpression to RAS-ERK signaling pathway
N00277  
EREG-EGFR-RAS-ERK signaling pathway
N00278  
EREG-overexpression to RAS-ERK signaling pathway
N00279  
AREG-EGFR-RAS-ERK signaling pathway
N00280  
AREG-overexpression to RAS-ERK signaling pathway
N10007  
Kinase inhibitor to BRAF mutation
Disease
H00032  
Thyroid cancer
H00038  
Melanoma
H00523  
Noonan syndrome and related disorders
H01512  
Langerhans cell histiocytosis
H01738  
Noonan syndrome
H01984  
Leopard syndrome
Drug target
Dabrafenib (DG00721): 
Encorafenib: 
Regorafenib (DG00720): 
Sorafenib (DG00713): 
Vemurafenib: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    673 (BRAF)
   04010 MAPK signaling pathway
    673 (BRAF)
   04012 ErbB signaling pathway
    673 (BRAF)
   04068 FoxO signaling pathway
    673 (BRAF)
   04024 cAMP signaling pathway
    673 (BRAF)
   04150 mTOR signaling pathway
    673 (BRAF)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    673 (BRAF)
  Cell motility
   04810 Regulation of actin cytoskeleton
    673 (BRAF)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    673 (BRAF)
   04062 Chemokine signaling pathway
    673 (BRAF)
  Endocrine system
   04910 Insulin signaling pathway
    673 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    673 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    673 (BRAF)
  Circulatory system
   04270 Vascular smooth muscle contraction
    673 (BRAF)
  Nervous system
   04726 Serotonergic synapse
    673 (BRAF)
   04720 Long-term potentiation
    673 (BRAF)
   04730 Long-term depression
    673 (BRAF)
   04722 Neurotrophin signaling pathway
    673 (BRAF)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    673 (BRAF)
   05205 Proteoglycans in cancer
    673 (BRAF)
   05210 Colorectal cancer
    673 (BRAF)
   05212 Pancreatic cancer
    673 (BRAF)
   05225 Hepatocellular carcinoma
    673 (BRAF)
   05226 Gastric cancer
    673 (BRAF)
   05214 Glioma
    673 (BRAF)
   05216 Thyroid cancer
    673 (BRAF)
   05221 Acute myeloid leukemia
    673 (BRAF)
   05220 Chronic myeloid leukemia
    673 (BRAF)
   05218 Melanoma
    673 (BRAF)
   05211 Renal cell carcinoma
    673 (BRAF)
   05219 Bladder cancer
    673 (BRAF)
   05215 Prostate cancer
    673 (BRAF)
   05213 Endometrial cancer
    673 (BRAF)
   05224 Breast cancer
    673 (BRAF)
   05223 Non-small cell lung cancer
    673 (BRAF)
  Substance dependence
   05034 Alcoholism
    673 (BRAF)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    673 (BRAF)
  Infectious diseases
   05160 Hepatitis C
    673 (BRAF)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    673 (BRAF)
   01522 Endocrine resistance
    673 (BRAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     673 (BRAF)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   673 (BRAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
P15056(Tclin)
UniProt: 
Structure
PDB: 

Jmol
Position
7q34
AA seq 766 aa AA seqDB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 2301 nt NT seq  +upstreamnt  +downstreamnt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccggcgccgcggcctcttcggctgcggac
cctgccattccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacat
atagaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggag
gcctatgaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattg
gaatctctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgtt
acatcttcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaat
cccacagatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttc
ctgcccaacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagt
ctaaagaaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaatt
caggatggagagaagaaaccaattggttgggacactgatatttcctggcttactggagaa
gaattgcatgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaa
acgtttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgc
tgtcaaacatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgt
gttaattatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaata
ccacaggaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgca
cccgcctcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccatt
ccaattccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacga
gaccgatcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgat
gacttgattagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgct
accccccctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctcca
ggacctcagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaaca
cttggtagacgggactcgagtgatgattgggagattcctgatgggcagattacagtggga
caaagaattggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtg
gcagtgaaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaat
gaagtaggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattcc
acaaagccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccat
ctccatatcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagact
gcacagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaat
aatatatttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtg
aaatctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatg
gcaccagaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatat
gcatttggaattgttctgtatgaattgatgactggacagttaccttattcaaacatcaac
aacagggaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaag
gtacggagtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaa
agagatgagagaccactctttccccaaattctcgcctctattgagctgctggcccgctca
ttgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaaca
gaggattttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatat
ggtgcgtttcctgtccactga

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