KEGG   Homo sapiens (human): 6850Help
Entry
6850              CDS       T01001                                 

Gene name
SYK, p72-Syk
Definition
spleen tyrosine kinase (EC:2.7.10.2)
Orthology
K05855  
spleen tyrosine kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Epstein-Barr virus infection
Viral carcinogenesis
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    6850 (SYK)
   04151 PI3K-Akt signaling pathway
    6850 (SYK)
 Organismal Systems
  Immune system
   04611 Platelet activation
    6850 (SYK)
   04650 Natural killer cell mediated cytotoxicity
    6850 (SYK)
   04662 B cell receptor signaling pathway
    6850 (SYK)
   04664 Fc epsilon RI signaling pathway
    6850 (SYK)
   04666 Fc gamma R-mediated phagocytosis
    6850 (SYK)
  Development
   04380 Osteoclast differentiation
    6850 (SYK)
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    6850 (SYK)
  Infectious diseases
   05152 Tuberculosis
    6850 (SYK)
   05169 Epstein-Barr virus infection
    6850 (SYK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     6850 (SYK)
Protein kinases [BR:hsa01001]
 Tyrosine protein kinases
  Syk family
   6850 (SYK)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
9q22
AA seq 612 aa AA seqDB search
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY
EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG
TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES
WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV
TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW
EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE
LRLRNYYYDVVN
NT seq 1839 nt NT seq  +upstreamnt  +downstreamnt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgtcctcccctgcccaagggaaccggcaagagagtactgtgtcattcaatccgtat
gagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagccctacccatg
gacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggcccaaggaggtt
tacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggtaattttgga
actgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaata
ctgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaagcaaatgtc
atgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgaggccgagtcc
tggatgctggttatggagatggcagaacttggtcccctcaataagtatttgcagcagaac
agacatgtcaaggataagaacatcatagaactggttcatcaggtttccatgggcatgaag
tacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtgttgctagtt
acccaacattacgccaagatcagtgatttcggactttccaaagcactgcgtgctgatgaa
aactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgctccggaatgc
atcaactactacaagttctccagcaaaagcgatgtctggagctttggagtgttgatgtgg
gaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaagtcaccgct
atgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagagatgtacgat
ctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgcagcagtggaa
ctgcggctgcgcaattactactatgacgtggtgaactaa

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