KEGG   Homo sapiens (human): 7403Help
Entry
7403              CDS       T01001                                 

Gene name
KDM6A, KABUK2, UTX, bA386N14.2
Definition
(RefSeq) lysine demethylase 6A
  KO
K11447  
histone demethylase [EC:1.14.11.-]
Organism
hsa  Homo sapiens (human)
Pathway
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    7403 (KDM6A)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.-  
     7403 (KDM6A)
Chromosome [BR:hsa03036]
 Eukaryotic Type
  Histone modification proteins
   HMT complexes
    MLL3/MLL4 complex
     7403 (KDM6A)
   Histone demethylases
    7403 (KDM6A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
Xp11.2
AA seq 1401 aa AA seqDB search
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFV
RFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYY
SLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVN
TDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQ
VKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKV
QDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGT
LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIE
EAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQL
RANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSG
QQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITG
SGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPL
SSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKP
SGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQL
SALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNS
VTSLNSPHSGLHTINGEGMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKAC
RNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFC
TNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKI
WHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFK
TIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPG
SRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDL
YEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNK
LQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWH
GRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKM
EDLMQVYDQFTLAPPLPSASS
NT seq 4206 nt NT seq  +upstreamnt  +downstreamnt
atgaaatcctgcggagtgtcgctcgctaccgccgccgctgccgccgccgctttcggtgat
gaggaaaagaaaatggcggcgggaaaagcgagcggcgagagcgaggaggcgtcccccagc
ctgacagccgaggagagggaggcgctcggcggactggacagccgcctctttgggttcgtg
agatttcatgaagatggcgccaggacgaaggccctactgggcaaggctgttcgctgctat
gaatctctaatcttaaaagctgaaggaaaagtggagtctgatttcttttgtcaattaggt
cacttcaacctcttattggaagattatccaaaagcattatctgcataccagaggtactac
agtttacagtctgactactggaagaatgctgcctttttatatggtcttggtttggtctac
ttccattataatgcatttcagtgggcaattaaagcatttcaggaggtgctttatgttgat
cccagcttttgtcgagccaaggaaattcatttacgacttgggcttatgttcaaagtgaac
acagactatgagtctagtttaaagcattttcagttagctttggttgactgtaatccctgc
actttgtccaatgctgaaattcaatttcacattgcccacttatatgaaacccagaggaaa
tatcattctgcaaaagaagcttatgaacaacttttgcagacagagaatctttctgcacaa
gtaaaagcaactgtcttacaacagttaggttggatgcatcacactgtagatctcctggga
gataaagccaccaaggaaagctatgctattcagtatctccaaaagtccttggaagcagat
cctaattctggccagtcctggtatttcctcggaaggtgctattcaagtattgggaaagtt
caggatgcctttatatcttacaggcagtctattgataaatcagaagcaagtgcagataca
tggtgttcaataggtgtgctatatcagcagcaaaatcagcccatggatgctttacaggcc
tatatttgtgctgtacaattggaccatggccatgctgcagcctggatggacctaggcact
ctctatgaatcctgcaaccagcctcaggatgccattaaatgctacttaaatgcaactaga
agcaaaagttgtagtaatacctctgcacttgcagcacgaattaagtatttacaggctcag
ttgtgtaaccttccacaaggtagtctacagaataaaactaaattacttcctagtattgag
gaggcgtggagcctaccaattcccgcagagcttacctccaggcagggtgccatgaacaca
gcacagcagaatacttctgacaattggagtggtggacatgctgtgtcacatcctccagta
cagcaacaagctcattcatggtgtttgacaccacagaaattacagcatttggaacagctc
cgcgcaaatagaaataatttaaatccagcacagaaactgatgctggaacagctggaaagt
cagtttgtcttaatgcaacaacaccaaatgagaccaacaggagttgcacaggtacgatct
actggaattcctaatgggccaacagctgactcatcactgcctacaaactcagtctctggc
cagcagccacagcttgctctgaccagagtgcctagcgtctctcagcctggagtccgtcct
gcctgccctgggcagcctttggccaatggacccttttctgcaggccatgttccctgtagc
acatcaagaacgctgggaagtacagacactattttgataggcaataatcatataacagga
agtggaagtaatggaaacgtgccttacctgcagcgaaacgcactcactctacctcataac
cgcacaaacctgaccagcagcgcagaggagccgtggaaaaaccaactatctaactccact
caggggcttcacaaaggtcagagttcacattcggcaggtcctaatggtgaacgacctctc
tcttccactgggccttcccagcatctccaggcagctggctctggtattcagaatcagaac
ggacatcccaccctgcctagcaattcagtaacacagggggctgctctcaatcacctctcc
tctcacactgctacctcaggtggacaacaaggcattaccttaaccaaagagagcaagcct
tcaggaaacatattgacggtgcctgaaacaagcaggcacactggagagacacctaacagc
actgccagtgtcgagggacttcctaatcatgtccatcagatgacggcagatgctgtttgc
agtcctagccatggagattctaagtcaccaggtttactaagttcagacaatcctcagctc
tctgccttgttgatgggaaaagccaataacaatgtgggtactggaacctgtgacaaagtc
aataacatccacccagctgttcatacaaagactgataactctgttgcctcttcaccatct
tcagccatttcaacagcaacaccttctccaaaatccactgagcagacaaccacaaacagt
gttaccagccttaacagccctcacagtgggctacacacaattaatggagaagggatggaa
gaatctcagagccccatgaaaacagatctgcttctggttaaccacaaacctagtccacag
atcataccatcaatgtctgtgtccatataccccagctcagcagaagttctgaaggcatgc
aggaatctaggtaaaaatggcttatctaacagtagcattttgttggataaatgtccacct
ccaagaccaccatcttcaccataccctcccttgccaaaggacaagttgaatccacctaca
cctagtatttacttggaaaataaacgtgatgctttctttcctccattacatcaattttgt
acaaatccgaacaaccctgttacagtaatacgtggccttgctggagctcttaagttagac
ctgggacttttctctactaaaactttggtggaagctaacaatgaacatatggtagaagtg
aggacacagttgttgcagccagcagatgaaaactgggatcccactggaacaaagaaaatc
tggcattgtgaaagtaatagatctcatactacaattgctaaatatgcacagtaccaggcc
tcctcattccaggaatcattgagagaagaaaatgaaaaaagaagtcatcataaagaccac
tcagatagtgaatctacatcgtcagataattctgggaggaggaggaaaggaccctttaaa
accataaagtttgggaccaatattgacctatctgatgacaaaaagtggaagttgcagcta
catgagctgactaaacttcctgcttttgtgcgtgtcgtatcagcaggaaatcttctaagc
catgttggtcataccatattgggcatgaacacagttcaactatacatgaaagttccaggg
agcagaacaccaggtcatcaggaaaataacaacttctgttcagttaacataaatattggc
ccaggtgactgtgaatggtttgttgttcctgaaggttactggggtgttctgaatgacttc
tgtgaaaaaaataatttgaatttcctaatgggttcttggtggcccaatcttgaagatctt
tatgaagcaaatgttccagtgtataggtttattcagcgacctggagatttggtctggata
aatgcaggcactgttcattgggttcaggctattggctggtgcaacaacattgcttggaat
gttggtccacttacagcctgccagtataaattggcagtggaacggtacgaatggaacaaa
ttgcaaagtgtgaagtcaatagtacccatggttcatctttcctggaatatggcacgaaat
atcaaggtctcagatccaaagctttttgaaatgattaagtattgtcttctaagaactctg
aagcaatgtcagacattgagggaagctctcattgctgcaggaaaagagattatatggcat
gggcggacaaaagaagaaccagctcattactgtagcatttgtgaagtggaggtttttgat
ctgctttttgtcactaatgagagtaattcacgaaagacctacatagtacattgccaagat
tgtgcacgaaaaacaagcggaaacttggaaaactttgtggtgctagaacagtacaaaatg
gaggacctgatgcaagtctatgaccaatttacattagctcctccattaccatccgcctca
tcttga

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