KEGG   Homo sapiens (human): 773Help
Entry
773               CDS       T01001                                 

Gene name
CACNA1A, APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
Definition
(RefSeq) calcium voltage-gated channel subunit alpha1 A
  KO
K04344  
voltage-dependent calcium channel P/Q type alpha-1A
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
Disease
H00063  
Spinocerebellar ataxia (SCA)
H00749  
Episodic ataxias
H00775  
Familial or sporadic hemiplegic migraine
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    773 (CACNA1A)
   04020 Calcium signaling pathway
    773 (CACNA1A)
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    773 (CACNA1A)
   04727 GABAergic synapse
    773 (CACNA1A)
   04725 Cholinergic synapse
    773 (CACNA1A)
   04728 Dopaminergic synapse
    773 (CACNA1A)
   04726 Serotonergic synapse
    773 (CACNA1A)
   04730 Long-term depression
    773 (CACNA1A)
   04723 Retrograde endocannabinoid signaling
    773 (CACNA1A)
   04721 Synaptic vesicle cycle
    773 (CACNA1A)
  Sensory system
   04742 Taste transduction
    773 (CACNA1A)
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    773 (CACNA1A)
   05033 Nicotine addiction
    773 (CACNA1A)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    773 (CACNA1A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Ca2+ channel, CACN alpha-1, CaVx.x
   773 (CACNA1A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
19p13
AA seq 2506 aa AA seqDB search
MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMA
LYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQH
LPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTG
ILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIF
AIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQ
FDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS
GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDAL
RRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIR
RMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGL
GTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLR
NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTV
FQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ
ELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSE
MRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRA
AEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRE
SDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRA
HRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARRE
DKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAA
PHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTP
ENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEE
KKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIAL
AAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVV
SGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNIL
IVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEF
HYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFF
FVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQ
FVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFG
ILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRIL
LWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRT
FFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFL
MLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSP
PLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDA
ELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQ
DRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQ
KTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAEN
QRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSH
RASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHP
PPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPR
RGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRR
YPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEG
PPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGP
ACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEPYSESDDDWC
NT seq 7521 nt NT seq  +upstreamnt  +downstreamnt
atggcccgcttcggagacgagatgccggcccgctacgggggaggaggctccggggcagcc
gccggggtggtcgtgggcagcggaggcgggcgaggagccgggggcagccggcagggcggg
cagcccggggcgcaaaggatgtacaagcagtcaatggcgcagagagcgcggaccatggca
ctctacaaccccatccccgtccgacagaactgcctcacggttaaccggtctctcttcctc
ttcagcgaagacaacgtggtgagaaaatacgccaaaaagatcaccgaatggcctcccttt
gaatatatgattttagccaccatcatagcgaattgcatcgtcctcgcactggagcagcat
ctgcctgatgatgacaagaccccgatgtctgaacggctggatgacacagaaccatacttc
attggaattttttgtttcgaggctggaattaaaatcattgcccttgggtttgccttccac
aaaggctcctacttgaggaatggctggaatgtcatggactttgtggtggtgctaacgggc
atcttggcgacagttgggacggagtttgacctacggacgctgagggcagttcgagtgctg
cggccgctcaagctggtgtctggaatcccaagtttacaagtcgtcctgaagtcgatcatg
aaggcgatgatccctttgctgcagatcggcctcctcctattttttgcaatccttattttt
gcaatcatagggttagaattttatatgggaaaatttcataccacctgctttgaagagggg
acagatgacattcagggtgagtctccggctccatgtgggacagaagagcccgcccgcacc
tgccccaatgggaccaaatgtcagccctactgggaagggcccaacaacgggatcactcag
ttcgacaacatcctgtttgcagtgctgactgttttccagtgcataaccatggaagggtgg
actgatctcctctacaatagcaacgatgcctcagggaacacttggaactggttgtacttc
atccccctcatcatcatcggctccttttttatgctgaaccttgtgctgggtgtgctgtca
ggggagtttgccaaagaaagggaacgggtggagaaccggcgggcttttctgaagctgagg
cggcaacaacagattgaacgtgagctcaatgggtacatggagtggatctcaaaagcagaa
gaggtgatcctcgccgaggatgaaactgacggggagcagaggcatccctttgatgctctg
cggagaaccaccataaagaaaagcaagacagatttgctcaaccccgaagaggctgaggat
cagctggctgatatagcctctgtgggttctcccttcgcccgagccagcattaaaagtgcc
aagctggagaactcgaccttttttcacaaaaaggagaggaggatgcgtttctacatccgc
cgcatggtcaaaactcaggccttctactggactgtactcagtttggtagctctcaacacg
ctgtgtgttgctattgttcactacaaccagcccgagtggctctccgacttcctttactat
gcagaattcattttcttaggactctttatgtccgaaatgtttataaaaatgtacgggctt
gggacgcggccttacttccactcttccttcaactgctttgactgtggggttatcattggg
agcatcttcgaggtcatctgggctgtcataaaacctggcacatcctttggaatcagcgtg
ttacgagccctcaggttattgcgtattttcaaagtcacaaagtactgggcatctctcaga
aacctggtcgtctctctcctcaactccatgaagtccatcatcagcctgttgtttctcctt
ttcctgttcattgtcgtcttcgcccttttgggaatgcaactcttcggcggccagtttaat
ttcgatgaagggactcctcccaccaacttcgatacttttccagcagcaataatgacggtg
tttcagatcctgacgggcgaagactggaacgaggtcatgtacgacgggatcaagtctcag
gggggcgtgcagggcggcatggtgttctccatctatttcattgtactgacgctctttggg
aactacaccctcctgaatgtgttcttggccatcgctgtggacaatctggccaacgcccag
gagctcaccaaggacgagcaagaggaagaagaagcagcgaaccagaaacttgccctacag
aaagccaaggaggtggcagaagtgagtcctctgtccgcggccaacatgtctatagctgtg
aaagagcaacagaagaatcaaaagccagccaagtccgtgtgggagcagcggaccagtgag
atgcgaaagcagaacttgctggccagccgggaggccctgtataacgaaatggacccggac
gagcgctggaaggctgcctacacgcggcacctgcggccagacatgaagacgcacttggac
cggccgctggtggtggacccgcaggagaaccgcaacaacaacaccaacaagagccgggcg
gccgagcccaccgtggaccagcgcctcggccagcagcgcgccgaggacttcctcaggaaa
caggcccgctaccacgatcgggcccgggaccccagcggctcggcgggcctggacgcacgg
aggccctgggcgggaagccaggaggccgagctgagccgggagggaccctacggccgcgag
tcggaccaccacgcccgggagggcagcctggagcaacccgggttctgggagggcgaggcc
gagcgaggcaaggccggggacccccaccggaggcacgtgcaccggcaggggggcagcagg
gagagccgcagcgggtccccgcgcacgggcgcggacggggagcatcgacgtcatcgcgcg
caccgcaggcccggggaggagggtccggaggacaaggcggagcggagggcgcggcaccgc
gagggcagccggccggcccggggcggcgagggcgagggcgagggccccgacgggggcgag
cgcaggagaaggcaccggcatggcgctccagccacgtacgagggggacgcgcggagggag
gacaaggagcggaggcatcggaggaggaaagagaaccagggctccggggtccctgtgtcg
ggccccaacctgtcaaccacccggccaatccagcaggacctgggccgccaagacccaccc
ctggcagaggatattgacaacatgaagaacaacaagctggccaccgcggagtcggccgct
ccccacggcagccttggccacgccggcctgccccagagcccagccaagatgggaaacagc
accgaccccggccccatgctggccatccctgccatggccaccaacccccagaacgccgcc
agccgccggacgcccaacaacccggggaacccatccaatcccggcccccccaagaccccc
gagaatagccttatcgtcaccaaccccagcggcacccagaccaattcagctaagactgcc
aggaaacccgaccacaccacagtggacatccccccagcctgcccaccccccctcaaccac
accgtcgtacaagtgaacaaaaacgccaacccagacccactgccaaaaaaagaggaagag
aagaaggaggaggaggaagacgaccgtggggaagacggccctaagccaatgcctccctat
agctccatgttcatcctgtccacgaccaacccccttcgccgcctgtgccattacatcctg
aacctgcgctactttgagatgtgcatcctcatggtcattgccatgagcagcatcgccctg
gccgccgaggaccctgtgcagcccaacgcacctcggaacaacgtgctgcgatactttgac
tacgtttttacaggcgtctttacctttgagatggtgatcaagatgattgacctggggctc
gtcctgcatcagggtgcctacttccgtgacctctggaatattctcgacttcatagtggtc
agtggggccctggtagcctttgccttcactggcaatagcaaaggaaaagacatcaacacg
attaaatccctccgagtcctccgggtgctacgacctcttaaaaccatcaagcggctgcca
aagctcaaggctgtgtttgactgtgtggtgaactcacttaaaaacgtcttcaacatcctc
atcgtctacatgctattcatgttcatcttcgccgtggtggctgtgcagctcttcaagggg
aaattcttccactgcactgacgagtccaaagagtttgagaaagattgtcgaggcaaatac
ctcctctacgagaagaatgaggtgaaggcgcgagaccgggagtggaagaagtatgaattc
cattacgacaatgtgctgtgggctctgctgaccctcttcaccgtgtccacgggagaaggc
tggccacaggtcctcaagcattcggtggacgccacctttgagaaccagggccccagcccc
gggtaccgcatggagatgtccattttctacgtcgtctactttgtggtgttccccttcttc
tttgtcaatatctttgtggccttgatcatcatcaccttccaggagcaaggggacaagatg
atggaggaatacagcctggagaaaaatgagagggcctgcattgatttcgccatcagcgcc
aagccgctgacccgacacatgccgcagaacaagcagagcttccagtaccgcatgtggcag
ttcgtggtgtctccgcctttcgagtacacgatcatggccatgatcgccctcaacaccatc
gtgcttatgatgaagttctatggggcttctgttgcttatgaaaatgccctgcgggtgttc
aacatcgtcttcacctccctcttctctctggaatgtgtgctgaaagtcatggcttttggg
attctgaattatttccgcgatgcctggaacatcttcgactttgtgactgttctgggcagc
atcaccgatatcctcgtgactgagtttgggaataacttcatcaacctgagctttctccgc
ctcttccgagctgcccggctcatcaaacttctccgtcagggttacaccatccgcattctt
ctctggacctttgtgcagtccttcaaggccctgccttatgtctgtctgctgatcgccatg
ctcttcttcatctatgccatcattgggatgcaggtgtttggtaacattggcatcgacgtg
gaggacgaggacagtgatgaagatgagttccaaatcactgagcacaataacttccggacc
ttcttccaggccctcatgcttctcttccggagtgccaccggggaagcttggcacaacatc
atgctttcctgcctcagcgggaaaccgtgtgataagaactctggcatcctgactcgagag
tgtggcaatgaatttgcttatttttactttgtttccttcatcttcctctgctcgtttctg
atgctgaatctctttgtcgccgtcatcatggacaactttgagtacctcacccgagactcc
tccatcctgggcccccaccacctggatgagtacgtgcgtgtctgggccgagtatgacccc
gcagcttggggccgcatgccttacctggacatgtatcagatgctgagacacatgtctccg
cccctgggtctggggaagaagtgtccggccagagtggcttacaagcggcttctgcggatg
gacctgcccgtcgcagatgacaacaccgtccacttcaattccaccctcatggctctgatc
cgcacagccctggacatcaagattgccaagggaggagccgacaaacagcagatggacgct
gagctgcggaaggagatgatggcgatttggcccaatctgtcccagaagacgctagacctg
ctggtcacacctcacaagtccacggacctcaccgtggggaagatctacgcagccatgatg
atcatggagtactaccggcagagcaaggccaagaagctgcaggccatgcgcgaggagcag
gaccggacacccctcatgttccagcgcatggagcccccgtccccaacgcaggaaggggga
cctggccagaacgccctcccctccacccagctggacccaggaggagccctgatggctcac
gaaagcggcctcaaggagagcccgtcctgggtgacccagcgtgcccaggagatgttccag
aagacgggcacatggagtccggaacaaggcccccctaccgacatgcccaacagccagcct
aactctcagtccgtggagatgcgagagatgggcagagatggctactccgacagcgagcac
tacctccccatggaaggccagggccgggctgcctccatgccccgcctccctgcagagaac
cagaggagaaggggccggccacgtgggaataacctcagtaccatctcagacaccagcccc
atgaagcgttcagcctccgtgctgggccccaaggcccgacgcctggacgattactcgctg
gagcgggtcccgcccgaggagaaccagcggcaccaccagcggcgccgcgaccgcagccac
cgcgcctctgagcgctccctgggccgctacaccgatgtggacacaggcttggggacagac
ctgagcatgaccacccaatccggggacctgccgtcgaaggagcgggaccaggagcggggc
cggcccaaggatcggaagcatcgacagcaccaccaccaccaccaccaccaccaccatccc
ccgccccccgacaaggaccgctatgcccaggaacggccggaccacggccgggcacgggct
cgggaccagcgctggtcccgctcgcccagcgagggccgagagcacatggcgcaccggcag
ggcagtagttccgtaagtggaagcccagccccctcaacatctggtaccagcactccgcgg
cggggccgccgccagctcccccagaccccctccaccccccggccacacgtgtcctattcc
cctgtgatccgtaaggccggcggctcggggcccccgcagcagcagcagcagcagcagcag
cagcagcagcagcaggcggtggccaggccgggccgggcggccaccagcggccctcggagg
tacccaggccccacggccgagcctctggccggagatcggccgcccacggggggccacagc
agcggccgctcgcccaggatggagaggcgggtcccaggcccggcccggagcgagtccccc
agggcctgtcgacacggcggggcccggtggccggcatctggcccgcacgtgtccgagggg
cccccgggtccccggcaccatggctactaccggggctccgactacgacgaggccgatggc
ccgggcagcgggggcggcgaggaggccatggccggggcctacgacgcgccaccccccgta
cgacacgcgtcctcgggcgccaccgggcgctcgcccaggactccccgggcctcgggcccg
gcctgcgcctcgccttctcggcacggccggcgactccccaacggctactacccggcgcac
ggactggccaggccccgcgggccgggctccaggaagggcctgcacgaaccctacagcgag
agtgacgatgattggtgctaa

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