KEGG   Homo sapiens (human): 7786Help
Entry
7786              CDS       T01001                                 

Gene name
MAP3K12, DLK, MEKK12, MUK, ZPK, ZPKP1
Definition
(RefSeq) mitogen-activated protein kinase kinase kinase 12
  KO
K04423  
mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Module
MAPK (JNK) signaling
MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    7786 (MAP3K12)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     7786 (MAP3K12)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: TKL group
  MLK family
   7786 (MAP3K12)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
Pharos: 
Q12852(Tchem)
UniProt: 
Structure
PDB: 

Jmol
Position
12q13.13
AA seq 859 aa AA seqDB search
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
NT seq 2580 nt NT seq  +upstreamnt  +downstreamnt
atggcttgcctccatgagacccgaacaccctctccttcctttgggggctttgtgtctacc
ctaagtgaggcatccatgcgcaagctggacccagacacttctgactgcactcccgagaag
gacctgacgcctacccatgtcctgcagctacatgagcaggatgcagggggcccaggggga
gcagctgggtcacctgagagtcgggcatccagagttcgagctgacgaggtgcgactgcag
tgccagagtggcagtggcttccttgagggcctctttggctgcctgcgccctgtctggacc
atgattggcaaagcctactccactgagcacaagcagcagcaggaagacctttgggaggtc
ccctttgaggaaatcctggacctgcagtgggtgggctcaggggcccagggtgctgtcttc
ctggggcgcttccacggggaggaggtggctgtgaagaaggtgcgagacctcaaagaaacc
gacatcaagcacttgcgaaagctgaagcaccccaacatcatcactttcaagggtgtgtgc
acccaggctccctgctactgcatcctcatggagttctgcgcccagggccagctgtatgag
gtactgcgggctggccgccctgtcaccccctccttactggttgactggtccatgggcatc
gctggtggcatgaactacctgcacctgcacaagattatccacagggatctcaagtcaccc
aacatgctaatcacctacgacgatgtggtgaagatctcagattttggcacttccaaggag
ctgagtgacaagagcaccaagatgtcctttgcagggacagtagcctggatggcccctgag
gtgatccgcaatgaacctgtgtctgagaaggtcgacatctggtcctttggcgtggtgcta
tgggaactgctgactggtgagatcccctacaaagacgtagattcctcagccattatctgg
ggtgtgggaagcaacagtctccatctgcccgtgccctccagttgcccagatggtttcaag
atcctgcttcgccagtgctggaatagcaaaccacgaaatcgcccatcattccgacagatc
ctgctgcatctggacattgcctcagctgatgtactctccacaccccaggagacttacttt
aagtcccaggcagagtggcgggaagaagtaaaactgcactttgaaaagattaagtcagaa
gggacctgtctgcaccgcctagaagaggaactggtgatgaggaggagggaggagctcaga
cacgccctggacatcagggagcactatgaaaggaagctggagagagccaacaacctgtat
atggaacttaatgccctcatgttgcagctggaactcaaggagagggagctgctcaggcga
gagcaagctttagagcggaggtgcccaggcctgctgaagccacacccttcccggggcctc
ctgcatggaaacacaatggagaagcttatcaagaagaggaatgtgccacagaagctgtca
ccccatagcaaaaggccagatatcctcaagacggagtctttgctccctaaactagatgca
gccctgagtggggtggggcttcctgggtgtcctaagggccccccctcaccaggacggagt
cgccgtggcaagacccgtcaccgcaaggccagcgccaaggggagctgtggggacctgcct
gggcttcgtacagctgtgccaccccatgaacctggaggaccaggaagcccagggggccta
ggagggggaccctcagcctgggaggcctgccctcccgccctccgtgggcttcatcatgac
ctcctgctccgcaaaatgtcttcatcgtccccagacctgctgtcagcagcactagggtcc
cggggccggggggccacaggcggagctggggatcctggctcaccacctccggcccggggt
gacaccccaccaagtgagggctcagcccctggctccaccagcccagattcacctggggga
gccaaaggggaaccacctcctccagtagggcctggtgaaggtgtggggcttctgggaact
ggaagggaagggacctcaggccggggaggaagccgggctgggtcccagcacttgacccca
gctgcactgctgtacagggctgccgtcacccgaagtcagaaacgtggcatctcatcggaa
gaggaggaaggagaggtagacagtgaagtagagctgacatcaagccagaggtggcctcag
agcctgaacatgcgccagtcactatctaccttcagctcagagaatccatcagatggggag
gaaggcacagctagtgaaccttcccccagtggcacacctgaagttggcagcaccaacact
gatgagcggccagatgagcggtctgatgacatgtgctcccagggctcagaaatcccactg
gacccacctccttcagaggtcatccctggccctgaacccagctccctgcccattccacac
caggaacttctcagagagcggggccctcccaattctgaggactcagactgtgacagcact
gaattggacaactccaacagcgttgatgccttgcggcccccagcttccctccctccatga

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