KEGG   Homo sapiens (human): 7874
Entry
7874              CDS       T01001                                 
Symbol
USP7, C16DELp13.2, DEL16P13.2, HAFOUS, HAUSP, TEF1
Name
(RefSeq) ubiquitin specific peptidase 7
  KO
K11838  ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04068  FoxO signaling pathway
hsa05169  Epstein-Barr virus infection
hsa05203  Viral carcinogenesis
Network
nt06165  Epstein-Barr virus (EBV)
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N00223  EBV EBNA1 to p53-mediated transcription
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
Disease
H02528  Hao-Fountain syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    7874 (USP7)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    7874 (USP7)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    7874 (USP7)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    7874 (USP7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7874 (USP7)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7874 (USP7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     7874 (USP7)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C19: ubiquitin-specific protease family
   7874 (USP7)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    7874 (USP7)
SSDB
Motif
Pfam: USP7_ICP0_bdg UCH USP7_C2 MATH UCH_1
Other DBs
NCBI-GeneID: 7874
NCBI-ProteinID: NP_003461
OMIM: 602519
HGNC: 12630
Ensembl: ENSG00000187555
UniProt: Q93009 Q6U8A4
Structure
Position
16:complement(8892097..8963906)
AA seq 1102 aa
MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDME
DDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQ
CNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPE
KGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRK
AVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELC
RVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNI
FESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIK
INDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKF
DDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQL
VERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNS
SLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTI
FLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVM
CDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSEL
PTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFF
KSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLN
SQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLE
CLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREV
MKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLD
HFNKAPKRSRYTYLEKAIKIHN
NT seq 3309 nt   +upstreamnt  +downstreamnt
atgaaccaccagcagcagcagcagcagcagaaagcgggcgagcagcagttgagcgagccc
gaggacatggagatggaagcgggagatacagatgacccaccaagaattactcagaaccct
gtgatcaatgggaatgtggccctgagtgatggacacaacaccgcggaggaggacatggag
gatgacaccagttggcgctccgaggcaacctttcagttcactgtggagcgcttcagcaga
ctgagtgagtcggtccttagccctccgtgttttgtgcgaaatctgccatggaagattatg
gtgatgccacgcttttatccagacagaccacaccaaaaaagcgtaggattctttctccag
tgcaatgctgaatctgattccacgtcatggtcttgccatgcacaagcagtgctgaagata
ataaattacagagatgatgaaaagtcgttcagtcgtcgtattagtcatttgttcttccat
aaagaaaatgattggggattttccaattttatggcctggagtgaagtgaccgatcctgag
aaaggatttatagatgatgacaaagttacctttgaagtctttgtacaggcggatgctccc
catggagttgcgtgggattcaaagaagcacacaggctacgtcggcttaaagaatcaggga
gcgacttgttacatgaacagcctgctacagacgttatttttcacgaatcagctacgaaag
gctgtgtacatgatgccaaccgagggggatgattcgtctaaaagcgtccctttagcatta
caaagagtgttctatgaattacagcatagtgataaacctgtaggaacaaaaaagttaaca
aagtcatttgggtgggaaactttagatagcttcatgcaacatgatgttcaggagctttgt
cgagtgttgctcgataatgtggaaaataagatgaaaggcacctgtgtagagggcaccata
cccaaattattccgcggcaaaatggtgtcctatatccagtgtaaagaagtagactatcgg
tctgatagaagagaagattattatgatatccagctaagtatcaaaggaaagaaaaatata
tttgaatcatttgtggattatgtggcagtagaacagctcgatggggacaataaatacgac
gctggggaacatggcttacaggaagcagagaaaggtgtgaaattcctaacattgccacca
gtgttacatctacaactgatgagatttatgtatgaccctcagacggaccaaaatatcaag
atcaatgataggtttgaattcccagagcagttaccacttgatgaatttttgcaaaaaaca
gatcctaaggaccctgcaaattatattcttcatgcagtcctggttcatagtggagataat
catggtggacattatgtggtttatctaaaccccaaaggggatggcaaatggtgtaaattt
gatgacgacgtggtgtcaaggtgtactaaagaggaagcaattgagcacaattatgggggt
cacgatgacgacctgtctgttcgacactgcactaatgcttacatgttagtctacatcagg
gaatcaaaactgagtgaagttttacaggcggtcaccgaccatgatattcctcagcagttg
gtggagcgattacaagaagagaaaaggatcgaggctcagaagcggaaggagcggcaggaa
gcccatctctatatgcaagtgcagatagtcgcagaggaccagttttgtggccaccaaggg
aatgacatgtacgatgaagaaaaagtgaaatacactgtgttcaaagtattgaagaactcc
tcgcttgctgagtttgttcagagcctctctcagaccatgggatttccacaagatcaaatt
cgattgtggcccatgcaagcaaggagtaatggaacaaaacgaccagcaatgttagataat
gaagccgacggcaataaaacaatgattgagctcagtgataatgaaaacccttggacaata
ttcctggaaacagttgatcccgagctggctgctagtggagcgaccttacccaagtttgat
aaagatcatgatgtaatgttatttttgaagatgtatgatcccaaaacgcggagcttgaat
tactgtgggcatatctacacaccaatatcctgtaaaatacgtgacttgctcccagttatg
tgtgacagagcaggatttattcaagatactagccttatcctctatgaggaagttaaaccg
aatttaacagagagaattcaggactatgacgtgtctcttgataaagcccttgatgaacta
atggatggtgacatcatagtatttcagaaggatgaccctgaaaatgataacagtgaatta
cccaccgcaaaggagtatttccgagatctctaccaccgcgttgatgtcattttctgtgat
aaaacaatccctaatgatcctggatttgtggttacgttatcaaatagaatgaattatttt
caggttgcaaagacagttgcacagaggctcaacacagatccaatgttgctgcagtttttc
aagtctcaaggttatagggatggcccaggtaatcctcttagacataattatgaaggtact
ttaagagatcttctacagttcttcaagcctagacaacctaagaaactttactatcagcag
cttaagatgaaaatcacagactttgagaacaggcgaagttttaaatgtatatggttaaac
agccaatttagggaagaggaaataacactatatccagacaagcatgggtgtgtccgggac
ctgttagaagaatgtaaaaaggccgtggagcttggggagaaagcatcagggaaacttagg
ctgctagaaattgtaagctacaaaatcattggtgttcatcaagaagatgaactattagaa
tgtttatctcctgcaacgagccggacgtttcgaatagaggaaatccctttggaccaggtg
gacatagacaaagagaatgagatgcttgtcacagtggcgcatttccacaaagaggtcttc
ggaacgttcggaatcccgtttttgctgaggatacaccagggcgagcattttcgagaagtg
atgaagcgaatccagagcctgctggacatccaggagaaggagtttgagaagtttaaattt
gcaattgtaatgatgggccgacaccagtacataaatgaagacgagtatgaagtaaatttg
aaagactttgagccacagcccggtaatatgtctcatcctcggccttggctagggctcgac
cacttcaacaaagccccaaagaggagtcgctacacttaccttgaaaaggccattaaaatc
cataactga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (4)   
   KEGG NETWORK (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (27)   
   RefSeq(nuc) (7)   
   GenBank (10)   
   EMBL (10)   
3D Structure (63)   
   PDB (63)   
Protein domain (5)   
   Pfam (5)   
All databases (143)   

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