KEGG   Homo sapiens (human): 814Help
Entry
814               CDS       T01001                                 

Gene name
CAMK4, CaMK_IV, CaMK-GR, caMK
Definition
(RefSeq) calcium/calmodulin dependent protein kinase IV
  KO
K05869  calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04211  Longevity regulating pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04921  Oxytocin signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    814 (CAMK4)
   04020 Calcium signaling pathway
    814 (CAMK4)
   04024 cAMP signaling pathway
    814 (CAMK4)
 Organismal Systems
  Endocrine system
   04921 Oxytocin signaling pathway
    814 (CAMK4)
   04925 Aldosterone synthesis and secretion
    814 (CAMK4)
  Nervous system
   04725 Cholinergic synapse
    814 (CAMK4)
   04720 Long-term potentiation
    814 (CAMK4)
   04722 Neurotrophin signaling pathway
    814 (CAMK4)
  Development
   04380 Osteoclast differentiation
    814 (CAMK4)
  Aging
   04211 Longevity regulating pathway - mammal
    814 (CAMK4)
 Human Diseases
  Substance dependence
   05031 Amphetamine addiction
    814 (CAMK4)
   05034 Alcoholism
    814 (CAMK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     814 (CAMK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK1 family [OT]
   814 (CAMK4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kinase-like FTA2 Kdo DUF1103 APH YrbL-PhoP_reg
Motif
Other DBs
NCBI-GeneID: 814
NCBI-ProteinID: NP_001310303
OMIM: 114080
HGNC: 1464
Ensembl: ENSG00000152495
Vega: OTTHUMG00000128792
Pharos: Q16566(Tbio)
UniProt: Q16566
Structure
PDB: 

Jmol
Position
5q22.1
AA seq 473 aa AA seqDB search
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
NT seq 1422 nt NT seq  +upstreamnt  +downstreamnt
atgctcaaagtcacggtgccctcctgctccgcctcgtcctgctcttcggtcaccgccagt
gcggccccggggaccgcgagcctcgtcccggattactggatcgacggctccaacagggat
gcgctgagcgatttcttcgaggtggagtcggagctgggacggggtgctacatccattgtg
tacagatgcaaacagaaggggacccagaagccttatgctctcaaagtgttaaagaaaaca
gtggacaaaaaaatcgtaagaactgagataggagttcttcttcgcctctcacatccaaac
attataaaacttaaagagatatttgaaacccctacagaaatcagtctggtcctagaactc
gtcacaggaggagaactgtttgataggattgtggaaaagggatattacagtgagcgagat
gctgcagatgccgttaaacaaatcctggaggcagttgcttatctacatgaaaatgggatt
gtccatcgtgatctcaaaccagagaatcttctttatgcaactccagccccagatgcacca
ctcaaaatcgctgattttggactctctaaaattgtggaacatcaagtgctcatgaagaca
gtatgtggaaccccagggtactgcgcacctgaaattcttagaggttgtgcctatggacct
gaggtggacatgtggtctgtaggaataatcacctacatcttactttgtggatttgaacca
ttctatgatgaaagaggcgatcagttcatgttcaggagaattctgaattgtgaatattac
tttatctccccctggtgggatgaagtatctctaaatgccaaggacttggtcagaaaatta
attgttttggatccaaagaaacggctgactacatttcaagctctccagcatccgtgggtc
acaggtaaagcagccaattttgtacacatggataccgctcaaaagaagctccaagaattc
aatgcccggcgtaagcttaaggcagcggtgaaggctgtggtggcctcttcgcgcctggga
agtgccagcagcagccatggcagcatccaggagagccacaaggctagccgagacccttct
ccaatccaagatggcaacgaggacatgaaagctattccagaaggagagaaaattcaaggc
gatggggcccaagccgcagttaagggggcacaggctgagctgatgaaggtgcaagcctta
gagaaagttaaaggtgcagatataaatgctgaagaggcccccaaaatggtgcccaaggca
gtggaggatgggataaaggtggctgacctggaactagaggagggcctagcagaggagaag
ctgaagactgtggaggaggcagcagctcccagagaagggcaaggaagctctgctgtgggt
tttgaagttccacagcaagatgtgatcctgccagagtactaa

KEGG   Homo sapiens (human): 815Help
Entry
815               CDS       T01001                                 

Gene name
CAMK2A, CAMKA, MRD53
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II alpha
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing's syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    815 (CAMK2A)
   04310 Wnt signaling pathway
    815 (CAMK2A)
   04066 HIF-1 signaling pathway
    815 (CAMK2A)
   04020 Calcium signaling pathway
    815 (CAMK2A)
   04024 cAMP signaling pathway
    815 (CAMK2A)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    815 (CAMK2A)
   04217 Necroptosis
    815 (CAMK2A)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    815 (CAMK2A)
   04922 Glucagon signaling pathway
    815 (CAMK2A)
   04912 GnRH signaling pathway
    815 (CAMK2A)
   04921 Oxytocin signaling pathway
    815 (CAMK2A)
   04916 Melanogenesis
    815 (CAMK2A)
   04925 Aldosterone synthesis and secretion
    815 (CAMK2A)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    815 (CAMK2A)
  Digestive system
   04971 Gastric acid secretion
    815 (CAMK2A)
  Nervous system
   04725 Cholinergic synapse
    815 (CAMK2A)
   04728 Dopaminergic synapse
    815 (CAMK2A)
   04720 Long-term potentiation
    815 (CAMK2A)
   04722 Neurotrophin signaling pathway
    815 (CAMK2A)
  Sensory system
   04740 Olfactory transduction
    815 (CAMK2A)
   04750 Inflammatory mediator regulation of TRP channels
    815 (CAMK2A)
  Development
   04360 Axon guidance
    815 (CAMK2A)
  Environmental adaptation
   04713 Circadian entrainment
    815 (CAMK2A)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    815 (CAMK2A)
   05205 Proteoglycans in cancer
    815 (CAMK2A)
   05214 Glioma
    815 (CAMK2A)
  Substance dependence
   05031 Amphetamine addiction
    815 (CAMK2A)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    815 (CAMK2A)
  Infectious diseases
   05152 Tuberculosis
    815 (CAMK2A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     815 (CAMK2A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   815 (CAMK2A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr SnoaL_3 DUF4440 APH Kdo SnoaL_2 SnoaL_4
Motif
Other DBs
NCBI-GeneID: 815
NCBI-ProteinID: NP_741960
OMIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808
Vega: OTTHUMG00000134281
Pharos: Q9UQM7(Tchem)
UniProt: Q9UQM7 A8K161 Q7LDD5 Q8IWE0
Structure
PDB: 

Jmol
Position
5q32
AA seq 478 aa AA seqDB search
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
NT seq 1437 nt NT seq  +upstreamnt  +downstreamnt
atggccaccatcacctgcacccgcttcacggaagagtaccagctcttcgaggaattgggc
aagggagccttctcggtggtgcgaaggtgtgtgaaggtgctggctggccaggagtatgct
gccaagatcatcaacacaaagaagctgtcagccagagaccatcagaagctggagcgtgaa
gcccgcatctgccgcctgctgaagcaccccaacatcgtccgactacatgacagcatctca
gaggagggacaccactacctgatcttcgacctggtcactggtggggaactgtttgaagat
atcgtggcccgggagtattacagtgaggcggatgccagtcactgtatccagcagatcctg
gaggctgtgctgcactgccaccagatgggggtggtgcaccgggacctgaagcctgagaat
ctgttgctggcctccaagctcaagggtgccgcagtgaagctggcagactttggcctggcc
atagaggtggagggggagcagcaggcatggtttgggtttgcagggactcctggatatctc
tccccagaagtgctgcggaaggacccgtacgggaagcctgtggacctgtgggcttgtggg
gtcatcctgtacatcctgctggttgggtaccccccgttctgggatgaggaccagcaccgc
ctgtaccagcagatcaaagccggcgcctatgatttcccatcgccggaatgggacactgtc
accccggaagccaaggatctgatcaataagatgctgaccattaacccatccaaacgcatc
acagctgccgaagcccttaagcacccctggatctcgcaccgctccaccgtggcatcctgc
atgcacagacaggagaccgtggactgcctgaagaagttcaatgccaggaggaaactgaag
ggagccattctcaccacgatgctggccaccaggaacttctccggagggaagagtggggga
aacaagaagagcgatggtgtgaaggaatcctcagagagcaccaacaccaccatcgaggat
gaagacaccaaagtgcggaaacaggaaattataaaagtgacagagcagctgattgaagcc
ataagcaatggagattttgagtcctacacgaagatgtgcgaccctggcatgacagccttc
gaacctgaggccctggggaacctggttgagggcctggacttccatcgattctattttgaa
aacctgtggtcccggaacagcaagcccgtgcacaccaccatcctgaatccccacatccac
ctgatgggcgacgagtcagcctgcatcgcctacatccgcatcacgcagtacctggacgct
ggcggcatcccacgcaccgcccagtcggaggagacccgtgtctggcaccgccgggatggc
aaatggcagatcgtccacttccacagatctggggcgccctccgtcctgccccactga

KEGG   Homo sapiens (human): 816Help
Entry
816               CDS       T01001                                 

Gene name
CAMK2B, CAM2, CAMK2, CAMKB, MRD54
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II beta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing's syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    816 (CAMK2B)
   04310 Wnt signaling pathway
    816 (CAMK2B)
   04066 HIF-1 signaling pathway
    816 (CAMK2B)
   04020 Calcium signaling pathway
    816 (CAMK2B)
   04024 cAMP signaling pathway
    816 (CAMK2B)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    816 (CAMK2B)
   04217 Necroptosis
    816 (CAMK2B)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    816 (CAMK2B)
   04922 Glucagon signaling pathway
    816 (CAMK2B)
   04912 GnRH signaling pathway
    816 (CAMK2B)
   04921 Oxytocin signaling pathway
    816 (CAMK2B)
   04916 Melanogenesis
    816 (CAMK2B)
   04925 Aldosterone synthesis and secretion
    816 (CAMK2B)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    816 (CAMK2B)
  Digestive system
   04971 Gastric acid secretion
    816 (CAMK2B)
  Nervous system
   04725 Cholinergic synapse
    816 (CAMK2B)
   04728 Dopaminergic synapse
    816 (CAMK2B)
   04720 Long-term potentiation
    816 (CAMK2B)
   04722 Neurotrophin signaling pathway
    816 (CAMK2B)
  Sensory system
   04740 Olfactory transduction
    816 (CAMK2B)
   04750 Inflammatory mediator regulation of TRP channels
    816 (CAMK2B)
  Development
   04360 Axon guidance
    816 (CAMK2B)
  Environmental adaptation
   04713 Circadian entrainment
    816 (CAMK2B)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    816 (CAMK2B)
   05205 Proteoglycans in cancer
    816 (CAMK2B)
   05214 Glioma
    816 (CAMK2B)
  Substance dependence
   05031 Amphetamine addiction
    816 (CAMK2B)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    816 (CAMK2B)
  Infectious diseases
   05152 Tuberculosis
    816 (CAMK2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     816 (CAMK2B)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   816 (CAMK2B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr DUF4440 SnoaL_3 SnoaL_2 Kdo SnoaL_4
Motif
Other DBs
NCBI-GeneID: 816
NCBI-ProteinID: NP_001211
OMIM: 607707
HGNC: 1461
Ensembl: ENSG00000058404
Vega: OTTHUMG00000023491
Pharos: Q13554(Tchem)
UniProt: Q13554 A4D2J9
Structure
PDB: 

Jmol
Position
7p13
AA seq 666 aa AA seqDB search
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
KGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTK
NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR
RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSP
ALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIK
TTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHT
TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGA
PVAPLQ
NT seq 2001 nt NT seq  +upstreamnt  +downstreamnt
atggccaccacggtgacctgcacccgcttcaccgacgagtaccagctctacgaggatatt
ggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtat
gcagccaagatcatcaacaccaagaagctgtcagccagagatcaccagaagctggagaga
gaggctcggatctgccgccttctgaagcattccaacatcgtgcgtctccacgacagcatc
tccgaggagggcttccactacctggtcttcgatctggtcactggtggggagctctttgaa
gacattgtggcgagagagtactacagcgaggctgatgccagtcactgtatccagcagatc
ctggaggccgttctccattgtcaccaaatgggggtcgtccacagagacctcaagccggag
aacctgcttctggccagcaagtgcaaaggggctgcagtgaagctggcagacttcggccta
gctatcgaggtgcagggggaccagcaggcatggtttggtttcgctggcacaccaggctac
ctgtcccctgaggtccttcgcaaagaggcgtatggcaagcctgtggacatctgggcatgt
ggggtgatcctgtacatcctgctcgtgggctacccacccttctgggacgaggaccagcac
aagctgtaccagcagatcaaggctggtgcctatgacttcccgtcccctgagtgggacacc
gtcactcctgaagccaaaaacctcatcaaccagatgctgaccatcaaccctgccaagcgc
atcacagcccatgaggccctgaagcacccgtgggtctgccaacgctccacggtagcatcc
atgatgcacagacaggagactgtggagtgtctgaaaaagttcaatgccaggagaaagctc
aagggagccatcctcaccaccatgctggccacacggaatttctcagtgggcagacagacc
accgctccggccacaatgtccaccgcggcctccggcaccaccatggggctggtggaacaa
gccaagagtttactcaacaagaaagcagatggagtcaagccccagacgaatagcaccaaa
aacagtgcagccgccaccagccccaaagggacgcttcctcctgccgccctggagcctcaa
accaccgtcatccataacccagtggacgggattaaggagtcttctgacagtgccaatacc
accatagaggatgaagacgctaaagcccccagggtccccgacatcctgagctcagtgagg
aggggctcgggagccccagaagccgaggggcccctgccctgcccatctccggctcccttt
agccccctgccagccccatcccccaggatctctgacatcctgaactctgtgagaaggggt
tcaggaaccccagaagccgagggccccctctcagcggggcccccgccctgcctgtctccg
gctctcctaggccccctgtcctccccgtcccccaggatctctgacatcctgaactctgtg
aggaggggctcagggaccccagaagccgagggcccctcgccagtggggcccccgccctgc
ccatctccgactatccctggccccctgcccaccccatcccggaagcaggagatcattaag
accacggagcagctcatcgaggccgtcaacaacggtgactttgaggcctacgcgaaaatc
tgtgacccagggctgacctcgtttgagcctgaagcactgggcaacctggttgaagggatg
gacttccacagattctacttcgagaacctgctggccaagaacagcaagccgatccacacg
accatcctgaacccacacgtgcacgtcattggagaggatgccgcctgcatcgcttacatc
cggctcacgcagtacattgacgggcagggccggccccgcaccagccagtctgaggagacc
cgcgtgtggcaccgccgcgacggcaagtggcagaacgtgcacttccactgctcgggcgcg
cctgtggccccgctgcagtga

KEGG   Homo sapiens (human): 817Help
Entry
817               CDS       T01001                                 

Gene name
CAMK2D, CAMKD
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II delta
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing's syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    817 (CAMK2D)
   04310 Wnt signaling pathway
    817 (CAMK2D)
   04066 HIF-1 signaling pathway
    817 (CAMK2D)
   04020 Calcium signaling pathway
    817 (CAMK2D)
   04024 cAMP signaling pathway
    817 (CAMK2D)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    817 (CAMK2D)
   04217 Necroptosis
    817 (CAMK2D)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    817 (CAMK2D)
   04922 Glucagon signaling pathway
    817 (CAMK2D)
   04912 GnRH signaling pathway
    817 (CAMK2D)
   04921 Oxytocin signaling pathway
    817 (CAMK2D)
   04916 Melanogenesis
    817 (CAMK2D)
   04925 Aldosterone synthesis and secretion
    817 (CAMK2D)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    817 (CAMK2D)
  Digestive system
   04971 Gastric acid secretion
    817 (CAMK2D)
  Nervous system
   04725 Cholinergic synapse
    817 (CAMK2D)
   04728 Dopaminergic synapse
    817 (CAMK2D)
   04720 Long-term potentiation
    817 (CAMK2D)
   04722 Neurotrophin signaling pathway
    817 (CAMK2D)
  Sensory system
   04740 Olfactory transduction
    817 (CAMK2D)
   04750 Inflammatory mediator regulation of TRP channels
    817 (CAMK2D)
  Development
   04360 Axon guidance
    817 (CAMK2D)
  Environmental adaptation
   04713 Circadian entrainment
    817 (CAMK2D)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    817 (CAMK2D)
   05205 Proteoglycans in cancer
    817 (CAMK2D)
   05214 Glioma
    817 (CAMK2D)
  Substance dependence
   05031 Amphetamine addiction
    817 (CAMK2D)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    817 (CAMK2D)
  Infectious diseases
   05152 Tuberculosis
    817 (CAMK2D)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     817 (CAMK2D)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   817 (CAMK2D)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr DUF4440 SnoaL_3 Kdo SnoaL_4 SnoaL_2
Motif
Other DBs
NCBI-GeneID: 817
NCBI-ProteinID: NP_001212
OMIM: 607708
HGNC: 1462
Ensembl: ENSG00000145349
Vega: OTTHUMG00000132910
Pharos: Q13557(Tchem)
UniProt: Q13557 A0A024RDK3
Structure
PDB: 

Jmol
Position
4q26
AA seq 499 aa AA seqDB search
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
NT seq 1500 nt NT seq  +upstreamnt  +downstreamnt
atggcttcgaccacaacctgcaccaggttcacggacgagtatcagcttttcgaggagctt
ggaaagggggcattctcagtggtgagaagatgtatgaaaattcctactggacaagaatat
gctgccaaaattatcaacaccaaaaagctttctgctagggatcatcagaaactagaaaga
gaagctagaatctgccgtcttttgaagcaccctaatattgtgcgacttcatgatagcata
tcagaagagggctttcactacttggtgtttgatttagttactggaggtgaactgtttgaa
gacatagtggcaagagaatactacagtgaagctgatgccagtcattgtatacagcagatt
ctagaaagtgttaatcattgtcacctaaatggcatagttcacagggacctgaagcctgag
aatttgcttttagctagcaaatccaagggagcagctgtgaaattggcagactttggctta
gccatagaagttcaaggggaccagcaggcgtggtttggttttgctggcacacctggatat
ctttctccagaagttttacgtaaagatccttatggaaagccagtggatatgtgggcatgt
ggtgtcattctctatattctacttgtggggtatccacccttctgggatgaagaccaacac
agactctatcagcagatcaaggctggagcttatgattttccatcaccagaatgggacacg
gtgactcctgaagccaaagacctcatcaataaaatgcttactatcaaccctgccaaacgc
atcacagcctcagaggcactgaagcacccatggatctgtcaacgttctactgttgcttcc
atgatgcacagacaggagactgtagactgcttgaagaaatttaatgctagaagaaaacta
aagggtgccatcttgacaactatgctggctacaaggaatttctcagcagccaagagtttg
ttgaagaaaccagatggagtaaaggagtcaactgagagttcaaatacaacaattgaggat
gaagatgtgaaagcacgaaagcaagagattatcaaagtcactgaacaactgatcgaagct
atcaacaatggggactttgaagcctacacaaaaatctgtgacccaggccttactgctttt
gaacctgaagctttgggtaatttagtggaagggatggattttcaccgattctactttgaa
aatgctttgtccaaaagcaataaaccaatccacactattattctaaaccctcatgtacat
ctggtaggggatgatgccgcctgcatagcatatattaggctcacacagtacatggatggc
agtggaatgccaaagacaatgcagtcagaagagactcgtgtgtggcaccgccgggatgga
aagtggcagaatgttcattttcatcgctcggggtcaccaacagtacccatcaagccaccc
tgtattccaaatgggaaagaaaacttctcaggaggcacctctttgtggcaaaacatctaa

KEGG   Homo sapiens (human): 818Help
Entry
818               CDS       T01001                                 

Gene name
CAMK2G, CAMK, CAMK-II, CAMKG
Definition
(RefSeq) calcium/calmodulin dependent protein kinase II gamma
  KO
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04114  Oocyte meiosis
hsa04217  Necroptosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04740  Olfactory transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04921  Oxytocin signaling pathway
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04934  Cushing's syndrome
hsa04971  Gastric acid secretion
hsa05031  Amphetamine addiction
hsa05152  Tuberculosis
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05214  Glioma
Network
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00028  PDGF-PDGFR-PLCG-CAMK signaling pathway
N00029  Amplified PDGFR to PLCG-CAMK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    818 (CAMK2G)
   04310 Wnt signaling pathway
    818 (CAMK2G)
   04066 HIF-1 signaling pathway
    818 (CAMK2G)
   04020 Calcium signaling pathway
    818 (CAMK2G)
   04024 cAMP signaling pathway
    818 (CAMK2G)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    818 (CAMK2G)
   04217 Necroptosis
    818 (CAMK2G)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    818 (CAMK2G)
   04922 Glucagon signaling pathway
    818 (CAMK2G)
   04912 GnRH signaling pathway
    818 (CAMK2G)
   04921 Oxytocin signaling pathway
    818 (CAMK2G)
   04916 Melanogenesis
    818 (CAMK2G)
   04925 Aldosterone synthesis and secretion
    818 (CAMK2G)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    818 (CAMK2G)
  Digestive system
   04971 Gastric acid secretion
    818 (CAMK2G)
  Nervous system
   04725 Cholinergic synapse
    818 (CAMK2G)
   04728 Dopaminergic synapse
    818 (CAMK2G)
   04720 Long-term potentiation
    818 (CAMK2G)
   04722 Neurotrophin signaling pathway
    818 (CAMK2G)
  Sensory system
   04740 Olfactory transduction
    818 (CAMK2G)
   04750 Inflammatory mediator regulation of TRP channels
    818 (CAMK2G)
  Development
   04360 Axon guidance
    818 (CAMK2G)
  Environmental adaptation
   04713 Circadian entrainment
    818 (CAMK2G)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    818 (CAMK2G)
   05205 Proteoglycans in cancer
    818 (CAMK2G)
   05214 Glioma
    818 (CAMK2G)
  Substance dependence
   05031 Amphetamine addiction
    818 (CAMK2G)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    818 (CAMK2G)
  Infectious diseases
   05152 Tuberculosis
    818 (CAMK2G)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     818 (CAMK2G)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CAMK2 family
   818 (CAMK2G)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase CaMKII_AD Pkinase_Tyr SnoaL_3 DUF4440 APH Kdo SnoaL_2 RIO1
Motif
Other DBs
NCBI-GeneID: 818
NCBI-ProteinID: NP_751909
OMIM: 602123
HGNC: 1463
Ensembl: ENSG00000148660
Vega: OTTHUMG00000018492
Pharos: Q13555(Tchem)
UniProt: Q13555
Structure
PDB: 

Jmol
Position
10q22.2
AA seq 527 aa AA seqDB search
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI
LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
KGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVH
LMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTK
ICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAY
IRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
NT seq 1584 nt NT seq  +upstreamnt  +downstreamnt
atggccaccaccgccacctgcacccgtttcaccgacgactaccagctcttcgaggagctt
ggcaagggtgctttctctgtggtccgcaggtgtgtgaagaaaacctccacgcaggagtac
gcagcaaaaatcatcaataccaagaagttgtctgcccgggatcaccagaaactagaacgt
gaggctcggatatgtcgacttctgaaacatccaaacatcgtgcgcctccatgacagtatt
tctgaagaagggtttcactacctcgtgtttgaccttgttaccggcggggagctgtttgaa
gacattgtggccagagagtactacagtgaagcagatgccagccactgtatacatcagatt
ctggagagtgttaaccacatccaccagcatgacatcgtccacagggacctgaagcctgag
aacctgctgctggcgagtaaatgcaagggtgccgccgtcaagctggctgattttggccta
gccatcgaagtacagggagagcagcaggcttggtttggttttgctggcaccccaggttac
ttgtcccctgaggtcttgaggaaagatccctatggaaaacctgtggatatctgggcctgc
ggggtcatcctgtatatcctcctggtgggctatcctcccttctgggatgaggatcagcac
aagctgtatcagcagatcaaggctggagcctatgatttcccatcaccagaatgggacacg
gtaactcctgaagccaagaacttgatcaaccagatgctgaccataaacccagcaaagcgc
atcacggctgaccaggctctcaagcacccgtgggtctgtcaacgatccacggtggcatcc
atgatgcatcgtcaggagactgtggagtgtttgcgcaagttcaatgcccggagaaaactg
aagggtgccatcctcacgaccatgcttgtctccaggaacttctcagttggcaggcagagc
tccgcccccgcctcgcctgccgcgagcgccgccggcctggccgggcaagctgccaaaagc
ctattgaacaagaagtcggatggcggtgtcaagaaaaggaagtcgagttccagcgtgcac
ctaatggagccacaaaccactgtggtacacaacgctacagatgggatcaagggctccaca
gagagctgcaacaccaccacagaagatgaggacctcaaagtgcgaaaacaggagatcatt
aagattacagaacagctgattgaagccatcaacaatggggactttgaggcctacacgaag
atttgtgatccaggcctcacttcctttgagcctgaggcccttggtaacctcgtggagggg
atggatttccataagttttactttgagaatctcctgtccaagaacagcaagcctatccat
accaccatcctaaacccacacgtccacgtgattggggaggacgcagcgtgcatcgcctac
atccgcctcacccagtacatcgacgggcagggtcggcctcgcaccagccagtcagaagag
acccgggtctggcaccgtcgggatggcaagtggctcaatgtccactatcactgctcaggg
gcccctgccgcaccgctgcagtga

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