KEGG T01001: 8471

Homo sapiens (human): 8471

Entry

8471 CDS T01001

Gene name

IRS4, IRS-4, PY160

Definition

insulin receptor substrate 4

Orthology

K07187

insulin receptor substrate 2/3/4

Organism

hsa Homo sapiens (human)

Pathway

hsa04910	Insulin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04930	Type II diabetes mellitus

Class

Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:hsa04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:hsa04920]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:hsa04930]

SSDB

Motif

Pfam:

IRS PH PH_8 PH_11

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Position

Xq22.3

AA seq 1257 aa
MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR

NT seq 3774 nt +upstreamnt +downstreamnt
atggcgagttgctccttcactcgcgaccaagcgacaagaagactaagaggtgcagcagcg
gcggcagcggcagctctagcagcagtggtgaccaccccgcttctttcctcgggaaccccg
accgcactcattgggaccgggtcgtcttgtccgggagccatgtggctctccacggccact
ggctcccggtcagactccgagtccgaagaggaggacctgcccgtcggggaggaagtctgc
aaacgcggctacctgcggaaacagaagcatgggcacaggcgctacttcgtgctcaaactc
gagactgctgacgccccagctcggctggaatactacgaaaatgccaggaagttccggcac
agtgtccgcgccgcggcggctgcagcagcggcggccgcctctggcgccgcgatccccccg
ctcattccaccgcggcgcgtgatcaccctataccagtgcttttccgtgagccagcgagca
gatgcaaggtaccgacacctcattgctcttttcacccaagacgaatacttcgcgatggtg
gccgagaacgagtcggagcaggaaagctggtacttgctgctcagccgcctcatcctcgag
agcaagcgccgccgctgcggcacgctcggcgcgcagccggacggagagccggccgcgctg
gcggcggcagcggcggcggagccacccttctataaagatgtgtggcaggtaatagtcaaa
cccagggggctggggcacagaaaagagctgagcggcgtgttccggctgtgtctaaccgac
gaggaggtcgtgtttgtgaggctgaacaccgaagtggccagcgtggtcgtccagctcctg
agcatccgtcgctgtggacactcggagcagtatttcttcttggaagtaggcaggtccact
gtcatcggtccgggagagctctggatgcaggtcgatgactgtgtggttgcccaaaacatg
catgagctgtttttggagaagatgagagccttgtgtgcagacgaatacagagcccgctgc
cgcagctacagcatcagcatcggcgcccacctgttaaccctgctgtccgctaggaggcac
ctgggcttggtgccgctcgagccgggaggctggctcagaaggtcccgctttgagcagttt
tgccacctcagggccatcggcgacggggaagacgagatgcttttcaccaggcgcttcgta
acacccagcgagcctgtggcccactccaggcgaggaagactgcacctgcccagagggcgc
aggtcaaggagagcggtttcagtgccggccagcttttttcgccgcttagcacccagccca
gcacgtccccggcaccctgcagaagccccgaacaatggagctcgcctgtcttctgaagtg
tctggttctggctctggcaactttggggaggaaggcaatccccagggcaaagaagatcag
gaaggaagcggaggtgactacatgcctatgaacaattggggctcaggaaatggccggggc
tcaggaggtggccagggctcaaatggccaaggctccagtagccatagctcgggaggaaac
cagtgttcaggcgagggacagggatcccgaggtggtcagggctcaaatggccagggctca
ggaggaaaccagtgctctagagatggccagggcaccgcaggtgggcacggttcaggtggt
ggccagagacctggaggtgggcatggctcaggtggtggccagggacctggagatggccat
ggctcaggtggtggcaagaactctggggggggcaaaggctcaggaagtgggaaaggatcc
gatggtgatggtgaacgtggaaaatctctgaagaaaagatcctattttggcaaattaact
caaagcaagcaacagcaaatgccaccacctccaccacctcctcctccacccccaccagct
ggaggaactggtggaaaagggaagtctgggggaagattcagactttatttttgtgttgac
agaggagccacgaaagaatgcaaagaagccaaagaagtgaaagatgcagagatcccagaa
ggtgcagctcgaggtccccacagagccagagcttttgatgaagatgaggatgacccatac
gtgccaatgaggccaggggtggccacccctcttgtaagctccagtgattatatgccaatg
gctcctcaaaatgtctctgcttcaaaaaagcgccactctcgatccccttttgaagattca
agagggtacatgatgatgtttcccagagtgagcccaccacctgctccgagtcctccaaaa
gcacctgatactaataaagaggatgactcaaaggacaatgacagtgagagtgactacatg
tttatggctcctggagccggtgcaattccaaaaaaccccagaaatcctcagggtggctct
tcctccaaaagttggagctcctacttctctctaccaaacccttttcggagctcacctttg
ggacagaatgacaacagtgagtatgtgccaatgttacctggaaagttcctggggaggggc
ctagacaaagaagtctcctataactgggaccccaaagatgcagcttcaaagccttcaggt
gagggatcattctcaaagcctggagatgggggatcaccttcaaagccttcagatcatgag
cccccaaagaataaagctaagagacctaaccgactttcttttattacaaaaggatataaa
atcaagccaaaaccacaaaagcccacacatgagcagagagaagctgacagctctagtgac
tacgtcaacatggacttcactaaaagagagagcaatacaccagctccctctactcaagga
ctaccagattcgtggggcataattgctgaacccagacagtcagccttttctaattatgtg
aatgttgagtttggagtgccatttccaaatccagcaaacgacctctcagatcttttaaga
gctataccacgtgccaaccccttatctctggacagtgctaggtggccacttcctcccctt
cccctcagtgctacaggtagcaatgctattgaggaagagggtgactacattgaagtaatt
ttcaactcagcaatgacaccagccatggctcttgctgacagtgccattcgctatgatgct
gaaacaggtcgaatctatgtggtcgacccattttctgagtgctgtatggatatttctctc
tcccccagccgatgttctgaaccaccacctgtagctaggctgctgcaggaagaagagcag
gagagaagacgcccacaaagccgttctcaaagtttctttgcagcagccagagccgctgtc
tctgcttttccaacagacagcctcgagagagacctttccccatcctcagccccggctgtc
gcttcggctgcagagccgactttagccctcagccaagttgtagctgcggcctccgcgctc
gccgcagccccgggcatcggcgcagcagccgcagctgctggatttgactccgcctctgcc
cgctggtttcaacctgttgctaatgctgctgatgccgaagcagtaaggggagcccaagac
gttgccggtggctcgaaccctggagcccacaacccatctgcaaaccttgccagaggtgat
aaccaggctggcggggctgccgctgcagctgccgctccggaaccaccacctcgcagtcgc
cgggtgccaagacccccggagagagaagattctgacaacgacgacgacactcacgtgaga
atggattttgccagacgtgataatcagttcgactctcccaaaagaggtcggtaa

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   Pfam (4)   
All databases (30)   

Download RDF

DBGET integrated database retrieval system