KEGG T01001: 8654

Homo sapiens (human): 8654

Entry

8654 CDS T01001

Gene name

PDE5A, CGB-PDE, CN5A, PDE5

Definition

phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35)

Orthology

K13762

cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]

Organism

hsa Homo sapiens (human)

Pathway

hsa00230

Purine metabolism

Drug target

Dipyridamole:

D00302

Sildenafil:

D02229 D08514

Tadalafil:

D02008

Vardenafil:

D02731 D03260 D08668 D09989

Other:

D03217 D03657 D09621 D09622 D10027

Class

Metabolism; Nucleotide metabolism; Purine metabolism [PATH:hsa00230]

SSDB

Motif

Pfam:

PDEase_I GAF GAF_3 GAF_2 HD

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

1TBF 1XOZ 3HC8 1XP0 3HDZ 2H44 2H40 3TGG 3SIE 3TGE 3BJC 1T9S 1RKP 3B2R 1T9R 3TSE 2H42 1UDT 3TSF 3SHZ 2XSS 1UHO 3SHY 3LFV 1UDU 3JWQ 3JWR 3MF0 2CHM

Position

4q27

AA seq 875 aa
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

NT seq 2628 nt +upstreamnt +downstreamnt
atggagcgggccggccccagcttcgggcagcagcgacagcagcagcagccccagcagcag
aagcagcagcagagggatcaggactcggtcgaagcatggctggacgatcactgggacttt
accttctcatactttgttagaaaagccaccagagaaatggtcaatgcatggtttgctgag
agagttcacaccatccctgtgtgcaaggaaggtatcagaggccacaccgaatcttgctct
tgtcccttgcagcagagtcctcgtgcagataacagtgcccctggaacaccaaccaggaaa
atctctgcctctgaatttgaccggcctcttagacccattgttgtcaaggattctgaggga
actgtgagcttcctctctgactcagaaaagaaggaacagatgcctctaacccctccaagg
tttgatcatgatgaaggggaccagtgctcaagactcttggaattagtgaaggatatttct
agtcatttggatgtcacagccttatgtcacaaaattttcttgcatatccatggactgata
tctgctgaccgctattccctgttccttgtctgtgaagacagctccaatgacaagtttctt
atcagccgcctctttgatgttgctgaaggttcaacactggaagaagtttcaaataactgt
atccgcttagaatggaacaaaggcattgtgggacatgtggcagcgcttggtgagcccttg
aacatcaaagatgcatatgaggatcctcggttcaatgcagaagttgaccaaattacaggc
tacaagacacaaagcattctttgtatgccaattaagaatcatagggaagaggttgttggt
gtagcccaggccatcaacaagaaatcaggaaacggtgggacatttactgaaaaagatgaa
aaggactttgctgcttatttggcattttgtggtattgttcttcataatgctcagctctat
gagacttcactgctggagaacaagagaaatcaggtgctgcttgaccttgctagtttaatt
tttgaagaacaacaatcattagaagtaattttgaagaaaatagctgccactattatctct
ttcatgcaagtgcagaaatgcaccattttcatagtggatgaagattgctccgattctttt
tctagtgtgtttcacatggagtgtgaggaattagaaaaatcatctgatacattaacaagg
gaacatgatgcaaacaaaatcaattacatgtatgctcagtatgtcaaaaatactatggaa
ccacttaatatcccagatgtcagtaaggataaaagatttccctggacaactgaaaataca
ggaaatgtaaaccagcagtgcattagaagtttgctttgtacacctataaaaaatggaaag
aagaataaagttataggggtttgccaacttgttaataagatggaggagaatactggcaag
gttaagcctttcaaccgaaatgacgaacagtttctggaagcttttgtcatcttttgtggc
ttggggatccagaacacgcagatgtatgaagcagtggagagagccatggccaagcaaatg
gtcacattggaggttctgtcgtatcatgcttcagcagcagaggaagaaacaagagagcta
cagtcgttagcggctgctgtggtgccatctgcccagacccttaaaattactgactttagc
ttcagtgactttgagctgtctgatctggaaacagcactgtgtacaattcggatgtttact
gacctcaaccttgtgcagaacttccagatgaaacatgaggttctttgcagatggatttta
agtgttaagaagaattatcggaagaatgttgcctatcataattggagacatgcctttaat
acagctcagtgcatgtttgctgctctaaaagcaggcaaaattcagaacaagctgactgac
ctggagatacttgcattgctgattgctgcactaagccacgatttggatcaccgtggtgtg
aataactcttacatacagcgaagtgaacatccacttgcccagctttactgccattcaatc
atggaacaccatcattttgaccagtgcctgatgattcttaatagtccaggcaatcagatt
ctcagtggcctctccattgaagaatataagaccacgttgaaaataatcaagcaagctatt
ttagctacagacctagcactgtacattaagaggcgaggagaattttttgaacttataaga
aaaaatcaattcaatttggaagatcctcatcaaaaggagttgtttttggcaatgctgatg
acagcttgtgatctttctgcaattacaaaaccctggcctattcaacaacggatagcagaa
cttgtagcaactgaattttttgatcaaggagacagagagagaaaagaactcaacatagaa
cccactgatctaatgaacagggagaagaaaaacaaaatcccaagtatgcaagttgggttc
atagatgccatctgcttgcaactgtatgaggccctgacccacgtgtcagaggactgtttc
cctttgctagatggctgcagaaagaacaggcagaaatggcaggcccttgcagaacagcag
gagaagatgctgattaatggggaaagcggccaggccaagcggaactga

All links

Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (13)   
   KEGG DRUG (13)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (24)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (2)   
   RefSeq(pep) (3)   
DNA sequence (55)   
   RefSeq(nuc) (3)   
   GenBank (26)   
   EMBL (26)   
3D Structure (29)   
   PDB (29)   
Protein domain (5)   
   Pfam (5)   
All databases (151)   

Download RDF

DBGET integrated database retrieval system