KEGG   Homo sapiens (human): 8817Help
Entry
8817              CDS       T01001                                 

Gene name
FGF18, FGF-18, ZFGF5
Definition
(RefSeq) fibroblast growth factor 18
  KO
K04358  fibroblast growth factor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05200  Pathways in cancer
hsa05218  Melanoma
hsa05224  Breast cancer
hsa05226  Gastric cancer
Network
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    8817 (FGF18)
   04015 Rap1 signaling pathway
    8817 (FGF18)
   04010 MAPK signaling pathway
    8817 (FGF18)
   04151 PI3K-Akt signaling pathway
    8817 (FGF18)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    8817 (FGF18)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    8817 (FGF18)
   05226 Gastric cancer
    8817 (FGF18)
   05218 Melanoma
    8817 (FGF18)
   05224 Breast cancer
    8817 (FGF18)
Cytokines [BR:hsa04052]
 PDGF family
  Beta-trefoil growth factors
   8817 (FGF18)
Cell adhesion molecules and their ligands [BR:hsa04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    FGFR1; fibroblast growth factor receptor 1 [KO:K04362]
     8817 (FGF18)
    FGFR2; fibroblast growth factor receptor 2 [KO:K05093]
     8817 (FGF18)
    FGFR3; fibroblast growth factor receptor [KO:K05094]
     8817 (FGF18)
    FGFR4; fibroblast growth factor receptor 4 [KO:K05095]
     8817 (FGF18)
 6. Sialomucin Family
  GLG1, ESL1; golgi apparatus protein 1 [KO:K06816]
   8817 (FGF18)
 7. Others
  SDC4; syndecan 4 [KO:K16338]
   8817 (FGF18)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Growth factors/receptors (General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis
   8817 (FGF18)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: FGF
Motif
Other DBs
NCBI-GeneID: 8817
NCBI-ProteinID: NP_003853
OMIM: 603726
HGNC: 3674
Ensembl: ENSG00000156427
Vega: OTTHUMG00000130464
Pharos: O76093(Tbio)
UniProt: O76093
Structure
PDB: 

Jmol
Position
5q35.1
AA seq 207 aa AA seqDB search
MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSR
TSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKP
DGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPK
GQPELQKPFKYTTVTKRSRRIRPTHPA
NT seq 624 nt NT seq  +upstreamnt  +downstreamnt
atgtattcagcgccctccgcctgcacttgcctgtgtttacacttcctgctgctgtgcttc
caggtacaggtgctggttgccgaggagaacgtggacttccgcatccacgtggagaaccag
acgcgggctcgggacgatgtgagccgtaagcagctgcggctgtaccagctctacagccgg
accagtgggaaacacatccaggtcctgggccgcaggatcagtgcccgcggcgaggatggg
gacaagtatgcccagctcctagtggagacagacaccttcggtagtcaagtccggatcaag
ggcaaggagacggaattctacctgtgcatgaaccgcaaaggcaagctcgtggggaagccc
gatggcaccagcaaggagtgtgtgttcatcgagaaggttctggagaacaactacacggcc
ctgatgtcggctaagtactccggctggtacgtgggcttcaccaagaaggggcggccgcgg
aagggccccaagacccgggagaaccagcaggacgtgcatttcatgaagcgctaccccaag
gggcagccggagcttcagaagcccttcaagtacacgacggtgaccaagaggtcccgtcgg
atccggcccacacaccctgcctag

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