KEGG   Homo sapiens (human): 8836Help
Entry
8836              CDS       T01001                                 

Gene name
GGH, GH
Definition
(RefSeq) gamma-glutamyl hydrolase
  KO
K01307  gamma-glutamyl hydrolase [EC:3.4.19.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00790  Folate biosynthesis
hsa01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    8836 (GGH)
 Human Diseases
  Drug resistance
   01523 Antifolate resistance
    8836 (GGH)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.9  gamma-glutamyl hydrolase
     8836 (GGH)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C26: gamma-glutamyl hydrolase family
   8836 (GGH)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_C26 GATase
Motif
Other DBs
NCBI-GeneID: 8836
NCBI-ProteinID: NP_003869
OMIM: 601509
HGNC: 4248
Ensembl: ENSG00000137563
Vega: OTTHUMG00000164365
Pharos: Q92820(Tchem)
UniProt: Q92820
Structure
PDB: 

Jmol
Position
8q12.3
AA seq 318 aa AA seqDB search
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD
NT seq 957 nt NT seq  +upstreamnt  +downstreamnt
atggccagtccgggctgcctgctgtgcgtgctgggcctgctactctgcggggcggcgagc
ctcgagctgtctagaccccacggcgacaccgccaagaagcccatcatcggaatattaatg
caaaaatgccgtaataaagtcatgaaaaactatggaagatactatattgctgcgtcctat
gtaaagtacttggagtctgcaggtgcgagagttgtaccagtaaggctggatcttacagag
aaagactatgaaatacttttcaaatctattaatggaatccttttccctggaggaagtgtt
gacctcagacgctcagattatgctaaagtggccaaaatattttataacttgtccatacag
agttttgatgatggagactattttcctgtgtggggcacatgccttggatttgaagagctt
tcactgctgattagtggagagtgcttattaactgccacagatactgttgacgtggcaatg
ccgctgaacttcactggaggtcaattgcacagcagaatgttccagaattttcctactgag
ttgttgctgtcattagcagtagaacctctgactgccaatttccataagtggagcctctcc
gtgaagaattttacaatgaatgaaaagttaaagaagtttttcaatgtcttaactacaaat
acagatggcaagattgagtttatttcaacaatggaaggatataagtatccagtatatggt
gtccagtggcatccagagaaagcaccttatgagtggaagaatttggatggcatttcccat
gcacctaatgctgtgaaaaccgcattttatttagcagagttttttgttaatgaagctcgg
aaaaacaaccatcattttaaatctgaatctgaagaggagaaagcattgatttatcagttc
agtccaatttatactggaaatatttcttcatttcagcaatgttacatatttgattga

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