KEGG H.sapiens: 9453

Homo sapiens (human): 9453

Entry

9453 CDS H.sapiens

Gene name GGPS1

Definition geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29)

Orthology K00787 dimethylallyltranstransferase [EC:2.5.1.1]
K00795 geranyltranstransferase [EC:2.5.1.10]
K00804 geranylgeranyl pyrophosphate synthetase [EC:2.5.1.29]

Pathway hsa00900 Terpenoid backbone biosynthesis
hsa01100 Metabolic pathways

Class Metabolism; Biosynthesis of Secondary Metabolites; Terpenoid
backbone biosynthesis [PATH:hsa00900]

SSDB

Motif Pfam: polyprenyl_synt
PROSITE: POLYPRENYL_SYNTHET_2 POLYPRENYL_SYNTHET_1

Other DBs NCBI-GI: 83700220
NCBI-GeneID: 9453
OMIM: 606982
HGNC: 4249
HPRD: 06099
Ensembl: ENSG00000152904
UniProt: O95749

Structure

PDB: 2Q80

Position 1q43

AA seq 300 aa
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE

NT seq 903 nt +upstreamnt +downstreamnt
atggagaagactcaagaaacagtccaaagaattcttctagaaccctataaatacttactt
cagttaccaggtaaacaagtgagaaccaaactttcacaggcatttaatcattggctgaaa
gttccagaggacaagctacagattattattgaagtgacagaaatgttgcataatgccagt
ttactcatcgatgatattgaagacaactcaaaactccgacgtggctttccagtggcccac
agcatctatggaatcccatctgtcatcaattctgccaattacgtgtatttccttggcttg
gagaaagtcttaacccttgatcacccagatgcagtgaagctttttacccgccagcttttg
gaactccatcagggacaaggcctagatatttactggagggataattacacttgtcccact
gaagaagaatataaagctatggtgctgcagaaaacaggtggactgtttggattagcagta
ggtctcatgcagttgttctctgattacaaagaagatttaaaaccgctacttaatacactt
gggctctttttccaaattagggatgattatgctaatctacactccaaagaatatagtgaa
aacaaaagtttttgtgaagatctgacagagggaaagttctcatttcctactattcatgct
atttggtcaaggcctgaaagcacccaggtgcagaatatcttgcgccagagaacagaaaac
atagatataaaaaaatactgtgtacattatcttgaggatgtaggttcttttgaatacact
cgtaatacccttaaagagcttgaagctaaagcctataaacagattgatgcacgtggtggg
aaccctgagctagtagccttagtaaaacacttaagtaagatgttcaaagaagaaaatgaa
taa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (3)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (3)   
   IPI (4)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (1)   
   PROSITE (2)   
All databases (41)

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