KEGG   ORTHOLOGY: K01353Help
Entry
K01353                      KO                                     

Name
GZMB
Definition
granzyme B [EC:3.4.21.79]
Pathway
Apoptosis
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Transcriptional misregulation in cancer
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K01353  GZMB; granzyme B
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01353  GZMB; granzyme B
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K01353  GZMB; granzyme B
  Immune diseases
   05320 Autoimmune thyroid disease
    K01353  GZMB; granzyme B
   05330 Allograft rejection
    K01353  GZMB; granzyme B
   05332 Graft-versus-host disease
    K01353  GZMB; granzyme B
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K01353  GZMB; granzyme B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.79  granzyme B
     K01353  GZMB; granzyme B
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   K01353  GZMB; granzyme B
BRITE hierarchy
Genes
HSA: 
3002(GZMB)
PTR: 
452825(GZMB)
PPS: 
100987153(GZMB)
GGO: 
101133374(GZMB)
PON: 
100432682(GZMB)
NLE: 
100604300(GZMH)
MCC: 
716518(GZMB)
MCF: 
102130260(GZMB)
CSAB: 
103228744(GZMB)
RRO: 
104662660(GZMB)
RBB: 
108515190(GZMB)
CJC: 
100389206(GZMB)
SBQ: 
101039443(GZMB)
MMU: 
14939(Gzmb)
RNO: 
100361468(Gzmbl2) 171528(Gzmb)
CGE: 
NGI: 
HGL: 
101702156(Gzmb)
CCAN: 
OCU: 
TUP: 
CFA: 
490630(GZMB)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
100015759(GZMB)
SHR: 
OAA: 
791103(GZMB)
ASN: 
AMJ: 
102574848(GZMB)
PSS: 
CMY: 
CPIC: 
XLA: 
NPR: 
DRE: 
100000986(gzm3) 100001138(si:ch211-165b19.8)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Afonina IS, Cullen SP, Martin SJ
  Title
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.
  Journal
Immunol Rev 235:105-16 (2010)
DOI:10.1111/j.0105-2896.2010.00908.x
Reference
  Authors
Anthony DA, Andrews DM, Watt SV, Trapani JA, Smyth MJ
  Title
Functional dissection of the granzyme family: cell death and inflammation.
  Journal
Immunol Rev 235:73-92 (2010)
DOI:10.1111/j.0105-2896.2010.00907.x
Reference
  Authors
Packard BZ, Telford WG, Komoriya A, Henkart PA
  Title
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes.
  Journal
J Immunol 179:3812-20 (2007)
DOI:10.4049/jimmunol.179.6.3812
  Sequence
[hsa:3002]

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