KEGG   ORTHOLOGY: K01353Help
Entry
K01353                      KO                                     

Name
GZMB
Definition
granzyme B [EC:3.4.21.79]
Pathway
ko04210  Apoptosis
ko04650  Natural killer cell mediated cytotoxicity
ko04940  Type I diabetes mellitus
ko05202  Transcriptional misregulation in cancer
ko05320  Autoimmune thyroid disease
ko05330  Allograft rejection
ko05332  Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K01353  GZMB; granzyme B
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01353  GZMB; granzyme B
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K01353  GZMB; granzyme B
  Immune diseases
   05320 Autoimmune thyroid disease
    K01353  GZMB; granzyme B
   05330 Allograft rejection
    K01353  GZMB; granzyme B
   05332 Graft-versus-host disease
    K01353  GZMB; granzyme B
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K01353  GZMB; granzyme B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.79  granzyme B
     K01353  GZMB; granzyme B
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   K01353  GZMB; granzyme B
BRITE hierarchy
Genes
HSA: 3002(GZMB)
PTR: 452825(GZMB)
PPS: 100987153(GZMB)
GGO: 101133374(GZMB)
PON: 100432682
NLE: 100604300(GZMH)
MCC: 716518(GZMB)
MCF: 102130260(GZMB)
CSAB: 103228744(GZMB)
RRO: 104662660(GZMB)
RBB: 108515190(GZMB)
CJC: 100389206(GZMB)
SBQ: 101039443(GZMB)
MMU: 14939(Gzmb)
RNO: 100361468(Gzmbl2) 171528(Gzmb)
HGL: 101702156(Gzmb)
CFA: 490630(GZMB)
AML: 100464420
UMR: 103679303
FCA: 100127106(GZMB)
PTG: 102957957(GZMB) 102967670
SSC: 100233184(GZMB) 100739080
CFR: 102518030 102518273(GZMB)
CDK: 105094200(GZMB) 105106640
BACU: 103000247 103010961(GZMB)
LVE: 103087729(GZMB) 103088275
OOR: 101287187
PALE: 102881520 102881776(GZMB)
MDO: 100015759(GZMB)
OAA: 791103(GZMB)
ASN: 102387989
AMJ: 102574848(GZMB)
XLA: 108704981
NPR: 108788431
DRE: 100000986(gzm3) 100001138(gzm3.3)
IPU: 100304651(Gzmf) 108267046
TRU: 101070721
HCQ: 109523326
BPEC: 110156126
ELS: 105009271(cma1) 105011524 105029813(cma1)
LCM: 102345749
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Afonina IS, Cullen SP, Martin SJ
  Title
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.
  Journal
Immunol Rev 235:105-16 (2010)
DOI:10.1111/j.0105-2896.2010.00908.x
Reference
  Authors
Anthony DA, Andrews DM, Watt SV, Trapani JA, Smyth MJ
  Title
Functional dissection of the granzyme family: cell death and inflammation.
  Journal
Immunol Rev 235:73-92 (2010)
DOI:10.1111/j.0105-2896.2010.00907.x
Reference
  Authors
Packard BZ, Telford WG, Komoriya A, Henkart PA
  Title
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes.
  Journal
J Immunol 179:3812-20 (2007)
DOI:10.4049/jimmunol.179.6.3812
  Sequence
[hsa:3002]

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