KEGG   ORTHOLOGY: K01398Help
Entry
K01398                      KO                                     

Name
MMP2
Definition
matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
Pathway
ko01522  Endocrine resistance
ko04670  Leukocyte transendothelial migration
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05219  Bladder cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00025  Penile cancer
H00028  Choriocarcinoma
H00472  Multicentric osteolysis, nodulosis, and arthropathy (MONA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  Endocrine system
   04912 GnRH signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04915 Estrogen signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04926 Relaxin signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05205 Proteoglycans in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05219 Bladder cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  Drug resistance
   01522 Endocrine resistance
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.24  gelatinase A
     K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M10
   K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
BRITE hierarchy
Genes
HSA: 4313(MMP2)
PTR: 454094(MMP2)
PPS: 100970966(MMP2)
GGO: 101147102(MMP2)
PON: 100451667(MMP2)
NLE: 100597186(MMP2)
MCC: 698478(MMP2)
MCF: 101865544(MMP2)
CSAB: 103233007(MMP2)
RRO: 104671481(MMP2)
RBB: 108531264(MMP2)
CJC: 100387448(MMP2)
SBQ: 101042210(MMP2)
MMU: 17390(Mmp2)
RNO: 81686(Mmp2)
CGE: 100774744(Mmp2)
NGI: 103731682(Mmp2)
HGL: 101696977(Mmp2)
CCAN: 109690723(Mmp2)
OCU: 100009000(MMP2)
TUP: 102483061(MMP2)
CFA: 403733(MMP2)
AML: 100476183(MMP2)
UMR: 103673901(MMP2)
ORO: 101378425(MMP2)
FCA: 101098838(MMP2)
PTG: 102956398(MMP2)
AJU: 106973291(MMP2)
BTA: 282872(MMP2)
BOM: 102269336(MMP2)
BIU: 109572595(MMP2)
PHD: 102315493(MMP2)
CHX: 102184364(MMP2)
OAS: 443115(MMP2)
SSC: 397391(MMP2)
CFR: 102511505 102521167(MMP2)
CDK: 105097506(MMP2)
BACU: 103016736(MMP2)
LVE: 103071760(MMP2)
OOR: 101275485(MMP2)
ECB: 100033948(MMP2)
EPZ: 103553197(MMP2)
EAI: 106822484(MMP2)
MYB: 102260608(MMP2)
MYD: 102767174(MMP2)
HAI: 109383663(MMP2)
RSS: 109457119(MMP2)
PALE: 102883808(MMP2)
LAV: 100659450(MMP2)
TMU: 101358817
MDO: 100020585(MMP2)
SHR: 100935012(MMP2)
OAA: 100077120(MMP9)
GGA: 386583(MMP2)
MGP: 100125331(MMP2)
CJO: 107319190(MMP2)
APLA: 101802059(MMP2) 101805293
ACYG: 106043076(MMP2)
TGU: 100228546(MMP2)
GFR: 102040497(MMP2)
FAB: 101815345(MMP2)
PHI: 102107059(MMP2)
PMAJ: 107209744(MMP2)
CCW: 104687474(MMP2)
FPG: 101924896(MMP2)
FCH: 102056005(MMP2)
CLV: 102092170(MMP2)
EGZ: 104125198(MMP2)
AAM: 106483196(MMP2)
ASN: 102372370(MMP2)
AMJ: 102562302(MMP2)
PSS: 102463152(MMP2)
CMY: 102946066(MMP2)
CPIC: 101941088(MMP2)
ACS: 100557569(mmp2)
PVT: 110071465 110082478(MMP2)
PBI: 103055844(MMP2)
GJA: 107108344(MMP2)
XLA: 380389(mmp2.S)
XTR: 548506(mmp2)
NPR: 108797889(MMP2)
DRE: 337179(mmp2)
SANH: 107657110(mmp2) 107696695
CCAR: 109092592
IPU: 108259638(mmp2)
TRU: 653022(mmp2)
LCO: 104926945(mmp2)
NCC: 104964801(mmp2)
MZE: 101472680(mmp2)
OLA: 100125419(mmp2)
XMA: 102226344(mmp2)
PRET: 103462668(mmp2)
NFU: 107381256(mmp2)
CSEM: 103378988(mmp2)
LCF: 108876984(mmp2)
HCQ: 109513920(mmp2)
BPEC: 110175240(mmp2)
SASA: 100194903(mmp2) 106562416(MMP2)
ELS: 105023458(mmp2)
LCM: 102350008(MMP2)
CMK: 103176101(mmp2)
CIN: 100181993
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2834383
  Authors
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI
  Title
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
  Journal
J Biol Chem 263:6579-87 (1988)
  Sequence
[hsa:4313]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)

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