KEGG   ORTHOLOGY: K02620Help
Entry
K02620                      KO                                     

Name
TCF7
Definition
transcription factor 7
Pathway
Wnt signaling pathway
Hippo signaling pathway
Adherens junction
Melanogenesis
Human papillomavirus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Acute myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  
Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7; transcription factor 7
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7; transcription factor 7
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K02620  TCF7; transcription factor 7
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02620  TCF7; transcription factor 7
   05210 Colorectal cancer
    K02620  TCF7; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7; transcription factor 7
   05224 Breast cancer
    K02620  TCF7; transcription factor 7
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K02620  TCF7; transcription factor 7
  Infectious diseases
   05165 Human papillomavirus infection
    K02620  TCF7; transcription factor 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K02620  TCF7; transcription factor 7
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7; transcription factor 7
BRITE hierarchy
Genes
HSA: 
6932(TCF7)
PTR: 
745839(TCF7)
PPS: 
100980839(TCF7)
GGO: 
101149731(TCF7)
PON: 
100461234(TCF7)
NLE: 
100595737(TCF7)
MCC: 
710234(TCF7)
MCF: 
102142248(TCF7)
CSAB: 
103244543(TCF7)
RRO: 
104659811(TCF7)
RBB: 
108529562(TCF7)
CJC: 
100399154(TCF7)
SBQ: 
101029076(TCF7)
MMU: 
21414(Tcf7)
RNO: 
363595(Tcf7)
CGE: 
100757390(Tcf7)
NGI: 
103729786(Tcf7)
HGL: 
101707882(Tcf7)
CCAN: 
109689465(Tcf7)
OCU: 
100339216(TCF7)
TUP: 
102484318(TCF7)
CFA: 
481506(TCF7)
AML: 
100476528(TCF7)
UMR: 
103663815(TCF7)
ORO: 
101376237(TCF7)
FCA: 
101098768(TCF7)
PTG: 
102957988(TCF7)
AJU: 
106984911(TCF7)
BTA: 
782690(TCF7)
BOM: 
102266633(TCF7)
BIU: 
109562015(TCF7)
PHD: 
102338430(TCF7)
CHX: 
102173736(TCF7)
OAS: 
101101980(TCF7)
SSC: 
100512951(TCF7)
CFR: 
102519063(TCF7)
CDK: 
105090254(TCF7)
BACU: 
103018264(TCF7)
LVE: 
103074150(TCF7)
ECB: 
100072786(TCF7)
EPZ: 
103543120(TCF7)
EAI: 
106834657(TCF7)
MYB: 
102250528(TCF7)
MYD: 
102757003(TCF7)
HAI: 
109382635(TCF7)
RSS: 
109451821(TCF7)
PALE: 
102885788(TCF7)
LAV: 
100663559(TCF7)
TMU: 
MDO: 
100017589(TCF7)
SHR: 
100930141(TCF7)
OAA: 
100082332(TCF7)
GGA: 
395229(TCF7)
MGP: 
100544924(TCF7)
CJO: 
107320225(TCF7)
APLA: 
101803610(TCF7)
ACYG: 
106032766(TCF7)
TGU: 
100221008(TCF7)
GFR: 
102036749(TCF7)
FAB: 
101820491(TCF7)
PHI: 
102110510(TCF7)
PMAJ: 
107210639(TCF7)
CCW: 
104683724(TCF7)
FPG: 
101919678(TCF7)
FCH: 
102058554(TCF7)
CLV: 
102094656(TCF7)
EGZ: 
104133478(TCF7)
AAM: 
106487174(TCF7)
ASN: 
102383175(TCF7)
AMJ: 
102576120(TCF7)
PSS: 
102446665(TCF7)
CMY: 
CPIC: 
101937399(TCF7)
ACS: 
100554608(tcf7)
PVT: 
110079405(TCF7)
PBI: 
103067042(TCF7)
GJA: 
107125983(TCF7)
XLA: 
398658(tcf7.S)
XTR: 
395061(tcf7)
NPR: 
108792126(TCF7)
SRX: 
SANH: 
107661683(tcf7)
SGH: 
CCAR: 
AMEX: 
NCC: 
104960861(tcf7)
OLA: 
PRET: 
HCQ: 
SFM: 
LCM: 
102350321(TCF7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1569101
  Authors
van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H
  Title
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
  Journal
J Biol Chem 267:8530-6 (1992)
  Sequence
[hsa:6932]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
  Authors
Ioannidis V, Beermann F, Clevers H, Held W
  Title
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
  Journal
Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623
  Sequence
[mmu:21414]

KEGG   ORTHOLOGY: K04490Help
Entry
K04490                      KO                                     

Name
TCF7L1
Definition
transcription factor 7-like 1
Pathway
Wnt signaling pathway
Hippo signaling pathway
Adherens junction
Melanogenesis
Human papillomavirus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Acute myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  
Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04490  TCF7L1; transcription factor 7-like 1
  Infectious diseases
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1
BRITE hierarchy
Genes
HSA: 
83439(TCF7L1)
PTR: 
744526(TCF7L1)
PPS: 
100968002(TCF7L1)
GGO: 
101151621(TCF7L1)
NLE: 
100601518(TCF7L1)
MCC: 
694560(TCF7L1)
MCF: 
102125513(TCF7L1)
CSAB: 
103219950(TCF7L1)
RRO: 
104659731(TCF7L1)
RBB: 
108542809(TCF7L1)
CJC: 
SBQ: 
101033762(TCF7L1)
MMU: 
21415(Tcf7l1)
RNO: 
312451(Tcf7l1)
CGE: 
100753225(Tcf7l1)
NGI: 
103739783(Tcf7l1)
HGL: 
101699909(Tcf7l1)
CCAN: 
109686184(Tcf7l1)
OCU: 
100340471(TCF7L1)
TUP: 
102481394(TCF7L1)
CFA: 
612070(TCF7L1)
AML: 
100480690(TCF7L1)
UMR: 
103671448(TCF7L1)
ORO: 
101382778(TCF7L1)
FCA: 
101089850(TCF7L1)
PTG: 
102958078(TCF7L1)
AJU: 
106978197(TCF7L1)
BTA: 
515303(TCF7L1)
BOM: 
102281039(TCF7L1)
BIU: 
109565564(TCF7L1)
PHD: 
102325013(TCF7L1)
CHX: 
102187776(TCF7L1)
OAS: 
100913162(TCF7L1)
SSC: 
100523899(TCF7L1)
CFR: 
102516787(TCF7L1)
CDK: 
105104146(TCF7L1)
BACU: 
103010166(TCF7L1)
LVE: 
103069353(TCF7L1)
ECB: 
100067427(TCF7L1)
EPZ: 
103548276(TCF7L1)
EAI: 
106838609(TCF7L1)
MYB: 
102240393(TCF7L1)
MYD: 
102768915(TCF7L1)
HAI: 
109371340(TCF7L1)
RSS: 
109436180(TCF7L1)
PALE: 
102886093(TCF7L1)
LAV: 
100664310(TCF7L1)
TMU: 
MDO: 
100030368(TCF7L1)
SHR: 
100922609(TCF7L1)
GGA: 
395230(TCF7L1)
MGP: 
104917108(TCF7L1)
CJO: 
107323707(TCF7L1)
APLA: 
101801135(TCF7L1)
ACYG: 
106048886(TCF7L1)
GFR: 
102039905(TCF7L1)
FAB: 
101817952(TCF7L1)
PHI: 
102105833(TCF7L1)
PMAJ: 
107213891(TCF7L1)
CCW: 
104683181(TCF7L1)
FPG: 
101922879(TCF7L1)
FCH: 
102051021(TCF7L1)
CLV: 
102084814(TCF7L1)
EGZ: 
104121757(TCF7L1)
AAM: 
ASN: 
102382172(TCF7L1)
AMJ: 
102559656(TCF7L1)
PSS: 
102456229(TCF7L1)
CMY: 
102947844(TCF7L1)
CPIC: 
101943923(TCF7L1)
ACS: 
100553130(tcf7l1)
PVT: 
110084320(TCF7L1)
PBI: 
103066724(TCF7L1)
GJA: 
107117396(TCF7L1)
XLA: 
100329123(tcf7l1-d) 394281(tcf7l1.S) 397863(tcf7l1.L) 397969(tcf7l1-c)
XTR: 
448107(tcf7l1)
NPR: 
DRE: 
30523(tcf7l1a)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
104946533(tcf7l1)
MZE: 
OLA: 
100820729(tcf7l1)
XMA: 
PRET: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102364488(TCF7L1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
PMID:1741298
  Authors
Castrop J, van Norren K, Clevers H
  Title
A gene family of HMG-box transcription factors with homology to TCF-1.
  Journal
Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611
  Sequence
[hsa:83439]

KEGG   ORTHOLOGY: K04491Help
Entry
K04491                      KO                                     

Name
TCF7L2
Definition
transcription factor 7-like 2
Pathway
Wnt signaling pathway
Hippo signaling pathway
Adherens junction
Melanogenesis
Human papillomavirus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Acute myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  
Wnt signaling
Disease
H00409  
Type II diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
   04390 Hippo signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04491  TCF7L2; transcription factor 7-like 2
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04491  TCF7L2; transcription factor 7-like 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05210 Colorectal cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05225 Hepatocellular carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05226 Gastric cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05216 Thyroid cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05221 Acute myeloid leukemia
    K04491  TCF7L2; transcription factor 7-like 2
   05217 Basal cell carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05215 Prostate cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05213 Endometrial cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05224 Breast cancer
    K04491  TCF7L2; transcription factor 7-like 2
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04491  TCF7L2; transcription factor 7-like 2
  Infectious diseases
   05165 Human papillomavirus infection
    K04491  TCF7L2; transcription factor 7-like 2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04491  TCF7L2; transcription factor 7-like 2
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04491  TCF7L2; transcription factor 7-like 2
BRITE hierarchy
Genes
HSA: 
6934(TCF7L2)
PTR: 
450743(TCF7L2)
PPS: 
100978424(TCF7L2)
GGO: 
PON: 
100434811(TCF7L2)
NLE: 
100605701(TCF7L2)
MCC: 
701759(TCF7L2)
MCF: 
102116470(TCF7L2)
CSAB: 
103216817(TCF7L2)
RRO: 
104664436(TCF7L2)
RBB: 
108542456(TCF7L2)
CJC: 
100406757(TCF7L2)
SBQ: 
101037011(TCF7L2)
MMU: 
21416(Tcf7l2)
RNO: 
679869(Tcf7l2)
CGE: 
100758400(Tcf7l2)
NGI: 
103731749(Tcf7l2)
HGL: 
101710380(Tcf7l2)
CCAN: 
109688561(Tcf7l2)
OCU: 
100358378(TCF7L2)
TUP: 
102472810(TCF7L2)
CFA: 
486894(TCF7L2)
AML: 
100467719(TCF7L2)
UMR: 
103657263(TCF7L2)
ORO: 
101385846(TCF7L2)
FCA: 
101095618(TCF7L2)
PTG: 
102961321(TCF7L2)
AJU: 
106974119(TCF7L2)
BTA: 
540481(TCF7L2)
BOM: 
102272230(TCF7L2)
BIU: 
109553057(TCF7L2)
PHD: 
102322359(TCF7L2)
CHX: 
102180102(TCF7L2)
OAS: 
101118068(TCF7L2)
SSC: 
100153922(TCF7L2)
CFR: 
102510763(TCF7L2)
CDK: 
105091689(TCF7L2)
BACU: 
103010923(TCF7L2)
LVE: 
103068781(TCF7L2)
ECB: 
100059146(TCF7L2)
EPZ: 
103564289(TCF7L2)
EAI: 
106848101(TCF7L2)
MYB: 
102245737(TCF7L2)
MYD: 
102767014(TCF7L2)
HAI: 
109384898(TCF7L2)
RSS: 
109444072(TCF7L2)
PALE: 
102880370(TCF7L2)
LAV: 
100656106(TCF7L2)
TMU: 
MDO: 
100021451(TCF7L2)
SHR: 
100922675(TCF7L2)
OAA: 
100080633(TCF7L2)
GGA: 
395508(TCF7L2)
MGP: 
100545943(TCF7L2)
CJO: 
107316122(TCF7L2)
APLA: 
101790790(TCF7L2)
ACYG: 
106031894(TCF7L2)
TGU: 
100229459(TCF7L2)
GFR: 
102035103(TCF7L2)
FAB: 
101808150(TCF7L2)
PHI: 
102110960(TCF7L2)
PMAJ: 
107206579(TCF7L2)
CCW: 
104695213(TCF7L2)
FPG: 
101911463(TCF7L2)
FCH: 
102053252(TCF7L2)
CLV: 
102092542(TCF7L2)
EGZ: 
104130428(TCF7L2)
AAM: 
106483723(TCF7L2)
ASN: 
102373887(TCF7L2)
AMJ: 
102558653(TCF7L2)
PSS: 
102459521(TCF7L2)
CMY: 
102935138(TCF7L2)
CPIC: 
101938831(TCF7L2)
ACS: 
PVT: 
110071969(TCF7L2)
PBI: 
103067231(TCF7L2)
GJA: 
107121002(TCF7L2)
XLA: 
108697306 399164(tcf7l2.L)
XTR: 
100101719(tcf7l2)
NPR: 
108793512(TCF7L2)
DRE: 
30510(tcf7l2)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108274114(tcf7l2)
AMEX: 
103031257(tcf7l2)
TRU: 
101067664(tcf7l2)
TNG: 
LCO: 
104932553(tcf7l2)
NCC: 
104943463(tcf7l2)
MZE: 
OLA: 
XMA: 
102216716(tcf7l2)
PRET: 
CSEM: 
LCF: 
HCQ: 
109513392(tcf7l2)
BPEC: 
110154410(tcf7l2)
SASA: 
ELS: 
105007703(tcf7l2)
SFM: 
LCM: 
102346208(TCF7L2)
CMK: 
103186546(tcf7l2)
BFO: 
CIN: 
778773(tcf/lef)
SPU: 
373203(Tcf/Lef)
APLC: 
SKO: 
100303556(tcf7l)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
726671(Tcf)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
641465(Pan)
DPA: 
NVL: 
BMOR: 
DPL: 
PMAC: 
PXY: 
API: 
DNX: 
PHU: 
ZNE: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG04236(Cbr-pop-1)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
EPA: 
ADF: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL
  Title
Tissue-specific alternative splicing of TCF7L2.
  Journal
Hum Mol Genet 18:3795-804 (2009)
DOI:10.1093/hmg/ddp321
  Sequence
[hsa:6934]
Reference
PMID:9065401
  Authors
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H
  Title
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
  Journal
Science 275:1784-7 (1997)
DOI:10.1126/science.275.5307.1784
  Sequence
[hsa:6934]

KEGG   ORTHOLOGY: K04492Help
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
Wnt signaling pathway
Hippo signaling pathway
Adherens junction
Melanogenesis
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Acute myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Module
M00677  
Wnt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Organismal Systems
  Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  Cardiovascular diseases
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04492  LEF1; lymphoid enhancer-binding factor 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
BRITE hierarchy
Genes
HSA: 
51176(LEF1)
PTR: 
461425(LEF1)
PPS: 
100995847(LEF1)
GGO: 
101140253(LEF1)
PON: 
100447785(LEF1)
NLE: 
100593051(LEF1)
MCC: 
695776(LEF1)
MCF: 
101925349(LEF1)
CSAB: 
103236088(LEF1)
RRO: 
104670045(LEF1)
RBB: 
108515891(LEF1)
CJC: 
100399759(LEF1)
SBQ: 
101047688(LEF1)
MMU: 
16842(Lef1)
RNO: 
161452(Lef1)
CGE: 
100761200(Lef1)
NGI: 
103742515(Lef1)
HGL: 
101711023(Lef1)
CCAN: 
OCU: 
100352691(LEF1)
TUP: 
102474621(LEF1)
CFA: 
478507(LEF1)
AML: 
100465982(LEF1)
UMR: 
103661728(LEF1)
ORO: 
101372325(LEF1)
FCA: 
101088077(LEF1)
PTG: 
102970026(LEF1)
AJU: 
106983664(LEF1)
BTA: 
535399(LEF1)
BOM: 
102266946(LEF1)
BIU: 
109560266(LEF1)
PHD: 
102341699(LEF1)
CHX: 
100860901(LEF1)
OAS: 
780521(LEF1)
SSC: 
100170126(LEF1)
CFR: 
102510619(LEF1)
CDK: 
105105289(LEF1)
BACU: 
103020844(LEF1)
LVE: 
103068879(LEF1)
ECB: 
100072938(LEF1)
EPZ: 
103557035(LEF1)
EAI: 
106829814(LEF1)
MYB: 
102255910(LEF1)
MYD: 
102767379(LEF1)
HAI: 
109379461(LEF1)
RSS: 
109452751(LEF1)
PALE: 
102886933(LEF1)
LAV: 
100658960(LEF1)
TMU: 
MDO: 
100011783(LEF1)
SHR: 
OAA: 
GGA: 
395865(LEF1)
MGP: 
100542839(LEF1)
CJO: 
107313267(LEF1)
APLA: 
101792052(LEF1)
ACYG: 
106038656(LEF1)
TGU: 
100228376(LEF1)
GFR: 
102034937(LEF1)
FAB: 
101821185(LEF1)
PHI: 
102109576(LEF1)
PMAJ: 
107203557(LEF1)
CCW: 
104697293(LEF1)
FPG: 
101917929(LEF1)
FCH: 
102050307(LEF1)
CLV: 
102084626(LEF1)
EGZ: 
104135527(LEF1)
AAM: 
106491833(LEF1)
ASN: 
102385539(LEF1)
AMJ: 
102560337(LEF1)
PSS: 
102456780(LEF1)
CMY: 
102930185(LEF1)
CPIC: 
101953582(LEF1)
ACS: 
100556215(lef1)
PVT: 
110080460(LEF1)
PBI: 
103064656(LEF1)
GJA: 
107123114(LEF1)
XLA: 
100337575(lef-1) 398238(lef1.L) 779101(lef1)
XTR: 
100493178(lef1)
NPR: 
108785415(LEF1)
DRE: 
30701(lef1)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
108262963(lef1)
AMEX: 
103033630(lef1)
TRU: 
101064872(lef1)
TNG: 
LCO: 
104927262(lef1)
NCC: 
MZE: 
101464688(lef1)
OLA: 
101167344(lef1)
XMA: 
102226301(lef1)
PRET: 
103472749(lef1)
CSEM: 
LCF: 
108888246(lef1)
HCQ: 
BPEC: 
110165341(lef1)
SASA: 
ELS: 
105020989(lef1)
SFM: 
LCM: 
CMK: 
HRO: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

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