KEGG   ORTHOLOGY: K03176Help
Entry
K03176                      KO                                     

Name
NTRK1, TRKA
Definition
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
ko05230  Central carbon metabolism in cancer
Disease
H00032  Thyroid cancer
H00043  Neuroblastoma
H00265  Hereditary sensory and autonomic neuropathy (HSAN)
H01836  Congenital pain insensitivity with anhidrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancers
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
BRITE hierarchy
Genes
HSA: 4914(NTRK1)
PTR: 457408(NTRK1)
PPS: 100995426(NTRK1)
GGO: 101125993(NTRK1)
PON: 100452269(NTRK1)
NLE: 100585466(NTRK1)
MCC: 719670(NTRK1)
MCF: 102129364(NTRK1)
CSAB: 103223823(NTRK1)
RRO: 104676442(NTRK1)
RBB: 108515538(NTRK1)
CJC: 103789024(NTRK1)
SBQ: 101035626(NTRK1)
MMU: 18211(Ntrk1)
RNO: 59109(Ntrk1)
CGE: 100751271(Ntrk1)
NGI: 103750263(Ntrk1)
HGL: 101724441(Ntrk1)
CCAN: 109686202(Ntrk1)
OCU: 100354292(NTRK1)
TUP: 102485200(NTRK1)
CFA: 490404(NTRK1)
AML: 100474165(NTRK1)
ORO: 101374117(NTRK1)
FCA: 101081603(NTRK1)
AJU: 106988854(NTRK1)
BTA: 353111(NTRK1)
BOM: 102264869(NTRK1)
BIU: 109556725(NTRK1)
PHD: 102316134(NTRK1)
CHX: 102172584(NTRK1)
OAS: 101109763(NTRK1)
SSC: 100154471(NTRK1)
CFR: 102518397(NTRK1)
CDK: 105105672(NTRK1)
BACU: 103003654(NTRK1)
LVE: 103071756(NTRK1)
OOR: 101273503(NTRK1)
ECB: 100064594(NTRK1)
EPZ: 103548862(NTRK1) 103548863
EAI: 106828447(NTRK1)
MYD: 102765751(NTRK1)
HAI: 109393379(NTRK1)
RSS: 109434344(NTRK1)
LAV: 100668650(NTRK1)
TMU: 101351378
MDO: 100618744(NTRK1)
SHR: 100916388(NTRK1)
GGA: 396337(NTRK1)
MGP: 100541244(NTRK1)
CJO: 107324385(NTRK1)
GFR: 102039729(NTRK1)
FAB: 101810326(NTRK1)
PHI: 102113646(NTRK1)
PMAJ: 107214529(NTRK1)
CCW: 104683563(NTRK1)
FPG: 101920297(NTRK1)
FCH: 102060232(NTRK1)
CLV: 102086876(NTRK1)
AAM: 106495087(NTRK1)
ASN: 102381668(NTRK1)
AMJ: 102568424(NTRK1)
PSS: 102456174(NTRK1)
CMY: 102940175(NTRK1)
CPIC: 101934097(NTRK1)
ACS: 100556611(ntrk1)
PVT: 110081467(NTRK1)
PBI: 103064232(NTRK1)
GJA: 107114884(NTRK1)
XTR: 100489637(ntrk1)
NPR: 108802180(NTRK1)
DRE: 30546(ntrk1)
SRX: 107726660(ntrk1) 107728446
IPU: 108256584(ntrk1)
AMEX: 103025260(ntrk1)
TRU: 101074407(ntrk1)
LCO: 104933369(ntrk1)
NCC: 104949794(ntrk1)
MZE: 101473195(ntrk1)
OLA: 101164184(ntrk1)
XMA: 102217423
PRET: 103477579(ntrk1)
NFU: 107379148(ntrk1)
CSEM: 103388944(ntrk1)
LCF: 108899467(ntrk1)
HCQ: 109512189(ntrk1)
BPEC: 110172749
ELS: 105019278(ntrk1)
SFM: 108926773(ntrk1) 108930374
LCM: 102354132(NTRK1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011
  Sequence
[hsa:4914]

KEGG   ORTHOLOGY: K04360Help
Entry
K04360                      KO                                     

Name
NTRK2, TRKB
Definition
neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04722  Neurotrophin signaling pathway
ko05034  Alcoholism
Disease
H00043  Neuroblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04010 MAPK signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04151 PI3K-Akt signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 Human Diseases
  Substance dependence
   05034 Alcoholism
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
BRITE hierarchy
Genes
HSA: 4915(NTRK2)
PTR: 735394(NTRK2)
PPS: 100994887(NTRK2)
GGO: 101140182(NTRK2)
PON: 100441207(NTRK2)
NLE: 100605330(NTRK2)
MCC: 709757(NTRK2)
MCF: 102132446(NTRK2)
CSAB: 103219672(NTRK2)
RRO: 104673903(NTRK2)
RBB: 108520515(NTRK2)
CJC: 100388984(NTRK2)
SBQ: 101053284(NTRK2)
MMU: 18212(Ntrk2)
RNO: 25054(Ntrk2)
CGE: 100754339(Ntrk2)
NGI: 103747093(Ntrk2)
HGL: 101720037(Ntrk2)
CCAN: 109677416(Ntrk2)
OCU: 100352548(NTRK2)
TUP: 102468349(NTRK2) 102497563
CFA: 484147(NTRK2)
AML: 100477127(NTRK2)
UMR: 103667631(NTRK2) 103667632
ORO: 101364921(NTRK2)
FCA: 101101347(NTRK2)
PTG: 102950315(NTRK2)
AJU: 106978572(NTRK2)
BTA: 505824(NTRK2)
BOM: 102269089(NTRK2)
BIU: 109563216(NTRK2)
PHD: 102319248(NTRK2)
CHX: 102180223(NTRK2)
OAS: 101116015(NTRK2)
SSC: 100519209(NTRK2)
CFR: 102507254(NTRK2)
CDK: 105100473(NTRK2)
BACU: 103020777(NTRK2)
LVE: 103069787 103083316(NTRK2)
OOR: 101281465(NTRK2)
ECB: 100061700(NTRK2)
EPZ: 103551809(NTRK2)
EAI: 106822031(NTRK2)
MYB: 102238774(NTRK2)
MYD: 102755544(NTRK2)
RSS: 109457312(NTRK2)
PALE: 102882910(NTRK2)
LAV: 100675363(NTRK2)
TMU: 101342178
MDO: 100029389(NTRK2)
SHR: 100927322(NTRK2)
OAA: 100080080(NTRK2)
GGA: 396157(NTRK2)
MGP: 100545915(NTRK2)
CJO: 107306253(NTRK2)
APLA: 101797842(NTRK2)
ACYG: 106045383(NTRK2)
TGU: 751985(NTRK2)
GFR: 102044793(NTRK2)
FAB: 101810339(NTRK2)
PHI: 102100533(NTRK2)
PMAJ: 107216220(NTRK2)
CCW: 104692002(NTRK2)
FPG: 101919319(NTRK2)
FCH: 102055826(NTRK2)
CLV: 102092182(NTRK2)
EGZ: 104135554(NTRK2)
ASN: 102372380(NTRK2) 102385821
AMJ: 102559730(NTRK2)
PSS: 102446411(NTRK2)
CMY: 102937131(NTRK2)
CPIC: 101947563(NTRK2) 101953939
ACS: 100558067(ntrk2)
PVT: 110089898(NTRK2)
PBI: 103063871(NTRK2)
GJA: 107117206(NTRK2)
XLA: 379266(ntrk2.S) 779173(ntrk2.L)
XTR: 780110(ntrk2)
NPR: 108798612(NTRK2)
DRE: 570240(ntrk2b) 65090(ntrk2a)
IPU: 108259739 108265887(ntrk2)
AMEX: 103036414(ntrk2) 103044160
TRU: 101077811(ntrk2) 101078202
NCC: 104961592(ntrk2)
OLA: 101159930 101172248(ntrk2)
XMA: 102228507(ntrk2) 102229659
NFU: 107374736 107394032(ntrk2)
LCF: 108873999 108878348(ntrk2)
HCQ: 109514240(ntrk2) 109527923
BPEC: 110153486(ntrk2) 110157504
ELS: 105014455(ntrk2) 105027931
SFM: 108931316 108938645(ntrk2)
LCM: 102363882(NTRK2)
CMK: 103187358(ntrk2)
APLC: 110977267
SKO: 100313758
TUT: 107362661
MYI: 110443153
OBI: 106877811
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC
  Title
Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease.
  Journal
Am J Med Genet B Neuropsychiatr Genet 147:363-9 (2008)
DOI:10.1002/ajmg.b.30607

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