KEGG   ORTHOLOGY: K04289Help
Entry
K04289                      KO                                     

Name
LPAR1, EDG2
Definition
lysophosphatidic acid receptor 1
Pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Gap junction
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
   04072 Phospholipase D signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
   04151 PI3K-Akt signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
G protein-coupled receptors [BR:ko04030]
 Class A. Rhodopsin family
  Lipid
   Lysophosphatidic acid [OT]
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1902(LPAR1)
PTR: 
464655(LPAR1)
PPS: 
100981266(LPAR1)
GGO: 
101144872(LPAR1)
PON: 
100458931(LPAR1)
NLE: 
100589911(LPAR1)
MCC: 
709208(LPAR1)
MCF: 
CSAB: 
103219021(LPAR1)
RRO: 
104664137(LPAR1)
RBB: 
CJC: 
100414340(LPAR1)
SBQ: 
101035023(LPAR1)
MMU: 
14745(Lpar1)
RNO: 
116744(Lpar1)
CGE: 
100757522(Lpar1)
NGI: 
103732526(Lpar1)
HGL: 
101713333(Lpar1)
CCAN: 
109692877(Lpar1)
OCU: 
100355169(LPAR1)
TUP: 
102503029(LPAR1)
CFA: 
474800(LPAR1)
AML: 
100479569(LPAR1)
UMR: 
103678568(LPAR1)
FCA: 
101092556(LPAR1)
PTG: 
102968521(LPAR1)
AJU: 
106971772(LPAR1)
BTA: 
281136(LPAR1)
BOM: 
102273019(LPAR1)
BIU: 
PHD: 
102316257(LPAR1)
CHX: 
102189399(LPAR1)
OAS: 
443346(LPAR1)
SSC: 
100512581(LPAR1)
CFR: 
102522277(LPAR1)
CDK: 
105096434(LPAR1)
BACU: 
103015300(LPAR1)
LVE: 
103091078(LPAR1)
ECB: 
100053797(LPAR1)
EPZ: 
103546686(LPAR1)
EAI: 
106826903(LPAR1)
MYB: 
102258769(LPAR1)
MYD: 
102762844(LPAR1)
HAI: 
109379349(LPAR1)
RSS: 
109456987(LPAR1)
PALE: 
102891503(LPAR1)
LAV: 
100668056(LPAR1)
MDO: 
100016607(LPAR1)
SHR: 
100928953(LPAR1)
OAA: 
100077696(LPAR1)
GGA: 
427339(LPAR1)
MGP: 
100541536(LPAR1)
CJO: 
107306591(LPAR1)
APLA: 
101802482(LPAR1)
ACYG: 
106043035(LPAR1)
TGU: 
100223722(LPAR1)
GFR: 
102038748(LPAR1)
FAB: 
PHI: 
102111782(LPAR1)
PMAJ: 
107198333(LPAR1)
CCW: 
104690481(LPAR1)
FPG: 
101920309(LPAR1)
FCH: 
102058846(LPAR1)
CLV: 
102084885(LPAR1)
AAM: 
106499585(LPAR1)
ASN: 
102382491(LPAR1)
AMJ: 
102563758(LPAR1)
PSS: 
102445645(LPAR1)
CMY: 
102935396(LPAR1)
CPIC: 
101932155(LPAR1)
ACS: 
100565601(lpar1)
PVT: 
110077739(LPAR1)
PBI: 
103053763(LPAR1)
GJA: 
107114523(LPAR1)
XLA: 
373591(lpar1.L) 379403(lpar1.S)
XTR: 
100124893(lpar1)
NPR: 
108787629(LPAR1)
DRE: 
368461(lpar1)
SRX: 
SANH: 
107653498(lpar1)
SGH: 
IPU: 
108257275(lpar2) 108277333(lpar1)
AMEX: 
TRU: 
101075588(lpar1)
TNG: 
LCO: 
NCC: 
104964645(lpar1)
MZE: 
101483503(lpar2) 101487294(lpar1)
OLA: 
101164735(lpar1)
XMA: 
102222146(lpar1)
CSEM: 
LCF: 
108880309(lpar1)
HCQ: 
109530147(lpar1)
BPEC: 
SASA: 
ELS: 
105023381(lpar2) 105026669(lpar1)
SFM: 
LCM: 
CMK: 
CIN: 
TCA: 
TSP: 
LGI: 
CRG: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Noguchi K, Herr D, Mutoh T, Chun J
  Title
Lysophosphatidic acid (LPA) and its receptors.
  Journal
Curr Opin Pharmacol 9:15-23 (2009)
DOI:10.1016/j.coph.2008.11.010
Reference
PMID:9070858
  Authors
An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ
  Title
Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.
  Journal
Biochem Biophys Res Commun 231:619-22 (1997)
DOI:10.1006/bbrc.1997.6150
  Sequence
[hsa:1902]

KEGG   ORTHOLOGY: K04291Help
Entry
K04291                      KO                                     

Name
LPAR2, EDG4
Definition
lysophosphatidic acid receptor 2
Pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
   04072 Phospholipase D signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
   04151 PI3K-Akt signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
G protein-coupled receptors [BR:ko04030]
 Class A. Rhodopsin family
  Lipid
   Lysophosphatidic acid [OT]
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
BRITE hierarchy
Other DBs
Genes
HSA: 
9170(LPAR2)
PTR: 
455878(LPAR2)
PPS: 
100988354(LPAR2)
GGO: 
101126528(LPAR2)
PON: 
100458628(LPAR2)
NLE: 
100587344(LPAR2)
MCC: 
719844(LPAR2)
MCF: 
102120852(LPAR2)
CSAB: 
103234222(LPAR2)
RRO: 
104680662(LPAR2)
RBB: 
108515641(LPAR2)
CJC: 
100391457(LPAR2)
SBQ: 
101048307(LPAR2)
MMU: 
53978(Lpar2)
RNO: 
498609(Lpar2)
CGE: 
100753903(Lpar2)
NGI: 
103726831(Lpar2)
HGL: 
101721970(Lpar2)
CCAN: 
109687178(Lpar2)
OCU: 
100343700(LPAR2)
TUP: 
102502351(LPAR2)
CFA: 
484802(LPAR2)
AML: 
100483313(LPAR2)
UMR: 
103675138(LPAR2)
FCA: 
101100950(LPAR2)
PTG: 
102966758(LPAR2)
AJU: 
106969061(LPAR2)
BTA: 
509748(LPAR2)
BOM: 
102268794(LPAR2)
BIU: 
109561368(LPAR2)
PHD: 
102339881(LPAR2)
CHX: 
102187119(LPAR2)
OAS: 
101104572(LPAR2)
SSC: 
100038015(LPAR2)
CFR: 
102504628(LPAR2)
CDK: 
105103737(LPAR2)
BACU: 
103016779(LPAR2)
LVE: 
103074802(LPAR2)
ECB: 
100071198(LPAR2)
EPZ: 
103561322(LPAR2)
EAI: 
106825461(LPAR2)
MYB: 
102246865(LPAR2)
MYD: 
102761006(LPAR2)
HAI: 
109382376(LPAR2)
RSS: 
109450064(LPAR2)
PALE: 
102891807(LPAR2)
LAV: 
100674529(LPAR2)
MDO: 
100014105(LPAR2)
SHR: 
100915220(LPAR2)
GGA: 
426086(LPAR2)
MGP: 
100550166(LPAR2)
CJO: 
107307021(LPAR2)
APLA: 
ACYG: 
106049475(LPAR2)
GFR: 
102032251(LPAR2)
PHI: 
102112903(LPAR2)
PMAJ: 
107199132(LPAR2)
FPG: 
101923045(LPAR2)
FCH: 
102058075(LPAR2)
CLV: 
AAM: 
106500202(LPAR2)
ASN: 
102369379(LPAR2)
AMJ: 
102561509(LPAR2)
PSS: 
102447107(LPAR2)
CMY: 
102942984(LPAR2)
CPIC: 
101951112(LPAR2)
ACS: 
100565184(lpar2)
PVT: 
110071644(LPAR2)
PBI: 
103067510(LPAR2)
GJA: 
107124321(LPAR2)
XLA: 
108711685(lpar2.L) 447460(lpar2.S)
XTR: 
493190(lpar2)
NPR: 
108800357(LPAR2)
SRX: 
TRU: 
TNG: 
NCC: 
104952496(lpar2)
MZE: 
XMA: 
CSEM: 
LCF: 
HCQ: 
109511043(lpar2)
BPEC: 
SASA: 
ELS: 
LAK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Noguchi K, Herr D, Mutoh T, Chun J
  Title
Lysophosphatidic acid (LPA) and its receptors.
  Journal
Curr Opin Pharmacol 9:15-23 (2009)
DOI:10.1016/j.coph.2008.11.010
Reference
  Authors
Contos JJ, Ishii I, Chun J
  Title
Lysophosphatidic acid receptors.
  Journal
Mol Pharmacol 58:1188-96 (2000)
DOI:10.1124/mol.58.6.1188
  Sequence
[hsa:9170]

KEGG   ORTHOLOGY: K04294Help
Entry
K04294                      KO                                     

Name
LPAR3, EDG7
Definition
lysophosphatidic acid receptor 3
Pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
   04072 Phospholipase D signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
   04151 PI3K-Akt signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
G protein-coupled receptors [BR:ko04030]
 Class A. Rhodopsin family
  Lipid
   Lysophosphatidic acid [OT]
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
23566(LPAR3)
PTR: 
736110(LPAR3)
PPS: 
100975023(LPAR3)
GGO: 
101142058(LPAR3)
PON: 
100448001(LPAR3)
NLE: 
100590490(LPAR3)
MCC: 
710828(LPAR3)
MCF: 
102142911(LPAR3)
CSAB: 
103224524(LPAR3)
RRO: 
RBB: 
108527700(LPAR3)
CJC: 
100392576(LPAR3)
SBQ: 
101044775(LPAR3)
MMU: 
65086(Lpar3)
RNO: 
66025(Lpar3)
CGE: 
100759265(Lpar3)
NGI: 
103728104(Lpar3)
HGL: 
101716212(Lpar3)
CCAN: 
109699400(Lpar3)
OCU: 
100009484(LPAR3)
TUP: 
102495978(LPAR3)
CFA: 
490187(LPAR3)
AML: 
100474288(LPAR3)
UMR: 
103662965(LPAR3)
FCA: 
101097996(LPAR3)
PTG: 
102968459(LPAR3)
AJU: 
106973342(LPAR3)
BTA: 
532829(LPAR3)
BOM: 
102268179(LPAR3)
BIU: 
109556129(LPAR3)
PHD: 
102327509(LPAR3)
CHX: 
102186820(LPAR3)
OAS: 
101111138(LPAR3)
SSC: 
100113360(LPAR3)
CFR: 
102508154(LPAR3)
CDK: 
105095047(LPAR3)
BACU: 
103013128(LPAR3)
LVE: 
103073033(LPAR3)
ECB: 
100052775(LPAR3)
EPZ: 
103562992(LPAR3)
EAI: 
106824051(LPAR3)
MYB: 
102242469(LPAR3)
MYD: 
102753374(LPAR3)
HAI: 
109372903(LPAR3)
RSS: 
109433720(LPAR3)
PALE: 
102880785(LPAR3)
LAV: 
100655832(LPAR3)
MDO: 
100012415(LPAR3)
SHR: 
100915601(LPAR3)
OAA: 
GGA: 
771215(LPAR3)
MGP: 
100547842(LPAR3)
CJO: 
107317576(LPAR3)
APLA: 
101793595(LPAR3)
ACYG: 
106034114(LPAR3)
TGU: 
100225154(LPAR3)
GFR: 
102041393(LPAR3)
FAB: 
101808273(LPAR3)
PHI: 
102111144(LPAR3)
PMAJ: 
107208287(LPAR3)
CCW: 
104695306(LPAR3)
FPG: 
101922607(LPAR3)
FCH: 
102053547(LPAR3)
CLV: 
102095525(LPAR3)
AAM: 
106499684(LPAR3)
ASN: 
102368731(LPAR3)
AMJ: 
102559286(LPAR3)
PSS: 
102451255(LPAR3)
CMY: 
102944638(LPAR3)
CPIC: 
101939177(LPAR3)
ACS: 
100554366(lpar3)
PVT: 
110079734(LPAR3)
PBI: 
103060593(LPAR3)
GJA: 
107117296(LPAR3)
XLA: 
108714179(lpar3.L) 108715493(lpar3.S)
XTR: 
100494791(lpar3)
NPR: 
108791384(LPAR3)
DRE: 
102216338(lpar3)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
103032282(lpar3)
TRU: 
101073172(lpar3)
TNG: 
LCO: 
104931932(lpar3)
NCC: 
104954258(lpar3)
MZE: 
101478332(lpar3)
OLA: 
101172645(lpar3)
XMA: 
102221110(lpar3)
CSEM: 
LCF: 
108881288(lpar3)
HCQ: 
109522048(lpar3)
BPEC: 
110160088(lpar3)
SASA: 
106613437(lpar3)
SFM: 
LCM: 
102362131(LPAR3)
CMK: 
103174698(lpar3)
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Noguchi K, Herr D, Mutoh T, Chun J
  Title
Lysophosphatidic acid (LPA) and its receptors.
  Journal
Curr Opin Pharmacol 9:15-23 (2009)
DOI:10.1016/j.coph.2008.11.010
Reference
  Authors
Contos JJ, Ishii I, Chun J
  Title
Lysophosphatidic acid receptors.
  Journal
Mol Pharmacol 58:1188-96 (2000)
DOI:10.1124/mol.58.6.1188
  Sequence
[hsa:23566]

KEGG   ORTHOLOGY: K04275Help
Entry
K04275                      KO                                     

Name
LPAR4, GPR23
Definition
lysophosphatidic acid receptor 4
Pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
   04072 Phospholipase D signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
   04151 PI3K-Akt signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
G protein-coupled receptors [BR:ko04030]
 Class A. Rhodopsin family
  Lipid
   Lysophosphatidic acid [OT]
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
BRITE hierarchy
Other DBs
Genes
HSA: 
2846(LPAR4)
PTR: 
465729(LPAR4)
PPS: 
100989638(LPAR4)
GGO: 
101150616(LPAR4)
PON: 
100459511(LPAR4)
NLE: 
100588179(LPAR4)
MCC: 
707170(LPAR4)
MCF: 
101864899(LPAR4)
CSAB: 
103232244(LPAR4)
RRO: 
104654349(LPAR4)
RBB: 
108529808(LPAR4)
CJC: 
100395819(LPAR4)
SBQ: 
101044548(LPAR4)
MMU: 
78134(Lpar4)
RNO: 
302378(Lpar4)
CGE: 
100752179(Lpar4)
NGI: 
103737817(Lpar4)
OCU: 
100344512(LPAR4)
TUP: 
102500888(LPAR4)
CFA: 
491978(LPAR4)
AML: 
100477865(LPAR4)
UMR: 
103675824(LPAR4)
FCA: 
101087973(LPAR4)
PTG: 
102962731(LPAR4)
AJU: 
106987200(LPAR4)
BTA: 
539738(LPAR4)
BOM: 
102277938(LPAR4)
PHD: 
102330620(LPAR4)
CHX: 
102184511(LPAR4)
OAS: 
101118506(LPAR4)
SSC: 
100038017(LPAR4)
CFR: 
102505523(LPAR4)
CDK: 
105090092(LPAR4)
BACU: 
LVE: 
103078023(LPAR4)
ECB: 
100071749(LPAR4)
EPZ: 
103561874(LPAR4)
EAI: 
106827637(LPAR4)
MYB: 
102246973(LPAR4)
MYD: 
102762209(LPAR4)
HAI: 
109385677(LPAR4)
RSS: 
109437989(LPAR4)
PALE: 
102881134(LPAR4)
LAV: 
100656506(LPAR4)
MDO: 
100020275(LPAR4)
SHR: 
100914083(LPAR4)
GGA: 
422149(LPAR4)
MGP: 
100539306(LPAR4)
CJO: 
107312621(LPAR4)
APLA: 
101804888(LPAR4)
ACYG: 
106042983(LPAR4)
TGU: 
100226504(LPAR4)
GFR: 
102036590(LPAR4)
FAB: 
101818510(LPAR4)
PHI: 
102099403(LPAR4)
PMAJ: 
107203848(LPAR4)
CCW: 
104691290(LPAR4)
FPG: 
101916616(LPAR4)
FCH: 
102058845(LPAR4)
CLV: 
102084800(LPAR4)
AAM: 
106482083(LPAR4)
ASN: 
AMJ: 
PSS: 
102445780(LPAR4)
CMY: 
102946452(LPAR4)
CPIC: 
101944244(LPAR4)
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
108795346(LPAR4)
DRE: 
794698(lpar4)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101078478(lpar4)
TNG: 
LCO: 
104920594(lpar4)
NCC: 
104946178(lpar4)
MZE: 
OLA: 
XMA: 
CSEM: 
103391316(lpar4)
LCF: 
HCQ: 
109524498(lpar4)
BPEC: 
110153794(lpar4)
SASA: 
ELS: 
105007557(lpar4)
SFM: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Noguchi K, Herr D, Mutoh T, Chun J
  Title
Lysophosphatidic acid (LPA) and its receptors.
  Journal
Curr Opin Pharmacol 9:15-23 (2009)
DOI:10.1016/j.coph.2008.11.010
Reference
  Authors
Noguchi K, Ishii S, Shimizu T
  Title
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.
  Journal
J Biol Chem 278:25600-6 (2003)
DOI:10.1074/jbc.M302648200
  Sequence
[hsa:2846]

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