KEGG   ORTHOLOGY: K04344Help
Entry
K04344                      KO                                     

Name
CACNA1A
Definition
voltage-dependent calcium channel P/Q type alpha-1A
Pathway
MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
Disease
H00063  
Spinocerebellar ataxia (SCA)
H00606  
Early infantile epileptic encephalopathy
H00749  
Episodic ataxias
H00775  
Familial or sporadic hemiplegic migraine
H01808  
Hemiconvulsion-hemiplegia-epilepsy syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04020 Calcium signaling pathway
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
 Organismal Systems
  Nervous system
   04724 Glutamatergic synapse
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04727 GABAergic synapse
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04725 Cholinergic synapse
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04728 Dopaminergic synapse
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04726 Serotonergic synapse
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04730 Long-term depression
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04723 Retrograde endocannabinoid signaling
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   04721 Synaptic vesicle cycle
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
  Sensory system
   04742 Taste transduction
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
   05033 Nicotine addiction
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Ca2+ channel, CACN alpha-1, CaVx.x
   K04344  CACNA1A; voltage-dependent calcium channel P/Q type alpha-1A
BRITE hierarchy
Other DBs
Genes
HSA: 
773(CACNA1A)
PTR: 
455766(CACNA1A)
PPS: 
100971898(CACNA1A)
GGO: 
101127257(CACNA1A)
PON: 
NLE: 
100602682(CACNA1A)
MCC: 
718291(CACNA1A)
MCF: 
102130052(CACNA1A)
CSAB: 
103234371(CACNA1A)
RRO: 
104661142(CACNA1A)
RBB: 
108544091(CACNA1A)
CJC: 
100390599(CACNA1A)
SBQ: 
101046396(CACNA1A)
MMU: 
12286(Cacna1a)
RNO: 
25398(Cacna1a)
CGE: 
100758171(Cacna1a)
NGI: 
103751913(Cacna1a)
HGL: 
101725815(Cacna1a)
CCAN: 
109681262(Cacna1a)
OCU: 
100009265(CACNA1A)
TUP: 
102473903(CACNA1A)
CFA: 
100686650(CACNA1A)
AML: 
100473951(CACNA1A)
UMR: 
FCA: 
101094827(CACNA1A)
PTG: 
102962991(CACNA1A)
AJU: 
106986103(CACNA1A)
BTA: 
282648(CACNA1A)
BOM: 
102266763(CACNA1A)
BIU: 
109560900(CACNA1A)
PHD: 
102336555(CACNA1A)
CHX: 
102168441(CACNA1A)
OAS: 
101120920(CACNA1A)
SSC: 
100525387(CACNA1A)
CFR: 
102516820(CACNA1A)
CDK: 
105100784(CACNA1A)
BACU: 
103007483(CACNA1A)
LVE: 
103068318(CACNA1A)
ECB: 
100063873(CACNA1A)
EPZ: 
103566268(CACNA1A)
EAI: 
106844288(CACNA1A)
MYB: 
102257882(CACNA1A)
MYD: 
102771143(CACNA1A)
HAI: 
109394251(CACNA1A)
RSS: 
109454914(CACNA1A)
PALE: 
102891789(CACNA1A)
LAV: 
100655176(CACNA1A)
MDO: 
100021108(CACNA1A)
SHR: 
100925240(CACNA1A)
OAA: 
100078981(CACNA1A)
PHI: 
102099919(CACNA1A)
FPG: 
101919186(CACNA1A)
FCH: 
AAM: 
ASN: 
102376033(CACNA1A)
AMJ: 
102564806(CACNA1A)
PSS: 
CMY: 
102933709(CACNA1A)
CPIC: 
101943820(CACNA1A)
ACS: 
100557580(cacna1a)
PVT: 
110082653(CACNA1A)
PBI: 
103050605(CACNA1A)
GJA: 
107116856(CACNA1A)
XLA: 
108710372 373828(cacna1a.S)
XTR: 
100492135(cacna1a)
NPR: 
108794965(CACNA1A)
DRE: 
569528(cacna1ab)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101072720(cacna1a)
TNG: 
LCO: 
NCC: 
MZE: 
101484868(cacna1a)
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102354855(CACNA1A)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rose SJ, Kriener LH, Heinzer AK, Fan X, Raike RS, van den Maagdenberg AM, Hess EJ
  Title
The first knockin mouse model of episodic ataxia type 2.
  Journal
Exp Neurol 261:553-62 (2014)
DOI:10.1016/j.expneurol.2014.08.001
  Sequence
[hsa:773]

KEGG   ORTHOLOGY: K04849Help
Entry
K04849                      KO                                     

Name
CACNA1B
Definition
voltage-dependent calcium channel N type alpha-1B
Pathway
MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
Disease
H00831  
Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04020 Calcium signaling pathway
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
 Organismal Systems
  Nervous system
   04727 GABAergic synapse
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04725 Cholinergic synapse
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04728 Dopaminergic synapse
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04726 Serotonergic synapse
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04723 Retrograde endocannabinoid signaling
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   04721 Synaptic vesicle cycle
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
   05033 Nicotine addiction
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Ca2+ channel, CACN alpha-1, CaVx.x
   K04849  CACNA1B; voltage-dependent calcium channel N type alpha-1B
BRITE hierarchy
Other DBs
Genes
HSA: 
774(CACNA1B)
PTR: 
464893(CACNA1B)
PPS: 
100979369(CACNA1B)
GGO: 
101123776(CACNA1B)
PON: 
100450868(CACNA1B)
NLE: 
100584807(CACNA1B)
MCC: 
721452(CACNA1B)
MCF: 
CSAB: 
103239541(CACNA1B)
RRO: 
104669605(CACNA1B)
RBB: 
108542921(CACNA1B)
CJC: 
100390442(CACNA1B)
SBQ: 
101049976(CACNA1B)
MMU: 
12287(Cacna1b)
RNO: 
257648(Cacna1b)
NGI: 
103732608(Cacna1b)
HGL: 
101697609(Cacna1b)
CCAN: 
OCU: 
100008979(CACNA1B)
TUP: 
102498317(CACNA1B)
CFA: 
480660(CACNA1B)
AML: 
100466608(CACNA1B)
UMR: 
103675324(CACNA1B)
FCA: 
101087362(CACNA1B)
PTG: 
102954775(CACNA1B)
AJU: 
BTA: 
282410(CACNA1B)
BOM: 
102266839(CACNA1B)
BIU: 
109565692(CACNA1B)
PHD: 
102330644(CACNA1B)
CHX: 
102189138(CACNA1B)
OAS: 
SSC: 
102164336(CACNA1B)
CFR: 
102521766(CACNA1B)
CDK: 
105102103(CACNA1B)
BACU: 
103004988(CACNA1B)
LVE: 
103073411(CACNA1B)
ECB: 
100058760(CACNA1B)
EPZ: 
103554173(CACNA1B)
EAI: 
106822757(CACNA1B)
MYB: 
102245786(CACNA1B)
MYD: 
102756826(CACNA1B)
HAI: 
109382541(CACNA1B)
RSS: 
109437268(CACNA1B)
PALE: 
102877847(CACNA1B)
LAV: 
100660444(CACNA1B)
MDO: 
100023896(CACNA1B)
SHR: 
100933192(CACNA1B)
OAA: 
100681261(CACNA1B)
GGA: 
374169(CACNA1B)
MGP: 
100539318(CACNA1B)
CJO: 
107321666(CACNA1B)
APLA: 
101794161(CACNA1B)
ACYG: 
106037093(CACNA1B)
TGU: 
100230125(CACNA1B)
GFR: 
102043304(CACNA1B)
FAB: 
101812454(CACNA1B)
PHI: 
102107124(CACNA1B)
PMAJ: 
107211935(CACNA1B)
CCW: 
104688232(CACNA1B)
FPG: 
101922058(CACNA1B)
FCH: 
102058219(CACNA1B)
CLV: 
102086328(CACNA1B)
AAM: 
106497478(CACNA1B)
ASN: 
102374664(CACNA1B)
AMJ: 
102564626(CACNA1B)
PSS: 
102452356(CACNA1B)
CMY: 
102935334(CACNA1B)
CPIC: 
101941901(CACNA1B)
ACS: 
100565533(cacna1b)
PVT: 
110089800(CACNA1B)
PBI: 
GJA: 
107118784(CACNA1B)
XLA: 
100462926(cacna1b.S) 108699890
XTR: 
NPR: 
108794388(CACNA1B)
DRE: 
555941(cacna1ba) 562796(cacna1bb)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101072690(cacna1b)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102345610(CACNA1B)
CMK: 
103180424(cacna1b)
CIN: 
LGI: 
OBI: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Keum D, Baek C, Kim DI, Kweon HJ, Suh BC
  Title
Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized beta subunit.
  Journal
J Gen Physiol 144:297-309 (2014)
DOI:10.1085/jgp.201411245
  Sequence
[hsa:774]

KEGG   ORTHOLOGY: K04852Help
Entry
K04852                      KO                                     

Name
CACNA1E
Definition
voltage-dependent calcium channel R type alpha-1E
Pathway
MAPK signaling pathway
Calcium signaling pathway
Type II diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04852  CACNA1E; voltage-dependent calcium channel R type alpha-1E
   04020 Calcium signaling pathway
    K04852  CACNA1E; voltage-dependent calcium channel R type alpha-1E
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K04852  CACNA1E; voltage-dependent calcium channel R type alpha-1E
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Ca2+ channel, CACN alpha-1, CaVx.x
   K04852  CACNA1E; voltage-dependent calcium channel R type alpha-1E
BRITE hierarchy
Other DBs
Genes
HSA: 
777(CACNA1E)
PTR: 
457564(CACNA1E)
PPS: 
100973580(CACNA1E)
GGO: 
101152448(CACNA1E)
PON: 
NLE: 
100607010(CACNA1E)
MCC: 
718092(CACNA1E)
MCF: 
102137898(CACNA1E)
CSAB: 
103230478(CACNA1E)
RRO: 
104666781(CACNA1E)
RBB: 
CJC: 
100406548(CACNA1E)
SBQ: 
101040860(CACNA1E)
MMU: 
12290(Cacna1e)
RNO: 
54234(Cacna1e)
CGE: 
100773594(Cacna1e)
NGI: 
103731375(Cacna1e)
HGL: 
101701145(Cacna1e)
CCAN: 
109680409(Cacna1e)
OCU: 
100009403(CACNA1E)
TUP: 
102488737(CACNA1E)
CFA: 
490305(CACNA1E)
AML: 
100466242(CACNA1E)
UMR: 
103672437(CACNA1E)
FCA: 
101093985(CACNA1E)
PTG: 
AJU: 
106966786(CACNA1E)
BTA: 
353113(CACNA1E)
BOM: 
102271361(CACNA1E)
BIU: 
109570739(CACNA1E)
PHD: 
102323438(CACNA1E)
CHX: 
102184834(CACNA1E)
OAS: 
101102503(CACNA1E)
SSC: 
100511769(CACNA1E)
CFR: 
102509504(CACNA1E)
CDK: 
105096253(CACNA1E)
BACU: 
103008378(CACNA1E)
LVE: 
103070069(CACNA1E)
ECB: 
100054582(CACNA1E)
EPZ: 
103552092(CACNA1E)
EAI: 
106833978(CACNA1E)
MYB: 
102258772(CACNA1E)
MYD: 
102766294(CACNA1E)
HAI: 
109371489(CACNA1E)
RSS: 
109448740(CACNA1E)
PALE: 
102894818(CACNA1E)
LAV: 
100663606(CACNA1E)
MDO: 
100017762(CACNA1E)
SHR: 
100915867(CACNA1E)
OAA: 
100081909(CACNA1E)
GGA: 
424412(CACNA1E)
MGP: 
100547277(CACNA1E)
CJO: 
107317272(CACNA1E)
APLA: 
101795250(CACNA1E)
ACYG: 
106047781(CACNA1E)
TGU: 
100221799(CACNA1E)
GFR: 
102043868(CACNA1E)
FAB: 
101806626(CACNA1E)
PHI: 
102110220(CACNA1E)
PMAJ: 
107208269(CACNA1E)
CCW: 
FPG: 
101921612(CACNA1E)
FCH: 
102050734(CACNA1E)
CLV: 
102097507(CACNA1E)
AAM: 
ASN: 
102369133(CACNA1E)
AMJ: 
102561875(CACNA1E)
PSS: 
102444760(CACNA1E)
CMY: 
102946100(CACNA1E)
CPIC: 
101940446(CACNA1E)
ACS: 
100567913(cacna1e)
PVT: 
110077061(CACNA1E)
PBI: 
103051634(CACNA1E)
GJA: 
XLA: 
100462927(cacna1e.L) 108715639
XTR: 
100488514(cacna1e)
NPR: 
108792573(CACNA1E)
DRE: 
564274(cacna1e)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
101487658(cacna1e)
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102362201(CACNA1E)
CMK: 
103184804(cacna1e)
CRE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kamp MA, Krieger A, Henry M, Hescheler J, Weiergraber M, Schneider T
  Title
Presynaptic 'Ca2.3-containing' E-type Ca channels share dual roles during neurotransmitter release.
  Journal
Eur J Neurosci 21:1617-25 (2005)
DOI:10.1111/j.1460-9568.2005.03984.x
  Sequence
[hsa:777]

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