KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
MAPK signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Vascular smooth muscle contraction
Long-term depression
Regulation of actin cytoskeleton
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Organismal Systems
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 
2768(GNA12)
PTR: 
463234(GNA12)
PPS: 
100979605(GNA12)
GGO: 
101147243(GNA12)
PON: 
100173387(GNA12)
NLE: 
100591916(GNA12)
MCC: 
100429106(GNA12)
MCF: 
101867258(GNA12)
CSAB: 
103246857(GNA12)
RRO: 
104664964(GNA12)
RBB: 
108543875(GNA12)
CJC: 
100387912(GNA12)
SBQ: 
101042405(GNA12)
MMU: 
14673(Gna12)
RNO: 
81663(Gna12)
CGE: 
100760944(Gna12)
NGI: 
103748670(Gna12)
HGL: 
101697421(Gna12)
CCAN: 
109683409(Gna12)
OCU: 
100347293(GNA12)
TUP: 
102501406(GNA12)
CFA: 
102154318(GNA12)
AML: 
100465369(GNA12)
UMR: 
103669942(GNA12)
FCA: 
101093316(GNA12)
PTG: 
102961052(GNA12)
AJU: 
106984497(GNA12)
BTA: 
515159(GNA12)
BOM: 
102265273(GNA12)
BIU: 
109578204(GNA12)
PHD: 
102322053(GNA12)
CHX: 
102185175(GNA12)
OAS: 
101111070(GNA12)
SSC: 
100525156(GNA12)
CFR: 
102524525(GNA12)
CDK: 
105090390(GNA12)
BACU: 
103009974(GNA12)
LVE: 
103069136(GNA12)
ECB: 
100060005(GNA12)
EPZ: 
103549418(GNA12)
EAI: 
106834780(GNA12)
MYB: 
102260289(GNA12)
MYD: 
102763801(GNA12)
HAI: 
109380223(GNA12)
RSS: 
109461354(GNA12)
PALE: 
102891706(GNA12)
LAV: 
100676444(GNA12)
MDO: 
100010453(GNA12)
SHR: 
100916443(GNA12)
OAA: 
100082592(GNA12)
GGA: 
769924(GNA12)
MGP: 
100550659(GNA12)
CJO: 
107320696(GNA12)
APLA: 
101798445(GNA12)
ACYG: 
106032065(GNA12)
TGU: 
100225137(GNA12)
GFR: 
102044790(GNA12)
FAB: 
101818259(GNA12)
PHI: 
102104762(GNA12)
PMAJ: 
107211274(GNA12)
CCW: 
104684810(GNA12)
FPG: 
101917262(GNA12)
FCH: 
102059010(GNA12)
CLV: 
102088372(GNA12)
AAM: 
106483939(GNA12)
ASN: 
102377286(GNA12)
AMJ: 
102559993(GNA12)
PSS: 
102445616(GNA12)
CMY: 
102931254(GNA12)
CPIC: 
101947834(GNA12)
ACS: 
100564021(gna12)
PVT: 
110083721(GNA12)
PBI: 
103050241(GNA12)
GJA: 
DRE: 
503589(gna12a)
SRX: 
SANH: 
SGH: 
IPU: 
108257129(gna12)
TRU: 
101078184(gna12)
TNG: 
LCO: 
104929956(gna12)
NCC: 
MZE: 
101473086(gna12)
OLA: 
101166935(gna12)
XMA: 
CSEM: 
103383240(gna12)
LCF: 
108888452(gna12)
HCQ: 
109511425(gna12)
BPEC: 
110153513(gna12)
SASA: 
ELS: 
105006302(gna12)
SFM: 
108927048(gna12)
LCM: 
102367557(GNA12)
CMK: 
103185131(gna12)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD17672(Dsim_GD17672)
DWI: 
DYA: 
Dyak_GE22695(Dyak_cta)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410906(GB12482) 727645
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
100862775(Galpha12)
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_F18G5.3(gpa-12)
CBR: 
CBG16182(Cbr-gpa-12)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
LAK: 
SHX: 
NVE: 
ADF: 
HMG: 
100192290(gna12)
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]

KEGG   ORTHOLOGY: K04347Help
Entry
K04347                      KO                                     

Name
GNG12
Definition
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Pathway
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Apelin signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Regulation of actin cytoskeleton
Relaxin signaling pathway
Morphine addiction
Alcoholism
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04010 MAPK signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04371 Apelin signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04151 PI3K-Akt signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Endocrine system
   04926 Relaxin signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Nervous system
   04724 Glutamatergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04727 GABAergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04725 Cholinergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04728 Dopaminergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04726 Serotonergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04723 Retrograde endocannabinoid signaling
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Environmental adaptation
   04713 Circadian entrainment
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Substance dependence
   05032 Morphine addiction
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   05034 Alcoholism
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Exosomal proteins of colorectal cancer cells
   K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
BRITE hierarchy
Genes
HSA: 
55970(GNG12)
PTR: 
100609242(GNG12)
GGO: 
PON: 
100173039(GNG12)
NLE: 
100584569(GNG12)
MCC: 
100424606(GNG12)
MCF: 
102126944(GNG12)
CSAB: 
103224649(GNG12)
RRO: 
104657305(GNG12)
RBB: 
CJC: 
SBQ: 
MMU: 
100503710(Gm5741) 14701(Gng12)
RNO: 
114120(Gng12) 685513
CGE: 
100757536(Gng12)
NGI: 
HGL: 
101725110(Gng12)
CCAN: 
OCU: 
TUP: 
102501535(GNG12)
CFA: 
AML: 
UMR: 
103663028(GNG12)
FCA: 
PTG: 
102951416(GNG12)
AJU: 
106985197(GNG12)
BTA: 
286850(GNG12) 529425
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
100270820(GNG12) 100520008(GNG14)
CFR: 
CDK: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
772239(GNG12)
MGP: 
100539211(GNG12)
CJO: 
107317807(GNG12)
APLA: 
101790756(GNG12)
ACYG: 
106043621(GNG12)
TGU: 
100190560(GNG12)
GFR: 
102042757(GNG12)
FAB: 
101807832(GNG12)
PHI: 
102102678(GNG12)
PMAJ: 
107208454(GNG12)
CCW: 
104695124(GNG12)
FPG: 
101918590(GNG12)
FCH: 
102049350(GNG12)
CLV: 
102084634(GNG12)
AAM: 
106486519(GNG12)
ASN: 
102371926(GNG12)
AMJ: 
102574789(GNG12)
PSS: 
102449936(GNG12)
CMY: 
CPIC: 
ACS: 
100554637(gng12)
PVT: 
110079856(GNG12)
PBI: 
103059345(GNG12)
GJA: 
XLA: 
108715518 595043(gng12.L)
XTR: 
100124710(gng12)
NPR: 
108795949(GNG12)
DRE: 
100331581(si:dkey-44g17.6) 406604(gng12a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101074215(gng12)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102348748(GNG12)
CMK: 
103189133(gng12)
DPX: 
LOA: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cook LA, Schey KL, Cleator JH, Wilcox MD, Dingus J, Hildebrandt JD
  Title
Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms.
  Journal
Protein Sci 10:2548-55 (2001)
DOI:10.1110/ps.ps.26401
  Sequence
[hsa:55970]

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