KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Organismal Systems
  Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 2768(GNA12)
PTR: 463234(GNA12)
PPS: 100979605(GNA12)
GGO: 101147243(GNA12)
PON: 100173387(GNA12)
NLE: 100591916(GNA12)
MCC: 100429106(GNA12)
MCF: 101867258(GNA12)
CSAB: 103246857(GNA12)
RRO: 104664964(GNA12)
RBB: 108543875(GNA12)
CJC: 100387912(GNA12)
SBQ: 101042405(GNA12)
MMU: 14673(Gna12)
RNO: 81663(Gna12)
CGE: 100760944(Gna12)
NGI: 103748670(Gna12)
HGL: 101697421(Gna12)
CCAN: 109683409(Gna12)
OCU: 100347293(GNA12)
TUP: 102501406(GNA12)
CFA: 102154318(GNA12)
AML: 100465369(GNA12)
UMR: 103669942(GNA12)
ORO: 101371250(GNA12)
FCA: 101093316(GNA12)
PTG: 102961052(GNA12)
AJU: 106984497(GNA12)
BTA: 515159(GNA12)
BOM: 102265273(GNA12)
BIU: 109578204(GNA12)
PHD: 102322053(GNA12)
CHX: 102185175(GNA12)
OAS: 101111070(GNA12)
SSC: 100525156(GNA12)
CFR: 102524525(GNA12)
CDK: 105090390(GNA12)
BACU: 103009974(GNA12)
LVE: 103069136(GNA12)
OOR: 101281075(GNA12)
ECB: 100060005(GNA12)
EPZ: 103549418(GNA12)
EAI: 106834780(GNA12)
MYB: 102260289(GNA12)
MYD: 102763801(GNA12)
HAI: 109380223(GNA12)
RSS: 109461354(GNA12)
PALE: 102891706(GNA12)
LAV: 100676444(GNA12)
TMU: 101351796
MDO: 100010453(GNA12)
SHR: 100916443(GNA12)
OAA: 100082592(GNA12)
GGA: 769924(GNA12)
MGP: 100550659(GNA12)
CJO: 107320696(GNA12)
APLA: 101798445(GNA12)
ACYG: 106032065(GNA12)
TGU: 100225137(GNA12)
GFR: 102044790(GNA12)
FAB: 101818259(GNA12)
PHI: 102104762(GNA12)
PMAJ: 107211274(GNA12)
CCW: 104684810(GNA12)
FPG: 101917262(GNA12)
FCH: 102059010(GNA12)
CLV: 102088372(GNA12)
EGZ: 104132621(GNA12)
AAM: 106483939(GNA12)
ASN: 102377286(GNA12)
AMJ: 102559993(GNA12)
PSS: 102445616(GNA12)
CMY: 102931254(GNA12)
CPIC: 101947834(GNA12)
ACS: 100564021(gna12)
PVT: 110083721(GNA12)
PBI: 103050241(GNA12)
GJA: 107116703(GNA12) 107125403
DRE: 503589(gna12a)
IPU: 108257129(gna12)
AMEX: 103024018(gna12)
TRU: 101078184(gna12)
LCO: 104929956(gna12)
NCC: 104953206 104953227(gna12)
MZE: 101473086(gna12)
OLA: 101166935(gna12)
XMA: 102222306(gna12)
PRET: 103462653(gna12)
NFU: 107388805(gna12)
CSEM: 103383240(gna12)
LCF: 108888452(gna12)
HCQ: 109511425(gna12)
BPEC: 110153513(gna12)
ELS: 105006302(gna12)
SFM: 108927048(gna12)
LCM: 102367557(GNA12)
CMK: 103185131(gna12)
SPU: 414055
SKO: 100371005
DME: Dmel_CG17678(cta)
DSI: Dsimw501_GD17672(Dsim_GD17672)
DYA: Dyak_GE22695(Dyak_cta)
MDE: 101898580
AAG: 5570853
AME: 410906(GB12482) 727645
BIM: 100745931
BTER: 100649951
SOC: 105200292
AEC: 105147295
ACEP: 105624301
PBAR: 105431792
HST: 105181192
CFO: 105259283
LHU: 105675078
PGC: 109863777
NVI: 100115318(cta)
TCA: 661072
DPA: 109541992
BMOR: 100862775(Galpha12)
PMAC: 106720633
PRAP: 111001958
PXY: 105391521
API: 100165181
DNX: 107169778
ZNE: 110838798
FCD: 110848091
DPX: DAPPUDRAFT_190301(Gna12)
TUT: 107368817
CEL: CELE_F18G5.3(gpa-12)
CBR: CBG16182(Cbr-gpa-12)
BMY: Bm1_00355
TSP: Tsp_00479
CRG: 105341702
MYI: 110465109
LAK: 106174984
SHX: MS3_06267
EPA: 110251752
ADF: 107350389
HMG: 100192290(gna12)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8423800
  Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
  Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
  Journal
Mol Cell Biol 13:762-8 (1993)
  Sequence
[hsa:2768]
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]

KEGG   ORTHOLOGY: K04347Help
Entry
K04347                      KO                                     

Name
GNG12
Definition
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04371  Apelin signaling pathway
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04810  Regulation of actin cytoskeleton
ko04926  Relaxin signaling pathway
ko05032  Morphine addiction
ko05034  Alcoholism
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04010 MAPK signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04371 Apelin signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04151 PI3K-Akt signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Endocrine system
   04926 Relaxin signaling pathway
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Nervous system
   04724 Glutamatergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04727 GABAergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04725 Cholinergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04728 Dopaminergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04726 Serotonergic synapse
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   04723 Retrograde endocannabinoid signaling
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Environmental adaptation
   04713 Circadian entrainment
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Substance dependence
   05032 Morphine addiction
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
   05034 Alcoholism
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  Exosomal proteins of colorectal cancer cells
   K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
BRITE hierarchy
Genes
HSA: 55970(GNG12)
PTR: 100609242(GNG12)
GGO: 101147632(GNG12)
PON: 100173039(GNG12)
NLE: 100584569(GNG12)
MCC: 100424606(GNG12)
MCF: 102126944(GNG12)
CSAB: 103224649(GNG12)
RRO: 104657305(GNG12)
RBB: 108532869(GNG12) 108539612
CJC: 100394978(GNG12) 100396640
SBQ: 101046368(GNG12) 101051683
MMU: 100503710(Gm5741) 14701(Gng12)
RNO: 114120(Gng12) 685513
CGE: 100757536(Gng12)
NGI: 103743355(Gng12) 103751889
HGL: 101725110(Gng12)
CCAN: 109681247 109698314(Gng12)
OCU: 103350153(GNG12) 108176185
TUP: 102501535(GNG12)
CFA: 100686332(GNG12) 611002
AML: 100477221 100477225(GNG12)
UMR: 103663028(GNG12)
FCA: 101084346(GNG14) 101089378(GNG12)
PTG: 102951416(GNG12)
AJU: 106985197(GNG12)
BTA: 286850(GNG12) 529425
BOM: 102271265 102287427(GNG12)
BIU: 109556175(GNG12) 109561546
PHD: 102335353 102341852(GNG12)
CHX: 102175543(GNG12) 102182581
OAS: 106991180
SSC: 100270820(GNG12) 100520008(GNG14)
CFR: 106729205
CDK: 105104066
ECB: 100063518(GNG14) 100630574(GNG12)
EPZ: 103542772 103564847(GNG12)
EAI: 106825068(GNG12) 106826929
MYB: 102240295 102242875(GNG12)
MYD: 102752682(GNG12) 102773554
HAI: 109394259
RSS: 109447689(GNG12) 109454960
PALE: 102877921 102886682(GNG12)
LAV: 111750996(GNG12) 111751488(GNG14)
MDO: 100010184 100016914(GNG12)
SHR: 100914479(GNG12) 100920266(GNG14)
OAA: 100078907 100081920(GNG12)
GGA: 772239(GNG12)
MGP: 100539211(GNG12)
CJO: 107317807(GNG12)
APLA: 101790756(GNG12)
ACYG: 106043621(GNG12)
TGU: 100190560(GNG12)
GFR: 102042757(GNG12)
FAB: 101807832(GNG12)
PHI: 102102678(GNG12)
PMAJ: 107208454(GNG12)
CCW: 104695124(GNG12)
FPG: 101918590(GNG12)
FCH: 102049350(GNG12)
CLV: 102084634(GNG12)
EGZ: 104123920(GNG12)
AAM: 106486519(GNG12)
ASN: 102371926(GNG12)
AMJ: 102574789(GNG12)
PSS: 102449936(GNG12)
CMY: 102930776 102947603(GNG12)
CPIC: 101933719(GNG12) 101941988
ACS: 100554637(gng12)
PVT: 110079856(GNG12)
PBI: 103059345(GNG12)
GJA: 107114357(GNG12) 107114377
XLA: 108715518 595043(gng12.L)
XTR: 100124710(gng12)
NPR: 108795949(GNG12)
DRE: 100331581(si:dkey-44g17.6) 406604(gng12a)
TRU: 101074215(gng12)
NCC: 104956611
PRET: 103463990 103479128(gng12)
CSEM: 103392942 103396088(gng12)
HCQ: 109524140
LCM: 102348748(GNG12)
CMK: 103189133(gng12)
DPX: DAPPUDRAFT_44980(Gng2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cook LA, Schey KL, Cleator JH, Wilcox MD, Dingus J, Hildebrandt JD
  Title
Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms.
  Journal
Protein Sci 10:2548-55 (2001)
DOI:10.1110/ps.ps.26401
  Sequence
[hsa:55970]

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