KEGG   ORTHOLOGY: K04359Help
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
Transcriptional misregulation in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Disease
H00015  
Malignant pleural mesothelioma
H00042  
Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 Jak-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04359  PDGFA; platelet-derived growth factor subunit A
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancers
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  Infectious diseases
   05166 HTLV-I infection
    K04359  PDGFA; platelet-derived growth factor subunit A
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines [BR:ko04052]
 PDGF family
  Cysteine-knot growth factors
   Subclass I
    K04359  PDGFA; platelet-derived growth factor subunit A
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
    PDGFRB; platelet-derived growth factor receptor, beta polypeptide
     K04359 PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5154(PDGFA)
PTR: 
740202(PDGFA)
PPS: 
100991389(PDGFA)
GGO: 
101132059(PDGFA)
PON: 
100440212(PDGFA)
NLE: 
100583683(PDGFA)
MCC: 
707725(PDGFA)
MCF: 
102126620(PDGFA)
CSAB: 
103246906(PDGFA)
RRO: 
104664975(PDGFA)
RBB: 
108542315(PDGFA)
CJC: 
100412906(PDGFA)
SBQ: 
101034511(PDGFA)
MMU: 
18590(Pdgfa)
RNO: 
25266(Pdgfa)
CGE: 
100771503(Pdgfa)
NGI: 
103748699(Pdgfa)
HGL: 
101725739(Pdgfa)
CCAN: 
109684500(Pdgfa)
OCU: 
100352388(PDGFA)
TUP: 
102499235(PDGFA)
CFA: 
491597(PDGFA)
AML: 
100473486(PDGFA)
UMR: 
103670054(PDGFA)
FCA: 
101087287(PDGFA)
BTA: 
505908(PDGFA)
BOM: 
102271219(PDGFA)
BIU: 
109578611(PDGFA)
PHD: 
102338084(PDGFA)
CHX: 
102174268(PDGFA)
SSC: 
100519764(PDGFA)
CFR: 
102520052(PDGFA)
CDK: 
105102061(PDGFA)
BACU: 
103005337(PDGFA)
LVE: 
103089216(PDGFA)
ECB: 
100055086(PDGFA)
EPZ: 
103555992(PDGFA)
EAI: 
106834748(PDGFA)
MYB: 
102253551(PDGFA)
MYD: 
102762551(PDGFA)
HAI: 
109380137(PDGFA)
RSS: 
109455731(PDGFA)
PALE: 
102893670(PDGFA)
LAV: 
100675120(PDGFA)
MDO: 
100020951(PDGFA)
SHR: 
100924985(PDGFA)
OAA: 
100081033(PDGFA)
GGA: 
374196(PDGFA)
MGP: 
100545955(PDGFA)
CJO: 
107320713(PDGFA)
APLA: 
101803502(PDGFA)
ACYG: 
106033384(PDGFA)
TGU: 
100222155(PDGFA)
GFR: 
102032936(PDGFA)
FAB: 
101810376(PDGFA)
PHI: 
102099148(PDGFA)
PMAJ: 
107211209(PDGFA)
CCW: 
104685042(PDGFA)
FPG: 
101922505(PDGFA)
FCH: 
102059520(PDGFA)
CLV: 
102085857(PDGFA)
ASN: 
102386051(PDGFA)
AMJ: 
102568490(PDGFA)
PSS: 
102453111(PDGFA)
CMY: 
102936738(PDGFA)
CPIC: 
101940087(PDGFA)
ACS: 
100560004(pdgfa)
PVT: 
110090337(PDGFA)
PBI: 
103066198(PDGFA)
GJA: 
107115509(PDGFA)
XLA: 
108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 
100038202(pdgfa)
NPR: 
108800714(PDGFA)
DRE: 
103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
104945697(pdgfa)
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
110169079(pdgfa)
SASA: 
ELS: 
SFM: 
LCM: 
102352946(PDGFA)
CMK: 
SOC: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
Reference
  Authors
Wu E, Palmer N, Tian Z, Moseman AP, Galdzicki M, Wang X, Berger B, Zhang H, Kohane IS
  Title
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
  Journal
PLoS One 3:e3794 (2008)
DOI:10.1371/journal.pone.0003794
  Sequence
[dre:386856]

KEGG   ORTHOLOGY: K05450Help
Entry
K05450                      KO                                     

Name
PDGFC_D
Definition
platelet derived growth factor C/D
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Prostate cancer
Melanoma
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04015 Rap1 signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04010 MAPK signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04072 Phospholipase D signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05450  PDGFC_D; platelet derived growth factor C/D
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05450  PDGFC_D; platelet derived growth factor C/D
   04540 Gap junction
    K05450  PDGFC_D; platelet derived growth factor C/D
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05450  PDGFC_D; platelet derived growth factor C/D
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
   05218 Melanoma
    K05450  PDGFC_D; platelet derived growth factor C/D
   05215 Prostate cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05450  PDGFC_D; platelet derived growth factor C/D
Cytokines [BR:ko04052]
 PDGF family
  Cysteine-knot growth factors
   Subclass I
    K05450  PDGFC_D; platelet derived growth factor C/D
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   Enzymatic CD
    PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
     K05450 PDGFC_D; platelet derived growth factor C/D
    PDGFRB; platelet-derived growth factor receptor, beta polypeptide
     K05450 PDGFC_D; platelet derived growth factor C/D
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
56034(PDGFC) 80310(PDGFD)
PTR: 
466765(PDGFD) 736477(PDGFC)
PPS: 
100982459(PDGFC) 100992738(PDGFD)
GGO: 
101134877(PDGFD) 101144807(PDGFC)
PON: 
100172718(PDGFD) 100437861(PDGFC)
NLE: 
100585549(PDGFC) 100586178(PDGFD)
MCC: 
700236(PDGFC) 704310(PDGFD)
MCF: 
101925936(PDGFD) 102132043(PDGFC)
CSAB: 
103236438(PDGFC) 103248362(PDGFD)
RRO: 
104655283(PDGFD) 104658109(PDGFC)
RBB: 
108529019(PDGFC) 108534757(PDGFD)
CJC: 
100393010(PDGFC) 100398033(PDGFD)
SBQ: 
101038849(PDGFC) 101049234(PDGFD)
MMU: 
54635(Pdgfc) 71785(Pdgfd)
RNO: 
66018(Pdgfd) 79429(Pdgfc)
CGE: 
100756952(Pdgfd) 100765334(Pdgfc)
NGI: 
103731702(Pdgfd) 103751038(Pdgfc)
HGL: 
101696768(Pdgfd) 101710927(Pdgfc)
CCAN: 
109701575(Pdgfc) 109702404(Pdgfd)
OCU: 
100008912(PDGFD) 100350272(PDGFC)
TUP: 
102485007(PDGFD) 102487522(PDGFC)
CFA: 
479460(PDGFD) 482666(PDGFC)
AML: 
100479872(PDGFD) 100481171(PDGFC)
UMR: 
103658054(PDGFC) 103662543(PDGFD)
FCA: 
101084984(PDGFD) 101088742(PDGFC)
PTG: 
102949957(PDGFD) 102970530(PDGFC)
AJU: 
106974876(PDGFC) 106976474(PDGFD)
BTA: 
525931(PDGFD) 613787(PDGFC)
BOM: 
102273267(PDGFD) 102274384(PDGFC)
BIU: 
109569805(PDGFD) 109571395(PDGFC)
PHD: 
102331529(PDGFC) 102341549(PDGFD)
CHX: 
102168651(PDGFD) 102168934(PDGFC)
OAS: 
101112600(PDGFC) 101117784(PDGFD)
SSC: 
100515267(PDGFC) 100524161(PDGFD)
CFR: 
102508964(PDGFC) 102515439(PDGFD)
CDK: 
105101177(PDGFC) 105103704(PDGFD)
BACU: 
103015925(PDGFD) 103019677(PDGFC)
LVE: 
103076387(PDGFC) 103085046(PDGFD)
ECB: 
100061488(PDGFD) 100062015(PDGFC)
EPZ: 
103547315(PDGFC) 103558709(PDGFD)
EAI: 
106833032(PDGFC) 106843123(PDGFD)
MYB: 
102240259(PDGFD) 102248385(PDGFC)
MYD: 
102766117(PDGFC) 102772727(PDGFD)
HAI: 
109372936(PDGFC) 109394938(PDGFD)
RSS: 
109437504(PDGFD) 109448190(PDGFC)
PALE: 
102890668(PDGFC) 102894123(PDGFD)
LAV: 
100661451(PDGFD) 100672750(PDGFC)
MDO: 
100011261(PDGFD) 100023701(PDGFC)
SHR: 
100916102(PDGFD) 100928148(PDGFC)
OAA: 
100078558(PDGFD) 100079757(PDGFC)
GGA: 
395469(PDGFC) 418978(PDGFD)
MGP: 
CJO: 
107308377(PDGFD) 107313060(PDGFC)
APLA: 
101789650(PDGFC) 101798843(PDGFD)
ACYG: 
106032364(PDGFC) 106034125(PDGFD)
TGU: 
100217775(PDGFC) 100221512(PDGFD)
GFR: 
102035549(PDGFC) 102044886(PDGFD)
FAB: 
101806397(PDGFD) 101808607(PDGFC)
PHI: 
102106969(PDGFC) 102112153(PDGFD)
PMAJ: 
107203600(PDGFC) 107209392(PDGFD)
CCW: 
104690110(PDGFD) 104697317(PDGFC)
FPG: 
101910328(PDGFD) 101915028(PDGFC)
FCH: 
102048020(PDGFC) 102052290(PDGFD)
CLV: 
102087107(PDGFC) 102088608(PDGFD)
AAM: 
106491877(PDGFC) 106495523(PDGFD)
ASN: 
102378690(PDGFC) 102380973(PDGFD)
AMJ: 
102569106(PDGFC) 102572032(PDGFD)
PSS: 
102445898(PDGFD) 102452310(PDGFC)
CMY: 
102930493(PDGFD) 102939099(PDGFC)
CPIC: 
101938348(PDGFD) 101944573(PDGFC)
ACS: 
100551866(pdgfd) 100568114(pdgfc)
PVT: 
110072781(PDGFC) 110091114(PDGFD)
PBI: 
103051428(PDGFC) 103065334(PDGFD)
GJA: 
107126145(PDGFD) 107126248(PDGFC)
XLA: 
108699243(pdgfc.L) 108706647(pdgfc.S) 108707572 108709984(pdgfd.S)
XTR: 
100492060(pdgfd) 100494492(pdgfc)
NPR: 
DRE: 
100535718(pdgfd) 560564(pdgfc)
SRX: 
SANH: 
SGH: 
IPU: 
108269254(pdgfc) 108277755(pdgfd)
AMEX: 
103040737(pdgfc) 103045444(pdgfd)
TRU: 
101062634(pdgfc) 101063213(pdgfd)
TNG: 
LCO: 
NCC: 
104952384(pdgfc) 104961516(pdgfd)
MZE: 
101466155(pdgfc) 101473381(pdgfd)
OLA: 
101159654(pdgfc) 101163754(pdgfd)
XMA: 
CSEM: 
103378536(pdgfd) 103390671(pdgfc)
LCF: 
108885187(pdgfc) 108886631(pdgfd)
HCQ: 
109525495(pdgfd) 109526276(pdgfc)
BPEC: 
110153706(pdgfc) 110174393(pdgfd)
SASA: 
ELS: 
105024074(pdgfd) 105027646(pdgfc)
SFM: 
LCM: 
102351685(PDGFD) 102356509(PDGFC)
CMK: 
103182267(pdgfc) 103185765(pdgfd)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsai YJ, Lee RK, Lin SP, Chen YH
  Title
Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.
  Journal
Biochim Biophys Acta 1492:196-202 (2000)
DOI:10.1016/S0167-4781(00)00066-X
  Sequence
[hsa:56034]
Reference
  Authors
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA
  Title
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
  Journal
Arterioscler Thromb Vasc Biol 24:787-92 (2004)
DOI:10.1161/01.ATV.0000120785.82268.8b
  Sequence
[mmu:54635]

KEGG   ORTHOLOGY: K04357Help
Entry
K04357                      KO                                     

Name
EGF
Definition
epidermal growth factor
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
Hepatitis C
Human papillomavirus infection
Pathways in cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Disease
H00018  
Gastric cancer
H01210  
Hypomagnesemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04357  EGF; epidermal growth factor
   04015 Rap1 signaling pathway
    K04357  EGF; epidermal growth factor
   04010 MAPK signaling pathway
    K04357  EGF; epidermal growth factor
   04012 ErbB signaling pathway
    K04357  EGF; epidermal growth factor
   04630 Jak-STAT signaling pathway
    K04357  EGF; epidermal growth factor
   04066 HIF-1 signaling pathway
    K04357  EGF; epidermal growth factor
   04068 FoxO signaling pathway
    K04357  EGF; epidermal growth factor
   04072 Phospholipase D signaling pathway
    K04357  EGF; epidermal growth factor
   04151 PI3K-Akt signaling pathway
    K04357  EGF; epidermal growth factor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04357  EGF; epidermal growth factor
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04357  EGF; epidermal growth factor
   04540 Gap junction
    K04357  EGF; epidermal growth factor
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04357  EGF; epidermal growth factor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04357  EGF; epidermal growth factor
   05231 Choline metabolism in cancer
    K04357  EGF; epidermal growth factor
   05212 Pancreatic cancer
    K04357  EGF; epidermal growth factor
   05214 Glioma
    K04357  EGF; epidermal growth factor
   05218 Melanoma
    K04357  EGF; epidermal growth factor
   05219 Bladder cancer
    K04357  EGF; epidermal growth factor
   05215 Prostate cancer
    K04357  EGF; epidermal growth factor
   05213 Endometrial cancer
    K04357  EGF; epidermal growth factor
   05224 Breast cancer
    K04357  EGF; epidermal growth factor
   05223 Non-small cell lung cancer
    K04357  EGF; epidermal growth factor
  Infectious diseases
   05160 Hepatitis C
    K04357  EGF; epidermal growth factor
   05165 Human papillomavirus infection
    K04357  EGF; epidermal growth factor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04357  EGF; epidermal growth factor
Cytokines [BR:ko04052]
 PDGF family
  Other growth factors
   K04357  EGF; epidermal growth factor
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1950(EGF)
PTR: 
461435(EGF)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
698619(EGF)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
13645(Egf)
RNO: 
25313(Egf)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
403657(EGF)
AML: 
UMR: 
FCA: 
493978(EGF)
PTG: 
AJU: 
BTA: 
530315(EGF)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
397083(EGF)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
408035(EGF)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
403045(egf)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
SKO: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3491360
  Authors
Bell GI, Fong NM, Stempien MM, Wormsted MA, Caput D, Ku LL, Urdea MS, Rall LB, Sanchez-Pescador R
  Title
Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.
  Journal
Nucleic Acids Res 14:8427-46 (1986)
DOI:10.1093/nar/14.21.8427
  Sequence
[hsa:1950]
Reference
  Authors
Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT
  Title
Neurotrophic actions of a novel molluscan epidermal growth factor.
  Journal
J Neurosci 20:6355-64 (2000)
  Sequence
[mmu:13645]

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