KEGG   ORTHOLOGY: K04363Help
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00042  
Glioma
H01590  
Chronic eosinophilic leukemia
H01591  
Gastrotintestinal stromal tumor
H01599  
Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 Jak-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Infectious diseases
   05166 HTLV-I infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5156(PDGFRA)
PTR: 
461318(PDGFRA)
PPS: 
100982337(PDGFRA)
GGO: 
101124928(PDGFRA)
PON: 
100431735(PDGFRA)
NLE: 
100603207(PDGFRA)
MCC: 
697002(PDGFRA)
MCF: 
102138392(PDGFRA)
CSAB: 
103235675(PDGFRA)
RRO: 
104658857(PDGFRA)
RBB: 
108533750(PDGFRA)
CJC: 
100412331(PDGFRA)
SBQ: 
101040156(PDGFRA)
MMU: 
18595(Pdgfra)
RNO: 
25267(Pdgfra)
CGE: 
100760258(Pdgfra)
NGI: 
103734393(Pdgfra)
HGL: 
101697360(Pdgfra)
CCAN: 
OCU: 
100343006(PDGFRA)
TUP: 
102488187(PDGFRA)
CFA: 
442860(PDGFRA)
AML: 
100464991(PDGFRA)
UMR: 
103672737(PDGFRA)
FCA: 
101090765(PDGFRA)
PTG: 
102955481(PDGFRA)
AJU: 
106983998(PDGFRA)
BTA: 
282301(PDGFRA)
BOM: 
102282598(PDGFRA)
BIU: 
109560475(PDGFRA)
PHD: 
102329243(PDGFRA)
CHX: 
102174007(PDGFRA)
OAS: 
101106012(PDGFRA)
SSC: 
100627123(PDGFRA)
CFR: 
102512589(PDGFRA)
CDK: 
105103397(PDGFRA)
BACU: 
102998016(PDGFRA)
LVE: 
103071473(PDGFRA)
ECB: 
100059815(PDGFRA)
EPZ: 
103552305(PDGFRA)
EAI: 
106839051(PDGFRA)
MYB: 
102255326(PDGFRA)
MYD: 
102761943(PDGFRA)
HAI: 
109381815(PDGFRA)
RSS: 
109451713(PDGFRA)
PALE: 
102895362(PDGFRA)
LAV: 
100670735(PDGFRA)
MDO: 
100013088(PDGFRA)
SHR: 
100925116(PDGFRA)
OAA: 
100084432(PDGFRA)
GGA: 
395509(PDGFRA)
MGP: 
100542010(PDGFRA)
CJO: 
107313741(PDGFRA)
APLA: 
101797285(PDGFRA)
ACYG: 
106030788(PDGFRA)
TGU: 
100218386(PDGFRA)
GFR: 
102044274(PDGFRA)
FAB: 
101820996(PDGFRA)
PHI: 
102113476(PDGFRA)
PMAJ: 
107203533(PDGFRA)
CCW: 
104690630(PDGFRA)
FPG: 
101913531(PDGFRA)
FCH: 
102054310(PDGFRA)
CLV: 
102087625(PDGFRA)
AAM: 
106490172(PDGFRA)
ASN: 
102378120(PDGFRA)
AMJ: 
102575338(PDGFRA)
PSS: 
102443708(PDGFRA)
CMY: 
102935642(PDGFRA)
CPIC: 
101935558(PDGFRA)
ACS: 
PVT: 
110078407(PDGFRA)
PBI: 
103067713(PDGFRA)
GJA: 
107106036(PDGFRA)
XLA: 
108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 
100124862(pdgfra)
NPR: 
108804111(PDGFRA)
DRE: 
386856(pdgfra)
SRX: 
SANH: 
SGH: 
IPU: 
108258040(pdgfra)
AMEX: 
103044267(pdgfra)
TRU: 
101073543(pdgfra)
TNG: 
LCO: 
NCC: 
104947073(pdgfra)
MZE: 
101471693(pdgfra)
OLA: 
100049280(pdgfra)
XMA: 
CSEM: 
103376707(pdgfra)
LCF: 
108879100(pdgfra)
HCQ: 
109532287(pdgfra)
BPEC: 
110154688(pdgfra)
SASA: 
ELS: 
105011836(pdgfra)
SFM: 
108922803(pdgfra)
LCM: 
102353753(PDGFRA)
CMK: 
103178167(pdgfra)
EPA: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
Human papillomavirus infection
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00042  
Glioma
H01574  
Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Infectious diseases
   05166 HTLV-I infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5159(PDGFRB)
PTR: 
462188(PDGFRB)
PPS: 
100975853(PDGFRB)
GGO: 
101150577(PDGFRB)
PON: 
100460001(PDGFRB)
NLE: 
100597894(PDGFRB)
MCC: 
711353(PDGFRB)
MCF: 
101867161(PDGFRB)
CSAB: 
103244790(PDGFRB)
RRO: 
104670408(PDGFRB)
RBB: 
108532047(PDGFRB)
CJC: 
100389852(PDGFRB)
SBQ: 
101040158(PDGFRB)
MMU: 
18596(Pdgfrb)
RNO: 
24629(Pdgfrb)
CGE: 
100764374(Pdgfrb)
NGI: 
103747076(Pdgfrb)
HGL: 
101721151(Pdgfrb)
CCAN: 
OCU: 
100342872(PDGFRB)
TUP: 
102492413(PDGFRB)
CFA: 
442985(PDGFRB)
AML: 
100472005(PDGFRB)
UMR: 
103664600(PDGFRB)
FCA: 
101084600(PDGFRB)
PTG: 
102954207(PDGFRB)
AJU: 
106985388(PDGFRB)
BTA: 
527165(PDGFRB)
BOM: 
102270608(PDGFRB)
BIU: 
109562197(PDGFRB)
PHD: 
102333941(PDGFRB)
CHX: 
102184426(PDGFRB)
OAS: 
101122783(PDGFRB)
SSC: 
102166564(PDGFRB)
CFR: 
102512951(PDGFRB)
CDK: 
105098486(PDGFRB)
BACU: 
103019883(PDGFRB)
LVE: 
103082363(PDGFRB)
ECB: 
100071665(PDGFRB)
EPZ: 
103549125(PDGFRB)
EAI: 
106838493(PDGFRB)
MYB: 
102241145(PDGFRB)
MYD: 
102764172(PDGFRB)
HAI: 
109375002(PDGFRB)
RSS: 
109448748(PDGFRB)
PALE: 
102887643(PDGFRB)
LAV: 
100671240(PDGFRB)
MDO: 
100028943(PDGFRB)
SHR: 
100917212(PDGFRB)
OAA: 
100079459(PDGFRB)
GGA: 
770488(PDGFRB)
MGP: 
100550611(PDGFRB)
CJO: 
107320191(PDGFRB)
APLA: 
101799587(PDGFRB)
ACYG: 
106032823(PDGFRB)
TGU: 
100223375(PDGFRB)
GFR: 
102045343(PDGFRB)
FAB: 
101809926(PDGFRB)
PHI: 
102111524(PDGFRB)
PMAJ: 
107210844(PDGFRB)
CCW: 
104689579(PDGFRB)
FPG: 
101918438(PDGFRB)
FCH: 
102052718(PDGFRB)
CLV: 
102096790(PDGFRB)
AAM: 
106493441(PDGFRB)
ASN: 
102372962(PDGFRB)
AMJ: 
102566175(PDGFRB)
PSS: 
102460895(PDGFRB)
CMY: 
102944650(PDGFRB)
CPIC: 
101940553(PDGFRB)
ACS: 
100555784(pdgfrb)
PVT: 
110086089(PDGFRB)
PBI: 
103051588(PDGFRB)
GJA: 
XLA: 
108712643(pdgfrb.S)
XTR: 
100487523(pdgfrb)
NPR: 
108785807(PDGFRB)
DRE: 
559529(pdgfrb)
SRX: 
SANH: 
SGH: 
IPU: 
108274697(pdgfrb)
AMEX: 
TRU: 
101061130 101074724(PDGFR-beta)
TNG: 
LCO: 
NCC: 
104965701(pdgfrb)
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108936824(pdgfrb)
LCM: 
102361386(PDGFRB)
CMK: 
103188232(pdgfrb)
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]

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