KEGG   ORTHOLOGY: K04363Help
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00042  
Glioma
H01590  
Chronic eosinophilic leukemia
H01591  
Gastrotintestinal stromal tumor
H01599  
Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 Jak-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Infectious diseases
   05166 HTLV-I infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5156(PDGFRA)
PTR: 
461318(PDGFRA)
PPS: 
100982337(PDGFRA)
GGO: 
101124928(PDGFRA)
PON: 
100431735(PDGFRA)
NLE: 
100603207(PDGFRA)
MCC: 
697002(PDGFRA)
MCF: 
102138392(PDGFRA)
CSAB: 
103235675(PDGFRA)
RRO: 
104658857(PDGFRA)
RBB: 
108533750(PDGFRA)
CJC: 
100412331(PDGFRA)
SBQ: 
101040156(PDGFRA)
MMU: 
18595(Pdgfra)
RNO: 
25267(Pdgfra)
CGE: 
100760258(Pdgfra)
NGI: 
103734393(Pdgfra)
HGL: 
101697360(Pdgfra)
CCAN: 
OCU: 
100343006(PDGFRA)
TUP: 
102488187(PDGFRA)
CFA: 
442860(PDGFRA)
AML: 
100464991(PDGFRA)
UMR: 
103672737(PDGFRA)
FCA: 
101090765(PDGFRA)
PTG: 
102955481(PDGFRA)
AJU: 
106983998(PDGFRA)
BTA: 
282301(PDGFRA)
BOM: 
102282598(PDGFRA)
BIU: 
109560475(PDGFRA)
PHD: 
102329243(PDGFRA)
CHX: 
102174007(PDGFRA)
OAS: 
101106012(PDGFRA)
SSC: 
100627123(PDGFRA)
CFR: 
102512589(PDGFRA)
CDK: 
105103397(PDGFRA)
BACU: 
102998016(PDGFRA)
LVE: 
103071473(PDGFRA)
ECB: 
100059815(PDGFRA)
EPZ: 
103552305(PDGFRA)
EAI: 
106839051(PDGFRA)
MYB: 
102255326(PDGFRA)
MYD: 
102761943(PDGFRA)
HAI: 
109381815(PDGFRA)
RSS: 
109451713(PDGFRA)
PALE: 
102895362(PDGFRA)
LAV: 
100670735(PDGFRA)
MDO: 
100013088(PDGFRA)
SHR: 
100925116(PDGFRA)
OAA: 
100084432(PDGFRA)
GGA: 
395509(PDGFRA)
MGP: 
100542010(PDGFRA)
CJO: 
107313741(PDGFRA)
APLA: 
101797285(PDGFRA)
ACYG: 
106030788(PDGFRA)
TGU: 
100218386(PDGFRA)
GFR: 
102044274(PDGFRA)
FAB: 
101820996(PDGFRA)
PHI: 
102113476(PDGFRA)
PMAJ: 
107203533(PDGFRA)
CCW: 
104690630(PDGFRA)
FPG: 
101913531(PDGFRA)
FCH: 
102054310(PDGFRA)
CLV: 
102087625(PDGFRA)
AAM: 
106490172(PDGFRA)
ASN: 
102378120(PDGFRA)
AMJ: 
102575338(PDGFRA)
PSS: 
102443708(PDGFRA)
CMY: 
102935642(PDGFRA)
CPIC: 
101935558(PDGFRA)
ACS: 
PVT: 
110078407(PDGFRA)
PBI: 
103067713(PDGFRA)
GJA: 
107106036(PDGFRA)
XLA: 
108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 
100124862(pdgfra)
NPR: 
108804111(PDGFRA)
DRE: 
386856(pdgfra)
SRX: 
SANH: 
SGH: 
IPU: 
108258040(pdgfra)
AMEX: 
103044267(pdgfra)
TRU: 
101073543(pdgfra)
TNG: 
LCO: 
NCC: 
104947073(pdgfra)
MZE: 
101471693(pdgfra)
OLA: 
100049280(pdgfra)
XMA: 
CSEM: 
103376707(pdgfra)
LCF: 
108879100(pdgfra)
HCQ: 
109532287(pdgfra)
BPEC: 
110154688(pdgfra)
SASA: 
ELS: 
105011836(pdgfra)
SFM: 
108922803(pdgfra)
LCM: 
102353753(PDGFRA)
CMK: 
103178167(pdgfra)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
Human papillomavirus infection
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00042  
Glioma
H01574  
Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Infectious diseases
   05166 HTLV-I infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class III (PDGF receptor family)
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5159(PDGFRB)
PTR: 
462188(PDGFRB)
PPS: 
100975853(PDGFRB)
GGO: 
101150577(PDGFRB)
PON: 
100460001(PDGFRB)
NLE: 
100597894(PDGFRB)
MCC: 
711353(PDGFRB)
MCF: 
101867161(PDGFRB)
CSAB: 
103244790(PDGFRB)
RRO: 
104670408(PDGFRB)
RBB: 
108532047(PDGFRB)
CJC: 
100389852(PDGFRB)
SBQ: 
101040158(PDGFRB)
MMU: 
18596(Pdgfrb)
RNO: 
24629(Pdgfrb)
CGE: 
100764374(Pdgfrb)
NGI: 
103747076(Pdgfrb)
HGL: 
101721151(Pdgfrb)
CCAN: 
OCU: 
100342872(PDGFRB)
TUP: 
102492413(PDGFRB)
CFA: 
442985(PDGFRB)
AML: 
100472005(PDGFRB)
UMR: 
103664600(PDGFRB)
FCA: 
101084600(PDGFRB)
PTG: 
102954207(PDGFRB)
AJU: 
106985388(PDGFRB)
BTA: 
527165(PDGFRB)
BOM: 
102270608(PDGFRB)
BIU: 
109562197(PDGFRB)
PHD: 
102333941(PDGFRB)
CHX: 
102184426(PDGFRB)
OAS: 
101122783(PDGFRB)
SSC: 
102166564(PDGFRB)
CFR: 
102512951(PDGFRB)
CDK: 
105098486(PDGFRB)
BACU: 
103019883(PDGFRB)
LVE: 
103082363(PDGFRB)
ECB: 
100071665(PDGFRB)
EPZ: 
103549125(PDGFRB)
EAI: 
106838493(PDGFRB)
MYB: 
102241145(PDGFRB)
MYD: 
102764172(PDGFRB)
HAI: 
109375002(PDGFRB)
RSS: 
109448748(PDGFRB)
PALE: 
102887643(PDGFRB)
LAV: 
100671240(PDGFRB)
MDO: 
100028943(PDGFRB)
SHR: 
100917212(PDGFRB)
OAA: 
100079459(PDGFRB)
GGA: 
770488(PDGFRB)
MGP: 
100550611(PDGFRB)
CJO: 
107320191(PDGFRB)
APLA: 
101799587(PDGFRB)
ACYG: 
106032823(PDGFRB)
TGU: 
100223375(PDGFRB)
GFR: 
102045343(PDGFRB)
FAB: 
101809926(PDGFRB)
PHI: 
102111524(PDGFRB)
PMAJ: 
107210844(PDGFRB)
CCW: 
104689579(PDGFRB)
FPG: 
101918438(PDGFRB)
FCH: 
102052718(PDGFRB)
CLV: 
102096790(PDGFRB)
AAM: 
106493441(PDGFRB)
ASN: 
102372962(PDGFRB)
AMJ: 
102566175(PDGFRB)
PSS: 
102460895(PDGFRB)
CMY: 
102944650(PDGFRB)
CPIC: 
101940553(PDGFRB)
ACS: 
100555784(pdgfrb)
PVT: 
110086089(PDGFRB)
PBI: 
103051588(PDGFRB)
GJA: 
XLA: 
108712643(pdgfrb.S)
XTR: 
100487523(pdgfrb)
NPR: 
108785807(PDGFRB)
DRE: 
559529(pdgfrb)
SRX: 
SANH: 
SGH: 
IPU: 
108274697(pdgfrb)
AMEX: 
TRU: 
101061130 101074724(PDGFR-beta)
TNG: 
LCO: 
NCC: 
104965701(pdgfrb)
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108936824(pdgfrb)
LCM: 
102361386(PDGFRB)
CMK: 
103188232(pdgfrb)
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]

KEGG   ORTHOLOGY: K05087Help
Entry
K05087                      KO                                     

Name
IGF1R, CD221
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Autophagy - animal
Endocytosis
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
Breast cancer
Hepatocellular carcinoma
Disease
H00015  
Malignant pleural mesothelioma
H00048  
Hepatocellular carcinoma
H00050  
Synovial sarcoma
H01274  
Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Aging
   04211 Longevity regulating pathway - mammal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancers
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  InsR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
BRITE hierarchy
Other DBs
Genes
HSA: 
3480(IGF1R)
PTR: 
453676(IGF1R)
PPS: 
100981083(IGF1R)
GGO: 
101154546(IGF1R)
PON: 
100172156(IGF1R)
NLE: 
100593288(IGF1R)
MCC: 
708227(IGF1R)
MCF: 
102130142(IGF1R)
CSAB: 
103231259(IGF1R)
RRO: 
104677192(IGF1R)
RBB: 
108538668(IGF1R)
CJC: 
100408399(IGF1R)
SBQ: 
101039763(IGF1R)
MMU: 
16001(Igf1r)
RNO: 
25718(Igf1r)
CGE: 
100768531(Igf1r)
NGI: 
103749467(Igf1r)
HGL: 
101710224(Igf1r)
CCAN: 
OCU: 
100144342(IGF1R)
TUP: 
102473496(IGF1R)
CFA: 
442951(IGF1R)
AML: 
100471374(IGF1R)
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
281848(IGF1R)
BOM: 
102278105(IGF1R)
BIU: 
PHD: 
102324754(IGF1R)
CHX: 
100861165(IGF1R)
OAS: 
443515(IGF1R)
SSC: 
397350(IGF1R)
CFR: 
102524338(IGF1R)
CDK: 
BACU: 
103015537(IGF1R)
LVE: 
103081291(IGF1R)
ECB: 
100055698(IGF1R)
EPZ: 
103559577(IGF1R)
EAI: 
106836604(IGF1R)
MYB: 
102253516(IGF1R)
MYD: 
102770795(IGF1R)
HAI: 
109380372(IGF1R)
RSS: 
109444913(IGF1R)
PALE: 
102885962(IGF1R)
LAV: 
100655087(IGF1R)
MDO: 
100020095(IGF1R)
SHR: 
100916673(IGF1R)
OAA: 
100077556(IGF1R)
GGA: 
395889(IGF1R)
MGP: 
100539720(IGF1R)
CJO: 
107318870(IGF1R)
APLA: 
101802018(IGF1R)
ACYG: 
106036418(IGF1R)
TGU: 
100227374(IGF1R)
GFR: 
102036037(IGF1R)
FAB: 
101819893(IGF1R)
PHI: 
102103364(IGF1R)
PMAJ: 
107209439(IGF1R)
CCW: 
104684080(IGF1R)
FPG: 
101914715(IGF1R)
FCH: 
102046128(IGF1R)
CLV: 
102089963(IGF1R)
AAM: 
106485327(IGF1R)
ASN: 
102387852(IGF1R)
AMJ: 
106736787(IGF1R)
PSS: 
102455576(IGF1R)
CMY: 
102941686(IGF1R)
CPIC: 
101952328(IGF1R)
ACS: 
100554064(igf1r)
PVT: 
110072986(IGF1R)
PBI: 
103049336(IGF1R)
GJA: 
107121607(IGF1R)
XLA: 
108711478(igf1r.L) 398022(igf1r.S)
XTR: 
100329112(igf1r)
NPR: 
108787513(IGF1R)
DRE: 
245701(igf1ra) 245702(igf1rb)
SRX: 
SANH: 
SGH: 
IPU: 
100304999(igf1r) 108271091(Igf1r)
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102367342(IGF1R)
CMK: 
103188389(igf1r)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD19971(Dsim_GD19971)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
TSP: 
LGI: 
HMG: 
100214733(HTK7)
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

KEGG   ORTHOLOGY: K05098Help
Entry
K05098                      KO                                     

Name
KDR, VEGFR2, CD309
Definition
kinase insert domain protein receptor [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancer
Fluid shear stress and atherosclerosis
Disease
H01482  
Infantile hemangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04015 Rap1 signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04010 MAPK signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04370 VEGF signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04151 PI3K-Akt signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  VEGFR family [OT]
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class V (VEGF receptor family)
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class V (VEGF receptor family)
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
CD molecules [BR:ko04090]
 Proteins
  K05098  CD309, KDR; kinase insert domain receptor (a type III receptor tyrosine kinase)
BRITE hierarchy
Genes
HSA: 
3791(KDR)
PTR: 
461315(KDR)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
698293(KDR)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
16542(Kdr)
RNO: 
25589(Kdr)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
482154(KDR)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
407170(KDR)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
443087(KDR)
SSC: 
397311(KDR)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
395323(KDR)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
554230(kdr)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
NVI: 
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1656371
  Authors
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB
  Title
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
  Journal
Oncogene 6:1677-83 (1991)
  Sequence
[hsa:3791]
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K04361Help
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Apoptosis - fly
Dorso-ventral axis formation
Focal adhesion
Adherens junction
Gap junction
Jak-STAT signaling pathway
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Hepatitis C
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Disease
H00014  
Non-small cell lung cancer
H00016  
Oral cancer
H00017  
Esophageal cancer
H00018  
Gastric cancer
H00022  
Bladder cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00042  
Glioma
H00055  
Laryngeal cancer
H01508  
Salivary gland cancer
H01559  
Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 Jak-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Organismal Systems
  Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Development
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     K04361 EGFR, ERBB1; epidermal growth factor receptor
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1956(EGFR)
PTR: 
463415(EGFR)
PPS: 
100974885(EGFR)
GGO: 
101126190(EGFR)
PON: 
100459280(EGFR)
NLE: 
100597255(EGFR)
MCC: 
613027(EGFR)
MCF: 
102138724(EGFR)
CSAB: 
103226055(EGFR)
RRO: 
104675886(EGFR)
RBB: 
108522039(EGFR)
CJC: 
100412158(EGFR)
SBQ: 
101047461(EGFR)
MMU: 
13649(Egfr)
RNO: 
24329(Egfr)
CGE: 
100774580(Egfr)
NGI: 
HGL: 
101723771(Egfr)
CCAN: 
109693753(Egfr)
OCU: 
100008806(EGFR)
TUP: 
102485304(EGFR)
CFA: 
404306(EGFR)
UMR: 
103674660(EGFR)
FCA: 
100510799(EGFR)
PTG: 
102967370(EGFR)
AJU: 
106976977(EGFR)
BTA: 
407217(EGFR)
BOM: 
BIU: 
109576048(EGFR)
PHD: 
102337306(EGFR)
CHX: 
102172767(EGFR)
OAS: 
780479(EGFR)
SSC: 
397070(EGFR)
CFR: 
102504272(EGFR)
CDK: 
BACU: 
103017029(EGFR)
LVE: 
103071962(EGFR)
ECB: 
100067755(EGFR)
EPZ: 
103560128(EGFR)
EAI: 
106824133(EGFR)
MYB: 
102257758(EGFR)
MYD: 
102775204(EGFR)
HAI: 
109388365(EGFR)
RSS: 
109444752(EGFR)
PALE: 
102893495(EGFR)
LAV: 
100659125(EGFR)
MDO: 
100029625(EGFR)
SHR: 
100914017(EGFR)
OAA: 
100075894(EGFR)
GGA: 
396494(EGFR)
MGP: 
100543252(EGFR)
CJO: 
107309802(EGFR)
APLA: 
101797830(EGFR)
ACYG: 
106046417(EGFR)
TGU: 
100221035(EGFR)
GFR: 
102045482(EGFR)
FAB: 
101818290(EGFR)
PHI: 
102101445(EGFR)
PMAJ: 
107200328(EGFR)
CCW: 
104689262(EGFR)
FPG: 
101910521(EGFR)
FCH: 
102058683(EGFR)
CLV: 
102097879(EGFR)
AAM: 
106495273(EGFR)
ASN: 
102378285(EGFR)
AMJ: 
102565209(EGFR)
PSS: 
102443405(EGFR)
CMY: 
102933326(EGFR)
CPIC: 
101952725(EGFR)
ACS: 
100562231(egfr)
PVT: 
110081594(EGFR)
PBI: 
103050691(EGFR)
GJA: 
107119225(EGFR)
XLA: 
108719997(egfr.S) 724072(egfr.L)
XTR: 
100492965(egfr)
NPR: 
DRE: 
378478(egfra) 571431
SRX: 
SANH: 
SGH: 
IPU: 
108280575(egfr)
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
102236062(egfr)
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108937670(egfr)
LCM: 
CMK: 
103181270(egfr)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11601(Dsim_GD11601)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
100577393(Egfr)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
100118970(Egfr)
TCA: 
660037(DER)
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG00911(Cbr-let-23)
NAI: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
AQU: 
MBR: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
  Sequence
[hsa:1956]

KEGG   ORTHOLOGY: K05096Help
Entry
K05096                      KO                                     

Name
FLT1, VEGFR1
Definition
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Pathway
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04015 Rap1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04010 MAPK signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04066 HIF-1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04151 PI3K-Akt signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  Immune diseases
   05323 Rheumatoid arthritis
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  VEGFR family [OT]
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class V (VEGF receptor family)
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class V (VEGF receptor family)
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
BRITE hierarchy
Genes
HSA: 
2321(FLT1)
PTR: 
452512(FLT1)
PPS: 
100977352(FLT1)
GGO: 
101133492(FLT1)
PON: 
100456061(FLT1)
NLE: 
100590200(FLT1)
MCC: 
574133(FLT1)
MCF: 
102115442(FLT1)
CSAB: 
103249076(FLT1)
RRO: 
104661639(FLT1)
RBB: 
108512923(FLT1)
CJC: 
SBQ: 
101053773(FLT1)
MMU: 
14254(Flt1)
RNO: 
54251(Flt1)
CGE: 
100761329(Flt1)
NGI: 
103727233(Flt1)
HGL: 
101711333(Flt1)
CCAN: 
109694691(Flt1)
OCU: 
TUP: 
102480253(FLT1)
CFA: 
403727(FLT1)
AML: 
100483462(FLT1)
UMR: 
103664410(FLT1)
FCA: 
101088292(FLT1)
PTG: 
102955273(FLT1)
AJU: 
106985536(FLT1)
BTA: 
503620(FLT1)
BOM: 
102269660(FLT1)
BIU: 
109566823(FLT1)
PHD: 
102329661(FLT1)
CHX: 
100860837(FLT1)
OAS: 
443088(FLT1)
SSC: 
396763(FLT1)
CFR: 
102508666(FLT1)
CDK: 
105086584(FLT1)
BACU: 
103015874(FLT1)
LVE: 
103079754(FLT1)
ECB: 
100033957(FLT1)
EPZ: 
103561902(FLT1)
EAI: 
106832910(FLT1)
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
102891095(FLT1)
LAV: 
100668928(FLT1)
MDO: 
SHR: 
OAA: 
GGA: 
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
103048455(FLT1) 103057723(FLT4)
GJA: 
XLA: 
108698372(kdrl.L) 108700541(kdrl.S) 373789(flt1.L) 379546(flt1.S)
XTR: 
100492992(flt1) 100495109(kdrl)
NPR: 
DRE: 
544667(flt1) 796537(kdrl)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
778954(vegfr)
SPU: 
SKO: 
100313537(Vgfr)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD22428(Dsim_GD22428)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413303(Pvr)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
HMG: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
DOI:10.1007/s001090000082
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K05099Help
Entry
K05099                      KO                                     

Name
MET, HGFR
Definition
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Hepatocellular carcinoma
Central carbon metabolism in cancer
Disease
H00018  
Gastric cancer
H00021  
Renal cell carcinoma
H00046  
Cholangiocarcinoma
H00048  
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04015 Rap1 signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04010 MAPK signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04151 PI3K-Akt signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04520 Adherens junction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Organismal Systems
  Development
   04360 Axon guidance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05230 Central carbon metabolism in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05202 Transcriptional misregulation in cancers
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05206 MicroRNAs in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05205 Proteoglycans in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05225 Hepatocellular carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05218 Melanoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05211 Renal cell carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05100 Bacterial invasion of epithelial cells
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05144 Malaria
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  Met family
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class VI (HGF receptor family)
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class VI (HGF receptor family)
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
BRITE hierarchy
Genes
HSA: 
4233(MET)
PTR: 
463671(MET)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
704562(MET)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
17295(Met)
RNO: 
24553(Met)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
403438(MET)
AML: 
UMR: 
FCA: 
493669(MET)
PTG: 
AJU: 
BTA: 
280855(MET)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
443076(MET)
SSC: 
654328(MET)
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
396134(MET)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
108712362(met.S) 373551(met.L)
XTR: 
NPR: 
DRE: 
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
445767(rtkX)
SPU: 
SKO: 
ISC: 
TUT: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2819873
  Authors
Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G
  Title
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
  Journal
Proc Natl Acad Sci U S A 84:6379-83 (1987)
DOI:10.1073/pnas.84.18.6379
  Sequence
[hsa:4233]

KEGG   ORTHOLOGY: K05083Help
Entry
K05083                      KO                                     

Name
ERBB2, HER2, CD340
Definition
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
Tight junction
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Disease
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00022  
Bladder cancer
H00026  
Endometrial cancer
H00027  
Ovarian cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00031  
Breast cancer
H00046  
Cholangiocarcinoma
H01508  
Salivary gland cancer
H01554  
Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04530 Tight junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05230 Central carbon metabolism in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05212 Pancreatic cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05224 Breast cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01524 Platinum drug resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01522 Endocrine resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  EGFR family [OT]
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
CD molecules [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
BRITE hierarchy
Genes
HSA: 
2064(ERBB2)
PTR: 
454636(ERBB2)
PPS: 
100977227(ERBB2)
GGO: 
101140885(ERBB2)
PON: 
100450307(ERBB2)
NLE: 
100601700(ERBB2)
MCC: 
697573(ERBB2)
MCF: 
102146608(ERBB2)
CSAB: 
103243533(ERBB2)
RRO: 
104674848(ERBB2)
RBB: 
108527784(ERBB2)
CJC: 
100391332(ERBB2)
SBQ: 
101043415(ERBB2)
MMU: 
13866(Erbb2)
RNO: 
24337(Erbb2)
CGE: 
100759983(Erbb2)
NGI: 
103743825(Erbb2)
HGL: 
101705227(Erbb2)
CCAN: 
109693877(Erbb2)
OCU: 
100009554(ERBB2)
TUP: 
102487164(ERBB2)
CFA: 
403883(ERBB2)
AML: 
100480029(ERBB2)
UMR: 
103661560(ERBB2)
FCA: 
751824(ERBB2)
PTG: 
102961961(ERBB2)
AJU: 
106980462(ERBB2)
BTA: 
505709(ERBB2)
BOM: 
102267975(ERBB2)
BIU: 
109573971(ERBB2)
PHD: 
102319937(ERBB2)
CHX: 
102181989(ERBB2)
OAS: 
780519(ERBB2)
SSC: 
100516641(ERBB2)
CFR: 
102519604(ERBB2)
CDK: 
105099069(ERBB2)
BACU: 
103002640(ERBB2)
LVE: 
103075672(ERBB2)
ECB: 
100054739(ERBB2)
EPZ: 
103550160(ERBB2)
EAI: 
106826341(ERBB2)
MYB: 
102243033(ERBB2)
MYD: 
102771013(ERBB2)
HAI: 
109380800(ERBB2)
RSS: 
109455834(ERBB2)
PALE: 
102885300(ERBB2)
LAV: 
100662583(ERBB2)
MDO: 
100017172(ERBB2)
SHR: 
100914727(ERBB2)
GGA: 
426130(ERBB2)
MGP: 
100550880(ERBB2)
CJO: 
107325215(ERBB2)
GFR: 
102032307(ERBB2)
FAB: 
101818019(ERBB2)
PHI: 
102108835(ERBB2)
PMAJ: 
107215327(ERBB2)
CCW: 
104697788(ERBB2)
FPG: 
101914383(ERBB2)
FCH: 
102057575(ERBB2)
CLV: 
102094013(ERBB2)
AAM: 
106486153(ERBB2)
ASN: 
102369818(ERBB2)
AMJ: 
102561352(ERBB2)
PSS: 
102457099(ERBB2)
CMY: 
102946701(ERBB2)
CPIC: 
101931763(ERBB2)
ACS: 
100565910(erbb2)
PVT: 
110082059(ERBB2)
PBI: 
103065858(ERBB2)
GJA: 
107114744(ERBB2)
XLA: 
108700774(erbb2.L) 108702492 724075(erbb2.S)
XTR: 
100492078(erbb2)
NPR: 
108792756(ERBB2)
DRE: 
386966(erbb2)
SRX: 
SANH: 
SGH: 
IPU: 
108273851(ERBB2)
AMEX: 
103042851(erbb2)
TRU: 
101074842(erbb2)
TNG: 
LCO: 
104926899(erbb2)
NCC: 
104946774(erbb2)
MZE: 
101482712(erbb2)
OLA: 
XMA: 
CSEM: 
103381605(erbb2)
LCF: 
108890417(erbb2)
HCQ: 
109523903(erbb2)
BPEC: 
110171045(erbb2)
SASA: 
106579080(erbb2)
ELS: 
105030222(erbb2)
SFM: 
LCM: 
102348821(ERBB2)
CMK: 
103183785(erbb2)
CIN: 
778955(egfr1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3003577
  Authors
Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K
  Title
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
  Journal
Nature 319:230-4 (1986)
DOI:10.1038/319230a0
  Sequence
[hsa:2064]

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