KEGG   ORTHOLOGY: K04363Help
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  Jak-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 Jak-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Infectious diseases
   05166 HTLV-I infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
MMU: 18595(Pdgfra)
RNO: 25267(Pdgfra)
CGE: 100760258(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
OCU: 100343006(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
ORO: 101372359(PDGFRA)
FCA: 101090765(PDGFRA)
PTG: 102955481(PDGFRA)
AJU: 106983998(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
PHD: 102329243(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CDK: 105103397(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
HAI: 109381815(PDGFRA)
RSS: 109451713(PDGFRA)
PALE: 102895362(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
MDO: 100013088(PDGFRA)
SHR: 100925116(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
TGU: 100218386(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCW: 104690630(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
AAM: 106490172(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
ACS: 100565834(pdgfra) 103278978
PVT: 110078407(PDGFRA)
PBI: 103067713(PDGFRA)
GJA: 107106036(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
DRE: 386856(pdgfra)
CCAR: 109112741
IPU: 108258040(pdgfra)
AMEX: 103044267(pdgfra)
TRU: 101073543(pdgfra)
LCO: 104919088(pdgfra) 109142841
NCC: 104947073(pdgfra)
MZE: 101471693(pdgfra)
OLA: 100049280(pdgfra)
XMA: 102219876(pdgfra)
PRET: 103463840(pdgfra)
NFU: 107393382(pdgfra)
CSEM: 103376707(pdgfra)
LCF: 108879100(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
SASA: 106560269 106584117(pdgfra)
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  Jak-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Infectious diseases
   05166 HTLV-I infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class III (PDGF receptor family)
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
MMU: 18596(Pdgfrb)
RNO: 24629(Pdgfrb)
CGE: 100764374(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CCAN: 109685664(Pdgfrb) 109685672
OCU: 100342872(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
ORO: 101374793(PDGFRB)
FCA: 101084600(PDGFRB)
PTG: 102954207(PDGFRB)
AJU: 106985388(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
PHD: 102333941(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CDK: 105098486(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
HAI: 109375002(PDGFRB)
RSS: 109448748(PDGFRB)
PALE: 102887643(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
MDO: 100028943(PDGFRB)
SHR: 100917212(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
TGU: 100223375(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCW: 104689579(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
AAM: 106493441(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
PBI: 103051588(PDGFRB)
GJA: 107116322(PDGFRB) 107123329
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
AMEX: 103036483
TRU: 101061130 101074724(PDGFR-beta)
LCO: 104919444 104927056(pdgfrb)
NCC: 104965701(pdgfrb)
MZE: 101466822 101484671(pdgfrb)
OLA: 101155039(pdgfrb) 101156428
XMA: 102229755 102233464(pdgfrb)
PRET: 103459902 103471279(pdgfrb)
NFU: 107375657(pdgfrb)
CSEM: 103391002(pdgfrb) 103392104
LCF: 108873646 108899186(pdgfrb)
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232(pdgfrb)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]

KEGG   ORTHOLOGY: K05087Help
Entry
K05087                      KO                                     

Name
IGF1R, CD221
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00015  Malignant pleural mesothelioma
H00048  Hepatocellular carcinoma
H00050  Synovial sarcoma
H01274  Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Aging
   04211 Longevity regulating pathway - mammal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancers
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
BRITE hierarchy
Other DBs
GO: 0005010 0031994
Genes
HSA: 3480(IGF1R)
PTR: 453676(IGF1R)
PPS: 100981083(IGF1R)
GGO: 101154546(IGF1R)
PON: 100172156(IGF1R)
NLE: 100593288(IGF1R)
MCC: 708227(IGF1R)
MCF: 102130142(IGF1R)
CSAB: 103231259(IGF1R)
RRO: 104677192(IGF1R)
RBB: 108538668(IGF1R)
CJC: 100408399(IGF1R)
SBQ: 101039763(IGF1R)
MMU: 16001(Igf1r)
RNO: 25718(Igf1r)
CGE: 100768531(Igf1r)
NGI: 103749467(Igf1r)
HGL: 101710224(Igf1r)
OCU: 100144342(IGF1R)
TUP: 102473496(IGF1R)
CFA: 442951(IGF1R)
AML: 100471374(IGF1R)
ORO: 101386211(IGF1R)
FCA: 100500937(IGF1R)
PTG: 102949680(IGF1R) 102949974
AJU: 106975140 106975144(IGF1R)
BTA: 281848(IGF1R)
BOM: 102278105(IGF1R)
PHD: 102324754(IGF1R)
CHX: 100861165(IGF1R)
OAS: 443515(IGF1R)
SSC: 397350(IGF1R)
CFR: 102524338(IGF1R)
BACU: 103015537(IGF1R)
LVE: 103081291(IGF1R)
OOR: 101281976(IGF1R)
ECB: 100055698(IGF1R)
EPZ: 103559577(IGF1R)
EAI: 106836604(IGF1R)
MYB: 102253516(IGF1R)
MYD: 102770795(IGF1R)
HAI: 109380372(IGF1R)
RSS: 109444913(IGF1R)
PALE: 102885962(IGF1R)
LAV: 100655087(IGF1R)
TMU: 101355333
MDO: 100020095(IGF1R)
SHR: 100916673(IGF1R)
OAA: 100077556(IGF1R)
GGA: 395889(IGF1R)
MGP: 100539720(IGF1R)
CJO: 107318870(IGF1R)
APLA: 101802018(IGF1R)
ACYG: 106036418(IGF1R)
TGU: 100227374(IGF1R)
GFR: 102036037(IGF1R)
FAB: 101819893(IGF1R)
PHI: 102103364(IGF1R)
PMAJ: 107209439(IGF1R)
CCW: 104684080(IGF1R)
FPG: 101914715(IGF1R)
FCH: 102046128(IGF1R)
CLV: 102089963(IGF1R)
EGZ: 104122851(IGF1R) 104122875
AAM: 106485327(IGF1R)
ASN: 102387852(IGF1R)
AMJ: 106736787(IGF1R)
PSS: 102455576(IGF1R)
CMY: 102941686(IGF1R)
CPIC: 101952328(IGF1R)
ACS: 100554064(igf1r)
PVT: 110072986(IGF1R)
PBI: 103049336(IGF1R)
GJA: 107121607(IGF1R)
XLA: 108711478(igf1r.L) 398022(igf1r.S)
XTR: 100329112(igf1r)
NPR: 108787513(IGF1R)
DRE: 245701(igf1ra) 245702(igf1rb)
IPU: 100304999(igf1r) 108271091(Igf1r)
MZE: 101469217 101479543(igf1r)
CSEM: 103379307
HCQ: 109513166 109513874(igf1r)
ELS: 105016672 105023472(igf1r)
LCM: 102367342(IGF1R)
CMK: 103188389(igf1r)
DME: Dmel_CG18402(InR)
DSI: Dsimw501_GD19971(Dsim_GD19971)
MDE: 101894251
TSP: Tsp_12077
HMG: 100214733(HTK7)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

KEGG   ORTHOLOGY: K05098Help
Entry
K05098                      KO                                     

Name
KDR, VEGFR2, CD309
Definition
kinase insert domain protein receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko05205  Proteoglycans in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01482  Infantile hemangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04015 Rap1 signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04010 MAPK signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04370 VEGF signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04151 PI3K-Akt signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  VEGFR family [OT]
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class V (VEGF receptor family)
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
CD molecules [BR:ko04090]
 Proteins
  K05098  CD309, KDR; kinase insert domain receptor (a type III receptor tyrosine kinase)
BRITE hierarchy
Genes
HSA: 3791(KDR)
PTR: 461315(KDR)
PPS: 100986594(KDR)
GGO: 101127110(KDR)
PON: 100462446(KDR)
NLE: 100604569(KDR)
MCC: 698293(KDR)
MCF: 102136227(KDR)
CSAB: 103235670(KDR)
RRO: 104662002(KDR)
RBB: 108531591(KDR)
CJC: 100407045(KDR)
SBQ: 101036336(KDR)
MMU: 16542(Kdr)
RNO: 25589(Kdr)
CGE: 100756294(Kdr)
NGI: 103734390(Kdr)
HGL: 101726029(Kdr)
CCAN: 109698964(Kdr)
OCU: 100008607(KDR)
TUP: 102489981(KDR)
CFA: 482154(KDR)
AML: 100484938(KDR)
UMR: 103672740(KDR)
ORO: 101371459(KDR)
FCA: 101090260(KDR)
PTG: 102955197(KDR)
AJU: 106983987(KDR)
BTA: 407170(KDR)
BOM: 102288007(KDR)
BIU: 109560478(KDR)
PHD: 102330690(KDR)
CHX: 100860836(KDR)
OAS: 443087(KDR)
SSC: 397311(KDR)
CFR: 102520881(KDR)
CDK: 105091598(KDR)
BACU: 102999852(KDR)
LVE: 103087802(KDR)
OOR: 101290288(KDR)
ECB: 100033959(KDR)
EPZ: 103554974(KDR)
EAI: 106836923(KDR)
MYB: 102256532(KDR)
MYD: 102760801(KDR)
HAI: 109381812(KDR)
RSS: 109451716(KDR)
PALE: 102896638(KDR)
LAV: 100656232(KDR)
TMU: 101348626
MDO: 100017311(KDR)
SHR: 100929091(KDR)
OAA: 100075389(KDR)
GGA: 395323(KDR)
MGP: 100542630
CJO: 107313758(KDR)
APLA: 101797579(KDR)
ACYG: 106030825(KDR)
TGU: 100231879(KDR)
GFR: 102042381(KDR)
FAB: 101821250(KDR)
PHI: 102113293(KDR)
PMAJ: 107202958(KDR)
CCW: 104690864(KDR)
FPG: 101920584(KDR)
FCH: 102059103(KDR)
CLV: 102095316(KDR)
EGZ: 104129460(KDR)
ASN: 102384502(KDR)
AMJ: 102567818(KDR)
PSS: 102451309(KDR)
CMY: 102936088(KDR)
CPIC: 101936813(KDR)
ACS: 100551738(kdr)
PVT: 110078415(KDR)
PBI: 103063796(KDR)
GJA: 107106034(KDR)
XLA: 108698463 108706593(kdr.S)
XTR: 100487501(kdr)
NPR: 108803904(KDR)
DRE: 554230(kdr)
IPU: 108258084(kdr)
AMEX: 103022603(kdr)
TRU: 101073989(kdr)
LCO: 104919091(kdr)
NCC: 104947077(kdr)
MZE: 101472847(kdr)
OLA: 101162439(kdr)
XMA: 102225837(kdr)
PRET: 103463836(kdr)
NFU: 107393390(kdr)
CSEM: 103376704(kdr)
LCF: 108879132(kdr) 108894371
HCQ: 109532106(kdr)
BPEC: 110154739(kdr)
SASA: 106584120(kdr)
ELS: 105011839(kdr)
SFM: 108922800(kdr)
LCM: 102362684(KDR)
CMK: 103178168(kdr)
NVI: 100123205
HMG: 100214305
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1656371
  Authors
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB
  Title
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
  Journal
Oncogene 6:1677-83 (1991)
  Sequence
[hsa:3791]
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K04361Help
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04214  Apoptosis - fly
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04540  Gap junction
ko04630  Jak-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing's syndrome
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 Jak-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Organismal Systems
  Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Development
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     K04361 EGFR, ERBB1; epidermal growth factor receptor
BRITE hierarchy
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
MMU: 13649(Egfr)
RNO: 24329(Egfr)
CGE: 100774580(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CCAN: 109693753(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
UMR: 103674660(EGFR)
ORO: 101386858(EGFR)
FCA: 100510799(EGFR)
PTG: 102967370(EGFR)
AJU: 106976977(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
PHD: 102337306(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CDK: 105105749
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
HAI: 109388365(EGFR)
RSS: 109444752(EGFR)
PALE: 102893495(EGFR)
LAV: 100659125(EGFR)
TMU: 101356822
MDO: 100029625(EGFR)
SHR: 100914017(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
TGU: 100221035(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCW: 104689262(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
AAM: 106495273(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
PBI: 103050691(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
DRE: 378478(egfra) 571431
IPU: 108280575(egfr)
TRU: 101069322(egfr) 101073748
MZE: 101477281 101483528(egfr)
OLA: 101159776(egfr) 101169984
PRET: 103456976 103479868(egfr)
NFU: 107383161 107383833(egfr)
CSEM: 103377298 103396351(egfr)
LCF: 108883329(egfr) 108894667
HCQ: 109521299(egfr) 109530291
SFM: 108937670(egfr)
CMK: 103181270(egfr)
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DSI: Dsimw501_GD11601(Dsim_GD11601)
MDE: 101887261
AGA: AgaP_AGAP008819(EGFR)
AAG: 5564544
AME: 100577393(Egfr)
BIM: 100740344
BTER: 100645521
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
HST: 105191569
CFO: 105257833
LHU: 105676042
PGC: 109852274
NVI: 100118970(Egfr)
TCA: 660037(DER)
DPA: 109536124
NVL: 108556379
BMOR: 101741679
PMAC: 106717252
PRAP: 110998172
PXY: 105385471
API: 100168353
DNX: 107162454
ZNE: 110832144
FCD: 110842323
TUT: 107359081
CEL: CELE_ZK1067.1(let-23)
CBR: CBG00911(Cbr-let-23)
BMY: Bm1_48745
CRG: 105330118(Egfr) 105339116
LAK: 106153603
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
  Sequence
[hsa:1956]

KEGG   ORTHOLOGY: K05096Help
Entry
K05096                      KO                                     

Name
FLT1, VEGFR1
Definition
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05202  Transcriptional misregulation in cancer
ko05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04015 Rap1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04010 MAPK signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04066 HIF-1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04151 PI3K-Akt signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  Immune diseases
   05323 Rheumatoid arthritis
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  VEGFR family [OT]
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class V (VEGF receptor family)
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
BRITE hierarchy
Genes
HSA: 2321(FLT1)
PTR: 452512(FLT1)
PPS: 100977352(FLT1)
GGO: 101133492(FLT1)
PON: 100456061(FLT1)
NLE: 100590200(FLT1)
MCC: 574133(FLT1)
MCF: 102115442(FLT1)
CSAB: 103249076(FLT1)
RRO: 104661639(FLT1)
RBB: 108512923(FLT1)
CJC: 100401993 100413680(FLT1)
SBQ: 101053773(FLT1)
MMU: 14254(Flt1)
RNO: 54251(Flt1)
CGE: 100761329(Flt1)
NGI: 103727233(Flt1)
HGL: 101711333(Flt1)
CCAN: 109694691(Flt1)
TUP: 102480253(FLT1)
CFA: 403727(FLT1)
AML: 100483462(FLT1)
UMR: 103664410(FLT1)
ORO: 101383542(FLT1)
FCA: 101088292(FLT1)
PTG: 102955273(FLT1)
AJU: 106985536(FLT1)
BTA: 503620(FLT1)
BOM: 102269660(FLT1)
BIU: 109566823(FLT1)
PHD: 102329661(FLT1)
CHX: 100860837(FLT1)
OAS: 443088(FLT1)
SSC: 396763(FLT1)
CFR: 102508666(FLT1)
CDK: 105086584(FLT1)
BACU: 103015874(FLT1)
LVE: 103079754(FLT1)
OOR: 101277470(FLT1)
ECB: 100033957(FLT1)
EPZ: 103561902(FLT1)
EAI: 106832910(FLT1)
HAI: 109390085 109395227(FLT1)
PALE: 102891095(FLT1)
LAV: 100668928(FLT1)
MDO: 100017469 100025304(FLT1)
SHR: 100921027 100930426(FLT1)
OAA: 100090501(FLT1) 100090796
GGA: 374100(FLT1) 422316
CJO: 107308289(FLT1) 107312792
ACYG: 106038554 106041123(FLT1)
TGU: 100223459(FLT1) 100229347
GFR: 102034196 102037593(FLT1)
FAB: 101806396(FLT1) 101808610
PHI: 102108061(FLT1) 102108458
PMAJ: 107202343(FLT1) 107203705
CCW: 104689893(FLT1) 104691716
FPG: 101913316 101922526(FLT1)
FCH: 102051492 102058347(FLT1)
CLV: 102087545 102094103(FLT1)
EGZ: 104126066 104133690(FLT1)
AAM: 106489849 106500427(FLT1)
ASN: 102368462 102372479(FLT1)
AMJ: 102561001 102566553(FLT1)
PSS: 102446651 102456773(FLT1)
CMY: 102930345 102931972(FLT1)
PVT: 110074293 110076449(FLT1)
PBI: 103048455(FLT1) 103057723(FLT4)
XLA: 108698372(kdrl.L) 108700541(kdrl.S) 373789(flt1.L) 379546(flt1.S)
XTR: 100492992(flt1) 100495109(kdrl)
NPR: 108791089 108796337(FLT1)
DRE: 544667(flt1) 796537(kdrl)
IPU: 108256487(flt1) 108269076
AMEX: 103032355(flt1) 103038588
TRU: 101071220 101071361(flt1)
LCO: 104923474 104924951(flt1)
MZE: 101478748 101479515(flt1)
OLA: 100049480 101172940(flt1)
XMA: 102219213(flt1) 102221726
PRET: 103456619(flt1) 103471632
NFU: 107378530 107382874(flt1)
LCF: 108872510 108881770(flt1)
ELS: 105021948(flt1) 105029482
LCM: 102345121(FLT1) 102365485
CMK: 103178759 103183246(flt1)
CIN: 778954(vegfr)
SPU: 579837
SKO: 100313537(Vgfr) 102806353
DME: Dmel_CG8222(Pvr)
DSI: Dsimw501_GD22428(Dsim_GD22428)
MDE: 101895886
AAG: 5563777
AME: 413303(Pvr)
BIM: 100741439
BTER: 100646978
SOC: 105207136
AEC: 105149416
ACEP: 105627372
HST: 105190724
CFO: 105257298
PGC: 109851977
NVI: 100116425
TCA: 662470
NVL: 108569966
BMOR: 101745869
PMAC: 106708843
PRAP: 110997017
API: 100159169
DNX: 107173314
CEL: CELE_F59F3.1(ver-3) CELE_T17A3.1(ver-1)
CBR: CBG17536
BMY: Bm1_37445
TSP: Tsp_00087
CRG: 105348465
MYI: 110447179
OBI: 106877728
LAK: 106159770
HMG: 100209153
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
DOI:10.1007/s001090000082
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

KEGG   ORTHOLOGY: K05099Help
Entry
K05099                      KO                                     

Name
MET, HGFR
Definition
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04520  Adherens junction
ko05100  Bacterial invasion of epithelial cells
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05144  Malaria
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05218  Melanoma
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00021  Renal cell carcinoma
H00046  Cholangiocarcinoma
H00048  Hepatocellular carcinoma
H01985  Desmoplastic small round cell tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04015 Rap1 signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04010 MAPK signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04151 PI3K-Akt signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04520 Adherens junction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Organismal Systems
  Development
   04360 Axon guidance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05230 Central carbon metabolism in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05202 Transcriptional misregulation in cancers
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05206 MicroRNAs in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05205 Proteoglycans in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05225 Hepatocellular carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05226 Gastric cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05218 Melanoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05211 Renal cell carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05100 Bacterial invasion of epithelial cells
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05144 Malaria
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  MET family
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class VI (HGF receptor family)
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
BRITE hierarchy
Genes
HSA: 4233(MET)
PTR: 463671(MET)
PPS: 100991777(MET)
GGO: 101127399(MET)
PON: 100137030(MET)
NLE: 100597172(MET)
MCC: 704562(MET)
MCF: 102123512(MET)
CSAB: 103226771(MET)
RRO: 104682633(MET)
RBB: 108528695(MET)
CJC: 100408551(MET)
SBQ: 101038696(MET)
MMU: 17295(Met)
RNO: 24553(Met)
CGE: 100751933(Met)
NGI: 103737431(Met)
HGL: 101725772(Met)
CCAN: 109689877(Met)
OCU: 100126565(MET)
TUP: 102485847(MET)
CFA: 403438(MET)
AML: 100480742(MET)
UMR: 103676585(MET)
ORO: 101365730(MET)
FCA: 493669(MET)
PTG: 102953616(MET)
AJU: 106970667(MET)
BTA: 280855(MET)
BOM: 102285634(MET)
BIU: 109557411(MET)
PHD: 102342883(MET)
CHX: 102181186(MET)
OAS: 443076(MET)
SSC: 654328(MET)
CFR: 102504138(MET)
CDK: 105085321(MET)
BACU: 103002086(MET)
LVE: 103090984(MET)
OOR: 101280136(MET)
ECB: 100056013(MET)
EPZ: 103562070(MET)
EAI: 106829287(MET)
MYB: 102263347(MET)
MYD: 102753524 102756693(MET)
HAI: 109389346(MET)
RSS: 109453474(MET)
PALE: 102885990(MET)
LAV: 100656285(MET)
TMU: 101345595
MDO: 100013788(MET)
SHR: 100917007(MET)
OAA: 100079345(MET)
GGA: 396134(MET)
MGP: 100544894(MET)
CJO: 107309125(MET)
APLA: 101801559(MET)
ACYG: 106042077(MET)
TGU: 100227998(MET)
GFR: 102035281(MET)
FAB: 101822032(MET)
PHI: 102099870(MET)
PMAJ: 107204940(MET)
CCW: 104698290(MET)
FPG: 101921590(MET)
FCH: 102046148(MET)
CLV: 102091194(MET)
EGZ: 104133409(MET)
AAM: 106488808(MET)
ASN: 102387009(MET)
AMJ: 102568767(MET)
PSS: 102447079(MET)
CPIC: 101931256(MET)
ACS: 100561443(met)
PVT: 110077032(MET)
PBI: 103067929(MET)
GJA: 107114504(MET)
XLA: 108712362(met.S) 373551(met.L)
XTR: 100485823(met)
NPR: 108788984(MET)
DRE: 100150664(met)
IPU: 108268944(met)
AMEX: 103023930
TRU: 100137507(met)
LCO: 104931751(met)
NCC: 104958176
MZE: 101465566(met)
OLA: 101174570(met)
XMA: 102219516(met)
PRET: 103465633(met)
NFU: 107388350(met)
CSEM: 103379587(met)
LCF: 108893984(met)
HCQ: 109530899(met)
BPEC: 110155115(met)
ELS: 105029522(met)
LCM: 102366006(MET)
CMK: 103179355(met)
CIN: 445767(rtkX)
SPU: 589012
TUT: 107359841
BMY: Bm1_37575
TSP: Tsp_05936
OBI: 106879211
AQU: 109580869
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2819873
  Authors
Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G
  Title
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
  Journal
Proc Natl Acad Sci U S A 84:6379-83 (1987)
DOI:10.1073/pnas.84.18.6379
  Sequence
[hsa:4233]

KEGG   ORTHOLOGY: K05083Help
Entry
K05083                      KO                                     

Name
ERBB2, HER2, CD340
Definition
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00019  Pancreatic cancer
H00022  Bladder cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00046  Cholangiocarcinoma
H01508  Salivary gland cancer
H01554  Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04151 PI3K-Akt signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04530 Tight junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05230 Central carbon metabolism in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05212 Pancreatic cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05226 Gastric cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05224 Breast cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01524 Platinum drug resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01522 Endocrine resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases
  EGFR family [OT]
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
CD molecules [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
BRITE hierarchy
Genes
HSA: 2064(ERBB2)
PTR: 454636(ERBB2)
PPS: 100977227(ERBB2)
GGO: 101140885(ERBB2)
PON: 100450307(ERBB2)
NLE: 100601700(ERBB2)
MCC: 697573(ERBB2)
MCF: 102146608(ERBB2)
CSAB: 103243533(ERBB2)
RRO: 104674848(ERBB2)
RBB: 108527784(ERBB2)
CJC: 100391332(ERBB2)
SBQ: 101043415(ERBB2)
MMU: 13866(Erbb2)
RNO: 24337(Erbb2)
CGE: 100759983(Erbb2)
NGI: 103743825(Erbb2)
HGL: 101705227(Erbb2)
CCAN: 109693877(Erbb2)
OCU: 100009554(ERBB2)
TUP: 102487164(ERBB2)
CFA: 403883(ERBB2)
AML: 100480029(ERBB2)
UMR: 103661560(ERBB2)
ORO: 101364161(ERBB2)
FCA: 751824(ERBB2)
PTG: 102961961(ERBB2)
AJU: 106980462(ERBB2)
BTA: 505709(ERBB2)
BOM: 102267975(ERBB2)
BIU: 109573971(ERBB2)
PHD: 102319937(ERBB2)
CHX: 102181989(ERBB2)
OAS: 780519(ERBB2)
SSC: 100516641(ERBB2)
CFR: 102519604(ERBB2)
CDK: 105099069(ERBB2)
BACU: 103002640(ERBB2)
LVE: 103075672(ERBB2)
OOR: 101283619(ERBB2)
ECB: 100054739(ERBB2)
EPZ: 103550160(ERBB2)
EAI: 106826341(ERBB2)
MYB: 102243033(ERBB2)
MYD: 102771013(ERBB2)
HAI: 109380800(ERBB2)
RSS: 109455834(ERBB2)
PALE: 102885300(ERBB2)
LAV: 100662583(ERBB2)
TMU: 101354844
MDO: 100017172(ERBB2)
SHR: 100914727(ERBB2)
GGA: 426130(ERBB2)
MGP: 100550880(ERBB2)
CJO: 107325215(ERBB2)
GFR: 102032307(ERBB2)
FAB: 101818019(ERBB2)
PHI: 102108835(ERBB2)
PMAJ: 107215327(ERBB2)
CCW: 104697788(ERBB2)
FPG: 101914383(ERBB2)
FCH: 102057575(ERBB2)
CLV: 102094013(ERBB2)
EGZ: 104129607(ERBB2)
AAM: 106486153(ERBB2)
ASN: 102369818(ERBB2)
AMJ: 102561352(ERBB2)
PSS: 102457099(ERBB2)
CMY: 102946701(ERBB2)
CPIC: 101931763(ERBB2)
ACS: 100565910(erbb2)
PVT: 110082059(ERBB2)
PBI: 103065858(ERBB2)
GJA: 107114744(ERBB2)
XLA: 108700774(erbb2.L) 108702492 724075(erbb2.S)
XTR: 100492078(erbb2)
NPR: 108792756(ERBB2)
DRE: 386966(erbb2)
IPU: 108273851(ERBB2)
AMEX: 103042851(erbb2)
TRU: 101074842(erbb2)
LCO: 104926899(erbb2)
NCC: 104946774(erbb2)
MZE: 101482712(erbb2)
OLA: 101174230
XMA: 102234046(erbb2)
PRET: 103481805
NFU: 107387934
CSEM: 103381605(erbb2)
LCF: 108890417(erbb2)
HCQ: 109523903(erbb2)
BPEC: 110171045(erbb2)
SASA: 106579080(erbb2)
ELS: 105030222(erbb2)
LCM: 102348821(ERBB2)
CMK: 103183785(erbb2)
CIN: 778955(egfr1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3003577
  Authors
Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K
  Title
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
  Journal
Nature 319:230-4 (1986)
DOI:10.1038/319230a0
  Sequence
[hsa:2064]

DBGET integrated database retrieval system