KEGG   ORTHOLOGY: K04386Help
Entry
K04386                      KO                                     

Name
IL1R1, CD121a
Definition
interleukin 1 receptor type I
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Osteoclast differentiation
Hematopoietic cell lineage
Th17 cell differentiation
Inflammatory mediator regulation of TRP channels
Amoebiasis
HTLV-I infection
Fluid shear stress and atherosclerosis
Disease
H01492  
Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04064 NF-kappa B signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04659 Th17 cell differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  Development
   04380 Osteoclast differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  Infectious diseases
   05166 HTLV-I infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05146 Amoebiasis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
Cytokine receptors [BR:ko04050]
 IL-1 receptor family
  K04386  IL1R1, CD121a; interleukin 1 receptor type I
CD molecules [BR:ko04090]
 Proteins
  K04386  CD121a, IL1R1; interleukin 1 receptor, type I
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3554(IL1R1)
PTR: 
459460(IL1R1)
PPS: 
100972617(IL1R1)
GGO: 
101133600(IL1R1)
PON: 
100172810(IL1R1)
NLE: 
100586658(IL1R1)
MCC: 
711726(IL1R1)
MCF: 
102146317(IL1R1)
CSAB: 
103241149(IL1R1)
RRO: 
104680311(IL1R1)
RBB: 
108524091(IL1R1)
CJC: 
100393945(IL1R1)
SBQ: 
101031937(IL1R1)
MMU: 
16177(Il1r1)
RNO: 
25663(Il1r1)
CGE: 
100758740(Il1r1)
NGI: 
103744180(Il1r1)
HGL: 
101711273(Il1r1)
CCAN: 
109682273(Il1r1)
OCU: 
100352905(IL1R1)
TUP: 
102492414(IL1R1)
CFA: 
481328(IL1R1)
AML: 
100472991(IL1R1)
UMR: 
103670641(IL1R1)
FCA: 
101080705(IL1R1)
PTG: 
102958342(IL1R1)
AJU: 
106968747(IL1R1)
BTA: 
515640(IL1R1)
BOM: 
102271047(IL1R1)
BIU: 
PHD: 
102320862(IL1R1)
CHX: 
102187231(IL1R1)
OAS: 
101103054(IL1R1)
SSC: 
100626904(IL1R1)
CFR: 
102503597(IL1R1)
CDK: 
105099109(IL1R1)
BACU: 
102998234(IL1R1)
LVE: 
ECB: 
100009699(IL1R1)
EPZ: 
103563183(IL1R1)
EAI: 
106839400(IL1R1)
MYB: 
102238676(IL1R1)
MYD: 
102775132(IL1R1)
HAI: 
109395478(IL1R1)
RSS: 
109459419(IL1R1)
PALE: 
102884439(IL1R1)
LAV: 
100657834(IL1R1)
MDO: 
100017751(IL1R1)
SHR: 
100913514(IL1R1)
OAA: 
100084073(IL1R1)
GGA: 
396481(IL1R1)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
100220817(IL1R1)
GFR: 
102040488(IL1R1)
FAB: 
101815105(IL1R1)
PHI: 
102106217(IL1R1)
PMAJ: 
CCW: 
FPG: 
FCH: 
102060155(IL1R1)
CLV: 
102097520(IL1R1)
AAM: 
106494064(IL1R1)
ASN: 
102377912(IL1R1)
AMJ: 
102558564(IL1R1)
PSS: 
102463929(IL1R1)
CMY: 
CPIC: 
101942308(IL1R1)
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
100491546(il1r1)
DRE: 
799204(zmp:0000000936)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
LCO: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2532321
  Authors
Chua AO, Gubler U
  Title
Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.
  Journal
Nucleic Acids Res 17:10114 (1989)
DOI:10.1093/nar/17.23.10114
  Sequence
[hsa:3554]
Reference
  Authors
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK
  Title
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
  Journal
J Biol Chem 275:4670-8 (2000)
DOI:10.1074/jbc.275.7.4670

KEGG   ORTHOLOGY: K04387Help
Entry
K04387                      KO                                     

Name
IL1R2, CD121b
Definition
interleukin 1 receptor type II
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
  Infectious diseases
   05166 HTLV-I infection
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
   05146 Amoebiasis
    K04387  IL1R2, CD121b; interleukin 1 receptor type II
Cytokine receptors [BR:ko04050]
 IL-1 receptor family
  K04387  IL1R2, CD121b; interleukin 1 receptor type II
CD molecules [BR:ko04090]
 Proteins
  K04387  CD121b, IL1R2; interleukin 1 receptor, type II
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7850(IL1R2)
PTR: 
470455(IL1R2)
PPS: 
100972054(IL1R2)
GGO: 
101132361(IL1R2)
PON: 
100440034(IL1R2)
NLE: 
100586097(IL1R2)
MCC: 
711638(IL1R2)
MCF: 
102143926(IL1R2)
CSAB: 
103241146(IL1R2)
RRO: 
104680312(IL1R2)
RBB: 
108524092(IL1R2)
CJC: 
100393582(IL1R2)
SBQ: 
101032260(IL1R2)
MMU: 
16178(Il1r2)
RNO: 
117022(Il1r2)
CGE: 
100759030(Il1r2)
NGI: 
103744179(Il1r2)
HGL: 
101710536(Il1r2)
CCAN: 
109682276(Il1r2)
OCU: 
100344048(IL1R2)
TUP: 
102491995(IL1R2)
CFA: 
481330(IL1R2)
AML: 
100475938(IL1R2)
UMR: 
103670643(IL1R2)
FCA: 
101080961(IL1R2)
PTG: 
102959004(IL1R2)
AJU: 
106968746(IL1R2)
BTA: 
515700(IL1R2)
BOM: 
102271891(IL1R2)
BIU: 
109565866(IL1R2)
PHD: 
102320276(IL1R2)
CHX: 
102186601(IL1R2)
OAS: 
101103308(IL1R2)
SSC: 
100628112(IL1R2)
CFR: 
102505984(IL1R2)
CDK: 
105099111(IL1R2)
BACU: 
102999629(IL1R2)
LVE: 
ECB: 
100033831(IL1R2)
EPZ: 
103559218(IL1R2)
EAI: 
106839396(IL1R2)
MYB: 
102239307(IL1R2)
MYD: 
102774276(IL1R2)
HAI: 
109395468(IL1R2)
RSS: 
109459384(IL1R2)
PALE: 
102884188(IL1R2)
LAV: 
100667125(IL1R2)
MDO: 
100017640(IL1R2)
SHR: 
100913252(IL1R2)
OAA: 
100084042(IL1R2)
GGA: 
418715(IL1R2)
MGP: 
100542672(IL1R2)
CJO: 
107306854(IL1R2)
APLA: 
101793878(IL1R2)
ACYG: 
106041632(IL1R2)
TGU: 
100230419(IL1R2)
GFR: 
102034720(IL1R2)
FAB: 
101815893(IL1R2)
PHI: 
102109460(IL1R2)
PMAJ: 
107213480(IL1R2)
CCW: 
104686062(IL1R2)
FPG: 
101912185(IL1R2)
FCH: 
102059985(IL1R2)
CLV: 
102086040(IL1R2)
AAM: 
106493981(IL1R2)
ASN: 
102377367(IL1R2)
AMJ: 
102558781(IL1R2)
PSS: 
102447027(IL1R2)
CMY: 
102937756(IL1R2)
CPIC: 
101942576(IL1R2)
ACS: 
100553195(il1r2)
PVT: 
110090149(IL1R2)
PBI: 
103053232(IL1R2)
GJA: 
XLA: 
108708406(il1r2.L)
XTR: 
548430(il1r2)
NPR: 
108785107(IL1R2)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101071789(il1r2)
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
102224450(il1r2)
CSEM: 
LCF: 
HCQ: 
109522273(il1r2)
BPEC: 
SASA: 
100270808(il1r2)
SFM: 
108926886(il1r2)
LCM: 
102361020(IL1R2)
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1833184
  Authors
McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI, et al.
  Title
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
  Journal
EMBO J 10:2821-32 (1991)
  Sequence
[hsa:7850]
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)

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