KEGG   ORTHOLOGY: K04388Help
Entry
K04388                      KO                                     

Name
TGFBR2
Definition
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
Cellular senescence
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Th17 cell differentiation
Relaxin signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Chagas disease (American trypanosomiasis)
HTLV-I infection
Pathways in cancer
Transcriptional misregulation in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Hepatocellular carcinoma
Module
M00680  
TGF-beta signaling
Disease
H00020  
Colorectal cancer
H00048  
Hepatocellular carcinoma
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  Development
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancers
    K04388  TGFBR2; TGF-beta receptor type-2
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
  Infectious diseases
   05166 HTLV-I infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05142 Chagas disease (American trypanosomiasis)
    K04388  TGFBR2; TGF-beta receptor type-2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00680  TGF-beta signaling
     K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
Enzyme-linked receptors [BR:ko01020]
 Receptor serine/threonine kinases
  Type II TGF-beta receptor
   K04388  TGFBR2; TGF-beta receptor type-2
Cytokine receptors [BR:ko04050]
 TGF-beta receptors
  Type II TGF-beta receptor
   K04388  TGFBR2; TGF-beta receptor type-2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7048(TGFBR2)
PTR: 
460243(TGFBR2)
PPS: 
100985497(TGFBR2)
GGO: 
101146131(TGFBR2)
PON: 
100459236(TGFBR2)
NLE: 
100606849(TGFBR2)
MCC: 
703088(TGFBR2)
MCF: 
102134273(TGFBR2)
CSAB: 
103241808(TGFBR2)
RRO: 
104655082(TGFBR2)
RBB: 
108516558(TGFBR2)
CJC: 
100404359(TGFBR2)
SBQ: 
101034142(TGFBR2)
MMU: 
21813(Tgfbr2)
RNO: 
81810(Tgfbr2)
CGE: 
100773953(Tgfbr2)
NGI: 
103744639(Tgfbr2)
HGL: 
101704397(Tgfbr2)
CCAN: 
109681522(Tgfbr2)
OCU: 
100344335(TGFBR2)
TUP: 
102486518(TGFBR2)
CFA: 
477039(TGFBR2)
AML: 
100482939(TGFBR2)
UMR: 
103682015(TGFBR2)
FCA: 
101091725(TGFBR2)
PTG: 
102958413(TGFBR2)
AJU: 
106984570(TGFBR2)
BTA: 
535376(TGFBR2)
BOM: 
102267018(TGFBR2)
BIU: 
109576148(TGFBR2)
PHD: 
102330019(TGFBR2)
CHX: 
100861300(TGFBR2)
OAS: 
494191(TGFBR2)
SSC: 
100038019(TGFBR2)
CFR: 
102509744(TGFBR2)
CDK: 
105087202(TGFBR2)
BACU: 
103005777(TGFBR2)
LVE: 
103077265(TGFBR2)
ECB: 
100033860(TGFBR2)
EPZ: 
EAI: 
106830994(TGFBR2)
MYB: 
102248472(TGFBR2)
MYD: 
102767756(TGFBR2)
HAI: 
109394441(TGFBR2)
RSS: 
109454546(TGFBR2)
PALE: 
102889618(TGFBR2)
LAV: 
100671392(TGFBR2)
MDO: 
100031897(TGFBR2)
SHR: 
100913352(TGFBR2)
OAA: 
100076965(TGFBR2)
GGA: 
396399(TGFBR2) 424261(AMHR2)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
102947040(TGFBR2)
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
108702885 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2.2.L)
XTR: 
100487430(tgfbr2.2) 100488582(tgfbr2)
NPR: 
DRE: 
30739(tgfbr2b) 560446(si:dkey-101k6.5)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
778778(tgfbr-iib)
SPU: 
APLC: 
SKO: 
100329004(TGFbRII)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]

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