KEGG   ORTHOLOGY: K04392Help
Entry
K04392                      KO                                     

Name
RAC1
Definition
Ras-related C3 botulinum toxin substrate 1
Pathway
MAPK signaling pathway
MAPK signaling pathway - fly
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Phagosome
PI3K-Akt signaling pathway
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Tight junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Pancreatic secretion
Amyotrophic lateral sclerosis (ALS)
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Choline metabolism in cancer
Viral myocarditis
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04015 Rap1 signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04010 MAPK signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04013 MAPK signaling pathway - fly
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04310 Wnt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04370 VEGF signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04071 Sphingolipid signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04024 cAMP signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04151 PI3K-Akt signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04520 Adherens junction
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04530 Tight junction
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04650 Natural killer cell mediated cytotoxicity
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04662 B cell receptor signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04664 Fc epsilon RI signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04666 Fc gamma R-mediated phagocytosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04670 Leukocyte transendothelial migration
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04062 Chemokine signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Digestive system
   04972 Pancreatic secretion
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Development
   04360 Axon guidance
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04380 Osteoclast differentiation
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05231 Choline metabolism in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05205 Proteoglycans in cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05203 Viral carcinogenesis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05210 Colorectal cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05212 Pancreatic cancer
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05211 Renal cell carcinoma
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05416 Viral myocarditis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05132 Salmonella infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05131 Shigellosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05100 Bacterial invasion of epithelial cells
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Endocytosis
  Lipid raft mediated endocytosis
   Arf6-dependent endocytosis
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Phagocytosis
   NADPH oxidase complex
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Macropinocytosis
   Ras GTPases
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of other body fluids (saliva and urine)
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of colorectal cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
  Exosomal proteins of bladder cancer cells
   K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
BRITE hierarchy
Genes
HSA: 
5879(RAC1)
PTR: 
107971891(RAC1) 741907(RAC1)
PPS: 
GGO: 
PON: 
100443271(RAC1)
NLE: 
MCC: 
717755(RAC1)
MCF: 
101866593(RAC1)
CSAB: 
103246815(RAC1)
RRO: 
104665823(RAC1)
RBB: 
CJC: 
100404109(RAC1)
SBQ: 
101042808(RAC1)
MMU: 
19353(Rac1)
RNO: 
363875(Rac1)
CGE: 
100756792(Rac1)
NGI: 
103726484(Rac1)
HGL: 
101706434(Rac1)
CCAN: 
109692922(Rac1)
OCU: 
100339873(RAC1)
TUP: 
102479102(RAC1)
CFA: 
403955(RAC1)
AML: 
100465648(RAC1)
UMR: 
103670095(RAC1)
FCA: 
101101277(RAC1)
PTG: 
102968561(RAC1)
AJU: 
106982604(RAC1)
BTA: 
281440(RAC1)
BOM: 
102273253(RAC1)
BIU: 
109578192(RAC1)
PHD: 
102315377(RAC1)
CHX: 
102173438(RAC1)
OAS: 
100101233(RAC1)
SSC: 
100627149(RAC1)
CFR: 
102516893(RAC1)
CDK: 
105099381(RAC1)
BACU: 
103007995(RAC1)
LVE: 
103074749(RAC1)
ECB: 
EPZ: 
EAI: 
106840518(RAC1)
MYB: 
102259160(RAC1)
MYD: 
102759477(RAC1)
HAI: 
109380150(RAC1)
RSS: 
PALE: 
102897644(RAC1)
LAV: 
100664204(RAC1)
MDO: 
100026992(RAC1)
SHR: 
100919657(RAC1)
OAA: 
100076220(RAC1)
GGA: 
395871(RAC1)
MGP: 
100548156(RAC1)
CJO: 
107320829(RAC1)
APLA: 
101801980(RAC1)
ACYG: 
106033506(RAC1)
TGU: 
100221287(RAC1)
GFR: 
102035279(RAC1)
FAB: 
101821415(RAC1)
PHI: 
102111634(RAC1)
PMAJ: 
107211176(RAC1)
CCW: 
104684856(RAC1)
FPG: 
101921306(RAC1)
FCH: 
102049998(RAC1)
CLV: 
102091892(RAC1)
AAM: 
106491345(RAC1)
ASN: 
102384525(RAC1)
AMJ: 
102576455(RAC1)
PSS: 
102455188(RAC1)
CMY: 
102945867(RAC1)
CPIC: 
101942767(RAC1)
ACS: 
100561917(rac1)
PVT: 
110082204(RAC1)
PBI: 
103055010(RAC1)
GJA: 
107123053(RAC1)
XLA: 
399379(rac3.S) 734382(rac1.L)
XTR: 
448118(rac1)
NPR: 
108794473(RAC1)
DRE: 
327204(rac1a) 562838(rac1b) 792699(rac1l)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
108880774(rac1)
HCQ: 
109516523(rac1)
BPEC: 
110159668(rac1)
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD13056(Dsim_GD13056) Dsimw501_GD13487(Dsim_GD13487) Dsimw501_GD20793(Dsim_GD20793) Dsimw501_GD21343(Dsim_GD21343)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
551554(Rac) 552138(GB17936) 552419
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG15031 CBG17302(Cbr-mig-2)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
EPA: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G20090(ROP2) AT1G75840(ARAC5) AT2G17800(ARAC1) AT2G44690(ARAC9) AT3G48040(ROP10) AT3G51300(ROP1) AT4G28950(ROP9) AT4G35020(RAC3) AT4G35950(RAC6) AT5G45970(RAC2) AT5G62880(RAC10)
ALY: 
CRB: 
CSAT: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0167719.1(Lj0g3v0167719.1) Lj1g3v0415230.1(Lj1g3v0415230.1) Lj1g3v2185260.1(Lj1g3v2185260.1) Lj1g3v2185270.1(Lj1g3v2185270.1) Lj1g3v2185270.2(Lj1g3v2185270.2) Lj1g3v2185270.3(Lj1g3v2185270.3) Lj1g3v2185280.1(Lj1g3v2185280.1) Lj1g3v3331690.3(Lj1g3v3331690.3) Lj2g3v0813080.1(Lj2g3v0813080.1) Lj2g3v1670990.1(Lj2g3v1670990.1) Lj2g3v1670990.2(Lj2g3v1670990.2) Lj3g3v2838500.1(Lj3g3v2838500.1) Lj3g3v3453430.1(Lj3g3v3453430.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
MCHA: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
NSY: 
NTO: 
INI: 
SIND: 
HAN: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os01t0229400-01(Os01g0229400) Os01t0540300-00(Os01g0540300) Os02t0120800-01(Os02g0120800) Os02t0312600-01(Os02g0312600) Os02t0742200-01(Os02g0742200) Os02t0834000-01(Os02g0834000) Os05t0513800-01(Os05g0513800) Os06t0234200-01(Os06g0234200)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
541773(rop1) 541774(rop3) 541930(GTPase) 542017(rop6) 542094(rop9) 542503(rop7) 542618(rop2) 542739(rop4) 542758(rop5)
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
OLU: 
BPG: 
MIS: 
CME: 
GSL: 
PGU: 
SPAA: 
CAL: 
CTP: 
CDU: 
YLI: 
CAUR: 
NCR: 
NCU02160(rac-1)
NTE: 
NEUTE1DRAFT118459(NEUTE1DRAFT_118459)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_224084(AO090020000127)
ANG: 
ANI_1_1302094(An11g10030)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
PCO: 
HIR: 
PSQ: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_140190(8.t00018) EHI_181250(97.t00016) EHI_197840(197.t00011)
EDI: 
EIV: 
ACAN: 
TET: 
PTM: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T
  Title
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
  Journal
Nat Med 14:1370-6 (2008)
DOI:10.1038/nm.1879
Reference
  Authors
Jordan P, Brazao R, Boavida MG, Gespach C, Chastre E
  Title
Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors.
  Journal
Oncogene 18:6835-9 (1999)
DOI:10.1038/sj.onc.1203233
  Sequence
[hsa:5879]

KEGG   ORTHOLOGY: K07860Help
Entry
K07860                      KO                                     

Name
RAC2
Definition
Ras-related C3 botulinum toxin substrate 2
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Adherens junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancer
Viral myocarditis
Fluid shear stress and atherosclerosis
Disease
H00099  
Leukocyte adhesion deficiency (LAD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04015 Rap1 signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04010 MAPK signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04310 Wnt signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04370 VEGF signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04071 Sphingolipid signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04024 cAMP signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04520 Adherens junction
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04662 B cell receptor signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04664 Fc epsilon RI signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04666 Fc gamma R-mediated phagocytosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04670 Leukocyte transendothelial migration
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04062 Chemokine signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  Development
   04360 Axon guidance
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05231 Choline metabolism in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05210 Colorectal cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05212 Pancreatic cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05416 Viral myocarditis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
BRITE hierarchy
Genes
HSA: 
5880(RAC2)
PTR: 
742575(RAC2)
PPS: 
100993959(RAC2)
GGO: 
101141534(RAC2)
PON: 
100431483(RAC2)
NLE: 
100598232(RAC2)
MCC: 
696709(RAC2)
MCF: 
102137056(RAC2)
CSAB: 
103223272(RAC2)
RRO: 
104682502(RAC2)
RBB: 
108512764(RAC2)
CJC: 
100395636(RAC2)
SBQ: 
101029481(RAC2)
MMU: 
19354(Rac2)
RNO: 
366957(Rac2)
CGE: 
100767225(Rac2)
NGI: 
103748617(Rac2)
HGL: 
101725000(Rac2)
CCAN: 
109698248(Rac2)
OCU: 
100356520(RAC2)
TUP: 
102495436(RAC2)
CFA: 
481271(RAC2)
AML: 
100469737(RAC2)
UMR: 
103676407(RAC2)
FCA: 
101096744(RAC2)
PTG: 
102961922(RAC2)
AJU: 
106981077(RAC2)
BTA: 
327671(RAC2)
BOM: 
102277352(RAC2)
BIU: 
109559531(RAC2)
PHD: 
102315491(RAC2)
CHX: 
102178149(RAC2)
OAS: 
101107592(RAC2)
SSC: 
100621675(RAC2)
CFR: 
102519112(RAC2)
CDK: 
105101582(RAC2)
BACU: 
103006132(RAC2)
LVE: 
103076541(RAC2)
ECB: 
100054701(RAC2)
EPZ: 
103564464(RAC2)
EAI: 
106837585(RAC2)
MYB: 
102239988(RAC2)
MYD: 
102768116(RAC2)
HAI: 
109394502(RAC2)
RSS: 
109458939(RAC2)
PALE: 
102885507(RAC2)
LAV: 
100670080(RAC2)
MDO: 
100017517(RAC2)
SHR: 
100932383(RAC2)
OAA: 
100092844(RAC2)
GGA: 
418044(RAC2)
MGP: 
100547045(RAC2)
CJO: 
107313854(RAC2)
APLA: 
101790794(RAC2)
ACYG: 
106035903(RAC2)
TGU: 
100230090(RAC2)
GFR: 
102031835(RAC2)
FAB: 
101808708(RAC2)
PHI: 
102106942(RAC2)
PMAJ: 
107205038(RAC2)
CCW: 
104696295(RAC2)
FPG: 
101915778(RAC2)
FCH: 
102059263(RAC2)
CLV: 
102092145(RAC2)
AAM: 
106488354(RAC2)
ASN: 
102388854(RAC2)
AMJ: 
102567702(RAC2)
PSS: 
102457520(RAC2)
CMY: 
102936049(RAC2)
CPIC: 
101933538(RAC2)
ACS: 
100557692(rac2)
PVT: 
110075970(RAC2)
PBI: 
103057074(RAC2)
GJA: 
107120055(RAC2)
XLA: 
XTR: 
496738(rac2)
NPR: 
108783678(RAC2)
DRE: 
415151(rac2)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101071607(rac2)
TNG: 
LCO: 
104925434(rac2)
MZE: 
OLA: 
101163549(rac2)
XMA: 
102225118(rac2)
CSEM: 
103383441(rac2)
LCF: 
HCQ: 
BPEC: 
SASA: 
106564435(RAC2) 106590297(RAC2) 106601466(RAC2) 106601467(RAC2)
ELS: 
105022954(rac2) 105031187(rac2)
SFM: 
LCM: 
102351732(RAC2)
EIV: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2674130
  Authors
Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R
  Title
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
  Journal
J Biol Chem 264:16378-82 (1989)
  Sequence
[hsa:5880]
Reference
  Authors
Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V
  Title
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.
  Journal
Blood 118:638-49 (2011)
DOI:10.1182/blood-2010-09-307330
  Sequence
[mmu:19354]

KEGG   ORTHOLOGY: K07861Help
Entry
K07861                      KO                                     

Name
RAC3
Definition
Ras-related C3 botulinum toxin substrate 3
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Adherens junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancer
Viral myocarditis
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04015 Rap1 signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04010 MAPK signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04310 Wnt signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04370 VEGF signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04071 Sphingolipid signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04024 cAMP signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04520 Adherens junction
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  Cell motility
   04810 Regulation of actin cytoskeleton
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04662 B cell receptor signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04664 Fc epsilon RI signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  Development
   04360 Axon guidance
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05231 Choline metabolism in cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05210 Colorectal cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05212 Pancreatic cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05416 Viral myocarditis
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
BRITE hierarchy
Genes
HSA: 
5881(RAC3)
PTR: 
747131(RAC3)
PPS: 
100988790(RAC3)
GGO: 
101150322(RAC3)
NLE: 
100602123(RAC3)
MCC: 
719305(RAC3)
MCF: 
102143597(RAC3)
CSAB: 
103243748(RAC3)
RRO: 
104654979(RAC3)
RBB: 
108534092(RAC3)
CJC: 
100400756(RAC3)
SBQ: 
101046124(RAC3)
MMU: 
170758(Rac3)
CGE: 
100757479(Rac3)
NGI: 
103730658(Rac3)
HGL: 
101723777(Rac3)
CCAN: 
109702872(Rac3)
TUP: 
102494727(RAC3)
AML: 
100468971(RAC3)
UMR: 
103666008(RAC3)
FCA: 
101080496(RAC3)
PTG: 
102955504(RAC3)
AJU: 
106986311(RAC3)
BTA: 
619066(RAC3)
BOM: 
102286986(RAC3)
BIU: 
109574290(RAC3)
PHD: 
102337574(RAC3)
CHX: 
102178569(RAC3)
OAS: 
101112406(RAC3)
SSC: 
110255928(RAC3)
CFR: 
102508710(RAC3)
CDK: 
105102215(RAC3)
BACU: 
103019253(RAC3)
LVE: 
103079514(RAC3)
ECB: 
100054738(RAC3)
EPZ: 
103551104(RAC3)
EAI: 
106846070(RAC3)
MYB: 
102249503(RAC3)
MYD: 
102760578(RAC3)
HAI: 
109393041(RAC3)
RSS: 
109449383(RAC3)
PALE: 
102887421(RAC3)
MDO: 
100029873(RAC3)
SHR: 
100924669(RAC3)
GGA: 
395870(RAC3)
MGP: 
100544672(RAC3)
CJO: 
107322082(RAC3)
APLA: 
101794915(RAC3)
ACYG: 
106046763(RAC3)
TGU: 
100220185(RAC3)
GFR: 
102043334(RAC3)
FAB: 
101821880(RAC3)
PHI: 
102103513(RAC3)
PMAJ: 
107212321(RAC3)
CCW: 
104698185(RAC3)
FPG: 
101915014(RAC3)
FCH: 
102054322(RAC3)
CLV: 
102094546(RAC3)
AAM: 
ASN: 
102384004(RAC3)
AMJ: 
102563759(RAC3)
PSS: 
102455375(RAC3)
CMY: 
102938636(RAC3)
CPIC: 
101934732(RAC3)
ACS: 
100568092(rac3)
PVT: 
110091292(RAC3)
PBI: 
103065986(RAC3)
GJA: 
107118111(RAC3)
XLA: 
XTR: 
100101726(rac3)
NPR: 
108791334(RAC3)
DRE: 
437027(rac3a) 795167(rac3b)
SRX: 
SANH: 
SGH: 
IPU: 
108259609(rac3)
AMEX: 
TRU: 
LCO: 
NCC: 
MZE: 
101467064(rac3)
OLA: 
XMA: 
102224880(rac3)
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108940081(rac3)
LCM: 
102364586(RAC3)
CMK: 
103175476(rac3)
LOA: 
ABP: 
AGABI1DRAFT96759(AGABI1DRAFT_96759)
ABV: 
AGABI2DRAFT239537(AGABI2DRAFT_239537)
ACAN: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9252344
  Authors
Haataja L, Groffen J, Heisterkamp N
  Title
Characterization of RAC3, a novel member of the Rho family.
  Journal
J Biol Chem 272:20384-8 (1997)
DOI:10.1074/jbc.272.33.20384
  Sequence
[hsa:5881]
Reference
  Authors
Haataja L, Kaartinen V, Groffen J, Heisterkamp N
  Title
The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.
  Journal
J Biol Chem 277:8321-8 (2002)
DOI:10.1074/jbc.M105363200
  Sequence
[hsa:5881]

KEGG   ORTHOLOGY: K04393Help
Entry
K04393                      KO                                     

Name
CDC42
Definition
cell division control protein 42
Pathway
MAPK signaling pathway
MAPK signaling pathway - yeast
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Endocytosis
Axon guidance
VEGF signaling pathway
Focal adhesion
Adherens junction
Tight junction
T cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
GnRH signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Human papillomavirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Renal cell carcinoma
Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04393  CDC42; cell division control protein 42
   04015 Rap1 signaling pathway
    K04393  CDC42; cell division control protein 42
   04010 MAPK signaling pathway
    K04393  CDC42; cell division control protein 42
   04011 MAPK signaling pathway - yeast
    K04393  CDC42; cell division control protein 42
   04370 VEGF signaling pathway
    K04393  CDC42; cell division control protein 42
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04393  CDC42; cell division control protein 42
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04393  CDC42; cell division control protein 42
   04520 Adherens junction
    K04393  CDC42; cell division control protein 42
   04530 Tight junction
    K04393  CDC42; cell division control protein 42
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04393  CDC42; cell division control protein 42
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K04393  CDC42; cell division control protein 42
   04666 Fc gamma R-mediated phagocytosis
    K04393  CDC42; cell division control protein 42
   04670 Leukocyte transendothelial migration
    K04393  CDC42; cell division control protein 42
   04062 Chemokine signaling pathway
    K04393  CDC42; cell division control protein 42
  Endocrine system
   04912 GnRH signaling pathway
    K04393  CDC42; cell division control protein 42
  Nervous system
   04722 Neurotrophin signaling pathway
    K04393  CDC42; cell division control protein 42
  Development
   04360 Axon guidance
    K04393  CDC42; cell division control protein 42
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04393  CDC42; cell division control protein 42
   05205 Proteoglycans in cancer
    K04393  CDC42; cell division control protein 42
   05203 Viral carcinogenesis
    K04393  CDC42; cell division control protein 42
   05212 Pancreatic cancer
    K04393  CDC42; cell division control protein 42
   05211 Renal cell carcinoma
    K04393  CDC42; cell division control protein 42
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04393  CDC42; cell division control protein 42
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04393  CDC42; cell division control protein 42
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04393  CDC42; cell division control protein 42
   05130 Pathogenic Escherichia coli infection
    K04393  CDC42; cell division control protein 42
   05132 Salmonella infection
    K04393  CDC42; cell division control protein 42
   05131 Shigellosis
    K04393  CDC42; cell division control protein 42
   05100 Bacterial invasion of epithelial cells
    K04393  CDC42; cell division control protein 42
   05165 Human papillomavirus infection
    K04393  CDC42; cell division control protein 42
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    K04393  CDC42; cell division control protein 42
 Endocytosis
  Lipid raft mediated endocytosis
   GRAF1-dependent endocytosis
    K04393  CDC42; cell division control protein 42
  Macropinocytosis
   Ras GTPases
    K04393  CDC42; cell division control protein 42
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04393  CDC42; cell division control protein 42
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   K04393  CDC42; cell division control protein 42
  Exosomal proteins of breast milk
   K04393  CDC42; cell division control protein 42
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K04393  CDC42; cell division control protein 42
BRITE hierarchy
Other DBs
COG: 
Genes
HSA: 
998(CDC42)
PTR: 
456609(CDC42) 745248
PPS: 
GGO: 
101124029(CDC42)
PON: 
100438199(CDC42)
NLE: 
100605245(CDC42)
MCC: 
707637(CDC42)
MCF: 
101925934(CDC42)
CSAB: 
103225423(CDC42)
RRO: 
104663221(CDC42)
RBB: 
108538451(CDC42)
CJC: 
100404291(CDC42)
SBQ: 
101050895(CDC42)
MMU: 
12540(Cdc42)
RNO: 
64465(Cdc42)
CGE: 
100765433(Cdc42)
NGI: 
103746394(Cdc42)
HGL: 
CCAN: 
109694921(Cdc42)
OCU: 
100008965(CDC42)
TUP: 
102488344(CDC42)
CFA: 
403934(CDC42)
AML: 
100465076(CDC42)
UMR: 
103666578(CDC42)
FCA: 
101094772(CDC42)
PTG: 
102973021(CDC42)
AJU: 
106977652(CDC42)
BTA: 
532712(CDC42)
BOM: 
102266310(CDC42)
BIU: 
109574100(CDC42)
PHD: 
102333527(CDC42)
CHX: 
102188638(CDC42)
OAS: 
101102792(CDC42) 106990095(CDC42)
SSC: 
780428(CDC42)
CFR: 
102514486(CDC42)
CDK: 
105088868(CDC42)
BACU: 
103008817(CDC42)
LVE: 
103088294(CDC42)
ECB: 
100058188(CDC42)
EPZ: 
103558482(CDC42)
EAI: 
106840004(CDC42)
MYB: 
MYD: 
102758165(CDC42)
HAI: 
109396744(CDC42)
RSS: 
109435051(CDC42)
PALE: 
102889114(CDC42)
LAV: 
100664103(CDC42)
MDO: 
100023099(CDC42)
SHR: 
100918370(CDC42)
OAA: 
100086186(CDC42)
GGA: 
395917(CDC42)
MGP: 
100546318(CDC42)
CJO: 
107323393(CDC42)
APLA: 
101791907(CDC42)
ACYG: 
106049156(CDC42)
TGU: 
100227983(CDC42)
GFR: 
102036055(CDC42)
FAB: 
101806194(CDC42)
PHI: 
102106254(CDC42)
PMAJ: 
107213677(CDC42)
CCW: 
104697540(CDC42)
FPG: 
101914879(CDC42)
FCH: 
102055425(CDC42)
CLV: 
102098077(CDC42)
AAM: 
106498596(CDC42)
ASN: 
102385507(CDC42)
AMJ: 
102558748(CDC42)
PSS: 
102447391(CDC42)
CMY: 
102931327(CDC42)
CPIC: 
101940859(CDC42)
ACS: 
PVT: 
110086811(CDC42)
PBI: 
103053939(CDC42)
GJA: 
107116700(CDC42)
XLA: 
108697660 379055(cdc42.L)
XTR: 
493389(cdc42)
NPR: 
108797397(CDC42)
DRE: 
336839(cdc42) 556226(cdc42l2) 793158(cdc42l)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
106565619(CDC42) 106567263(cdc42) 106569986(CDC42) 106572399(CDC42) 106576553(CDC42) 106583122(CDC42) 106588426 106605852
ELS: 
SFM: 
LCM: 
102358869(CDC42)
CMK: 
103181348(cdc42)
BFO: 
CIN: 
445701(cdc42) 445704
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD17456(Dsim_GD17456)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
411134(Cdc42)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
100145828(Cdc42)
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG09601(Cbr-crp-1) CBG13013(Cbr-cdc-42)
NAI: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
EPA: 
ADF: 
HMG: 
TAD: 
AQU: 
CCP: 
SCE: 
YLR229C(CDC42)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B02880(NCAS0B02880)
NDI: 
NDAI_0C04820(NDAI0C04820)
TPF: 
TPHA_0C02190(TPHA0C02190)
TBL: 
TBLA_0H00690(TBLA0H00690) TBLA_0H03330(TBLA0H03330)
TDL: 
TDEL_0F05450(TDEL0F05450)
KAF: 
KAFR_0B06320(KAFR0B06320)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NCU06454(cdc42)
NTE: 
NEUTE1DRAFT81132(NEUTE1DRAFT_81132)
SMP: 
SMAC_02216(cdc42)
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1240164(AO090001000693)
ANG: 
ANI_1_1958024(An02g14200)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
SPO: 
SPAC110.03(cdc42)
CNE: 
CNB: 
CGI: 
TMS: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT82759(AGABI1DRAFT_82759)
ABV: 
AGABI2DRAFT134270(AGABI2DRAFT_134270)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
MLR: 
ECU: 
EIN: 
NCE: 
MBR: 
SRE: 
EIV: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gao XD, Sperber LM, Kane SA, Tong Z, Tong AH, Boone C, Bi E
  Title
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
  Journal
Mol Biol Cell 18:2542-60 (2007)
DOI:10.1091/mbc.E06-09-0822
  Sequence
[sce:YLR229C]
Reference
PMID:2122236
  Authors
Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P
  Title
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
  Journal
Mol Cell Biol 10:5977-82 (1990)
DOI:10.1128/MCB.10.11.5977
  Sequence
[hsa:998]

DBGET integrated database retrieval system