KEGG   ORTHOLOGY: K04393Help
Entry
K04393                      KO                                     

Name
CDC42
Definition
cell division control protein 42
Pathway
ko04010  MAPK signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04062  Chemokine signaling pathway
ko04144  Endocytosis
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04660  T cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04912  GnRH signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05100  Bacterial invasion of epithelial cells
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04393  CDC42; cell division control protein 42
   04015 Rap1 signaling pathway
    K04393  CDC42; cell division control protein 42
   04010 MAPK signaling pathway
    K04393  CDC42; cell division control protein 42
   04011 MAPK signaling pathway - yeast
    K04393  CDC42; cell division control protein 42
   04370 VEGF signaling pathway
    K04393  CDC42; cell division control protein 42
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K04393  CDC42; cell division control protein 42
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04393  CDC42; cell division control protein 42
   04520 Adherens junction
    K04393  CDC42; cell division control protein 42
   04530 Tight junction
    K04393  CDC42; cell division control protein 42
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04393  CDC42; cell division control protein 42
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K04393  CDC42; cell division control protein 42
   04666 Fc gamma R-mediated phagocytosis
    K04393  CDC42; cell division control protein 42
   04670 Leukocyte transendothelial migration
    K04393  CDC42; cell division control protein 42
   04062 Chemokine signaling pathway
    K04393  CDC42; cell division control protein 42
  Endocrine system
   04912 GnRH signaling pathway
    K04393  CDC42; cell division control protein 42
  Nervous system
   04722 Neurotrophin signaling pathway
    K04393  CDC42; cell division control protein 42
  Development
   04360 Axon guidance
    K04393  CDC42; cell division control protein 42
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04393  CDC42; cell division control protein 42
   05205 Proteoglycans in cancer
    K04393  CDC42; cell division control protein 42
   05203 Viral carcinogenesis
    K04393  CDC42; cell division control protein 42
   05212 Pancreatic cancer
    K04393  CDC42; cell division control protein 42
   05211 Renal cell carcinoma
    K04393  CDC42; cell division control protein 42
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04393  CDC42; cell division control protein 42
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04393  CDC42; cell division control protein 42
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04393  CDC42; cell division control protein 42
   05130 Pathogenic Escherichia coli infection
    K04393  CDC42; cell division control protein 42
   05132 Salmonella infection
    K04393  CDC42; cell division control protein 42
   05131 Shigellosis
    K04393  CDC42; cell division control protein 42
   05100 Bacterial invasion of epithelial cells
    K04393  CDC42; cell division control protein 42
   05165 Human papillomavirus infection
    K04393  CDC42; cell division control protein 42
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    K04393  CDC42; cell division control protein 42
 Endocytosis
  Lipid raft mediated endocytosis
   GRAF1-dependent endocytosis
    K04393  CDC42; cell division control protein 42
  Macropinocytosis
   Ras GTPases
    K04393  CDC42; cell division control protein 42
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04393  CDC42; cell division control protein 42
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   K04393  CDC42; cell division control protein 42
  Exosomal proteins of breast milk
   K04393  CDC42; cell division control protein 42
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K04393  CDC42; cell division control protein 42
BRITE hierarchy
Other DBs
COG: COG1100
Genes
HSA: 998(CDC42)
PTR: 456609(CDC42)
PPS: 100990246(CDC42) 100993131 103786242
GGO: 101124029(CDC42)
PON: 100438199(CDC42)
NLE: 100605245(CDC42)
MCC: 707637(CDC42)
MCF: 101925934(CDC42)
CSAB: 103225423(CDC42)
RRO: 104663221(CDC42)
RBB: 108538451(CDC42)
CJC: 100404291(CDC42)
SBQ: 101050895(CDC42)
MMU: 12540(Cdc42)
RNO: 64465(Cdc42)
CGE: 100765433(Cdc42)
NGI: 103746394(Cdc42)
HGL: 101701374(Cdc42) 101711269
CCAN: 109694921(Cdc42)
OCU: 100008965(CDC42)
TUP: 102488344(CDC42)
CFA: 403934(CDC42)
AML: 100465076(CDC42)
UMR: 103666578(CDC42)
ORO: 101364638(CDC42) 101377814
FCA: 101094772(CDC42)
PTG: 102973021(CDC42)
AJU: 106977652(CDC42)
BTA: 532712(CDC42)
BOM: 102266310(CDC42)
BIU: 109574100(CDC42)
PHD: 102333527(CDC42)
CHX: 102188638(CDC42)
OAS: 101102792(CDC42) 106990095(CDC42)
SSC: 780428(CDC42)
CFR: 102514486(CDC42)
CDK: 105088868(CDC42)
BACU: 103008817(CDC42)
LVE: 103088294(CDC42)
OOR: 101270289(CDC42)
ECB: 100058188(CDC42)
EPZ: 103558482(CDC42)
EAI: 106840004(CDC42)
MYB: 102239987 102257260(CDC42)
MYD: 102758165(CDC42)
HAI: 109396744(CDC42)
RSS: 109435051(CDC42)
PALE: 102889114(CDC42)
LAV: 100664103(CDC42)
TMU: 101361943
MDO: 100023099(CDC42)
SHR: 100918370(CDC42)
OAA: 100086186(CDC42)
GGA: 395917(CDC42)
MGP: 100546318(CDC42)
CJO: 107323393(CDC42)
APLA: 101791907(CDC42)
ACYG: 106049156(CDC42)
TGU: 100227983(CDC42)
GFR: 102036055(CDC42)
FAB: 101806194(CDC42)
PHI: 102106254(CDC42)
PMAJ: 107213677(CDC42)
CCW: 104697540(CDC42)
FPG: 101914879(CDC42)
FCH: 102055425(CDC42)
CLV: 102098077(CDC42)
EGZ: 104131862(CDC42)
AAM: 106498596(CDC42)
ASN: 102385507(CDC42)
AMJ: 102558748(CDC42)
PSS: 102447391(CDC42)
CMY: 102931327(CDC42)
CPIC: 101940859(CDC42)
ACS: 103282300(cdc42) 107983928
PVT: 110086811(CDC42)
PBI: 103053939(CDC42)
GJA: 107116700(CDC42)
XLA: 108697660 379055(cdc42.L)
XTR: 493389(cdc42)
NPR: 108797397(CDC42)
DRE: 336839(cdc42) 556226(cdc42l2) 793158(cdc42l)
SASA: 106565619(CDC42) 106567263(cdc42) 106569986(CDC42) 106572399(CDC42) 106576553(CDC42) 106583122(CDC42) 106588426 106605852
LCM: 102358869(CDC42)
CMK: 103181348(cdc42)
CIN: 445701(cdc42) 445704
SPU: 584477
DME: Dmel_CG12530(Cdc42)
DSI: Dsimw501_GD17456(Dsim_GD17456)
AGA: AgaP_AGAP002440(CDC42_ANOGA) AgaP_AGAP006279
AME: 411134(Cdc42)
DPA: 109542387
NVL: 108560692
BMOR: 101742319
PMAC: 106717056
PRAP: 110996319
API: 100145828(Cdc42)
DNX: 107164525
ZNE: 110836944
FCD: 110852274
TUT: 107364892
CEL: CELE_R07G3.1(cdc-42) CELE_Y32F6B.3(crp-1)
CBR: CBG09601(Cbr-crp-1) CBG13013(Cbr-cdc-42)
SHX: MS3_08262
EPA: 110254357
ADF: 107344029
HMG: 100204156
SCE: YLR229C(CDC42)
ERC: Ecym_4146
KMX: KLMA_50127(CDC42)
NCS: NCAS_0B02880(NCAS0B02880)
NDI: NDAI_0C04820(NDAI0C04820)
TPF: TPHA_0C02190(TPHA0C02190)
TBL: TBLA_0H00690(TBLA0H00690) TBLA_0H03330(TBLA0H03330)
TDL: TDEL_0F05450(TDEL0F05450)
KAF: KAFR_0B06320(KAFR0B06320)
PIC: PICST_35277(CDC42)
CAL: CAALFM_C108450CA(CDC42)
CAUR: QG37_02515
SLB: AWJ20_1676(CDC42)
NCR: NCU06454(cdc42)
NTE: NEUTE1DRAFT81132(NEUTE1DRAFT_81132)
SMP: SMAC_02216(putative cdc42)
MGR: MGG_00466
TRE: TRIREDRAFT_50335(cdc42)
MAW: MAC_05067
MAJ: MAA_03565
CMT: CCM_00979
MBE: MBM_04474
ANI: AN7487.2
ANG: ANI_1_1958024(An02g14200)
ABE: ARB_03852
TVE: TRV_01751
PTE: PTT_09197
ZTR: MYCGRDRAFT_99553(MgCdc42)
SPO: SPAC110.03(cdc42)
ABP: AGABI1DRAFT82759(AGABI1DRAFT_82759)
ABV: AGABI2DRAFT134270(AGABI2DRAFT_134270)
MGL: MGL_0548
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gao XD, Sperber LM, Kane SA, Tong Z, Tong AH, Boone C, Bi E
  Title
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
  Journal
Mol Biol Cell 18:2542-60 (2007)
DOI:10.1091/mbc.E06-09-0822
  Sequence
[sce:YLR229C]
Reference
PMID:2122236
  Authors
Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P
  Title
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
  Journal
Mol Cell Biol 10:5977-82 (1990)
DOI:10.1128/MCB.10.11.5977
  Sequence
[hsa:998]

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