KEGG   ORTHOLOGY: K04402Help
Entry
K04402                      KO                                     

Name
GADD45
Definition
growth arrest and DNA-damage-inducible protein
Pathway
MAPK signaling pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
Apoptosis
Cellular senescence
Pathways in cancer
Transcriptional misregulation in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Thyroid cancer
Basal cell carcinoma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04068 FoxO signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04210 Apoptosis
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04115 p53 signaling pathway
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   04218 Cellular senescence
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05202 Transcriptional misregulation in cancers
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05210 Colorectal cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05212 Pancreatic cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05225 Hepatocellular carcinoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05226 Gastric cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05214 Glioma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05216 Thyroid cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05220 Chronic myeloid leukemia
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05217 Basal cell carcinoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05218 Melanoma
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05213 Endometrial cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05224 Breast cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05222 Small cell lung cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
   05223 Non-small cell lung cancer
    K04402  GADD45; growth arrest and DNA-damage-inducible protein
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K04402  GADD45; growth arrest and DNA-damage-inducible protein
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04402  GADD45; growth arrest and DNA-damage-inducible protein
BRITE hierarchy
Genes
HSA: 
10912(GADD45G) 1647(GADD45A) 4616(GADD45B)
PTR: 
456929(GADD45A) 464585(GADD45G) 744311(GADD45B)
PPS: 
100982764(GADD45B) 100990548(GADD45A) 100992917(GADD45G)
GGO: 
101131508(GADD45G) 101140270(GADD45B) 101146783(GADD45A)
PON: 
100436665(GADD45G) 100452809(GADD45B) 100456437(GADD45A)
NLE: 
MCC: 
697835(GADD45G) 701054(GADD45A) 711257(GADD45B)
MCF: 
102115080(GADD45B) 102128083(GADD45A) 102135480(GADD45G)
CSAB: 
103219731(GADD45G) 103224652(GADD45A) 103233650(GADD45B)
RRO: 
104656307(GADD45G) 104657306(GADD45A) 104671382(GADD45B)
RBB: 
108531451(GADD45B) 108532870(GADD45A) 108538612(GADD45G)
CJC: 
100394399(GADD45A) 100405303(GADD45G) 100412572(GADD45B)
SBQ: 
101030208(GADD45B) 101039106(GADD45G) 101047513(GADD45A)
MMU: 
13197(Gadd45a) 17873(Gadd45b) 23882(Gadd45g)
RNO: 
25112(Gadd45a) 291005(Gadd45g) 299626(Gadd45b)
CGE: 
100759228(Gadd45g) 100766127(Gadd45b) 103159266
NGI: 
103737285(Gadd45b) 103743354(Gadd45a) 103751225(Gadd45g)
HGL: 
101710909(Gadd45b) 101711314(Gadd45g) 101725746(Gadd45a)
CCAN: 
109691045(Gadd45b) 109696612(Gadd45g) 109698312(Gadd45a)
OCU: 
100353284(GADD45A) 100353742(GADD45G)
TUP: 
102476523(GADD45B) 102496861(GADD45G) 102502813(GADD45A)
CFA: 
100855728(GADD45A) 484198(GADD45G) 485069(GADD45B)
AML: 
100470600(GADD45G) 100477654(GADD45A) 100482871(GADD45B)
UMR: 
103663135(GADD45A) 103663314(GADD45G) 103681651(GADD45B)
FCA: 
101086509(GADD45G) 101087971(GADD45B)
PTG: 
102951885(GADD45A) 102964763(GADD45B)
AJU: 
106985200(GADD45A) 106989693(GADD45B)
BTA: 
504939(GADD45G) 505463(GADD45A) 618405(GADD45B)
BOM: 
102266978(GADD45B) 102276116(GADD45G) 102288000(GADD45A)
BIU: 
109556176(GADD45A) 109561788(GADD45B) 109563283(GADD45G)
PHD: 
102324661(GADD45B) 102341257(GADD45A) 102343412(GADD45G)
CHX: 
102179904(GADD45A) 102183684(GADD45B) 102188317(GADD45G)
OAS: 
100885762(GADD45G) 101115240(GADD45A) 101120573(GADD45B)
SSC: 
100152997(GADD45G) 100621090(GADD45B) 733669(GADD45A)
CFR: 
102508482(GADD45A) 102516207(GADD45B)
CDK: 
105086406(GADD45G) 105096626(GADD45A) 105103609(GADD45B)
BACU: 
103012188(GADD45G) 103016967(GADD45B) 103020367(GADD45A)
LVE: 
103079241(GADD45G) 103080866(GADD45A) 103089793(GADD45B)
ECB: 
100054996(GADD45G) 100059768(GADD45B) 100630299(GADD45A)
EPZ: 
103543986(GADD45B) 103552106(GADD45G) 103564848
EAI: 
106825069(GADD45A) 106825118(GADD45G) 106834158(GADD45B)
MYB: 
102239140(GADD45B) 102242156(GADD45A) 102246302(GADD45G)
MYD: 
102751752(GADD45B) 102752386(GADD45A) 102771581(GADD45G)
HAI: 
109374090(GADD45G) 109384926(GADD45A) 109390584(GADD45B)
RSS: 
109435719(GADD45G) 109447680(GADD45A) 109453894(GADD45B)
PALE: 
102878191(GADD45G) 102885790(GADD45B) 102886440(GADD45A)
LAV: 
100653562(GADD45A) 100655692(GADD45B) 100658253(GADD45G)
MDO: 
100010225(GADD45G) 100014651(GADD45B) 100016952(GADD45A)
SHR: 
100920439(GADD45B) 100926902(GADD45G)
OAA: 
100081893(GADD45A) 100090762(GADD45B)
GGA: 
100859853 429929(GADD45B) 693255(GADD45A)
MGP: 
100540601(GADD45A) 104915137(GADD45G)
CJO: 
107306297(GADD45G) 107317806(GADD45A) 107325480(GADD45B)
APLA: 
101792274(GADD45A) 101793631(GADD45B)
ACYG: 
106045084(GADD45G) 106048205(GADD45B)
TGU: 
100190269(GADD45B) 100223813(GADD45G)
FAB: 
101821221(GADD45G)
PHI: 
102102492(GADD45A) 102109500(GADD45G) 102109553(GADD45B)
PMAJ: 
107198526(GADD45G) 107208453(GADD45A) 107215503(GADD45B)
FPG: 
101915163(GADD45G) 101916621(GADD45B)
FCH: 
102057224(GADD45G) 102057932(GADD45B)
CLV: 
102084445(GADD45A) 102087532(GADD45B) 102090065(GADD45G)
AAM: 
ASN: 
102372381(GADD45G) 102374172(GADD45A) 102374205(GADD45B)
AMJ: 
102560377(GADD45G) 102570271(GADD45B) 102575022(GADD45A)
PSS: 
102447859(GADD45G) 102457123(GADD45A) 102460773
CMY: 
102935322(GADD45A) 102943336(GADD45G) 102945688(GADD45B)
CPIC: 
101933443(GADD45A) 101945211(GADD45B) 101945778(GADD45G)
ACS: 
100554443(gadd45a) 100567812(gadd45g)
PVT: 
110072507(GADD45B) 110079870(GADD45A) 110080579(GADD45G)
PBI: 
103059109(GADD45A) 103063697(GADD45B) 103064821(GADD45G)
GJA: 
107108632(GADD45G) 107114354(GADD45A) 107120631(GADD45B)
XLA: 
101027271(gadd45b.S) 108712402(gadd45b.L) 108714209 379224(gadd45a.L) 379285(gadd45g.S) 399196(gadd45g.L)
XTR: 
100487013(gadd45b) 448442(gadd45g) 548905(gadd45a)
NPR: 
108795520(GADD45G) 108795947(GADD45A) 108798643(GADD45B)
DRE: 
393548(gadd45aa) 402991(gadd45ga) 406304(gadd45ba) 431763(gadd45ab) 497646(gadd45bb)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102349018(GADD45A) 102353479(GADD45G) 102361538(GADD45B)
CMK: 
103181960(gadd45b) 103182857(gadd45g) 103189132(gadd45a)
SPU: 
APLC: 
SKO: 
100303593(gadd45a-like)
DME: 
Dmel_CG11086(Gadd45)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15338(Dsim_GD15338)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
NVE: 
EPA: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX
  Title
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure.
  Journal
J Biol Chem 279:29606-14 (2004)
DOI:10.1074/jbc.M312279200
  Sequence
[mmu:13197]
Reference
  Authors
Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, Zhao Z, Fu M, Tong T, Dong L, Fan F, Xu N, Zhan Q
  Title
Gadd45a interacts with aurora-A and inhibits its kinase activity.
  Journal
J Biol Chem 281:28943-50 (2006)
DOI:10.1074/jbc.M600235200
  Sequence
[hsa:1647] [mmu:13197]
Reference
  Authors
Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, Liao SK, Ambinder R, Tao Q
  Title
The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.
  Journal
Clin Cancer Res 11:6442-9 (2005)
DOI:10.1158/1078-0432.CCR-05-0267
  Sequence
[hsa:10912]
Reference
PMID:8226988
  Authors
Hollander MC, Alamo I, Jackman J, Wang MG, McBride OW, Fornace AJ Jr
  Title
Analysis of the mammalian gadd45 gene and its response to DNA damage.
  Journal
J Biol Chem 268:24385-93 (1993)
  Sequence
[hsa:1647]
Reference
PMID:1990262
  Authors
Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr
  Title
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.
  Journal
Mol Cell Biol 11:1009-16 (1991)
  Sequence
[hsa:1647]

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