KEGG   ORTHOLOGY: K04409Help
Entry
K04409                      KO                                     

Name
PAK1
Definition
p21-activated kinase 1 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04011  MAPK signaling pathway - yeast
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04360  Axon guidance
ko04392  Hippo signaling pathway - multiple species
ko04510  Focal adhesion
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04810  Regulation of actin cytoskeleton
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05205  Proteoglycans in cancer
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04010 MAPK signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04011 MAPK signaling pathway - yeast
    K04409  PAK1; p21-activated kinase 1
   04012 ErbB signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04392 Hippo signaling pathway - multiple species
    K04409  PAK1; p21-activated kinase 1
   04024 cAMP signaling pathway
    K04409  PAK1; p21-activated kinase 1
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04409  PAK1; p21-activated kinase 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04409  PAK1; p21-activated kinase 1
 Organismal Systems
  Immune system
   04625 C-type lectin receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04409  PAK1; p21-activated kinase 1
   04660 T cell receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04409  PAK1; p21-activated kinase 1
   04062 Chemokine signaling pathway
    K04409  PAK1; p21-activated kinase 1
  Development
   04360 Axon guidance
    K04409  PAK1; p21-activated kinase 1
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K04409  PAK1; p21-activated kinase 1
   05211 Renal cell carcinoma
    K04409  PAK1; p21-activated kinase 1
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04409  PAK1; p21-activated kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04409  PAK1; p21-activated kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K04409  PAK1; p21-activated kinase 1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K04409  PAK1; p21-activated kinase 1
 Endocytosis
  Macropinocytosis
   Kinases
    K04409  PAK1; p21-activated kinase 1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04409  PAK1; p21-activated kinase 1
BRITE hierarchy
Other DBs
COG: COG0515
Genes
HSA: 5058(PAK1)
PTR: 451439(PAK1)
PPS: 100973579(PAK1)
GGO: 101138276(PAK1)
PON: 100449316(PAK1)
NLE: 100588769(PAK1)
MCC: 698585(PAK1)
MCF: 101866132(PAK1)
CSAB: 103248093(PAK1)
RRO: 104664316(PAK1)
RBB: 108543210(PAK1)
CJC: 100392970(PAK1)
SBQ: 101042666(PAK1)
MMU: 18479(Pak1)
RNO: 29431(Pak1)
CGE: 100767503(Pak1)
NGI: 103743005(Pak1)
HGL: 101713465(Pak1)
OCU: 100352056(PAK1)
TUP: 102495430(PAK1)
CFA: 607885(PAK1)
AML: 100472811(PAK1)
UMR: 103678069(PAK1)
ORO: 101365642(PAK1)
FCA: 101087171(PAK1)
PTG: 102963927(PAK1)
AJU: 106976449(PAK1)
BTA: 533729(PAK1)
BOM: 102285596(PAK1)
BIU: 109554525(PAK1)
PHD: 102331930
CHX: 102180827(PAK1)
OAS: 101111756(PAK1)
SSC: 100525766(PAK1)
CFR: 102514942(PAK1)
CDK: 105097456(PAK1)
BACU: 103010714(PAK1)
LVE: 103072869(PAK1)
OOR: 101288086(PAK1)
ECB: 100063217(PAK1)
EPZ: 103553799(PAK1)
EAI: 106842897(PAK1)
MYB: 102240321(PAK1) 102257226
MYD: 102755302(PAK1)
HAI: 109376015(PAK1)
RSS: 109444772(PAK1)
PALE: 102880323(PAK1)
TMU: 101343358
MDO: 100018336(PAK1)
SHR: 100928883(PAK1)
OAA: 100086384(PAK1)
GGA: 419083(PAK1)
MGP: 100543242
CJO: 107308538(PAK1)
APLA: 101795474(PAK1)
ACYG: 106039890(PAK1)
TGU: 100190755(PAK1)
GFR: 102033628(PAK1) 102033882
FAB: 101820258(PAK1)
PHI: 102109199(PAK1)
PMAJ: 107200206(PAK1) 107215873
CCW: 104690290(PAK1)
FPG: 101923101(PAK1)
FCH: 102053816(PAK1)
CLV: 102084510(PAK1)
EGZ: 104124741(PAK1)
AAM: 106495371(PAK1)
ASN: 102367767(PAK1)
AMJ: 102576325(PAK1)
PSS: 102457223(PAK1)
CMY: 102936072(PAK1)
CPIC: 101936332(PAK1)
ACS: 100554656 100568195(pak1)
PVT: 110088575(PAK1)
GJA: 107118386(PAK1)
XLA: 398126(pak1.S) 398782
XTR: 100135731(pak1)
NPR: 108794638
DRE: 373103(pak1)
SRX: 107735921
SGH: 107594372(pak1) 107600821
CCAR: 109110512
IPU: 108264802(pak1)
AMEX: 103037975(pak1)
TRU: 101064146(pak1)
NCC: 104949351
MZE: 101483196(pak1)
OLA: 101164663(pak1)
XMA: 102217297(pak1)
PRET: 103475087(pak1)
NFU: 107379762(pak1)
CSEM: 103377945(pak1)
LCF: 108882370(pak1)
HCQ: 109510807
SASA: 100380347(pak3) 106612881
ELS: 105010576(pak1)
SFM: 108921266 108924646(pak1)
LCM: 102349047(PAK1)
CMK: 103172337
CIN: 100178153
SPU: 592256
APLC: 110985992
SKO: 100367190
DME: Dmel_CG10295(Pak) Dmel_CG14895(Pak3)
DPO: Dpse_GA10224(Dpse_Pak1) Dpse_GA13332(Dpse_Pak3)
DSI: Dsimw501_GD19869(Dsim_GD19869) Dsimw501_GD20287(Dsim_GD20287)
AAG: 5575304
AME: 551659 724453(Pak)
API: 100160077
DNX: 107169134
CEL: CELE_C09B8.7(pak-1) CELE_Y38F1A.10(max-2)
CBR: CBG02802(Cbr-max-2) CBG14818(Cbr-pak-1)
BMY: Bm1_34325
CRG: 105339997
OBI: 106875408
EPA: 110251135
ADF: 107330408
AQU: 100631850
SCE: YHL007C(STE20)
ERC: Ecym_2434
KMX: KLMA_30058(STE20)
NCS: NCAS_0A05050(NCAS0A05050) NCAS_0A12350(NCAS0A12350)
NDI: NDAI_0A03870(NDAI0A03870) NDAI_0K02100(NDAI0K02100)
TPF: TPHA_0G03290(TPHA0G03290)
TBL: TBLA_0I00280(TBLA0I00280)
TDL: TDEL_0A02720(TDEL0A02720)
KAF: KAFR_0A01760(KAFR0A01760) KAFR_0D03390(KAFR0D03390)
PIC: PICST_84188(CST20)
CAL: CAALFM_C502340CA(CST20)
CDU: CD36_52140(CST20)
CAUR: QG37_03001
SLB: AWJ20_1432(STE20)
NCR: NCU03894(stk-4)
NTE: NEUTE1DRAFT88085(NEUTE1DRAFT_88085)
SMP: SMAC_06321(ste20)
MGR: MGG_12821
MAW: MAC_02685
MAJ: MAA_02118
CMT: CCM_05107
MBE: MBM_08123
ANI: AN2067.2
ANG: ANI_1_592094(An11g04320)
ABE: ARB_05261
TVE: TRV_02300
PNO: SNOG_12486(SNOG_12485)
PTE: PTT_13099
ZTR: MYCGRDRAFT_85661(MgSte20)
SPO: SPBC1604.14c(shk1)
CNE: CNF00140
CNB: CNBF4570
ABP: AGABI1DRAFT118842(AGABI1DRAFT_118842)
ABV: AGABI2DRAFT205902(AGABI2DRAFT_205902)
WSE: WALSEDRAFT_13665(Ste20p)
MGL: MGL_0010
DDI: DDB_G0267450(pakC)
DFA: DFA_04841(mkcC) DFA_05233(mkcA) DFA_08719(mkcD)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8805275
  Authors
Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J
  Title
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
  Journal
Curr Biol 6:598-605 (1996)
DOI:10.1016/S0960-9822(02)00546-8
  Sequence
[hsa:5058]
Reference
  Authors
Zhao ZS, Lim JP, Ng YW, Lim L, Manser E
  Title
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
  Journal
Mol Cell 20:237-49 (2005)
DOI:10.1016/j.molcel.2005.08.035
Reference
PMID:1464311
  Authors
Leberer E, Dignard D, Harcus D, Thomas DY, Whiteway M
  Title
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.
  Journal
EMBO J 11:4815-24 (1992)
  Sequence
[sce:YHL007C]

KEGG   ORTHOLOGY: K04410Help
Entry
K04410                      KO                                     

Name
PAK2
Definition
p21-activated kinase 2 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K04410  PAK2; p21-activated kinase 2
   04010 MAPK signaling pathway
    K04410  PAK2; p21-activated kinase 2
   04012 ErbB signaling pathway
    K04410  PAK2; p21-activated kinase 2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K04410  PAK2; p21-activated kinase 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04410  PAK2; p21-activated kinase 2
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K04410  PAK2; p21-activated kinase 2
  Development
   04360 Axon guidance
    K04410  PAK2; p21-activated kinase 2
 Human Diseases
  Cancers
   05211 Renal cell carcinoma
    K04410  PAK2; p21-activated kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04410  PAK2; p21-activated kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K04410  PAK2; p21-activated kinase 2
BRITE hierarchy
Genes
HSA: 5062(PAK2)
PTR: 460965(PAK2)
PPS: 100989051(PAK2)
GGO: 101130725(PAK2)
PON: 100439815(PAK2) 100453746
NLE: 100601244(PAK2)
MCC: 710314(PAK2)
MCF: 102115437(PAK2)
CSAB: 103242063(PAK2)
RRO: 104676374(PAK2)
RBB: 108542265(PAK2)
CJC: 100405552(PAK2)
SBQ: 101035351(PAK2)
MMU: 224105(Pak2)
RNO: 100910732 29432(Pak2)
CGE: 100751503(Pak2)
NGI: 103738502(Pak2)
HGL: 101710712(Pak2)
CCAN: 109690046(Pak2)
OCU: 100009535(PAK2)
TUP: 102472173(PAK2)
CFA: 612814(PAK2)
AML: 100475388(PAK2)
UMR: 103678928(PAK2)
ORO: 101369067(PAK2)
FCA: 101082845(PAK2)
PTG: 102968498(PAK2)
AJU: 106987894(PAK2)
BTA: 513673(PAK2)
BOM: 102282641(PAK2)
PHD: 102344188(PAK2)
CHX: 102176919(PAK2)
OAS: 101123517(PAK2)
SSC: 100511837(PAK2)
CFR: 102504877(PAK2)
CDK: 105101281(PAK2)
BACU: 103005053 103006340(PAK2)
LVE: 103082256(PAK2)
OOR: 101272383(PAK2)
ECB: 100060183(PAK2)
EPZ: 103559943(PAK2)
EAI: 106848316(PAK2)
MYB: 102250137(PAK2)
MYD: 102752411(PAK2)
HAI: 109387639(PAK2)
RSS: 109443346(PAK2)
PALE: 102886796(PAK2)
LAV: 100664379(PAK2)
TMU: 101355178
MDO: 100015796(PAK2)
SHR: 100914804(PAK2)
OAA: 100075896(PAK2)
GGA: 424860(PAK2)
MGP: 100541412(PAK2)
CJO: 107317911(PAK2)
APLA: 101794632(PAK2)
ACYG: 106039215(PAK2)
TGU: 100229114(PAK2)
GFR: 102034742(PAK2)
FAB: 101810304(PAK2)
PHI: 102107441(PAK2)
PMAJ: 107208951(PAK2)
CCW: 104696713(PAK2)
FPG: 101910950(PAK2)
FCH: 102046818(PAK2)
CLV: 102088494(PAK2)
EGZ: 104131279(PAK2)
AAM: 106492613(PAK2)
ASN: 102385322(PAK2)
AMJ: 102571099(PAK2)
PSS: 102452394(PAK2)
CMY: 102943108(PAK2)
CPIC: 101946525(PAK2)
ACS: 100561625(pak2)
PVT: 110075278(PAK2)
PBI: 103051423(PAK2)
GJA: 107113978(PAK2)
XLA: 108717139 399090(pak2.S)
XTR: 733718(pak2)
NPR: 108790159(PAK2)
DRE: 266749(pak2a) 325034(pak2b)
IPU: 108267562 108271286(pak2)
AMEX: 103022965(pak2) 103038595
TRU: 101072607 101075040(pak2)
LCO: 104919114(pak2) 104939638
NCC: 104962686(pak2)
MZE: 101473947 101482829(pak2)
OLA: 101167280(pak2) 101169249
XMA: 102222129 102229449(pak2)
PRET: 103458433 103463803(pak2)
NFU: 107392096 107393427(pak2)
CSEM: 103376672(pak2) 103379106
LCF: 108875038 108879127(pak2)
HCQ: 109517331 109532388(pak2)
ELS: 105011658(pak2) 105019806
LCM: 102367003(PAK2)
CMK: 103172351 103172733(pak2)
TSP: Tsp_07847
OBI: 106869191
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7744004
  Authors
Martin GA, Bollag G, McCormick F, Abo A
  Title
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
  Journal
EMBO J 14:1970-8 (1995)
  Sequence
[hsa:5062]

KEGG   ORTHOLOGY: K05733Help
Entry
K05733                      KO                                     

Name
PAK3, MRX30
Definition
p21-activated kinase 3 [EC:2.7.11.1]
Pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05211  Renal cell carcinoma
Disease
H00480  Non-syndromic X-linked mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05733  PAK3, MRX30; p21-activated kinase 3
   04012 ErbB signaling pathway
    K05733  PAK3, MRX30; p21-activated kinase 3
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05733  PAK3, MRX30; p21-activated kinase 3
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05733  PAK3, MRX30; p21-activated kinase 3
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K05733  PAK3, MRX30; p21-activated kinase 3
  Development
   04360 Axon guidance
    K05733  PAK3, MRX30; p21-activated kinase 3
 Human Diseases
  Cancers
   05211 Renal cell carcinoma
    K05733  PAK3, MRX30; p21-activated kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05733  PAK3, MRX30; p21-activated kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K05733  PAK3, MRX30; p21-activated kinase 3
BRITE hierarchy
Genes
HSA: 5063(PAK3)
PTR: 450118(PAK3)
PPS: 100988375(PAK3)
GGO: 101141425(PAK3)
PON: 100294571(PAK3)
NLE: 100592637(PAK3)
MCC: 706217(PAK3)
MCF: 101866329(PAK3)
CSAB: 103232488(PAK3)
RRO: 104658196 104668306
CJC: 100413676(PAK3)
SBQ: 101030350(PAK3)
MMU: 18481(Pak3)
RNO: 29433(Pak3)
CGE: 100774215(Pak3)
NGI: 103750017(Pak3)
HGL: 101712811(Pak3)
CCAN: 109683839
OCU: 100347273(PAK3)
TUP: 102500036(PAK3)
CFA: 492067(PAK3)
AML: 100481001(PAK3)
UMR: 103679739(PAK3)
ORO: 101367940(PAK3)
FCA: 101092248(PAK3)
PTG: 102960506(PAK3)
AJU: 106985609(PAK3)
BTA: 534526(PAK3)
BOM: 102274792(PAK3)
BIU: 109555415(PAK3)
PHD: 102330386(PAK3)
CHX: 102183402(PAK3)
OAS: 101110391(PAK3)
SSC: 100624533(PAK3)
CFR: 102517603(PAK3)
CDK: 105102082(PAK3)
BACU: 103011843(PAK3)
LVE: 103077310(PAK3)
OOR: 101272214(PAK3)
ECB: 100054315(PAK3)
EPZ: 103566208(PAK3)
EAI: 106839173(PAK3)
MYB: 102250915(PAK3)
MYD: 102755275(PAK3)
HAI: 109392102(PAK3)
PALE: 102886090(PAK3)
LAV: 100668837(PAK3)
TMU: 101352984
MDO: 100012727(PAK3)
SHR: 100926699
OAA: 100073584(PAK3)
GGA: 422342(PAK3)
MGP: 100539360(PAK3)
CJO: 107312836(PAK3)
APLA: 101796600(PAK3)
ACYG: 106038527(PAK3)
TGU: 100218271 100220716(PAK3)
GFR: 102042620(PAK3)
FPG: 101915790(PAK3)
FCH: 102049349(PAK3)
CLV: 102088276(PAK3)
EGZ: 104135693(PAK3)
AAM: 106494786(PAK3)
ASN: 102383228(PAK3)
AMJ: 102571123(PAK3)
PSS: 102455282(PAK3)
CMY: 102944295(PAK3)
CPIC: 101948199(PAK3)
ACS: 100552681(pak3)
PVT: 110074346(PAK3)
PBI: 103051014(PAK3)
GJA: 107106346(PAK3)
XLA: 108700104 378493(pak3.L)
XTR: 100495025(pak3)
NPR: 108796965
SRX: 107712492
SGH: 107566210
CCAR: 109078806
IPU: 108260344
AMEX: 103043289
TRU: 101070991(pak3)
LCO: 104935297(pak3)
MZE: 101484450(pak3)
OLA: 101162700
XMA: 102230909
PRET: 103475835
NFU: 107386444
CSEM: 103395561(pak3)
LCF: 108893764
HCQ: 109517832
BPEC: 110158383
ELS: 105030442
LCM: 102350692 102367518(PAK3)
CMK: 103178926(pak3)
SPU: 576091
CRG: 105329587
HMG: 100205313
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9731525
  Authors
Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA
  Title
PAK3 mutation in nonsyndromic X-linked mental retardation.
  Journal
Nat Genet 20:25-30 (1998)
DOI:10.1038/1675
  Sequence
[hsa:5063]

KEGG   ORTHOLOGY: K05734Help
Entry
K05734                      KO                                     

Name
PAK4
Definition
p21-activated kinase 4 [EC:2.7.11.1]
Pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05734  PAK4; p21-activated kinase 4
   04012 ErbB signaling pathway
    K05734  PAK4; p21-activated kinase 4
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05734  PAK4; p21-activated kinase 4
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05734  PAK4; p21-activated kinase 4
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K05734  PAK4; p21-activated kinase 4
  Development
   04360 Axon guidance
    K05734  PAK4; p21-activated kinase 4
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K05734  PAK4; p21-activated kinase 4
   05211 Renal cell carcinoma
    K05734  PAK4; p21-activated kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05734  PAK4; p21-activated kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K05734  PAK4; p21-activated kinase 4
BRITE hierarchy
Genes
HSA: 10298(PAK4)
PTR: 100609406(PAK4)
PPS: 100977098(PAK4)
GGO: 101127864(PAK4)
PON: 100457556(PAK4)
NLE: 100597455(PAK4)
MCC: 696676(PAK4)
MCF: 102136180(PAK4)
CSAB: 103234655(PAK4)
RRO: 104676163(PAK4)
RBB: 108539083(PAK4)
CJC: 100394713(PAK4)
SBQ: 101030928(PAK4)
MMU: 70584(Pak4)
RNO: 292756(Pak4)
CGE: 100760399(Pak4)
NGI: 103750732(Pak4)
HGL: 101720492(Pak4)
CCAN: 109700193(Pak4)
OCU: 100341934(PAK4)
TUP: 102499692(PAK4)
CFA: 484513(PAK4)
AML: 100470043(PAK4)
UMR: 103661079(PAK4)
ORO: 101384125(PAK4)
FCA: 101098348(PAK4)
PTG: 102950254(PAK4)
AJU: 106988317(PAK4)
BTA: 539742(PAK4)
BOM: 102269333(PAK4)
PHD: 102321215(PAK4)
CHX: 102182530(PAK4)
OAS: 101115152(PAK4)
SSC: 100627936(PAK4)
CFR: 102522034(PAK4)
CDK: 105093311(PAK4)
BACU: 103005169(PAK4)
LVE: 103077393(PAK4)
OOR: 101278812(PAK4)
ECB: 100067000(PAK4)
EPZ: 103566036(PAK4)
EAI: 106836087(PAK4)
MYB: 102258522(PAK4)
MYD: 102765651(PAK4)
HAI: 109395380(PAK4)
RSS: 109458091(PAK4)
PALE: 102880509(PAK4)
LAV: 100661100(PAK4)
TMU: 101358969
MDO: 100013977(PAK4)
SHR: 100919323(PAK4)
GGA: 770462(PAK4)
MGP: 100540875(PAK4)
CJO: 107307364(PAK4)
APLA: 101801484
ACYG: 106029434(PAK4)
TGU: 100219560(PAK4)
PHI: 102100394(PAK4)
FPG: 101921802(PAK4)
FCH: 102047228
CLV: 102084671(PAK4)
ASN: 102373773(PAK4)
AMJ: 102557832(PAK4) 106738920
PSS: 102456757(PAK4)
CMY: 102932014(PAK4)
CPIC: 101941761(PAK4)
ACS: 100563762(pak4)
PVT: 110075619(PAK4)
PBI: 103068027(PAK4)
GJA: 107116363
XLA: 108700290 398224(pak5.L)
XTR: 100036644(pak4)
NPR: 108804973(PAK4)
DRE: 431769(pak4)
IPU: 108278171(pak4)
AMEX: 103028438(pak4)
TRU: 101062253(pak4)
LCO: 104931224(pak4)
NCC: 104949688(pak4)
MZE: 101465929
OLA: 101162543(pak4)
XMA: 102225392
PRET: 103475211(pak4)
NFU: 107379775
CSEM: 103377907(pak4)
LCF: 108872688(pak4)
HCQ: 109510834(pak4)
BPEC: 110172689(pak4)
ELS: 105012762(pak4)
SFM: 108928792(pak4)
LCM: 102367182(PAK4)
CEL: CELE_C45B11.1(pak-2)
CBR: CBG23079(Cbr-pak-2)
BMY: Bm1_15470
TSP: Tsp_02880
OBI: 106877174
EPA: 110253972
ADF: 107341495
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hofmann C, Shepelev M, Chernoff J
  Title
The genetics of Pak.
  Journal
J Cell Sci 117:4343-54 (2004)
DOI:10.1242/jcs.01392
Reference
PMID:9822598
  Authors
Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A
  Title
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
  Journal
EMBO J 17:6527-40 (1998)
DOI:10.1093/emboj/17.22.6527
  Sequence
[hsa:10298]

KEGG   ORTHOLOGY: K05735Help
Entry
K05735                      KO                                     

Name
PAK6
Definition
p21-activated kinase 6 [EC:2.7.11.1]
Pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05735  PAK6; p21-activated kinase 6
   04012 ErbB signaling pathway
    K05735  PAK6; p21-activated kinase 6
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05735  PAK6; p21-activated kinase 6
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05735  PAK6; p21-activated kinase 6
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K05735  PAK6; p21-activated kinase 6
  Development
   04360 Axon guidance
    K05735  PAK6; p21-activated kinase 6
 Human Diseases
  Cancers
   05211 Renal cell carcinoma
    K05735  PAK6; p21-activated kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05735  PAK6; p21-activated kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K05735  PAK6; p21-activated kinase 6
BRITE hierarchy
Genes
HSA: 106821730(BUB1B-PAK6) 56924(PAK6)
PTR: 453327(PAK6)
PPS: 100969934(PAK6)
GGO: 101140999(PAK6)
PON: 100172971(PAK6)
NLE: 100579258(PAK6)
MCC: 701589(PAK6)
MCF: 101926308(PAK6)
CSAB: 103245847(PAK6)
RRO: 104659671(PAK6)
RBB: 108526909(PAK6)
CJC: 100387874(PAK6)
SBQ: 101053141(PAK6)
MMU: 214230(Pak6)
RNO: 296078(Pak6)
CGE: 100758984(Pak6)
NGI: 103741500(Pak6)
HGL: 101706200(Pak6)
OCU: 100348921(PAK6)
TUP: 102493316(PAK6)
CFA: 100856038(PAK6)
AML: 100464295(PAK6)
UMR: 103673553(PAK6)
ORO: 101373249(PAK6)
FCA: 101091201
PTG: 102972937(PAK6)
AJU: 106968580(PAK6)
BTA: 539224(PAK6)
BOM: 102275091(PAK6)
BIU: 109564925(PAK6)
PHD: 102334454(PAK6)
CHX: 100860973(PAK6)
OAS: 101112573(PAK6)
SSC: 100153981(PAK6)
CFR: 102521615(PAK6)
CDK: 105096888(PAK6)
BACU: 103016702(PAK6)
LVE: 103078952(PAK6)
OOR: 101288739(PAK6)
ECB: 100071463(PAK6)
EPZ: 103561631(PAK6)
EAI: 106835170(PAK6)
MYB: 102251863(PAK6)
MYD: 102760811(PAK6)
HAI: 109384074
RSS: 109444242
PALE: 102896564(PAK6)
LAV: 100660904
TMU: 101346499
MDO: 100619824(PAK6)
SHR: 100924604(PAK6)
OAA: 100084781(PAK6)
GGA: 428837(PAK6)
MGP: 100543151(PAK6)
CJO: 107314231(PAK6)
APLA: 101804885(PAK6)
ACYG: 106047078(PAK6)
TGU: 100227771(PAK6)
GFR: 102033561(PAK6)
FAB: 101822249(PAK6)
PHI: 102105260(PAK6)
PMAJ: 107205813(PAK6)
CCW: 104692978(PAK6)
FPG: 101912126(PAK6)
FCH: 102047737(PAK6)
CLV: 102096449(PAK6)
EGZ: 104131361(PAK6)
AAM: 106486712(PAK6)
ASN: 102376676(PAK6)
AMJ: 102571681(PAK6)
PSS: 102460525(PAK6)
CMY: 102944557(PAK6)
CPIC: 101952992(PAK6)
ACS: 100554764(pak6)
PVT: 110080124(PAK6)
PBI: 103058713(PAK6)
GJA: 107119643(PAK6)
XLA: 108699252(pak6.L) 108700316(pak6.S)
XTR: 100495355(pak6)
NPR: 108789294(PAK6)
DRE: 100536197 567874(pak6b)
CCAR: 109076124
IPU: 108257961(PAK6) 108269614
AMEX: 103030407 103035957(pak6)
TRU: 101076479(pak6) 105418661
LCO: 104924815(pak6) 104933198
NCC: 104953739(pak6)
MZE: 101464122 101475185(pak6)
OLA: 101157339 101175447(pak6)
XMA: 102223926 102231183(pak6)
PRET: 103457125 103458560(pak6)
NFU: 107377909 107392482(pak6)
LCF: 108890034 108892603(pak6)
HCQ: 109516085(pak6)
BPEC: 110155399(pak6)
SFM: 108919555(pak6)
LCM: 102355098
HMG: 100200367
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schrantz N, da Silva Correia J, Fowler B, Ge Q, Sun Z, Bokoch GM
  Title
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
  Journal
J Biol Chem 279:1922-31 (2004)
DOI:10.1074/jbc.M311145200

KEGG   ORTHOLOGY: K05736Help
Entry
K05736                      KO                                     

Name
PAK5, PAK7
Definition
p21-activated kinase 5 [EC:2.7.11.1]
Pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04660  T cell receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
   04012 ErbB signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05736  PAK5, PAK7; p21-activated kinase 5
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05736  PAK5, PAK7; p21-activated kinase 5
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
  Development
   04360 Axon guidance
    K05736  PAK5, PAK7; p21-activated kinase 5
 Human Diseases
  Cancers
   05211 Renal cell carcinoma
    K05736  PAK5, PAK7; p21-activated kinase 5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05736  PAK5, PAK7; p21-activated kinase 5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE20 family
   K05736  PAK5, PAK7; p21-activated kinase 5
BRITE hierarchy
Genes
HSA: 57144(PAK5)
PTR: 469876(PAK5)
PPS: 100979774(PAK5)
GGO: 101124352(PAK5)
PON: 100174593(PAK7)
NLE: 100579630(PAK5)
MCC: 719458(PAK5)
MCF: 101926721(PAK5)
CSAB: 103246560(PAK5)
RRO: 104655775(PAK5)
RBB: 108527563(PAK5)
CJC: 100411048(PAK5)
SBQ: 101045496(PAK7)
MMU: 241656(Pak7)
RNO: 311450(Pak7)
CGE: 100770198(Pak5)
NGI: 103729196(Pak5)
HGL: 101697197(Pak5)
CCAN: 109688863(Pak5)
OCU: 100340742(PAK5)
TUP: 102474805(PAK5)
CFA: 485772(PAK5)
AML: 100481254(PAK5)
UMR: 103674429(PAK5)
ORO: 101362594(PAK7)
FCA: 101091011(PAK5)
PTG: 102959873(PAK5)
AJU: 106976429(PAK5)
BTA: 513432(PAK5)
BOM: 102288324(PAK5)
BIU: 109567943(PAK5)
PHD: 102317299(PAK5)
CHX: 102181217(PAK5)
OAS: 101107882(PAK7)
SSC: 100152316(PAK5)
CFR: 102512936(PAK5)
CDK: 105101260(PAK5)
BACU: 102999931(PAK5)
LVE: 103077706(PAK5)
OOR: 101271942(PAK7)
ECB: 100051415(PAK5)
EPZ: 103559731(PAK5)
EAI: 106823207(PAK5)
MYB: 102240345(PAK5)
MYD: 102752532(PAK5)
HAI: 109378999(PAK5)
RSS: 109449038(PAK5)
PALE: 102884535(PAK5)
LAV: 100666744(PAK5)
TMU: 101361889
MDO: 100033279(PAK5)
SHR: 100932749(PAK5)
OAA: 100084350(PAK5)
GGA: 416734(PAK5)
MGP: 100547824(PAK5)
CJO: 107310935(PAK5)
APLA: 101789812(PAK5)
ACYG: 106036610(PAK7)
TGU: 100224879(PAK5)
GFR: 102045516(PAK5)
FAB: 101810542(PAK5)
PHI: 102100245(PAK5)
PMAJ: 107201333(PAK5)
CCW: 104691523(PAK5)
FPG: 101917292(PAK5)
FCH: 102054246(PAK5)
CLV: 102098855(PAK5)
EGZ: 104132996(PAK7)
AAM: 106490395(PAK5)
ASN: 102376998(PAK5)
AMJ: 102558433(PAK5)
PSS: 102456678(PAK5)
CMY: 102943132(PAK5)
CPIC: 101953291(PAK5)
ACS: 100560563(pak5)
PVT: 110090819(PAK5)
PBI: 103058150(PAK5)
GJA: 107123895(PAK5)
XTR: 100145129(pak5)
NPR: 108795532(PAK5)
DRE: 405898(pak7)
IPU: 108257526(pak5)
AMEX: 103023523(pak5)
TRU: 101065597(pak5)
LCO: 104919803(pak5)
NCC: 104949786(pak7)
MZE: 101463583(pak5)
OLA: 101159788(pak5)
XMA: 102223306(pak5)
PRET: 103457878(pak5)
NFU: 107378108(pak7)
CSEM: 103381003(pak7)
LCF: 108896930(pak5)
HCQ: 109523359(pak5)
BPEC: 110168289(pak5)
ELS: 105017523(pak5)
SFM: 108929398(pak5)
LCM: 102347021(PAK5)
CMK: 103186430(pak5) 103187528(pak6)
CIN: 100175395
SPU: 587831
APLC: 110988957
SKO: 100378766
DME: Dmel_CG18582(mbt)
DPO: Dpse_GA15000(Dpse_mbt)
DSI: Dsimw501_GD17288(Dsim_GD17288)
MDE: 101893437
AAG: 5566181
AME: 726405(mbt)
BIM: 100744101
BTER: 100643434
SOC: 105193946
AEC: 105147967
ACEP: 105623486
PBAR: 105430497
HST: 105191062
CFO: 105249243
LHU: 105676520
PGC: 109859795
NVI: 100115383(Mbt)
FCD: 110844300
CRG: 105342389
MYI: 110466349
SHX: MS3_05477
AQU: 100639104
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wu X, Carr HS, Dan I, Ruvolo PP, Frost JA
  Title
p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.
  Journal
J Cell Biochem 105:167-75 (2008)
DOI:10.1002/jcb.21809

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