KEGG   ORTHOLOGY: K04416Help
Entry
K04416                      KO                                     

Name
MAP3K1, MEKK1
Definition
mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04530  Tight junction
ko04622  RIG-I-like receptor signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko05161  Hepatitis B
ko05166  HTLV-I infection
Module
M00688  MAPK (JNK) signaling
M00689  MAPK (p38) signaling
Disease
H00607  46,XY disorders of sex development (Disorders of gonadal development)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Cellular Processes
  Cellular community - eukaryotes
   04530 Tight junction
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  Endocrine system
   04912 GnRH signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 Human Diseases
  Infectious diseases
   05166 HTLV-I infection
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   05161 Hepatitis B
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
    M00689  MAPK (p38) signaling
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
BRITE hierarchy
Other DBs
GO: 0004709
Genes
HSA: 4214(MAP3K1)
PTR: 471543(MAP3K1)
PPS: 100994796(MAP3K1)
GGO: 101136722(MAP3K1) 109025231
PON: 100453309(MAP3K1)
NLE: 100606554(MAP3K1)
MCC: 710979(MAP3K1)
MCF: 102123041(MAP3K1)
CSAB: 103221701(MAP3K1)
RRO: 104657086(MAP3K1)
RBB: 108530959(MAP3K1)
CJC: 100389500(MAP3K1)
SBQ: 101054366(MAP3K1)
MMU: 26401(Map3k1)
RNO: 100912399 116667(Map3k1)
CGE: 100770540(Map3k1)
NGI: 103739909(Map3k1)
HGL: 101720769(Map3k1)
CCAN: 109695531(Map3k1)
OCU: 100348484(MAP3K1)
TUP: 102483890(MAP3K1)
CFA: 478061(MAP3K1)
AML: 100466442(MAP3K1)
UMR: 103663891(MAP3K1)
ORO: 101366511(MAP3K1)
FCA: 101090328(MAP3K1)
PTG: 102971191(MAP3K1)
AJU: 106975243(MAP3K1)
BTA: 523962(MAP3K1)
BOM: 102267592(MAP3K1)
BIU: 109574889(MAP3K1)
PHD: 102329106(MAP3K1)
CHX: 102187530(MAP3K1)
OAS: 101112260(MAP3K1)
SSC: 396617(MAP3K1)
CFR: 102505358(MAP3K1)
CDK: 105087133(MAP3K1)
BACU: 103002185(MAP3K1)
LVE: 103083385(MAP3K1)
OOR: 101288918(MAP3K1)
ECB: 100061688(MAP3K1)
EPZ: 103548212(MAP3K1)
EAI: 106843371(MAP3K1)
MYB: 102258632(MAP3K1)
MYD: 102763786(MAP3K1)
HAI: 109385705(MAP3K1)
RSS: 109453502(MAP3K1)
PALE: 102886741(MAP3K1)
LAV: 100655149(MAP3K1)
TMU: 101361190
MDO: 100032065(MAP3K1)
SHR: 100913571(MAP3K1)
OAA: 100076612(MAP3K1)
GGA: 427144(MAP3K1)
MGP: 100550623(MAP3K1)
CJO: 107306009(MAP3K1)
APLA: 101793656
ACYG: 106035615(MAP3K1)
TGU: 100225825(MAP3K1)
GFR: 102044899(MAP3K1)
FAB: 101807669(MAP3K1)
PHI: 102103765(MAP3K1)
PMAJ: 107216401(MAP3K1)
CCW: 104686679(MAP3K1)
FPG: 101911178(MAP3K1)
FCH: 102045898(MAP3K1)
CLV: 102097744(MAP3K1)
EGZ: 104134700(MAP3K1)
AAM: 106489299 106498914(MAP3K1)
ASN: 102376941(MAP3K1)
AMJ: 102562794(MAP3K1)
PSS: 102463619(MAP3K1)
CMY: 102938448(MAP3K1)
CPIC: 101933464(MAP3K1)
ACS: 100561745(map3k1)
PVT: 110085400(MAP3K1)
PBI: 103048285(MAP3K1)
GJA: 107123377(MAP3K1)
XLA: 108704427(map3k1.S) 108718321(map3k1.L)
XTR: 100490504(map3k1)
NPR: 108792018(MAP3K1)
DRE: 100334486(map3k1)
SGH: 107558252 107560413(map3k1)
IPU: 108277254(map3k1)
AMEX: 103042517(map3k1)
SASA: 106562896 106571505(map3k1)
ELS: 105021721(map3k1)
SFM: 108929962(map3k1)
LCM: 102355070(MAP3K1)
CMK: 103177870(map3k1)
SPU: 590478
APLC: 110989629
SKO: 102807412
ZNE: 110828229
CRG: 105331404
MYI: 110443661
OBI: 106881243
SHX: MS3_10207
EPA: 110255124
ADF: 107327485
HMG: 100202032
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T
  Title
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
  Journal
Mol Cell 9:945-56 (2002)
DOI:10.1016/S1097-2765(02)00519-1
Reference
PMID:9808624
  Authors
Xia Y, Wu Z, Su B, Murray B, Karin M
  Title
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
  Journal
Genes Dev 12:3369-81 (1998)
DOI:10.1101/gad.12.21.3369
  Sequence
[hsa:4214]

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