KEGG ORTHOLOGY: K04427

ORTHOLOGY: K04427

Entry

K04427 KO

Name

MAP3K7, TAK1

Definition

mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]

Pathway

ko04010	MAPK signaling pathway
ko04013	MAPK signaling pathway - fly
ko04064	NF-kappa B signaling pathway
ko04140	Autophagy - animal
ko04152	AMPK signaling pathway
ko04214	Apoptosis - fly
ko04310	Wnt signaling pathway
ko04380	Osteoclast differentiation
ko04520	Adherens junction
ko04620	Toll-like receptor signaling pathway
ko04621	NOD-like receptor signaling pathway
ko04622	RIG-I-like receptor signaling pathway
ko04624	Toll and Imd signaling pathway
ko04657	IL-17 signaling pathway
ko04660	T cell receptor signaling pathway
ko04668	TNF signaling pathway
ko05140	Leishmaniasis
ko05145	Toxoplasmosis
ko05162	Measles
ko05168	Herpes simplex infection
ko05169	Epstein-Barr virus infection
ko05418	Fluid shear stress and atherosclerosis

Module

M00686	Toll-like receptor signaling
M00688	MAPK (JNK) signaling
M00689	MAPK (p38) signaling

Brite

KEGG Orthology (KO) [BR:ko00001]
Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04310 Wnt signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04064 NF-kappa B signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04668 TNF signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04152 AMPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Cell growth and death
   04214 Apoptosis - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Cellular community - eukaryotes
   04520 Adherens junction
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04621 NOD-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04622 RIG-I-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04660 T cell receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04657 IL-17 signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Development
   04380 Osteoclast differentiation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Infectious diseases
   05162 Measles
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05168 Herpes simplex infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05169 Epstein-Barr virus infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05145 Toxoplasmosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05140 Leishmaniasis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
KEGG modules [BR:ko00002]
Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00689  MAPK (p38) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00686  Toll-like receptor signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Protein kinases [BR:ko01001]
Serine/threonine protein kinases: TKL group
  MLK family
   K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7

Other DBs

GO:

0004709

Genes

HSA:	6885(MAP3K7)
PTR:	462888(MAP3K7)
PPS:	100974026(MAP3K7)
GGO:	101144707(MAP3K7)
PON:	100171454(MAP3K7)
NLE:	100596471(MAP3K7)
MCC:	703101(MAP3K7)
MCF:	102140498(MAP3K7)
CSAB:	103240115(MAP3K7)
RRO:	104657888(MAP3K7)
RBB:	108539499(MAP3K7)
CJC:	100403175(MAP3K7)
SBQ:	101045636(MAP3K7)
MMU:	26409(Map3k7)
RNO:	100910771 313121(Map3k7)
CGE:	100774341(Map3k7)
NGI:	103739547(Map3k7)
HGL:	101718269(Map3k7)
CCAN:	109698497(Map3k7)
OCU:	100343571(MAP3K7)
TUP:	102477331(MAP3K7)
CFA:	102156745(MAP3K7)
AML:	100466506(MAP3K7)
UMR:	103660092(MAP3K7)
FCA:	101095899(MAP3K7)
PTG:	102963341(MAP3K7)
AJU:	106983077(MAP3K7)
BTA:	529146(MAP3K7)
BOM:	102264816(MAP3K7)
BIU:	109563902(MAP3K7)
PHD:	102316264(MAP3K7)
CHX:	102172719(MAP3K7)
OAS:	101108056(MAP3K7)
SSC:	100135663(MAP3K7)
CFR:	102519538(MAP3K7)
CDK:	105095522(MAP3K7)
BACU:	103019299(MAP3K7)
LVE:	103075340(MAP3K7)
ECB:	100065841(MAP3K7)
EPZ:	103548805(MAP3K7)
EAI:	106847421(MAP3K7)
MYB:	102254118(MAP3K7)
MYD:	102763957(MAP3K7)
HAI:	109389465(MAP3K7)
RSS:	109453514(MAP3K7)
PALE:	102882452(MAP3K7)
LAV:	100667170(MAP3K7)
MDO:	100019975(MAP3K7)
SHR:	100920997(MAP3K7)
OAA:	100076229(MAP3K7)
GGA:	421808(MAP3K7)
MGP:	100539749(MAP3K7)
CJO:	107311964(MAP3K7)
APLA:	101800996(MAP3K7)
ACYG:	106035399(MAP3K7)
TGU:	100221443(MAP3K7)
GFR:	102039929(MAP3K7)
FAB:	101814532(MAP3K7)
PHI:	102107403(MAP3K7)
PMAJ:	107201717(MAP3K7)
CCW:	104692210(MAP3K7)
FPG:	101917746(MAP3K7)
FCH:	102058816(MAP3K7)
AAM:	106489690(MAP3K7)
ASN:	102386999(MAP3K7)
AMJ:	102569201(MAP3K7)
CMY:	102936052(MAP3K7)
CPIC:	101931315(MAP3K7)
ACS:	100554725(map3k7)
PVT:	110074609(MAP3K7)
PBI:	103067633(MAP3K7)
GJA:	107114874(MAP3K7)
XLA:	379399(map3k7.S) 399459(map3k7.L)
XTR:	100101764(map3k7)
NPR:	108800110(MAP3K7)
DRE:	553788(map3k7)
SRX:	107737344 107755269
SANH:	107665363 107683934
SGH:	107597461 107601937
IPU:	108256841(map3k7)
TRU:	101063524(map3k7)
TNG:	GSTEN00000761G001 GSTEN00010129G001
LCO:	104924081(map3k7) 104928162
NCC:	104947845 104967255
MZE:	101475992 101484924(map3k7)
OLA:	101164271(map3k7)
XMA:	102226534(map3k7) 102232287
CSEM:	103380691(map3k7)
LCF:	108897885 108899288(map3k7)
HCQ:	109509350(map3k7) 109529256
BPEC:	110154967 110171242(map3k7)
SASA:	100196829(map3k7) 106571331 106572417 106610755
ELS:	105015746 105017873(map3k7)
SFM:	108929345(map3k7)
LCM:	102358159(MAP3K7)
CMK:	103178276(map3k7)
BFO:	BRAFLDRAFT_125878
CIN:	778771(tak1/mapkkk7)
SPU:	590951
SKO:	100313751
DME:	Dmel_CG18492(Tak1) Dmel_CG31421(Takl1) Dmel_CG4803(Takl2)
DPO:	Dpse_GA14958 Dpse_GA16242 Dpse_GA18443
DAN:	Dana_GF15984 Dana_GF18291 Dana_GF18313 Dana_GF18314
DER:	Dere_GG12489 Dere_GG15158 Dere_GG17579
DPE:	Dper_GL15931 Dper_GL23779 Dper_GL27129
DSE:	Dsec_GM22666 Dsec_GM23162 Dsec_GM23620
DSI:	Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD20035(Dsim_GD20035)
DWI:	Dwil_GK20056
DYA:	Dyak_GE15342(Dyak_Tak1)
DGR:	Dgri_GH10917 Dgri_GH14242 Dgri_GH16081 Dgri_GH17233 Dgri_GH17735 Dgri_GH23480
DMO:	Dmoj_GI15482 Dmoj_GI16905 Dmoj_GI17788 Dmoj_GI23232 Dmoj_GI26970
DVI:	Dvir_GJ14078 Dvir_GJ17190 Dvir_GJ19194 Dvir_GJ20893 Dvir_GJ22892 Dvir_GJ26047 Dvir_GJ26873
MDE:	101898114
AGA:	AgaP_AGAP013516
AAG:	AaeL_AAEL007035
CQU:	CpipJ_CPIJ006370
AME:	413809(Tak1)
BIM:	100746656
BTER:	100631093
SOC:	105207936
AEC:	105150983
ACEP:	105619960
PBAR:	105427629
HST:	105187438
CFO:	105256050
LHU:	105676340
PGC:	109853437
NVI:	100120628
TCA:	656961(Tak1)
DPA:	109538196
NVL:	108560912
BMOR:	101744000
DPL:	KGM_200403
PXY:	105380044
API:	100159713
DNX:	107169096
PHU:	Phum_PHUM125410
DPX:	DAPPUDRAFT_301643
ISC:	IscW_ISCW023496
TUT:	107362121
CEL:	CELE_Y105C5A.24(Y105C5A.24)
BMY:	Bm1_26085
LOA:	LOAG_02503
HRO:	HELRODRAFT_69369
LGI:	LOTGIDRAFT_217017
CRG:	105332318
OBI:	106880926
LAK:	106163922 106176484
OVI:	T265_06651
NVE:	NEMVE_v1g87118
ADF:	107335569
HMG:	100206143 100206191
TAD:	TRIADDRAFT_25066
BOE:	106339201
VRA:	106765909
CCAJ:	109817926
MTR:	MTR_5g019700
CAM:	101505952
CRE:	CHLREDRAFT_173118 CHLREDRAFT_182152
CVR:	CHLNCDRAFT_50283
APRO:	F751_0620 F751_5403
GSL:	Gasu_62740
EIV:	EIN_082010 EIN_122830 EIN_143500 EIN_220700 EIN_266660 EIN_391770 EIN_401340 EIN_451980 EIN_497030
SMIN:	v1.2.003218.t1(symbB.v1.2.003218.t1) v1.2.003218.t2(symbB.v1.2.003218.t2) v1.2.005256.t1(symbB.v1.2.005256.t1) v1.2.010154.t1(symbB.v1.2.010154.t1)
PIF:	PITG_10780 PITG_20772
PSOJ:	PHYSODRAFT_260691 PHYSODRAFT_289074 PHYSODRAFT_489243 PHYSODRAFT_494891 PHYSODRAFT_496725 PHYSODRAFT_506773 PHYSODRAFT_516459 PHYSODRAFT_518438 PHYSODRAFT_565559
SPAR:	SPRG_01258 SPRG_06533 SPRG_07990 SPRG_08663 SPRG_09304 SPRG_11593 SPRG_12270 SPRG_12770 SPRG_13523 SPRG_14201 SPRG_15119 SPRG_15120 SPRG_15195 SPRG_15453 SPRG_16387 SPRG_18684 SPRG_21534
EHX:	EMIHUDRAFT_118901 EMIHUDRAFT_54259
GTT:	GUITHDRAFT_116496 GUITHDRAFT_116789 GUITHDRAFT_151198 GUITHDRAFT_164427 GUITHDRAFT_40459 GUITHDRAFT_41962 GUITHDRAFT_45897 GUITHDRAFT_53290 GUITHDRAFT_58972 GUITHDRAFT_69012 GUITHDRAFT_72031
NGR:	NAEGRDRAFT_30678 NAEGRDRAFT_64576

» show all

Reference

PMID:9079627

Authors

Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E

Title

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.

Journal

J Biol Chem 272:8141-4 (1997)
DOI:10.1074/jbc.272.13.8141

Sequence

[hsa:6885]

Reference

PMID:9480845

Authors

Sakurai H, Shigemori N, Hasegawa K, Sugita T

Title

TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.

Journal

Biochem Biophys Res Commun 243:545-9 (1998)
DOI:10.1006/bbrc.1998.8124

Sequence

[hsa:6885]

All links

Ontology (6)   
   KEGG BRITE (5)   
   GO (1)   
Pathway (47)   
   KEGG PATHWAY (44)   
   KEGG MODULE (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (537)   
   KEGG GENES (268)   
   KEGG MGENES (157)   
   RefGene (37)   
   EGENES (45)   
   OC (30)   
Protein sequence (156)   
   UniProt (149)   
   SWISS-PROT (7)   
Literature (2)   
   PubMed (2)   
All databases (749)   

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