KEGG   ORTHOLOGY: K04427Help
Entry
K04427                      KO                                     

Name
MAP3K7, TAK1
Definition
mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
Pathway
MAPK signaling pathway
MAPK signaling pathway - fly
NF-kappa B signaling pathway
Autophagy - animal
AMPK signaling pathway
Apoptosis - fly
Wnt signaling pathway
Osteoclast differentiation
Adherens junction
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Toll and Imd signaling pathway
IL-17 signaling pathway
T cell receptor signaling pathway
TNF signaling pathway
Leishmaniasis
Toxoplasmosis
Measles
Herpes simplex infection
Epstein-Barr virus infection
Fluid shear stress and atherosclerosis
Module
M00686  
Toll-like receptor signaling
M00688  
MAPK (JNK) signaling
M00689  
MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04310 Wnt signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04064 NF-kappa B signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04668 TNF signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04152 AMPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Cell growth and death
   04214 Apoptosis - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Cellular community - eukaryotes
   04520 Adherens junction
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04621 NOD-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04622 RIG-I-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04660 T cell receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04657 IL-17 signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Development
   04380 Osteoclast differentiation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  Infectious diseases
   05162 Measles
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05168 Herpes simplex infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05169 Epstein-Barr virus infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05145 Toxoplasmosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05140 Leishmaniasis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00689  MAPK (p38) signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
    M00686  Toll-like receptor signaling
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  MLK family
   K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
6885(MAP3K7)
PTR: 
462888(MAP3K7)
PPS: 
100974026(MAP3K7)
GGO: 
101144707(MAP3K7)
PON: 
100171454(MAP3K7)
NLE: 
100596471(MAP3K7)
MCC: 
703101(MAP3K7)
MCF: 
102140498(MAP3K7)
CSAB: 
103240115(MAP3K7)
RRO: 
104657888(MAP3K7)
RBB: 
108539499(MAP3K7)
CJC: 
100403175(MAP3K7)
SBQ: 
101045636(MAP3K7)
MMU: 
26409(Map3k7)
RNO: 
100910771 313121(Map3k7)
CGE: 
100774341(Map3k7)
NGI: 
103739547(Map3k7)
HGL: 
101718269(Map3k7)
CCAN: 
109698497(Map3k7)
OCU: 
100343571(MAP3K7)
TUP: 
102477331(MAP3K7)
CFA: 
102156745(MAP3K7)
AML: 
100466506(MAP3K7)
UMR: 
103660092(MAP3K7)
ORO: 
101376824(MAP3K7)
FCA: 
101095899(MAP3K7)
PTG: 
102963341(MAP3K7)
AJU: 
106983077(MAP3K7)
BTA: 
529146(MAP3K7)
BOM: 
102264816(MAP3K7)
BIU: 
109563902(MAP3K7)
PHD: 
102316264(MAP3K7)
CHX: 
102172719(MAP3K7)
OAS: 
101108056(MAP3K7)
SSC: 
100135663(MAP3K7)
CFR: 
102519538(MAP3K7)
CDK: 
105095522(MAP3K7)
BACU: 
103019299(MAP3K7)
LVE: 
103075340(MAP3K7)
OOR: 
101283961(MAP3K7)
ECB: 
100065841(MAP3K7)
EPZ: 
103548805(MAP3K7)
EAI: 
106847421(MAP3K7)
MYB: 
102254118(MAP3K7)
MYD: 
102763957(MAP3K7)
HAI: 
109389465(MAP3K7)
RSS: 
109453514(MAP3K7)
PALE: 
102882452(MAP3K7)
LAV: 
100667170(MAP3K7)
TMU: 
101346094
MDO: 
100019975(MAP3K7)
SHR: 
100920997(MAP3K7)
OAA: 
100076229(MAP3K7)
GGA: 
421808(MAP3K7)
MGP: 
100539749(MAP3K7)
CJO: 
107311964(MAP3K7)
APLA: 
101800996(MAP3K7)
ACYG: 
106035399(MAP3K7)
TGU: 
100221443(MAP3K7)
GFR: 
102039929(MAP3K7)
FAB: 
101814532(MAP3K7)
PHI: 
102107403(MAP3K7)
PMAJ: 
107201717(MAP3K7)
CCW: 
104692210(MAP3K7)
FPG: 
101917746(MAP3K7)
FCH: 
102058816(MAP3K7)
CLV: 
110354865
EGZ: 
104135405(MAP3K7)
AAM: 
106489690(MAP3K7)
ASN: 
102386999(MAP3K7)
AMJ: 
102569201(MAP3K7)
CMY: 
102936052(MAP3K7)
CPIC: 
101931315(MAP3K7)
ACS: 
100554725(map3k7)
PVT: 
110074609(MAP3K7)
PBI: 
103067633(MAP3K7)
GJA: 
107114874(MAP3K7)
XLA: 
379399(map3k7.S) 399459(map3k7.L)
XTR: 
100101764(map3k7)
NPR: 
108800110(MAP3K7)
DRE: 
553788(map3k7)
SRX: 
107737344 107755269
SANH: 
107665363 107683934
SGH: 
107597461 107601937
CCAR: 
109064262 109089706
IPU: 
108256841(map3k7)
AMEX: 
103039333(map3k7)
TRU: 
101063524(map3k7)
TNG: 
GSTEN00000761G001 GSTEN00010129G001
LCO: 
104924081(map3k7) 104928162
NCC: 
104947845 104967255
MZE: 
101475992 101484924(map3k7)
OLA: 
101164271(map3k7) 105356874
XMA: 
102226534(map3k7) 102232287
PRET: 
103457977(map3k7) 103458953
NFU: 
107395980(map3k7)
CSEM: 
103380691(map3k7)
LCF: 
108897885 108899288(map3k7)
HCQ: 
109509350(map3k7) 109529256
BPEC: 
110154967 110171242(map3k7)
SASA: 
100196829(map3k7) 106571331 106572417 106610755
ELS: 
105015746 105017873(map3k7)
SFM: 
108929345(map3k7)
LCM: 
102358159(MAP3K7)
CMK: 
103178276(map3k7)
BFO: 
BRAFLDRAFT_125878
CIN: 
778771(tak1/mapkkk7)
SPU: 
590951
APLC: 
110983312
SKO: 
100313751
DME: 
Dmel_CG18492(Tak1) Dmel_CG31421(Takl1) Dmel_CG4803(Takl2)
DPO: 
Dpse_GA14958 Dpse_GA16242 Dpse_GA18443
DAN: 
Dana_GF15984 Dana_GF18291 Dana_GF18313 Dana_GF18314
DER: 
Dere_GG12489 Dere_GG15158 Dere_GG17579
DPE: 
Dper_GL15931 Dper_GL23779 Dper_GL27129
DSE: 
Dsec_GM22666 Dsec_GM23162 Dsec_GM23620
DSI: 
Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD20035(Dsim_GD20035)
DWI: 
Dwil_GK20056
DYA: 
Dyak_GE15342(Dyak_Tak1)
DGR: 
Dgri_GH10917 Dgri_GH14242 Dgri_GH16081 Dgri_GH17233 Dgri_GH17735 Dgri_GH23480
DMO: 
Dmoj_GI15482 Dmoj_GI16905 Dmoj_GI17788 Dmoj_GI23232 Dmoj_GI26970
DVI: 
Dvir_GJ14078 Dvir_GJ17190 Dvir_GJ19194 Dvir_GJ20893 Dvir_GJ22892 Dvir_GJ26047 Dvir_GJ26873
MDE: 
101898114
AGA: 
AgaP_AGAP013516
AAG: 
5568685
CQU: 
CpipJ_CPIJ006370
AME: 
413809(Tak1)
BIM: 
100746656
BTER: 
100631093
SOC: 
105207936
AEC: 
105150983
ACEP: 
105619960
PBAR: 
105427629
HST: 
105187438
CFO: 
105256050
LHU: 
105676340
PGC: 
109853437
NVI: 
100120628
TCA: 
656961(Tak1)
DPA: 
109538196
NVL: 
108560912
BMOR: 
101744000
DPL: 
KGM_200403
PMAC: 
106721022
PRAP: 
110998182
PXY: 
105380044
API: 
100159713
DNX: 
107169096
PHU: 
Phum_PHUM125410
ZNE: 
110836178
FCD: 
110853786
DPX: 
DAPPUDRAFT_301643
ISC: 
IscW_ISCW023496
TUT: 
107362121
CEL: 
CELE_Y105C5A.24(Y105C5A.24)
BMY: 
Bm1_26085
LOA: 
LOAG_02503
HRO: 
HELRODRAFT_69369
LGI: 
LOTGIDRAFT_217017
CRG: 
105332318
MYI: 
110455078
OBI: 
106880926
LAK: 
106156738 106163922
SMM: 
Smp_058790
SHX: 
MS3_10386
OVI: 
T265_06651
NVE: 
NEMVE_v1g87118
EPA: 
110249937
ADF: 
107335569
HMG: 
100206143 100206191
TAD: 
TRIADDRAFT_25066
BOE: 
106339201
CPAP: 
110806865
CCAJ: 
109817926
MTR: 
MTR_5g019700
CAM: 
101505952
OEU: 
111411346
CRE: 
CHLREDRAFT_173118 CHLREDRAFT_182152
MNG: 
MNEG_3565 MNEG_7011
MIS: 
MICPUN_81795
CVR: 
CHLNCDRAFT_50283
APRO: 
F751_0620 F751_5403
GSL: 
Gasu_62740
EIV: 
EIN_082010 EIN_116490 EIN_122830 EIN_143500 EIN_217240 EIN_220700 EIN_266660 EIN_391770 EIN_401340 EIN_451980 EIN_497030
ACAN: 
ACA1_092060 ACA1_332830
SMIN: 
v1.2.003218.t1(symbB.v1.2.003218.t1) v1.2.003218.t2(symbB.v1.2.003218.t2) v1.2.005256.t1(symbB.v1.2.005256.t1) v1.2.010154.t1(symbB.v1.2.010154.t1)
PIF: 
PITG_01824 PITG_17576 PITG_20767 PITG_20772
PSOJ: 
PHYSODRAFT_260691 PHYSODRAFT_289074 PHYSODRAFT_489243 PHYSODRAFT_494891 PHYSODRAFT_496725 PHYSODRAFT_506773 PHYSODRAFT_516459 PHYSODRAFT_518438 PHYSODRAFT_520072 PHYSODRAFT_565559
SPAR: 
SPRG_01258 SPRG_06533 SPRG_06534 SPRG_07990 SPRG_08663 SPRG_09304 SPRG_11593 SPRG_12270 SPRG_12770 SPRG_13523 SPRG_14201 SPRG_15119 SPRG_15120 SPRG_15195 SPRG_15453 SPRG_16387 SPRG_18684 SPRG_20248 SPRG_21534
EHX: 
EMIHUDRAFT_113443 EMIHUDRAFT_117187 EMIHUDRAFT_118901 EMIHUDRAFT_54259 EMIHUDRAFT_54443
GTT: 
GUITHDRAFT_116496 GUITHDRAFT_116789 GUITHDRAFT_151198 GUITHDRAFT_153870 GUITHDRAFT_164427 GUITHDRAFT_165367 GUITHDRAFT_40459 GUITHDRAFT_41962 GUITHDRAFT_45897 GUITHDRAFT_53290 GUITHDRAFT_58972 GUITHDRAFT_69012 GUITHDRAFT_72031
NGR: 
NAEGRDRAFT_30678 NAEGRDRAFT_64576
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9079627
  Authors
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E
  Title
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
  Journal
J Biol Chem 272:8141-4 (1997)
DOI:10.1074/jbc.272.13.8141
  Sequence
[hsa:6885]
Reference
PMID:9480845
  Authors
Sakurai H, Shigemori N, Hasegawa K, Sugita T
  Title
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
  Journal
Biochem Biophys Res Commun 243:545-9 (1998)
DOI:10.1006/bbrc.1998.8124
  Sequence
[hsa:6885]
DBGET integrated database retrieval system