KEGG   ORTHOLOGY: K04430Help
Entry
K04430                      KO                                     

Name
MAP2K4, MKK4
Definition
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Toll-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
GnRH signaling pathway
Relaxin signaling pathway
Epithelial cell signaling in Helicobacter pylori infection
Chagas disease (American trypanosomiasis)
Hepatitis B
Influenza A
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Fluid shear stress and atherosclerosis
Module
M00688  
MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05166 HTLV-I infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05164 Influenza A
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05142 Chagas disease (American trypanosomiasis)
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
6416(MAP2K4)
PTR: 
455065(MAP2K4)
PPS: 
100991495(MAP2K4)
GGO: 
PON: 
NLE: 
100587718(MAP2K4)
MCC: 
718155(MAP2K4)
MCF: 
102125035(MAP2K4)
CSAB: 
103242403(MAP2K4)
RRO: 
104672345(MAP2K4)
RBB: 
108517313(MAP2K4)
CJC: 
100386168(MAP2K4)
SBQ: 
101037589(MAP2K4)
MMU: 
26398(Map2k4)
RNO: 
287398(Map2k4)
CGE: 
100770977(Map2k4)
NGI: 
103752052(Map2k4)
HGL: 
101705822(Map2k4)
CCAN: 
109693003(Map2k4)
OCU: 
100344852(MAP2K4)
TUP: 
102493856(MAP2K4)
CFA: 
489508(MAP2K4)
AML: 
100475919(MAP2K4)
UMR: 
103660510(MAP2K4)
FCA: 
101086432(MAP2K4)
PTG: 
102966812(MAP2K4)
AJU: 
106986552(MAP2K4)
BTA: 
526469(MAP2K4)
BOM: 
102287278(MAP2K4)
BIU: 
109573969(MAP2K4)
PHD: 
102333652(MAP2K4)
CHX: 
102175799(MAP2K4)
OAS: 
101115045(MAP2K4)
SSC: 
100520100(MAP2K4)
CFR: 
102513578(MAP2K4)
CDK: 
105095916(MAP2K4)
BACU: 
103012105(MAP2K4)
LVE: 
103091203(MAP2K4)
ECB: 
100073094(MAP2K4)
EPZ: 
EAI: 
106845730(MAP2K4)
MYB: 
102244251(MAP2K4)
MYD: 
102769098(MAP2K4)
HAI: 
109389137(MAP2K4)
RSS: 
109460161(MAP2K4)
PALE: 
102894945(MAP2K4)
LAV: 
100655007(MAP2K4)
MDO: 
100019828(MAP2K4)
SHR: 
100931587(MAP2K4)
OAA: 
GGA: 
417312(MAP2K4)
MGP: 
100544828(MAP2K4)
CJO: 
107322213(MAP2K4)
APLA: 
101805315(MAP2K4)
ACYG: 
106047193(MAP2K4)
TGU: 
100219801(MAP2K4)
GFR: 
102037348(MAP2K4)
FAB: 
101822010(MAP2K4)
PHI: 
102102585(MAP2K4)
PMAJ: 
107212510(MAP2K4)
CCW: 
104695676(MAP2K4)
FPG: 
101918161(MAP2K4)
FCH: 
102047307(MAP2K4)
CLV: 
102085780(MAP2K4)
AAM: 
106496868(MAP2K4)
ASN: 
102379245(MAP2K4)
AMJ: 
102577347(MAP2K4)
PSS: 
102452927(MAP2K4)
CMY: 
CPIC: 
101939128(MAP2K4)
ACS: 
100556629(map2k4)
PVT: 
110075065(MAP2K4)
PBI: 
103061657(MAP2K4)
GJA: 
107123125(MAP2K4)
XLA: 
399471(map2k4.L) 431908(map2k4.S)
XTR: 
100135013(map2k4)
NPR: 
108801499(MAP2K4)
DRE: 
403052(map2k4a) 568951(map2k4b)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
108940146(map2k4)
LCM: 
102352547(MAP2K4)
CMK: 
103175698(map2k4)
BFO: 
CIN: 
778672(mapkk4)
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20857(Dsim_GD20857)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
410575(MAPKK4)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG01940(Cbr-mkk-4)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
EPA: 
HMG: 
TAD: 
AQU: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7716521
  Authors
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M
  Title
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
  Journal
Science 268:286-90 (1995)
DOI:10.1126/science.7716521
  Sequence
[hsa:6416]

KEGG   ORTHOLOGY: K04431Help
Entry
K04431                      KO                                     

Name
MAP2K7, MKK7
Definition
mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
ErbB signaling pathway
MAPK signaling pathway - fly
Protein processing in endoplasmic reticulum
Apoptosis - fly
Osteoclast differentiation
Tight junction
Toll-like receptor signaling pathway
Toll and Imd signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Relaxin signaling pathway
Influenza A
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Fluid shear stress and atherosclerosis
Module
M00688  
MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04012 ErbB signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04668 TNF signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Cellular Processes
  Cell growth and death
   04214 Apoptosis - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Cellular community - eukaryotes
   04530 Tight junction
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04660 T cell receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04664 Fc epsilon RI signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Endocrine system
   04912 GnRH signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04926 Relaxin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Nervous system
   04722 Neurotrophin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Development
   04380 Osteoclast differentiation
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Infectious diseases
   05164 Influenza A
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05169 Epstein-Barr virus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5609(MAP2K7)
PTR: 
743199(MAP2K7)
PPS: 
100989537(MAP2K7)
GGO: 
101124339(MAP2K7)
PON: 
100431600(MAP2K7)
NLE: 
100587140(MAP2K7)
MCC: 
710077(MAP2K7)
MCF: 
102126975(MAP2K7)
CSAB: 
103233823(MAP2K7)
RRO: 
104679497(MAP2K7)
RBB: 
108534524(MAP2K7)
CJC: 
100412930(MAP2K7)
SBQ: 
101047840(MAP2K7)
MMU: 
26400(Map2k7)
RNO: 
363855(Map2k7)
CGE: 
100754421(Map2k7)
NGI: 
103726522(Map2k7)
HGL: 
101710666(Map2k7)
CCAN: 
109698434(Map2k7)
OCU: 
103345313(MAP2K7)
TUP: 
102500732(MAP2K7)
CFA: 
485004(MAP2K7)
AML: 
100475975(MAP2K7)
UMR: 
103681888(MAP2K7)
FCA: 
101095157(MAP2K7)
PTG: 
102949140(MAP2K7)
AJU: 
106970785(MAP2K7)
BTA: 
787278(MAP2K7)
BOM: 
102272638(MAP2K7)
BIU: 
109560948(MAP2K7)
PHD: 
102327200(MAP2K7)
CHX: 
102173178(MAP2K7)
OAS: 
100302082(MAP2K7)
SSC: 
100520418(MAP2K7)
CFR: 
102506459(MAP2K7)
CDK: 
105087572(MAP2K7)
BACU: 
103011683(MAP2K7)
LVE: 
103091499(MAP2K7)
ECB: 
100147230(MAP2K7)
EPZ: 
103543808(MAP2K7)
EAI: 
106844503(MAP2K7)
MYB: 
102247950(MAP2K7)
MYD: 
102760954(MAP2K7)
HAI: 
109396087(MAP2K7)
RSS: 
109434721(MAP2K7)
PALE: 
102892533(MAP2K7)
LAV: 
100673238(MAP2K7)
MDO: 
100026752(MAP2K7)
SHR: 
100926110(MAP2K7)
OAA: 
100089737(MAP2K7)
GGA: 
CJO: 
APLA: 
101794019(MAP2K7)
GFR: 
102038813(MAP2K7)
FAB: 
PHI: 
102100701(MAP2K7)
PMAJ: 
107198843(MAP2K7)
FPG: 
101924219(MAP2K7)
FCH: 
102048069(MAP2K7)
CLV: 
ASN: 
102372350(MAP2K7)
AMJ: 
102562496(MAP2K7)
PSS: 
102463924(MAP2K7)
CMY: 
102932325(MAP2K7)
CPIC: 
101931768(MAP2K7)
ACS: 
100566152(map2k7)
PVT: 
110082669(MAP2K7)
PBI: 
103066234(MAP2K7)
GJA: 
107117671(MAP2K7)
XLA: 
108712658 394391(map2k7.S)
XTR: 
613115(map2k7)
NPR: 
108790540(MAP2K7)
DRE: 
560913(map2k7)
SRX: 
SANH: 
SGH: 
IPU: 
108258614(map2k7)
AMEX: 
103024363(map2k7)
TRU: 
101064650(map2k7)
TNG: 
LCO: 
104934939(map2k7)
NCC: 
104951572(map2k7)
MZE: 
101475777(map2k7)
OLA: 
101164950(map2k7)
XMA: 
102238025(map2k7)
CSEM: 
103383563(map2k7)
LCF: 
108875834(map2k7)
HCQ: 
109511101(map2k7)
BPEC: 
110166191(map2k7)
SASA: 
ELS: 
105021508(map2k7)
SFM: 
108939797(map2k7)
LCM: 
102365163(MAP2K7)
CMK: 
103173024(map2k7)
BFO: 
CIN: 
778674(mapkk7)
SPU: 
APLC: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15909(Dsim_GD15909)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
CQU: 
AME: 
413389(hem)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG16698(Cbr-mek-1)
NAI: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
SMM: 
OVI: 
NVE: 
EPA: 
ADF: 
HMG: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9372971
  Authors
Wu Z, Wu J, Jacinto E, Karin M
  Title
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
  Journal
Mol Cell Biol 17:7407-16 (1997)
DOI:10.1128/MCB.17.12.7407
  Sequence
[hsa:5609]

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