KEGG   ORTHOLOGY: K04430Help
Entry
K04430                      KO                                     

Name
MAP2K4, MKK4
Definition
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04620  Toll-like receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04912  GnRH signaling pathway
ko04926  Relaxin signaling pathway
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05164  Influenza A
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05418  Fluid shear stress and atherosclerosis
Module
M00688  MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05166 HTLV-I infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05164 Influenza A
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05142 Chagas disease (American trypanosomiasis)
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 6416(MAP2K4)
PTR: 455065(MAP2K4)
PPS: 100991495(MAP2K4)
GGO: 101143954(MAP2K4) 101154090
PON: 100439299(MAP2K4)
NLE: 100587718(MAP2K4)
MCC: 718155(MAP2K4)
MCF: 102125035(MAP2K4)
CSAB: 103242403(MAP2K4)
RRO: 104672345(MAP2K4)
RBB: 108517313(MAP2K4)
CJC: 100386168(MAP2K4)
SBQ: 101037589(MAP2K4)
MMU: 26398(Map2k4)
RNO: 287398(Map2k4)
CGE: 100770977(Map2k4)
NGI: 103752052(Map2k4)
HGL: 101705822(Map2k4)
CCAN: 109693003(Map2k4)
OCU: 100344852(MAP2K4)
TUP: 102493856(MAP2K4)
CFA: 489508(MAP2K4)
AML: 100475919(MAP2K4)
UMR: 103660510(MAP2K4)
ORO: 101386473(MAP2K4)
FCA: 101086432(MAP2K4)
PTG: 102966812(MAP2K4)
AJU: 106986552(MAP2K4)
BTA: 526469(MAP2K4)
BOM: 102287278(MAP2K4)
BIU: 109573969(MAP2K4)
PHD: 102333652(MAP2K4)
CHX: 102175799(MAP2K4)
OAS: 101115045(MAP2K4)
SSC: 100520100(MAP2K4)
CFR: 102513578(MAP2K4)
CDK: 105095916(MAP2K4)
BACU: 103012105(MAP2K4)
LVE: 103091203(MAP2K4)
OOR: 101270607(MAP2K4)
ECB: 100073094(MAP2K4)
EPZ: 103567795
EAI: 106845730(MAP2K4)
MYB: 102244251(MAP2K4)
MYD: 102769098(MAP2K4)
HAI: 109389137(MAP2K4)
RSS: 109460161(MAP2K4)
PALE: 102894945(MAP2K4)
LAV: 100655007(MAP2K4)
TMU: 101349700
MDO: 100019828(MAP2K4)
SHR: 100931587(MAP2K4)
OAA: 100091407
GGA: 417312(MAP2K4)
MGP: 100544828(MAP2K4)
CJO: 107322213(MAP2K4)
APLA: 101805315(MAP2K4)
ACYG: 106047193(MAP2K4)
TGU: 100219801(MAP2K4)
GFR: 102037348(MAP2K4)
FAB: 101822010(MAP2K4)
PHI: 102102585(MAP2K4)
PMAJ: 107212510(MAP2K4)
CCW: 104695676(MAP2K4)
FPG: 101918161(MAP2K4)
FCH: 102047307(MAP2K4)
CLV: 102085780(MAP2K4)
EGZ: 104133811(MAP2K4)
AAM: 106496868(MAP2K4)
ASN: 102379245(MAP2K4)
AMJ: 102577347(MAP2K4)
PSS: 102452927(MAP2K4)
CMY: 102929430
CPIC: 101939128(MAP2K4)
ACS: 100556629(map2k4)
PVT: 110075065(MAP2K4)
PBI: 103061657(MAP2K4)
GJA: 107123125(MAP2K4)
XLA: 399471(map2k4.L) 431908(map2k4.S)
XTR: 100135013(map2k4)
NPR: 108801499(MAP2K4)
DRE: 403052(map2k4a) 568951(map2k4b)
SANH: 107654000(map2k4) 107695698
IPU: 108272999(map2k4) 108274195
AMEX: 103042940 103045018(map2k4)
NCC: 104946717(map2k4) 104947390
OLA: 101161098 101174917(map2k4)
XMA: 102225231 102232155(map2k4)
NFU: 107397308(map2k4) 107397353
CSEM: 103382416(map2k4) 103392559
LCF: 108873371(map2k4) 108890897
SFM: 108940146(map2k4)
LCM: 102352547(MAP2K4)
CMK: 103175698(map2k4)
CIN: 778672(mapkk4)
SPU: 589763
APLC: 110976118
SKO: 100329105
DME: Dmel_CG9738(Mkk4)
DSI: Dsimw501_GD20857(Dsim_GD20857)
MDE: 101894864
AAG: 5580276
AME: 410575(MAPKK4)
BIM: 100747905
BTER: 100652087
SOC: 105196567
AEC: 105148189
ACEP: 105627432
PBAR: 105430971
HST: 105185937
CFO: 105249095
LHU: 105671428
PGC: 109859606
NVI: 100119456
TCA: 662917
DPA: 109538313
NVL: 108569750
BMOR: 101735877
PMAC: 106718060
PRAP: 110993585
PXY: 105391083
API: 100161114
DNX: 107170671
ZNE: 110836450
FCD: 110859794
CEL: CELE_F42G10.2(mkk-4) CELE_VZC374L.1(sek-6)
CBR: CBG01940(Cbr-mkk-4)
BMY: Bm1_10515
TSP: Tsp_00085
CRG: 105345787
MYI: 110442146
OBI: 106873711
SHX: MS3_10235
EPA: 110238540
HMG: 100200909
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7716521
  Authors
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M
  Title
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
  Journal
Science 268:286-90 (1995)
DOI:10.1126/science.7716521
  Sequence
[hsa:6416]

KEGG   ORTHOLOGY: K04431Help
Entry
K04431                      KO                                     

Name
MAP2K7, MKK7
Definition
mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04141  Protein processing in endoplasmic reticulum
ko04214  Apoptosis - fly
ko04380  Osteoclast differentiation
ko04530  Tight junction
ko04620  Toll-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko04926  Relaxin signaling pathway
ko05164  Influenza A
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05418  Fluid shear stress and atherosclerosis
Module
M00688  MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04012 ErbB signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04668 TNF signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Cellular Processes
  Cell growth and death
   04214 Apoptosis - fly
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Cellular community - eukaryotes
   04530 Tight junction
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04660 T cell receptor signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04664 Fc epsilon RI signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Endocrine system
   04912 GnRH signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   04926 Relaxin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Nervous system
   04722 Neurotrophin signaling pathway
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Development
   04380 Osteoclast differentiation
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
  Infectious diseases
   05164 Influenza A
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
   05169 Epstein-Barr virus infection
    K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00688  MAPK (JNK) signaling
     K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5609(MAP2K7)
PTR: 743199(MAP2K7)
PPS: 100989537(MAP2K7)
GGO: 101124339(MAP2K7)
PON: 100431600(MAP2K7)
NLE: 100587140(MAP2K7)
MCC: 710077(MAP2K7)
MCF: 102126975(MAP2K7)
CSAB: 103233823(MAP2K7)
RRO: 104679497(MAP2K7)
RBB: 108534524(MAP2K7)
CJC: 100412930(MAP2K7)
SBQ: 101047840(MAP2K7)
MMU: 26400(Map2k7)
RNO: 363855(Map2k7)
CGE: 100754421(Map2k7)
NGI: 103726522(Map2k7)
HGL: 101710666(Map2k7)
CCAN: 109698434(Map2k7)
OCU: 103345313(MAP2K7)
TUP: 102500732(MAP2K7)
CFA: 485004(MAP2K7)
AML: 100475975(MAP2K7)
UMR: 103681888(MAP2K7)
ORO: 101382078(MAP2K7)
FCA: 101095157(MAP2K7)
PTG: 102949140(MAP2K7)
AJU: 106970785(MAP2K7)
BTA: 787278(MAP2K7)
BOM: 102272638(MAP2K7)
BIU: 109560948(MAP2K7)
PHD: 102327200(MAP2K7)
CHX: 102173178(MAP2K7)
OAS: 100302082(MAP2K7)
SSC: 100520418(MAP2K7)
CFR: 102506459(MAP2K7)
CDK: 105087572(MAP2K7)
BACU: 103011683(MAP2K7)
LVE: 103091499(MAP2K7)
OOR: 101288079(MAP2K7)
ECB: 100147230(MAP2K7)
EPZ: 103543808(MAP2K7)
EAI: 106844503(MAP2K7)
MYB: 102247950(MAP2K7)
MYD: 102760954(MAP2K7)
HAI: 109396087(MAP2K7)
RSS: 109434721(MAP2K7)
PALE: 102892533(MAP2K7)
LAV: 100673238(MAP2K7)
TMU: 101346746
MDO: 100026752(MAP2K7)
SHR: 100926110(MAP2K7)
OAA: 100089737(MAP2K7)
GGA: 107050551
CJO: 107307804
APLA: 101794019(MAP2K7)
GFR: 102038813(MAP2K7)
PHI: 102100701(MAP2K7)
PMAJ: 107198843(MAP2K7)
FPG: 101924219(MAP2K7)
FCH: 102048069(MAP2K7)
EGZ: 104129979(MAP2K7)
ASN: 102372350(MAP2K7)
AMJ: 102562496(MAP2K7)
PSS: 102463924(MAP2K7)
CMY: 102932325(MAP2K7)
CPIC: 101931768(MAP2K7)
ACS: 100566152(map2k7)
PVT: 110082669(MAP2K7)
PBI: 103066234(MAP2K7)
GJA: 107117671(MAP2K7)
XLA: 108712658 394391(map2k7.S)
XTR: 613115(map2k7)
NPR: 108790540(MAP2K7)
DRE: 560913(map2k7)
SGH: 107567797(map2k7) 107602992
IPU: 108258614(map2k7)
AMEX: 103024363(map2k7)
TRU: 101064650(map2k7)
LCO: 104934939(map2k7)
NCC: 104951572(map2k7)
MZE: 101475777(map2k7)
OLA: 101164950(map2k7)
XMA: 102238025(map2k7)
PRET: 103467648(map2k7)
NFU: 107382265(map2k7)
CSEM: 103383563(map2k7)
LCF: 108875834(map2k7)
HCQ: 109511101(map2k7)
BPEC: 110166191(map2k7)
ELS: 105021508(map2k7)
SFM: 108939797(map2k7)
LCM: 102365163(MAP2K7)
CMK: 103173024(map2k7)
CIN: 778674(mapkk7)
SPU: 591137
APLC: 110986882
SKO: 100376238
DME: Dmel_CG4353(hep)
DSI: Dsimw501_GD15909(Dsim_GD15909)
MDE: 101892997
AAG: 5578019
AME: 413389(hem)
BIM: 100740833
BTER: 100631092
SOC: 105195984
AEC: 105151228
ACEP: 105619941
PBAR: 105424720
HST: 105185444
LHU: 105675778
PGC: 109857214
NVI: 100121060
TCA: 103315236(hep)
DPA: 109543217
NVL: 108566466
BMOR: 100862753
PMAC: 106711754
PRAP: 111002093
API: 100165019
DNX: 107167783
ZNE: 110838369
FCD: 110847803
TUT: 107371332
CEL: CELE_K08A8.1(mek-1)
CBR: CBG16698(Cbr-mek-1)
BMY: Bm1_27865
CRG: 105339236
MYI: 110464981
OBI: 106868012
EPA: 110244754
ADF: 107332902
HMG: 100201328
AQU: 100640493
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9372971
  Authors
Wu Z, Wu J, Jacinto E, Karin M
  Title
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.
  Journal
Mol Cell Biol 17:7407-16 (1997)
DOI:10.1128/MCB.17.12.7407
  Sequence
[hsa:5609]

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