KEGG   ORTHOLOGY: K04432Help
Entry
K04432                      KO                                     

Name
MAP2K3, MKK3
Definition
mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04218  Cellular senescence
ko04620  Toll-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05164  Influenza A
ko05169  Epstein-Barr virus infection
Module
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04010 MAPK signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04013 MAPK signaling pathway - fly
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04668 TNF signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 Cellular Processes
  Cell growth and death
   04218 Cellular senescence
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04624 Toll and Imd signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04664 Fc epsilon RI signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  Endocrine system
   04912 GnRH signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  Environmental adaptation
   04714 Thermogenesis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 Human Diseases
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  Infectious diseases
   05164 Influenza A
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05169 Epstein-Barr virus infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05145 Toxoplasmosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00689  MAPK (p38) signaling
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5606(MAP2K3)
PTR: 107972404
PPS: 100975020(MAP2K3)
GGO: 101145420(MAP2K3)
PON: 100457536(MAP2K3)
NLE: 100588703(MAP2K3)
MCC: 705195(MAP2K3)
MCF: 102116823(MAP2K3)
CSAB: 103242535(MAP2K3)
RRO: 104678467(MAP2K3)
RBB: 108521513(MAP2K3)
CJC: 100398593(MAP2K3)
SBQ: 101034633(MAP2K3)
MMU: 26397(Map2k3)
RNO: 108348082 303200(Map2k3)
CGE: 100756793(Map2k3)
NGI: 103724822(Map2k3)
HGL: 101718318(Map2k3)
CCAN: 109692052(Map2k3)
OCU: 100339953(MAP2K3)
TUP: 102499419(MAP2K3)
CFA: 489547(MAP2K3)
AML: 100476678(MAP2K3)
UMR: 103658475(MAP2K3)
ORO: 101378651(MAP2K3)
FCA: 101082274(MAP2K3)
PTG: 102949954(MAP2K3)
AJU: 106981449(MAP2K3)
BTA: 516039(MAP2K3)
BOM: 102267773(MAP2K3)
BIU: 109574182(MAP2K3)
PHD: 102315849(MAP2K3)
CHX: 102173967(MAP2K3)
OAS: 101122959(MAP2K3)
SSC: 110256149(MAP2K3)
CFR: 102523780(MAP2K3)
CDK: 105100607(MAP2K3)
BACU: 103019100(MAP2K3)
LVE: 103091611(MAP2K3)
OOR: 101275666(MAP2K3)
ECB: 100053481(MAP2K3)
EPZ: 103563092(MAP2K3)
EAI: 106825518(MAP2K3)
MYB: 102259712(MAP2K3)
MYD: 102765923(MAP2K3)
HAI: 109390353(MAP2K3)
RSS: 109437043(MAP2K3)
PALE: 102886389(MAP2K3)
LAV: 100675607(MAP2K3)
TMU: 101355711
MDO: 100016872(MAP2K3)
SHR: 100925586(MAP2K3)
OAA: 100080734(MAP2K3)
GGA: 416496(MAP2K3)
MGP: 100542290(MAP2K3)
CJO: 107320760(MAP2K3)
APLA: 101803371(MAP2K3)
ACYG: 106032094(MAP2K3)
TGU: 100229860(MAP2K3)
GFR: 102039295(MAP2K3)
FAB: 101809415(MAP2K3)
PHI: 102109535(MAP2K3)
PMAJ: 107211348(MAP2K3)
CCW: 104684789(MAP2K3)
FPG: 101919170(MAP2K3)
FCH: 102052703(MAP2K3)
CLV: 102085143(MAP2K3)
EGZ: 104132608(MAP2K3)
AAM: 106486833
ASN: 102383945(MAP2K3)
AMJ: 102566638(MAP2K3)
PSS: 102454019(MAP2K3)
CMY: 102939584(MAP2K3)
CPIC: 101936976(MAP2K3)
ACS: 100561588(map2k3)
PVT: 110087206(MAP2K3)
PBI: 103065723(MAP2K3)
GJA: 107120519
XLA: 108706146
SFM: 108923933(map2k3) 108941534
LCM: 102351267(MAP2K3)
CMK: 103185143
SKO: 102808764
DME: Dmel_CG12244(lic)
DSI: Dsimw501_GD24803(Dsim_lic)
MDE: 101897152
AAG: 5571505
AME: 725374(GB16739)
BIM: 100750211
BTER: 100650253
SOC: 105196733
AEC: 105144410
ACEP: 105622342
PBAR: 105431216
HST: 105192423
CFO: 105257778
LHU: 105669425
PGC: 109853168
NVI: 100120952
TCA: 661608
DPA: 109536941
NVL: 108559292
BMOR: 101744017
PMAC: 106718087
PRAP: 110992502
PXY: 105380228
API: 100164531
DNX: 107163491
ZNE: 110837639
FCD: 110850082
TSP: Tsp_02206
OBI: 106875802
SHX: MS3_03614
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8900184
  Authors
Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E
  Title
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.
  Journal
J Biol Chem 271:26981-8 (1996)
DOI:10.1074/jbc.271.43.26981
  Sequence
[hsa:5606] [mmu:26397]
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5606]

KEGG   ORTHOLOGY: K04433Help
Entry
K04433                      KO                                     

Name
MAP2K6, MKK6
Definition
mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04015  Rap1 signaling pathway
ko04212  Longevity regulating pathway - worm
ko04218  Cellular senescence
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05145  Toxoplasmosis
ko05164  Influenza A
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05418  Fluid shear stress and atherosclerosis
Module
M00689  MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Cellular Processes
  Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Development
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Human Diseases
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Infectious diseases
   05164 Influenza A
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00689  MAPK (p38) signaling
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5608(MAP2K6)
PTR: 468310(MAP2K6)
PPS: 100972424(MAP2K6)
GGO: 101142374(MAP2K6)
PON: 100448382(MAP2K6)
NLE: 100591256(MAP2K6)
MCC: 693914(MAP2K6)
MCF: 101925060(MAP2K6)
CSAB: 103243132(MAP2K6)
RRO: 104654038(MAP2K6)
RBB: 108523215(MAP2K6)
CJC: 100397389(MAP2K6)
SBQ: 101030219(MAP2K6)
MMU: 26399(Map2k6)
RNO: 114495(Map2k6)
CGE: 100771767(Map2k6)
NGI: 103742218(Map2k6)
HGL: 101703028(Map2k6)
CCAN: 109698990(Map2k6)
OCU: 100355230(MAP2K6)
TUP: 102482054(MAP2K6)
CFA: 480454(MAP2K6)
AML: 100469111(MAP2K6)
UMR: 103665687(MAP2K6)
ORO: 101382167(MAP2K6)
FCA: 101089813(MAP2K6)
PTG: 102966485(MAP2K6)
AJU: 106988444(MAP2K6)
BTA: 286883(MAP2K6)
BOM: 102272962(MAP2K6)
BIU: 109573853(MAP2K6)
PHD: 102317867(MAP2K6)
CHX: 102169516(MAP2K6)
OAS: 101115047(MAP2K6)
SSC: 100625946(MAP2K6)
CFR: 102519784(MAP2K6)
CDK: 105085694(MAP2K6)
BACU: 103012537(MAP2K6)
LVE: 103081641
OOR: 101280413(MAP2K6)
ECB: 100053056(MAP2K6)
EPZ: 103564566(MAP2K6)
EAI: 106830236(MAP2K6)
MYB: 102246913(MAP2K6)
MYD: 102759247(MAP2K6)
HAI: 109371344(MAP2K6)
RSS: 109448056(MAP2K6)
PALE: 102888822(MAP2K6)
LAV: 100662511(MAP2K6)
TMU: 101344286
MDO: 100029049(MAP2K6)
OAA: 100078394(MAP2K6)
GGA: 417445(MAP2K6)
MGP: 100545287(MAP2K6)
CJO: 107322198(MAP2K6)
APLA: 101799389(MAP2K6)
ACYG: 106034753(MAP2K6)
GFR: 102039445(MAP2K6)
FAB: 101819388(MAP2K6)
PHI: 102105268(MAP2K6)
PMAJ: 107212284(MAP2K6)
CCW: 104696025(MAP2K6)
FPG: 101913671(MAP2K6)
FCH: 102053088(MAP2K6)
CLV: 102086996(MAP2K6)
EGZ: 104132828(MAP2K6)
AAM: 106490233(MAP2K6)
ASN: 102373782(MAP2K6)
AMJ: 106736984(MAP2K6)
PSS: 102461243(MAP2K6)
CMY: 102942953(MAP2K6)
CPIC: 101935028(MAP2K6)
ACS: 100567963(map2k6)
PVT: 110077815(MAP2K6)
PBI: 103058491(MAP2K6)
GJA: 107122462(MAP2K6)
XLA: 379638(map2k6.L) 399150(map2k3)
XTR: 448132(map2k6)
DRE: 65239(map2k6)
SANH: 107684112
IPU: 108274084(map2k6)
AMEX: 111191499
TRU: 101064673 101073869(map2k6)
LCM: 102362389(MAP2K6)
CMK: 103175734(map2k6)
CIN: 778902(mapkk3/6)
SPU: 585817
APLC: 110980301
SKO: 102800622
CEL: CELE_R03G5.2(sek-1)
CBR: CBG16802(Cbr-sek-1)
BMY: Bm1_39990
MYI: 110465116
SHX: MS3_07915
EPA: 110248902
HMG: 100209591
AQU: 100633628
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5608]

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