KEGG   ORTHOLOGY: K04433Help
Entry
K04433                      KO                                     

Name
MAP2K6, MKK6
Definition
mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Pathway
MAPK signaling pathway
Rap1 signaling pathway
Longevity regulating pathway - worm
Cellular senescence
Osteoclast differentiation
Toll-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Amyotrophic lateral sclerosis (ALS)
Toxoplasmosis
Influenza A
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Fluid shear stress and atherosclerosis
Module
M00689  
MAPK (p38) signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Cellular Processes
  Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Development
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 Human Diseases
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  Infectious diseases
   05164 Influenza A
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00689  MAPK (p38) signaling
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5608(MAP2K6)
PTR: 
468310(MAP2K6)
PPS: 
100972424(MAP2K6)
GGO: 
101142374(MAP2K6)
PON: 
100448382(MAP2K6)
NLE: 
100591256(MAP2K6)
MCC: 
693914(MAP2K6)
MCF: 
101925060(MAP2K6)
CSAB: 
103243132(MAP2K6)
RRO: 
104654038(MAP2K6)
RBB: 
108523215(MAP2K6)
CJC: 
100397389(MAP2K6)
SBQ: 
101030219(MAP2K6)
MMU: 
26399(Map2k6)
RNO: 
114495(Map2k6)
CGE: 
100771767(Map2k6)
NGI: 
103742218(Map2k6)
HGL: 
101703028(Map2k6)
CCAN: 
109698990(Map2k6)
OCU: 
100355230(MAP2K6)
TUP: 
102482054(MAP2K6)
CFA: 
480454(MAP2K6)
AML: 
100469111(MAP2K6)
UMR: 
103665687(MAP2K6)
FCA: 
101089813(MAP2K6)
PTG: 
102966485(MAP2K6)
AJU: 
106988444(MAP2K6)
BTA: 
286883(MAP2K6)
BOM: 
102272962(MAP2K6)
BIU: 
109573853(MAP2K6)
PHD: 
102317867(MAP2K6)
CHX: 
102169516(MAP2K6)
OAS: 
101115047(MAP2K6)
SSC: 
100625946(MAP2K6)
CFR: 
102519784(MAP2K6)
CDK: 
105085694(MAP2K6)
BACU: 
103012537(MAP2K6)
LVE: 
ECB: 
100053056(MAP2K6)
EPZ: 
103564566(MAP2K6)
EAI: 
106830236(MAP2K6)
MYB: 
102246913(MAP2K6)
MYD: 
102759247(MAP2K6)
HAI: 
109371344(MAP2K6)
RSS: 
109448056(MAP2K6)
PALE: 
102888822(MAP2K6)
LAV: 
100662511(MAP2K6)
MDO: 
100029049(MAP2K6)
OAA: 
100078394(MAP2K6)
GGA: 
417445(MAP2K6)
MGP: 
100545287(MAP2K6)
CJO: 
107322198(MAP2K6)
APLA: 
101799389(MAP2K6)
ACYG: 
106034753(MAP2K6)
GFR: 
102039445(MAP2K6)
FAB: 
101819388(MAP2K6)
PHI: 
102105268(MAP2K6)
PMAJ: 
107212284(MAP2K6)
CCW: 
104696025(MAP2K6)
FPG: 
101913671(MAP2K6)
FCH: 
102053088(MAP2K6)
CLV: 
102086996(MAP2K6)
AAM: 
106490233(MAP2K6)
ASN: 
102373782(MAP2K6)
AMJ: 
106736984(MAP2K6)
PSS: 
102461243(MAP2K6)
CMY: 
102942953(MAP2K6)
CPIC: 
101935028(MAP2K6)
ACS: 
100567963(map2k6)
PVT: 
110077815(MAP2K6)
PBI: 
103058491(MAP2K6)
GJA: 
107122462(MAP2K6)
XLA: 
379638(map2k6.L) 399150(map2k3)
XTR: 
448132(map2k6)
DRE: 
65239(map2k6)
SRX: 
SANH: 
SGH: 
IPU: 
108274084(map2k6)
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102362389(MAP2K6)
CMK: 
103175734(map2k6)
BFO: 
CIN: 
778902(mapkk3/6)
SPU: 
SKO: 
CEL: 
CBR: 
CBG16802(Cbr-sek-1)
NAI: 
BMY: 
LOA: 
HRO: 
NVE: 
HMG: 
AQU: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5608]

DBGET integrated database retrieval system